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Patho-mechanism ofdegenerated disc disorders of lumbar spine and development of the minimally invasive treatment system

Research Project

Project/Area Number 21300189
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical systems
Research InstitutionKobe University

Principal Investigator

NISHIDA Kotaro  神戸大学, 医学部附属病院, 講師 (00379372)

Co-Investigator(Kenkyū-buntansha) DOITA Minoru  神戸大学, 医学研究科, 医学研究員 (60237170)
MAENO Koichiro  神戸大学, 医学研究科, 助教 (70403269)
KAKUTANI Kenichiro  神戸大学, 医学部附属病院, 助教 (10533739)
Project Period (FY) 2009 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2009: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Keywords低侵襲治療システム / 椎間板変性 / 退行性脊椎疾患 / 腰部脊柱管狭窄症 / 椎間板ヘルニア / 低侵襲治療 / 腰痛 / Fas ligand / 棘突起間スペーサー
Research Abstract

Low back pain and associated spinal disorders including lumbardisc herniation (LDH) and lumbar spinal-canal stenosis (LSS) are formidable problems for society. In this study, we
1) established animal model of disc degeneration and investigated the significant factors for progressive disc degeneration, and developed a new strategy against degenerated disc;
2) developed and modified the novel implant which enable us for minimally invasive surgery against LSS patients;
3) developed LDH animal model and obtained useful data by analyzing this model, that can be potentially used for the new treatment for LDH patients.

Report

(5 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (60 results)

All 2013 2012 2011 2010 2009 Other

All Journal Article (14 results) (of which Peer Reviewed: 12 results) Presentation (37 results) (of which Invited: 2 results) Book (2 results) Patent(Industrial Property Rights) (7 results) (of which Overseas: 3 results)

  • [Journal Article] Fas ligand plays an important role for the production of pro-inflammatory cytokines in intervertebral disc nucleus pulposus cells2013

    • Author(s)
      Yamamoto J
    • Journal Title

      J Orthop Res

      Volume: 31(4) Issue: 4 Pages: 608-15

    • DOI

      10.1002/jor.22274

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 椎間板ヘルニアの病態2012

    • Author(s)
      高田 徹、 西田康太郎
    • Journal Title

      整形外科看護

      Volume: 17(6) Pages: 546-552

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Journal Article] Intervertebral disc and macrophage interaction induce mechanical hyperalgesia and cytokine production in a herniated disc model.2012

    • Author(s)
      Takada T, Nishida K, Maeno K, Kakutani K, Yurube T, Doita M, Kurosaka M
    • Journal Title

      Arthritis Rheum

      Volume: 64(8) Pages: 2601-2610

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloprote inases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration.2012

    • Author(s)
      Yurube T, Takada T, Suzuki T, Kakutani K, Maeno K, Doita M, Kurosaka M, Nishida K
    • Journal Title

      Arthritis Res Ther

      Volume: 14(2)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of percutaneously insertable/removable interspinous process spacer for treatment of posture-dependent lumbar spinal-canal stenosis: preclinical feasibility study using porcine model2012

    • Author(s)
      Nishida K, Doita M, Kakutani K, Maeno K, Yurube T, Kurosaka M
    • Journal Title

      Eur Spine J

      Volume: 21(6) Pages: 1178-1185

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 第8章 腰痛関連遺伝子 (1)腰痛と遺伝子 椎間板再生と遺伝子2012

    • Author(s)
      西田康太郎
    • Journal Title

      脊椎脊髄ジャーナル 特集 腰痛のサイエンス

      Volume: 25(4) Pages: 439-443

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Intervertebraldisc and macrophage interaction induce mechanical hyperalgesia and cytokine production in a herniated disc model2012

    • Author(s)
      T.Takada, et al
    • Journal Title

      Arthritus Rheum

      Volume: Mar(未定)(掲載確定)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modified house-keeping gene expression in a rat tail compression loading-induced disc degeneration model.2011

    • Author(s)
      Yurube T, Takada T, Hirata H, Kakutani K, Maeno K, Zhang Z, Yamamoto J, Doita M, Kurosaka M, Nishida K
    • Journal Title

