Molecular design of protein-based nanocapsulesfor multifunctional platforms
| Project/Area Number |
21300190
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Kyushu University |
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Principal Investigator |
MURATA Masaharu 九州大学, 先端融合医療レドックスナビ研究拠点, 准教授 (30304744)
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| Co-Investigator(Kenkyū-buntansha) |
HASHIZUME Makoto 九州大学, 大学院・医学研究院, 教授 (90198664)
TABATA Shigekazu 九州大学, 大学院・薬学研究院, 学術研究員 (00538928)
TOITA Riki 九州大学, 先端融合医療レドックスナビ研究拠点, 特任助教 (40611554)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2009: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | ナノ材料 / 画像診断システム / 造影剤 / MRI / 癌 / 分子イメージング / ナノ構造体 / 機能化造影剤 |
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| Research Abstract |
The protein nanocapsules are self-organized complexes of protein oligomersand possess nanoscale inner cavities, and the three-dimensional architecture can be specified in complete detail. A variety of molecules including drugs and MRI contrast agents are encapsulated in the cavity. Such functionalized protein nanocapsules were applied to effective drug delivery, in vitro and in vivo bioimaging. The protein-based nanocapsules have the potential to offer special advantages in gaining new functions that show responsiveness to biochemical signals in many different cellular processes.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Gold nanoparticle-based colorimetric assay for cancer diagnosis2010
Author(s)
Jeong-Hun Kang, Yoji Asami, Masaharu Murata, Hirotaro Kitazaki, Noriaki Sadanaga, Eriko Tokunaga, Satoko Shiotani, Satoko Okada, Yoshihiko Maehara, Taktnu Niidome, Makoto Hashizume, Takeshi Mori, Yoshiki Katayama
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Journal Title
Biosensors and Bioelectronics
Volume: 25
Pages: 1869-1874
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[Journal Article] Nanoparticles of Adaptive Supramolecular Networks SelfAssembled from Nucleotides and Lanthanide Ions2009
Author(s)
Ryuhei Nishiyabu, Nozomi Hashimoto, Ten Cho, Kazuto Watanabe, Takefumi Yasunaga, Ayataka Endo, Kenji Kaneko, Talcum Niidome, Masaharu Murata, Chihaya Adarhi, Yoshild Katayama, Makoto Hashizume, and Nobuo Kimizuka
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Journal Title
Journal of the American Chemical Society
Volume: 131
Pages: 2151-2158
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[Journal Article] Liver cell specific targeting by the preSl domain of hepatitis B virus surface antigen displayed on protein nanocages
Author(s)
Masaharu Murata, Sayoko Narahara, Kaori Umezaki, Riki Toita, Shigekazu Tabata, , Jing Shu Piao, Kana Abe, Jeong-Hun Kang, Kenoki Oouchida, Lin Cul, Makoto Hashizume
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Journal Title
International Journal of Nanomedicine, in press
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