Development of non-invasive procedures for the diagnosis of chronic hepatitis and non-alcoholic steatohepatitis(NASH) using ultrasound technologies
Project/Area Number |
21300194
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Medical systems
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Research Institution | Hyogo Medical University |
Principal Investigator |
IIJIMA Hiroko 兵庫医科大学, 医学部, 教授 (80289066)
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Co-Investigator(Kenkyū-buntansha) |
NISHIGUCHI Shuhei 兵庫医科大学, 医学部, 教授 (10192246)
ARII Shigeki 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (50151171)
ICHINOSE Shizuko 東京医科歯科大学, 学内共同利用施設等, 助教 (60014156)
TANAKA Hiroshi 東京医科歯科大学, 大学院・疾患生命科学研究部, 教授 (60155158)
SATO Tetsuzi 鶴見大学, 歯学部, 教授 (10162447)
NISHIGAMI Takashi 兵庫医科大学, 医学部, 教授 (70131589)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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Keywords | 超音波医学 / 検査診断システム / 肝臓病学 / 画像診断学 |
Research Abstract |
The diagnostic performance of non-contrast enhanced ultrasound and contrast enhanced ultrasound(CEUS) for chronic hepatitis and non-alcoholic steatohepatitis(NASH) were evaluated. A new diagnostic method for chronic hepatitis was developed using Virtual Touch Tissue Quantification(VTTQ). The diagnosis of NASH by CEUS using Sonazoid was studied. Observations using intravital microscopy on a rat NASH model revealed that the uptake of Sonazoid by Kupffer cells(KCs) did not increase over time, and that was considered due to the decreased phagocytic ability of KCs. The diagnosis of NASH by VTTQ at early stages of the disease suggested some issues that still need to be explored.
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Report
(4 results)
Research Products
(75 results)
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[Journal Article] Cost-effectiveness analysis on the surveillance for hepatocellular carcinoma in liver cirrhosis patients using contrast-enhanced ultrasonography2012
Author(s)
Tanaka H, Iijima H, Nouso K, Aoki N, Iwai T, Takashima T, Sakai Y, Aizawa N, Iwata K, Ikeda N, Iwata Y, Enomoto H, Saito M, Imanishi H, Nishiguchi S.
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Journal Title
NAID
Related Report
Peer Reviewed
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[Journal Article] Acoustic Radiation Force Impulseによる非侵襲的肝線維化診断法の有用性2010
Author(s)
飯島尋子, 田中弘教, 吉田昌弘, 池田直人, 山本晃久, 岩田恵典, 榎本平之, 齋藤正紀, 今西宏安, 下村壯治, 中正恵二, 廣田誠一, 辻村亨, 西口修平
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Journal Title
肝臓
Volume: 51
Pages: 54-5
NAID
URL
Related Report
Peer Reviewed
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[Journal Article] Crucial role of impaired Kupffer cell phagocytosis on the decreased Sonazoid-enhanced echogenicity in a liver of a nonalchoholic steatohepatitis rat model2010
Author(s)
Yoshikawa S, Iijima H, Saito M, Tanaka H, Imanishi H, Yoshimoto N, Yoshimoto T, Futatsugi-Yumikura S, Nakanishi K, Tsujimura T, Nishigami T, Kudo A, Arii S, Nishiguchi S.
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Journal Title
Hepatol Res
Volume: 40
Pages: 823-31
NAID
URL
Related Report
Peer Reviewed
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[Presentation] Is ARFI elastography useful for fibrosis evaluation in patients with chronic HCV hepatitis in our clinical practice A multicenter international study2011
Author(s)
Sporea I, Sirli R, Bota S, Tanaka H, Iijima H, Badea R. I, Lupsor M, Fierbinteanu C, Takahashi H, Piscaglia F, D Onofrio M, Popescu A, Danila M.
Organizer
The 62th Annual Meeting of the American Association for the Study of Liver Diseases(AASLD2011)
Place of Presentation
San Francisco
Related Report
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[Presentation] VTTQ(Virtual Touch Tissue Quantification) for evaluation of liver tumors2011
Author(s)
Iijima H, Tanaka H, Yoshida M, Iwai T, Takashima T, Sakai Y, Aizawa N, Iwata K, Ikeda N, Iwata Y, Enomoto H, Saito M, Imanishi H, Iimuro Y, Fujimoto J, Nishiguchi S.
