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Experimental rehabilitation on rodents hemiplegia

Research Project

Project/Area Number 21300199
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionTokyo Medical and Dental University

Principal Investigator

KUMEI Yasuhiro  東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (30161714)

Co-Investigator(Kenkyū-buntansha) OJIMA Hisayuki  東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (00104539)
ISHIDA Takayoshi  東京医科歯科大学, 歯学部附属病院, 医員 (90549966)
森田 定雄  東京医科歯科大学, 医学部附属病院, 准教授 (20202426)
小海 暁  東京医科歯科大学, 歯学部附属病院, 医員 (50431937)
Co-Investigator(Renkei-kenkyūsha) JORGE Zeredo  東京医科歯科大学, 大学院・医歯学総合研究科, 非常勤講師 (10363459)
INOUE Ka  東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (90302877)
AOU Shuji  九州工業大学, 大学院・生命体工学研究科, 教授 (40150908)
HASEGAWA Katsuya  宇宙航空研究開発機構, 宇宙科学研究所, 開発員 (30425780)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Keywords片麻痺 / リハビリテーション / ニューロン活動 / 行動 / 高次脳機能 / 行動解析 / 作業記憶 / 連合野 / 八方向放射状迷路試験 / 大脳基底核
Research Abstract

We studied on various experimental rehabilitation using rodent hemiplegia models. X-ray analysis provides more significant detailed information about moving/behavior and its regulation on the joint-skeletal system of animals. Pain sensation makes a good indicator that reflects the recovery process of hemiplegia so as to prospect a reliable rehabilitation model. We succeeded for the first time in dual measurement of electrophysiological and neurochemical activities of the CNS that controls behavior/moving of rodents. These brain areas respond positively and negatively to mechanical loading and unloading. An appropriate mechanical loading enhances efficiency of synaptic transmission in hippocampus and amygdala that reflects stimulated function of learning/memory and emotional response. These molecular-based approaches would contribute to new rehabilitation for hemiplegia.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (6 results)

All 2011 2009

All Presentation (6 results)

  • [Presentation] Posture, Behavior, and Neuronal Activity in Partial Gravity2011

    • Author(s)
      Y. Kumei, K. Hasegawa, J. L. Zeredo, K. Narikiyo, K. A. Inoue, Y. Watanabe, Y. Maezawa, N. Ishioka, M. Yamashita, and S. Aou : Rodents Response to Lunar and Martian Gravity
    • Organizer
      27^<th> annual meeting, ASGSB
    • Place of Presentation
      San Jose
    • Year and Date
      2011-11-03
    • Related Report
      2011 Final Research Report
  • [Presentation] Rodents Response to Lunar and Martian Gravity : Posture, Behavior, and Neuronal Activity in Partial Gravity2011

    • Author(s)
      Yasuhiro Kumei
    • Organizer
      ASGSB 27^<th> annual meeting
    • Place of Presentation
      Sainte Clair Hotel San Jose, CA
    • Year and Date
      2011-11-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Newonal response of the hypothalamic arcuate nucleus to partial gravity levels in rats2011

    • Author(s)
      Jorge Zeredo, Yasuhiro Kumei
    • Organizer
      ELGRA symposium
    • Place of Presentation
      Antwerp大学(ベルギー)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Rat Defensive Behaviors Triggered by Graded Levels2009

    • Author(s)
      ゼレド・ジョージ、粂井康宏、石田宝義, 他
    • Organizer
      動物行動学会2009年総会
    • Place of Presentation
      筑波大学
    • Year and Date
      2009-11-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Japanese Research Group for Animal and Human Physiology in Lunar and Martian Gravity2009

    • Author(s)
      Y. Kumei, J. L. Zeredo, T. Yabushita, T. Ishida, S. Seki, T. Ikeda, K. Toda, M. Matsuura, Y. Nomura, K. Iwasaki, F. Kawano, Y. Ohira, M. Okuno, D. Kageyama, and M. Yamashita
    • Organizer
      25^<th> annual meeting, ASGSB
    • Place of Presentation
      Raleigh
    • Year and Date
      2009-11-07
    • Related Report
      2011 Final Research Report
  • [Presentation] Nociceptive behaviors in rats at low gravity conditions2009

    • Author(s)
      T. Ishida, J. L. Zeredo, T. Yabushita, S. Seki, Y. Fusejima, G. Fukushima, K. Toda, Y. Kumei
    • Organizer
      Congress Pain
    • Place of Presentation
      Lisbon
    • Year and Date
      2009-09-10
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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