| Project/Area Number |
21300196
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | National Center for Geriatrics and Gerontology |
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Principal Investigator |
NAKAI Toshiharu 独立行政法人国立長寿医療研究センター, 長寿医療工学研究部, 神経情報画像開発研究室長 (30344170)
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| Co-Investigator(Kenkyū-buntansha) |
MATUO Kayako 独立行政法人国立長寿医療研究センター, 長寿医療工学研究部, 研究員 (70399509)
MIYAKOSHI Makoto 独立行政法人国立長寿医療研究センター, 長寿医療工学研究部, 研究員 (00508046)
IWAKI Sunao 独立行政法人産業技術総合研究所, 人間福祉医工学研究部門, 研究グループ長 (70356525)
KAMIYA Naoki 独立行政法長寿医療研究センター, 長寿医療工学研究部, 研究員 (70610450)
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| Co-Investigator(Renkei-kenkyūsha) |
EPIFANIO Bagarinao スタンフォード大学, 医学部・麻酔科・神経システム痛覚研究室, 研究員 (00443218)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Keywords | 画像診断システム / 認知症 / 加齢 / 脳機能イメージング / fMRI / f MRI |
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| Research Abstract |
The fundamental algorism to estimate higher order functional connectivity representing the age-dependent characteristics of neuronal network response was developed by implementing over-all computation of the HRF correlation and its tensor analysis. The framework investigated by using qualitative and quantitative modulation of cognitive demand. wasThis method enabled visualization of the functional connectivity as spatially distributed coefficient. It was suggested that longitudinal change of behavioral data might be potentially correlated with age-related change of brain activation.
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