      J Orthop Res

      Volume: 29(8) Pages: 1284-1290

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Modified house-keeping gene expression in a rat tail compression load ing-induced disc degeneration model2011

    • Author(s)
      T.Yurube, et al
    • Journal Title

      Journal of Orthopaedic Research

      Volume: 29(8) Issue: 8 Pages: 1284-90

    • DOI

      10.1002/jor.21406

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of percutaneously insertable/remobable interspinous process spacer for treatment of posture-dependent lumbar spinal-canal stenosis : preclinical feasibility study using porcine podel2011

    • Author(s)
      K.Nishida, et al
    • Journal Title

      Eur Spine J

      Volume: Dec(Epub ahead of print)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of silent mating type information regulator 2 homolog 1 and its role in human intervertebral disc cell homeostasis2011

    • Author(s)
      Z Zhang, et al
    • Journal Title

      Arthritis Res Ther

      Volume: 13(6)(Epub ahead of print)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modified house-keeping gene expression in a rat tail compression loading-induced disc degeneration model.2011

    • Author(s)
      T.Yurube, et al.
    • Journal Title

      Journal of Orthopaedic Research

      Volume: Epub ahead of print

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Matrix metalloproteinase (MMP)-3 gene up-regulation in a rat tail compression loading-induced disc degeneration model.2010

    • Author(s)
      Yurube T, Nishida K,Suzuki T, Kaneyama S, Zhang Z, Kakutani K, MaenoK, Takada T, Fujii M, Kurosaka M, Doita M
    • Journal Title

      J Orthop Res

      Volume: 28(8) Pages: 1026-1032

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Matrix Metalloproteinase(MMP)-3 Gene Up-regulation in a Rat Tail Compression Loading-induced Disc Degeneration Model

    • Author(s)
      T.Yurube, K, Nishida, et al.
    • Journal Title

      Journal of Orthopaedic Research (accepted, In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Rat tail static compression model mimics extracellular matrix metabolism related to apoptosis relative to autophagy in interverbral disc degeneration2012

    • Author(s)
      Yurube t., et al
    • Organizer
      ORS (Orthopaedic Research Society)
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] Rat tail static compression model with loading removal mimics differential early to late stages of intervertebral disc degeneration2012

    • Author(s)
      Hirata H., et al
    • Organizer
      ORS (Orthopaedic Research Society)
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] Fas-ligand plays an important role in the production of pro-inflammatory cytokines in the human nucleus pulposus cells2012

    • Author(s)
      Yamamoto J., et al
    • Organizer
      ORS (Orthopaedic Reseaurch Society)
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] 腰部脊柱管狭窄症の病態と、脊椎外科医が考える治療について2011

    • Author(s)
      西田康太郎
    • Organizer
      愛媛pain2011(日本疼痛学会/日本ペインクリニック学会共催)
    • Place of Presentation
      愛媛
    • Year and Date
      2011-07-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 細胞生物学的な椎間板変性指標の確立を目指して ラット椎間板変性モデルを用いた検討2011

    • Author(s)
      由留部崇, 他
    • Organizer
      日本整形外科学会
    • Place of Presentation
      (震災のためWeb開催)
    • Year and Date
      2011-05-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] 腰部脊柱管狭窄症に対する最小侵襲手術を目的とした腰椎棘突起間スペーサーの開発ヒト屍体と大型動物を用いた前臨床研究2011

    • Author(s)
      西田康太郎, 他
    • Organizer
      日本脊椎脊髄病学会
    • Place of Presentation
      (震災のためWeb開催)
    • Year and Date
      2011-04-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 腰部脊柱管狭窄症の病態と、脊椎外科医が考える治療について2011

    • Author(s)
      西田康太郎
    • Organizer
      愛媛ペイン 2011(第45回日本ペインクリニック学会 + 第33回日本疼痛学会共催)
    • Place of Presentation
      松山
    • Related Report
      2012 Final Research Report
  • [Presentation] 腰部脊柱管狭窄症に対する最小侵襲手術を目的とした腰椎棘突起間スペーサーの開発 -ヒト屍体と大型動物を用いた前臨床研究-2011