Organizer
The 62th Annual Meeting of the American Association for the Study of Liver Diseases(AASLD2011)
Place of Presentation
San Francisco
Related Report
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[Presentation] Usefulness of VTTQ(Virtual Touch Tissue Quantification) to diagnose fibrosis stage and liver tumors2011
Author(s)
Tanaka H, Iijima H, Yoshida M, Takashima T, Sakai Y, Aizawa N, Ikeda N, Iwata Y, Enomoto H, Saito M, Shimomura S, Imanishi H, Nishigami T, Fujimoto J, Hirota S, Nishiguchi S.
Organizer
46th Annual Meeting of the European Association for the Study of the Liver(EASL2011)
Place of Presentation
Berlin
Related Report
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[Presentation] Prediction of portal venous invasion by malignant grading system for Hepatocellular carcinoma using Sonazoid contrast enhanced ultrasonography2010
Author(s)
Tanaka H, Iijima H, Higashiura A, Aizawa N, Ikeda N, Enomoto H, Iwata Y, Saito M, Imanishi H, Shimomura S, Hirota S, Nishigami T, Tujimura T, Fujimoto J, Nishiguchi S.
Organizer
12th International symposium on ultrasound contrast imaging
Place of Presentation
Tokyo
Related Report
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[Presentation] Cost-effectiveness analysis on the surveillance for hepatocellular carcinoma in liver cirrhosis patients using contrast-enhanced ultrasonography2010
Author(s)
Tanaka H, Iijima H, Nouso K, Takashima T, Sakai Y, Aizawa N, Ikeda N, Iwata Y, Enomoto H, Saito M, Imanishi H, Shimomura S, Nishiguchi S.
Organizer
The 61th Annual Meeting of the American Association for the Study of Liver Diseases(AASLD2010)
Place of Presentation
Boston
Related Report
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[Presentation] Usefulness of VTTQ(Virtual Touch Tissue Quantification) to diagnose fibrosis and inflammation in chronic hepatitis2010
Author(s)
Iijima H, Tanaka H, Ikeda N, Enomoto H, Iwata Y, Imanishi H, Shimomura S, Fujimoto J, Hirota S, Tsujimura T, Mogushi K, Tanaka H, Nishiguchi S.
Organizer
The 61th Annual Meeting of the American Association for the Study of Liver Diseases(AASLD2010)
Place of Presentation
Boston
Related Report
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[Presentation] Malignant grading system using the contrast enhanced agent"Sonazoid"could predict portal venous invasion by Hepatocellular carcinoma?2010
Author(s)
Iijima H, Tanaka H, Aizawa N, Ikeda N, Enomoto H, Saito M, Imanishi H, Shimomura S, Iimuro Y, Fujimoto J, Nishiguchi S.
Organizer
The 61th Annual Meeting of the American Association for the Study of Liver Diseases(AASLD2010)
Place of Presentation
Boston
Related Report
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[Presentation] Kupffer細胞の形態からみたNASH発症の要因2010
Author(s)
田中弘教, 飯島尋子, 西口修平, 和氣健二郎, 市野瀬志津子, 工藤篤, 石井昭生, 高嶋智之, 坂井良行, 會澤信弘, 山本晃久, 池田直人, 岩田恵典, 榎本平之, 齋藤正紀, 今西宏安, 下村壯治, 有井滋樹
Organizer
第96回日本消化器病学会総会
Place of Presentation
新潟
Related Report
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[Presentation] Sonazoid造影超音波のKupffer相もおける高音圧画像評価の有用性2010
Author(s)
田中弘教, 飯島尋子, 東浦晶子, 楊和典, 岩井孝史, 石井昭生, 高嶋智之, 坂井良行, 會澤信弘, 山本晃久, 池田直人, 岩田恵典, 榎本平之, 齋藤正紀, 今西宏安, 下村壯治, 西口修平
Organizer
第96回日本消化器病学会総会
Place of Presentation
新潟
Related Report
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[Presentation] 肝線維化診断におけるAcoustic Radiation Force Impulse(ARFI)の有用性2009
Author(s)
吉田昌弘, 田中弘教, 山平正浩, 吉本直喜, 東浦晶子, 柴田陽子, 橋本眞里子, 會澤信弘, 斎藤雅博, 平山秀男, 齋藤正紀, 辻村亨, 廣田誠一, 西口修平, 飯島尋子
Organizer
日本超音波医学会第36回関西地方会学術集会
Place of Presentation
大阪
Year and Date
2009-10-03
Related Report
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[Presentation] Non-invasive diagnosis of liver fibrosis using virtual touch tissue quantification2009
Author(s)
Iijima H, Tanaka H, Saito M, Aizawa N, Yamamoto T, Enomoto H, Iwata Y, Imanishi H, Shimomura S, Yamanaka J, Fujimoto J, Hirota S, Tsujimura T, Nishiguchi S.
