Experimental rehabilitation on rodents hemiplegia

• Project/Area Number: 21300199
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: KUMEI Yasuhiro 東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (30161714)
• Co-Investigator(Kenkyū-buntansha): OJIMA Hisayuki 東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (00104539) ; ISHIDA Takayoshi 東京医科歯科大学, 歯学部附属病院, 医員 (90549966) ; 森田 定雄 東京医科歯科大学, 医学部附属病院, 准教授 (20202426) ; 小海 暁 東京医科歯科大学, 歯学部附属病院, 医員 (50431937)
• Co-Investigator(Renkei-kenkyūsha): JORGE Zeredo 東京医科歯科大学, 大学院・医歯学総合研究科, 非常勤講師 (10363459) ; INOUE Ka 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (90302877) ; AOU Shuji 九州工業大学, 大学院・生命体工学研究科, 教授 (40150908) ; HASEGAWA Katsuya 宇宙航空研究開発機構, 宇宙科学研究所, 開発員 (30425780)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
• Keywords: 片麻痺 / リハビリテーション / ニューロン活動 / 行動 / 高次脳機能 / 行動解析 / 作業記憶 / 連合野 / 八方向放射状迷路試験 / 大脳基底核

Research Abstract

We studied on various experimental rehabilitation using rodent hemiplegia models. X-ray analysis provides more significant detailed information about moving/behavior and its regulation on the joint-skeletal system of animals. Pain sensation makes a good indicator that reflects the recovery process of hemiplegia so as to prospect a reliable rehabilitation model. We succeeded for the first time in dual measurement of electrophysiological and neurochemical activities of the CNS that controls behavior/moving of rodents. These brain areas respond positively and negatively to mechanical loading and unloading. An appropriate mechanical loading enhances efficiency of synaptic transmission in hippocampus and amygdala that reflects stimulated function of learning/memory and emotional response. These molecular-based approaches would contribute to new rehabilitation for hemiplegia.

Research Products

• [Presentation] Posture, Behavior, and Neuronal Activity in Partial Gravity (2011)
  • Author(s): Y. Kumei, K. Hasegawa, J. L. Zeredo, K. Narikiyo, K. A. Inoue, Y. Watanabe, Y. Maezawa, N. Ishioka, M. Yamashita, and S. Aou : Rodents Response to Lunar and Martian Gravity
  • Organizer: 27^<th> annual meeting, ASGSB
  • Place of Presentation: San Jose
  • Year and Date: 2011-11-03
• [Presentation] Rodents Response to Lunar and Martian Gravity : Posture, Behavior, and Neuronal Activity in Partial Gravity (2011)
  • Author(s): Yasuhiro Kumei
  • Organizer: ASGSB 27^<th> annual meeting
  • Place of Presentation: Sainte Clair Hotel San Jose, CA
  • Year and Date: 2011-11-03
• [Presentation] Newonal response of the hypothalamic arcuate nucleus to partial gravity levels in rats (2011)
  • Author(s): Jorge Zeredo, Yasuhiro Kumei
  • Organizer: ELGRA symposium
  • Place of Presentation: Antwerp大学(ベルギー)
• [Presentation] Rat Defensive Behaviors Triggered by Graded Levels (2009)
  • Author(s): ゼレド・ジョージ、粂井康宏、石田宝義, 他
  • Organizer: 動物行動学会2009年総会
  • Place of Presentation: 筑波大学
  • Year and Date: 2009-11-28
• [Presentation] Japanese Research Group for Animal and Human Physiology in Lunar and Martian Gravity (2009)
  • Author(s): Y. Kumei, J. L. Zeredo, T. Yabushita, T. Ishida, S. Seki, T. Ikeda, K. Toda, M. Matsuura, Y. Nomura, K. Iwasaki, F. Kawano, Y. Ohira, M. Okuno, D. Kageyama, and M. Yamashita
  • Organizer: 25^<th> annual meeting, ASGSB
  • Place of Presentation: Raleigh
  • Year and Date: 2009-11-07
• [Presentation] Nociceptive behaviors in rats at low gravity conditions (2009)
  • Author(s): T. Ishida, J. L. Zeredo, T. Yabushita, S. Seki, Y. Fusejima, G. Fukushima, K. Toda, Y. Kumei
  • Organizer: Congress Pain
  • Place of Presentation: Lisbon
  • Year and Date: 2009-09-10