    • Author(s)
      西田康太郎、前野耕一郎、角谷賢一朗、由留部崇、張鐘穎、山本潤哉、平田裕亮、黒坂昌弘
    • Organizer
      第40回 日本脊椎脊髄病学会(震災のため Web 開催)
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト椎間板髄核細胞においてFas ligandは炎症性サイトカイン産生に関与する椎間板ヘルニアにおける疼痛発生機序の解明に向けて2011

    • Author(s)
      山本潤哉, 他
    • Organizer
      日本整形外科基礎学会
    • Place of Presentation
      前橋(群馬)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 圧不可を解除することで多様な変性段階の再現を可能にした新た尾椎椎間板圧迫モデル2011

    • Author(s)
      平田裕亮, 他
    • Organizer
      日本整形外科基礎学会
    • Place of Presentation
      前橋(群馬)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Fas-ligand plays an important role in the production of proinflammatory cytokines in human nucleus pulposus cells2011

    • Author(s)
      Yamamoto J, et al
    • Organizer
      ISSLS (International Society of Study of Lumbar Spine)
    • Place of Presentation
      Gothenburg, Sweden
    • Related Report
      2011 Annual Research Report
  • [Presentation] Prolonged aggrecanolytic activation of matrix metalloproteinases (MMPs) relative to aggrecanases in a rat tail compression loading-induced disc degeneration model2011

    • Author(s)
      Yurube t., et al
    • Organizer
      ISSLS (International Society of Study of Lumbar Spine)
    • Place of Presentation
      Gothenburg, Sweden
    • Related Report
      2011 Annual Research Report
  • [Presentation] Radiological difference between sitting and standing posture of patients with lumbar canal stenosis2011

    • Author(s)
      Nishida K, et al.
    • Organizer
      ISSLS (International Society of Study of Lumbar Spine)
    • Place of Presentation
      Gothenburg, Sweden
    • Related Report
      2011 Annual Research Report
  • [Presentation] Imbalanced catabolic and anabolic gene alterations in a rat tail compression loading-induced disc degeneration model2010

    • Author(s)
      Yurube T, Nishida K, Suzuki T, Zhang Z, Yamamoto J, Kakutani K, Maeno K, Takada T, Kurosaka M, Doita M
    • Organizer
      56th Orthopaedic Research Society(ORS)
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Activated mitochondrial pathway of apoptosis in a rat tail compression loading-induced disc degeneration model2010

    • Author(s)
      Yurube T, Nishida K, Suzuki T, Zhang Z, Yamamoto J, Kakutani K, Maeno K, Takada T, Kurosaka M, Doita M
    • Organizer
      56th ORS
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Actin-beta should not be used as an endogenous control in real-time RT-PCR for intervertebral disc research under mechanical loading stress condition2010

    • Author(s)
      Yurube T, Nishida K, Suzuki T, Zhang Z, Yamamono J, Kakutani K, Maeno K, Takada T, Iguchi T, Kurosaka M, Doita M
    • Organizer
      37th International Society for the Study of the Lumbar Spine (ISSLS)
    • Place of Presentation
      Auckland, New Zealand
    • Related Report
      2012 Final Research Report
  • [Presentation] Activated apoptotic mitochondrial pathway in a rat tail compression loading-induced disc degeneration model2010

    • Author(s)
      Yurube T, Nishida K, Suzuki T, Zhang Z, Yamamono J, Kakutani K, Maeno K, Takada T, Iguchi T, Kurosaka M, Doita M
    • Organizer
      37th ISSLS
    • Place of Presentation
      Auckland, New Zealand
    • Related Report
      2012 Final Research Report
  • [Presentation] Imbalanced catabolic relative to anabolic gene alterations in a rat tail compression loading-induced disc degeneration model.2010