Organizer
The 60^<th> Annual Meeting of the American Association for the Study of Liver Diseases(AASLD2009)
Place of Presentation
Boston
Related Report
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[Presentation] 造影超音波検査を用いた輝度解析による慢性肝炎進展度の推定の試み2009
Author(s)
田中弘教, 飯島尋子, 齋藤正紀, 下村壯治, 今西宏安, 康典利, 榎本平之, 岩田恵典, 山本晃久, 會澤信弘, 坂井良行, 山田大輔, 中村秀次, 廣田誠一, 辻村亨, 西口修平
Organizer
第45回日本肝臓学会総会
Place of Presentation
神戸
Related Report
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[Presentation] 造影超音波によるピタバスタチンのNASH改善効果に関する検討2009
Author(s)
中野宏朗, 飯島尋子, 山田大輔, 坂井良行, 會澤信弘, 山本晃久, 岩田恵典, 田中弘教, 榎本平之, 康典利, 齋藤正紀, 今西宏安, 下村壯治, 中村秀次, 西口修平
Organizer
第45回日本肝臓学会総会
Place of Presentation
神戸
Related Report
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[Presentation] NASHラットモデル(MCDDラット)におけるクッパー細胞の貪食能の検討2009
Author(s)
吉川昌平, 飯島尋子, 石井昭生, 坂井良行, 會澤信弘, 山本晃久, 岩田恵典, 榎本平之, 田中弘教, 今西宏安, 下村壯治, 中村秀次, 西口修平, 工藤篤, 有井滋樹, 和氣健二郎
Organizer
第45回日本肝臓学会総会
Place of Presentation
神戸
Related Report
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[Presentation] 肝線維化診断におけるARFIの有用性2009
Author(s)
吉田昌弘, 田中弘教, 山平正浩, 吉本直喜, 東浦晶子, 柴田陽子, 橋本眞里子, 會澤信弘, 斎藤雅博, 平山秀男, 齋藤正紀, 辻村亨, 廣田誠一, 西口修平, 飯島尋子
Organizer
日本超音波医学会第82回学術集会
Place of Presentation
東京
Related Report
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[Presentation] びまん性肝疾患の超音波による評価造影超音波検査を用いた慢性肝疾患の肝実質と脾実質の輝度費(LS比)の検討2009
Author(s)
山平正浩, 田中弘教, 吉田昌弘, 柴田陽子, 吉本直喜, 東浦晶子, 橋本眞里子, 赤尾憲二, 會澤信弘, 西口修平, 飯島尋子
Organizer
日本超音波医学会第82回学術集会
Place of Presentation
東京
Related Report
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[Presentation] レボビスト造影超音波検査からみたピタバスタチンのNASH改善効果に関する基礎的検討2009
Author(s)
飯島尋子, 田中弘教, 吉川昌平, 齋藤正紀, 中村秀次, 下村壯治, 今西宏安, 康典利, 榎本平之, 岩田恵典, 山本晃久, 會澤信弘, 坂井良行, 山田大輔, 西口修平
Organizer
第95回日本消化器病学会総会
Place of Presentation
札幌
Related Report
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