Understanding and control of biodegradability of bioabsorbable Mg alloys

• Project/Area Number: 21300183
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: National Institute for Materials Science
• Principal Investigator: YAMAMOTO Akiko 独立行政法人物質・材料研究機構, 生体機能材料ユニット, グループリーダー (20343882)
• Co-Investigator(Kenkyū-buntansha): MUKAI Toshiji 神戸大学, 大学院工学研究科, 教授 (40254429) ; SHIMIZU Yoshinaka 東北大学, 大学院歯学研究科, 助教 (30302152)
• Project Period (FY): 2009 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2009: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
• Keywords: 生体機能材料 / 生体吸収性金属材料 / マグネシウム合金 / 生体内分解特性 / 生体適合性 / 組織制御

Research Abstract

Degradation properties of Mg alloys depend on the kind of alloys, which relates to the amount of gas cavity formed in the soft tissue surrounding the implant site. Extraordinary inflammation was not observed even for the Mg alloy having rapid degradation rate. The local pH increase due to the OH- release accompanying the degradation may suppress cell growth when it goes over the acceptable range of cells. Coating of pure Mg with bioabsorbable medical polymers is effective to reduce initial degradation rate of pure Mg and successfully improves cytocompatibility.

Research Products

• [Journal Article] Surface characterization and cytocompatibility evalution of silanized magnesium alloy AZ91 for biomedical applications (2012)
  • Author(s): A.Witecka, A.Yamamoto, H.Dybiec, W.Swieszkowski
  • Journal Title: Science and Technology of Advanced Materials Volume: 13巻 Issue: 6 Pages: 64214-64214
  • DOI: 10.1088/1468-6996/13/6/064214
  • Peer Reviewed
• [Journal Article] Characteristics and cytocompatibility of biodegradable polymer film on magnesium by spin coating (2012)
  • Author(s): L. Xu, A. Yamamoto
  • Journal Title: Colloids and Surfaces B: Biointerfaces Volume: 93巻 Pages: 67-74
  • DOI: 10.1016/j.colsurfb.2011.12.009
  • Peer Reviewed
• [Journal Article] In vitro degradation of biodegradable polymer-coated magnesium under cell culture condition (2012)
  • Author(s): L. Xu, A. Yamamoto
  • Journal Title: Applied Surface Science Volume: 258巻 Issue: 17 Pages: 6353-6358
  • DOI: 10.1016/j.apsusc.2012.03.036
  • Peer Reviewed
• [Journal Article] マグネシウム材の医療機器への適用 (2012)
  • Author(s): 山本玲子
  • Journal Title: アルトピア Volume: 42 Pages: 17-22
• [Journal Article] 生体内分解性材料としてのマグネシウム合金の医療応用 (2011)
  • Author(s): 山本玲子
  • Journal Title: 表面技術 Volume: 62巻 Pages: 204-210
  • NAID: 10028124601
  • Peer Reviewed
• [Presentation] 医療用Mg合金材料とその生体適合性 (2013)
  • Author(s): 山本 玲子
  • Organizer: 第48回高性能Mg合金創製加工研究会講演会、第4回先進Mg合金国際セミナー
  • Place of Presentation: 熊本大学（熊本市）
  • Invited
• [Presentation] Effect of nanostructure at the biointerface on cellular response (2012)
  • Author(s): A. Yamamoto
  • Organizer: WUT-NIMS-HHT Joint Symposium
  • Place of Presentation: ワルシャワ工科大(ワルシャワ・ポーランド)
  • Year and Date: 2012-10-16
• [Presentation] Improvement of cytocompability of magnesium alloy AZ91 by surface modification (2012)
  • Author(s): A.Witecka, A.Yamamoto, H.Dybiec, W.Swieszkowski
  • Organizer: IUMRS-ICEM2012
  • Place of Presentation: パシフィコ横浜(横浜市)
• [Presentation] Improvement of cytocompability of magnesium alloy AZ91 by surface modification (2012)