    • Author(s)
      Yurube T, Nishida K, Suzuki T, Zhang Z, Yamamono J, Kakutani K, Maeno K, Takada T, Iguchi T, Kurosaka M, Doita M
    • Organizer
      37th ISSLS
    • Place of Presentation
      Auckland, New Zealand
    • Related Report
      2012 Final Research Report
  • [Presentation] Development of a novel percutaneously insertable/removable interspinous process spacer for treatment of LSS patients: feasibility study using porcine model.2010

    • Author(s)
      Nishida K, Doita M, Maeno K, Kakutani K, Yurube T, Zhang Z, Yamamoto J, Iguchi T, Kurosaka M
    • Organizer
      37th ISSLS
    • Place of Presentation
      Auckland, New Zealand
    • Related Report
      2012 Final Research Report
  • [Presentation] Actin-beta should not be used as an endogenous control in real-time RT-PCR for intervertebral disc research under mechanical loading stress condition2010

    • Author(s)
      T.Yurube, et al.
    • Organizer
      37th International Society for the Study of the Lumbar Spine(ISSLS)
    • Place of Presentation
      Auckland, (New Zealand)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Activated apoptotic mitochondrial pathway in a rat tail compression loading-induced disc degeneration model2010

    • Author(s)
      T.Yurube, K, et al.
    • Organizer
      37th International Society for the Study of the Lumbar Spine(ISSLS)
    • Place of Presentation
      Auckland, (New Zealand)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Imbalanced catabolic relative to anabolic gene alterations in a rattail compression loading-induced disc degeneration model2010

    • Author(s)
      T.Yurube, K, et al.
    • Organizer
      37th International Society for the Study of the Lumbar Spine(ISSLS)
    • Place of Presentation
      Auckland, (New Zealand)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of a novel percutaneously insertable/removable interspinous process spacer for treatment of LSS patients : feasibility study using porcine model2010

    • Author(s)
      K, Nishida, et al.
    • Organizer
      37th International Society for the Study of the Lumbar Spine(ISSLS)
    • Place of Presentation
      Auckland, (New Zealand)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Progressive Imbalances between catabolism and anabolism in a rattail compression losding-induced disc degeneration model2010

    • Author(s)
      T.Yurube, et al.
    • Organizer
      7th Combined Meeting of the Orthopaedic Research Societies
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cell metabolism related with apoptosis in a rat tail compression loading-induced disc degeneration model2010

    • Author(s)
      T.Yurube, et al.
    • Organizer
      38th Annual Meeting of Cervical Spine Research Society
    • Place of Presentation
      Charlotte, (USA)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腰部脊柱管狭窄症において症状が発現する立位と軽快する座位の違いはなにか-形態機能的解析-2010

    • Author(s)
      西田康太郎, 他
    • Organizer
      第83回日本整形外科学会学術
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腰部脊柱管狭窄症に対する最小侵襲手術を目的とした腰椎棘突起間スペーサーの開発2010

    • Author(s)
      西田康太郎, 他
    • Organizer
      第39回脊椎脊髄病学会
    • Place of Presentation
      高知県立県民文化ホール(高知県)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腰部脊柱管狭窄症の症状発現に関する姿勢因子の関与-症状が増悪する立位と軽快する座位における責任椎間の動きについて-2010

    • Author(s)
      西田康太郎, 他
    • Organizer
      第39回脊椎脊髄病学会
    • Place of Presentation
      高知県立県民文化ホール(高知県)
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラット尾椎椎間板圧迫モデルを用いた椎間板変性におけるアポトーシス機序の解明2010

    • Author(s)
      由留部崇, 他
    • Organizer
      第39回脊椎脊髄病学会
    • Place of Presentation
      高知県立県民文化ホール(高知県)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 椎間板とマクロファージの相互作用によって椎間板ヘルニアの疼痛に関与する炎症が形成される2010

    • Author(s)
      高田徹, 他
    • Organizer
      第25回日本整形外科学術集会基礎学術集会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 経皮的に挿入・抜去が可能な腰椎棘突起間スペーサーの開発 -腰部脊柱管狭窄症に対する最小侵襲手術をめざして-2009

