| Project/Area Number |
21300200
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Nagasaki University |
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Principal Investigator |
OKITA Minoru 長崎大学, 大学院・医歯薬学総合研究科, 教授 (50244091)
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| Co-Investigator(Kenkyū-buntansha) |
ORIGUCHI Tomoki 長崎大学, 大学院・医歯薬学総合研究科, 教授 (90295105)
NAKANO Jiro 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (20380834)
SAKAMOTO Jyunya 長崎大学, 大学院・医歯薬学総合研究科, 助教 (20584080)
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| Co-Investigator(Renkei-kenkyūsha) |
SAKAMOTO Jyunya 長崎大学病院, リハビリテーション部, 理学療法士 (20584080)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2009: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
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| Keywords | 障害学 / 拘縮 / 骨格筋 / 皮膚 / 関節包 / コラーゲン / 線維化 / TGF-β / 筋線維芽細胞 / 不動 / collagen / 筋内膜 / 皮下組織 / 滑膜 / 筋線維 / titin / 電気泳動法 / type I・III collagen / 蛍光免疫染色 |
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| Research Abstract |
Clinically, the contracture that is one of the functional disorders is often caused by immobilization of a joint with a plastic cast etc, however, this mechanism is not yet clear. The objective of this study is to clarify the mechanism of contracture based on comprehensive analysis concerning surrounding tissue of joint in experimental animal model. Our results suggest that the molecular mechanism of immobilization-induced muscle fibrosis relate the cytokine signal by TGF-βis activated, the differentiation from the fibroblast to myofibroblast is accelerated, and the type I and III collagen increase. Additionally, the immobilization-induced muscle fibrosis may progress by a decrease in mechanical stimulation. Immobilization of the joint causes the fibrosis of the synovial membrane and the tissue under the skin. There is an important relation in the mechanism because the contracture progresses by these changes.
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