  • Author(s): A.Witecka, A.Yamamoto, H.Dybiec, W.Swieszkowski
  • Organizer: IUMRS-ICEM2012
  • Place of Presentation: パシフィコ横浜（横浜市）
• [Presentation] Effect of nanostructure at the biointerface on cellular response (2012)
  • Author(s): Akiko Yamamoto
  • Organizer: WUT-NIMS-HHT Joint Symposium
  • Place of Presentation: ワルシャワ工科大（ワルシャワ・ポーランド）
  • Invited
• [Presentation] 生体材料への適用について (2011)
  • Author(s): 山本玲子
  • Organizer: 平成23年度マグネシウムの利用に関する講演会
  • Place of Presentation: 江戸東京博物館(墨田区)(招待講演)
  • Year and Date: 2011-12-13
• [Presentation] Mg合金の医療応用と生体適合性評価 (2011)
  • Author(s): 山本玲子
  • Organizer: 東北大学金属材料研究所共同研究ワークショップ
  • Place of Presentation: 東北大学(仙台市)(招待講演)
  • Year and Date: 2011-09-29
• [Presentation] Biocompatibility Evaluation of Magnesium Alloys for Biomedical Application (2011)
  • Author(s): Akiko Yamamoto
  • Organizer: WUT-NIMS-HHT Joint Symposium
  • Place of Presentation: 物質・材料研究機構(つくば市)
  • Year and Date: 2011-07-21
• [Presentation] 生体吸収性金属材料とその評価 (2011)
  • Author(s): 山本玲子
  • Organizer: 第58回若手材料研究会
  • Place of Presentation: 名古屋工業大学(愛知県)
  • Year and Date: 2011-01-25
• [Presentation] Biocompatibility evaluation of Mg alloys for biomedical application (2010)
  • Author(s): A.Yamamoto
  • Organizer: 3rd WUT-NIMS-EMPA workshop 2010
  • Place of Presentation: EMPA(スイス)
• [Presentation] 医療用生体吸収性マグネシウム合金の研究開発動向 (2010)
  • Author(s): 山本玲子
  • Organizer: 軽金属学会 第118回春期大会
  • Place of Presentation: 関西大学(大阪市)
• [Presentation] 医療用生体吸収性マグネシウム合金の研究開発動向 (2010)
  • Author(s): 山本玲子
  • Organizer: 軽金属学会 第118回春期大会
  • Place of Presentation: 関西大学(大阪府)
• [Presentation] 生体吸収性金属材料の細胞適合性に及ぼす培養環境の影響 (2010)
  • Author(s): 山本玲子、神山祐子
  • Organizer: 日本金属学会2010年度秋期大会
  • Place of Presentation: 北海道大学(北海道)
• [Presentation] Biodegradation behavior of magnesium alloys in vitro and in vivo (2009)
  • Author(s): Akiko Yamamoto
  • Organizer: 2009 Fall Conf of the Korean Institute of Metals & Materials
  • Place of Presentation: EXCO, Daegu, Korea
  • Year and Date: 2009-11-22
• [Presentation] 生体吸収性マグネシウム合金の生体内分解挙動観察 (2009)
  • Author(s): 山本玲子
  • Organizer: 第31回日本バイオマテリアル学会大会
  • Place of Presentation: 京都テルサ(京都市)
  • Year and Date: 2009-11-17
• [Presentation] Cytocompatibility Evaluation of Biodegradable Magnesium Alloys (2009)
  • Author(s): A. Yamamoto
  • Organizer: 22nd European Conference on Biomaterials (ESB2009)
  • Place of Presentation: Beaulieu, Lausanne, Switzerland
  • Year and Date: 2009-09-09
• [Presentation] Cytocompatibility Evaluation of Biodegradable Magnesium Alloys (2009)
  • Author(s): Akiko Yamamoto
  • Organizer: 22^<nd> European Conference on Biomaterials(ESB2009)
  • Place of Presentation: Beaulieu, Lausanne, Switzerland
  • Year and Date: 2009-09-09
• [Presentation] Biocompatibility Evaluation of Biodegradable magnesium alloys (2009)
  • Author(s): A. Yamamoto
  • Organizer: ICMAT & IUMRS-ICA
  • Place of Presentation: Suntec, Singapore(シンガポール)
  • Year and Date: 2009-06-30
• [Presentation] Biocompatibility Evaluation of Biodegradable magnesium alloys (2009)
  • Author(s): Akiko Yamamoto
  • Organizer: ICMAT & IUMRS-ICA 2009
  • Place of Presentation: Suntec, Singapore
  • Year and Date: 2009-06-30