    • Author(s)
      西田康太郎, ら
    • Organizer
      第24回 日本整形外科学会基礎学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-11-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 基質代謝関連遺伝子の発現変動からみた椎間板変性の機序 -ラット椎間板静的圧迫モデルを用いた長期の検討-2009

    • Author(s)
      由留部崇, 西田康太郎, ら
    • Organizer
      第24回 日本整形外科学会基礎学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-11-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 腰部脊柱管狭窄症に対する最少侵撃手術をめざした棘突起間スペーサーの開発 -Why not IPD?-2009

    • Author(s)
      西田康太郎, ら
    • Organizer
      第113回中部日本整形外科災害外科学術集会
    • Place of Presentation
      神戸国際展示場(兵庫県)
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脊椎疾患に伴う疼痛のメカニズムとその治療、今後の課題について

    • Author(s)
      西田康太郎
    • Organizer
      高知県脊椎疼痛を考える会
    • Place of Presentation
      高知
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 脊椎疾患に伴う慢性疼痛への対策と今後の課題

    • Author(s)
      西田康太郎
    • Organizer
      第25回日本臨床整形外科学会学術集会・関西
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 腰痛の保存的加療とその限界 -腰部脊柱管狭窄症を中心として-

    • Author(s)
      西田康太郎
    • Organizer
      第25回日本臨床整形外科学会学術集会・関西
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] Dominant involvement of apoptosis relative to autophagy in a rat tail sustained static compression loading-induced disc degeneration model.

    • Author(s)
      Takashi Yurube
    • Organizer
      39th International Society for the Study of the Lumber Spine
    • Place of Presentation
      Amsterdam
    • Related Report
      2012 Annual Research Report
  • [Book] Gene therapy applications Section8 : Potential gene therapy for intervertebral disc degeneration(分担)2011

    • Author(s)
      Nishida K., et al
    • Publisher
      Intech
    • Related Report
      2011 Annual Research Report
  • [Book] Gene Therapy Applications. Kang C (Ed) Captor 8: Potential gene therapy for intervertebral disc degeneration

    • Author(s)
      Nishida K, Maeno K, Kakutani K, Yurube T, Kurosaka M
    • Publisher
      Intech, Croatia
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 棘突起間の開大を目的とした低侵襲インプラントとそれを用いて棘突起間を経皮的に拡大する方法.2012

    • Inventor(s)
      西田康太郎
    • Industrial Property Rights Holder
      神戸大学
    • Acquisition Date
      2012-10-02
    • Related Report
      2012 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 棘突起間インプラント2011

    • Inventor(s)
      西田康太郎
    • Industrial Property Rights Holder
      神戸大学
    • Filing Date
      2011
    • Related Report
      2012 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 棘突起間の開大を目的とした低侵襲インプラントとそれを用いて棘突起間を経皮的に拡大する方法.2011

    • Inventor(s)
      西田康太郎
    • Industrial Property Rights Holder
      神戸大学
    • Acquisition Date
      2011-08-12
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 棘突起間インプラント2011

    • Inventor(s)
      西田康太郎
    • Industrial Property Rights Holder
      神戸大学
    • Filing Date
      2011-02-11
    • Related Report
      2010 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 棘突起間スペーサー,抜去用ドライバー,固定用内ネジ,手術用キットおよび棘突起間スペーサーの抜き去り方法.2010

    • Inventor(s)
      西田康太郎
    • Industrial Property Rights Holder
      神戸大学
    • Acquisition Date
      2010-09-10
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 棘突起間スペーサー、抜去用ドライバー、固定用内ネジ、手術用キットおよび棘突起間スペーサーの抜き去り法2010

    • Inventor(s)
      西田康太郎
    • Industrial Property Rights Holder
      神戸大学
    • Acquisition Date
      2010-09-10
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 棘起間インプラント2010

    • Inventor(s)
      西田康太郎
    • Industrial Property Rights Holder
      神戸大学
    • Industrial Property Number
      2010-052414
    • Filing Date
      2010-03-09
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2019-07-29  

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