Research for the mechanism of neuro-bionics; basic and clinical approach

• Project/Area Number: 21300207
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Tohoku University
• Principal Investigator: NAKAGAWA Haruo 東北大学, 大学院・医学系研究科, 准教授 (80333574)
• Co-Investigator(Kenkyū-buntansha): HANDA Yasunobu 東北大学, 大学院・医学系研究科, 名誉教授 (00111790) ; KAIHO Yasuhiro 東北大学, 病院, 講師 (30447130)
• Project Period (FY): 2009 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2010: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
• Keywords: ニューロバイオニクス / 治療的電気刺激 / 過活動膀胱 / 血流 / 排尿障害 / 神経調 整 / 脳磁図 / 神経調整 / MRI

Research Abstract

We evaluated the blood flow during sacral electrical stimulation. In the mice, pelvic blood flow promptly increases after electrical stimulation. This result suggests that one of the mechanisms of neuro-bionics is improvement of ischemia of pelvic organ. An evoked magnetic field was useful to optimize neuro-bionics with magnetoencephalography. This magnetoencephalography study shows that stronger stimuli given through large electrodes evoke larger responses than small stimuli through smallelectrodes.

Research Products

• [Journal Article] 男性尿失禁の現状 (2011)
  • Author(s): 中川晴夫、海法康裕、荒井陽一
  • Journal Title: 臨床と研究 Volume: Vol.88No.10 Pages: 103-106
• [Journal Article] 【排尿障害の私の治療2 OAB・間質性膀胱炎】薬剤抵抗性過活動膀胱に対する仙骨表面治療的電気刺激治療 (2011)
  • Author(s): 中川晴夫
  • Journal Title: 排尿障害プラクティス Volume: Vol.19 No.3 Pages: 216-220
• [Journal Article] 【排尿障害の私の治療2OAB・間質性膀胱炎】薬剤抵抗性過活動膀胱に対する仙骨表面治療的電気刺激治療 (2011)
  • Author(s): 中川晴夫
  • Journal Title: 排尿障害プラクティス Volume: 19(3) Pages: 216-220
• [Journal Article] 【ケアマネージャーに必要な疾患の知識と活用】過活動膀胱 (2011)
  • Author(s): 中川晴夫
  • Journal Title: 達人ケアマネ Volume: 6(1) Pages: 66-71
• [Journal Article] 男性尿失禁の現状について (2011)
  • Author(s): 中川晴夫、海法康裕、荒井陽一
  • Journal Title: 臨床と研究 Volume: 88(10) Pages: 103-106
• [Journal Article] 脳磁図 (2010)
  • Author(s): 松下真史, 中川晴夫, 中里信和, 菅野彰剛, 海法康裕, 川守田直樹, 荒井陽一
  • Journal Title: 臨床検査 Volume: 54巻7号 Pages: 819-822
• [Journal Article] 仙台っこ(タウン誌)2010年 (2010)
  • Author(s): 中川晴夫
  • Journal Title: 薬の効かない頻尿や尿失禁 Volume: 4・5月号 Pages: 24-24
• [Journal Article] Impact of sacral surface therapeutic electrical stimulation on early recovery of urinary continence after radical retropubic prostatectomy: a pilot study (2010)
  • Author(s): Nakagawa H, Kaiho Y, Namiki S, Ishidoya S, Saito S, Arai Y.
  • Journal Title: Adv Urol. Volume 2010 Volume: Article ID 102751 Pages: 5-5
  • DOI: 10.1155/2010/102751
  • Peer Reviewed
• [Journal Article] Impact of sacral surface therapeutic electrical stimulation on early recovery of urinary continence after radical retropubic prostatectomy : a pilot study (2010)
  • Author(s): Nakagawa H, et.al
  • Journal Title: Advances in Urology Pages: 102751-6
  • Peer Reviewed
• [Journal Article] 脳磁図(排尿障害) (2010)
  • Author(s): 松下真史、中川晴夫, 他
  • Journal Title: 臨床検査 Volume: 54(7) Pages: 819-822
• [Journal Article] 難治性夜尿症に対する仙骨表面治療的電気刺激 (2009)
  • Author(s): 中川晴夫, 海法康裕, 松下真史, 川守田直樹, 山下慎一, 荒井陽一
  • Journal Title: 夜尿症研究 Volume: VOl.14 Pages: 71-75
  • Peer Reviewed
• [Journal Article] Evoked magnetic fields as a tool to optimize therapeutic electrical stimulation of the sacral surface (2009)
  • Author(s): Matsushita M, Nakasato N, Nakagawa H, Kanno A, Kaiho Y, Kawamorita N, Arai Y.
  • Journal Title: J Clin Neurosci Volume: 16(10) Issue: 10 Pages: 1330-3
  • DOI: 10.1016/j.jocn.2008.12.023
  • Peer Reviewed
• [Journal Article] 【前立腺手術後の尿失禁に対する治療戦略】 前立腺全摘術後の尿失禁 (2009)
  • Author(s): 中川晴夫, 海法康裕, 荒井陽一
  • Journal Title: 泌尿器外科(0914-6180) Volume: 22巻9号 Pages: 1145-1149
• [Journal Article] Evoked magnetic fields as a tool to optimize therapeutic electrical stimulation of the sacral surface. (2009)
  • Author(s): Matsushita, Nakagawa, et.al
  • Journal Title: Journal of Clinical Neuroscience 16(10) Pages: 1330-1333
  • Peer Reviewed
• [Presentation] どうする日本のデバイスラグ (2012)
  • Author(s): 中川晴夫、海法康裕、荒井陽一
  • Organizer: 第26回日本泌尿器内視鏡学会総会
  • Place of Presentation: (仙台市)シンポジウム
  • Year and Date: 2012-11-23
• [Presentation] 難治性下部尿路機能障害に挑む「電気刺激療法」 (2012)
  • Author(s): 中川晴夫、海法康裕、半田康延、荒井陽一
  • Organizer: 第100回日本泌尿器科学会総会
  • Place of Presentation: (横浜市)シンポジウム
  • Year and Date: 2012-04-21
• [Presentation] Overactive Bladder and Sacral Surface Therapeutic Electrical Stimulation. (Singapore, Singapore) (2011)
  • Author(s): Nakagawa H.
  • Organizer: Healthcare Innovation Forum 2011
  • Place of Presentation: Keynote Lecture
  • Year and Date: 2011-10-22
• [Presentation] Overactive Bladder and Sacral Surface Therapeutic Electrical Stimulation (2011)
  • Author(s): Haruo Nakagawa
  • Organizer: Healthcare Innovation Forum 2011
  • Place of Presentation: Singapore
  • Year and Date: 2011-10-22
• [Presentation] 「末梢感覚入力によるニューロモデュレーション:泌尿器科分野:排尿障害」 (2011)
  • Author(s): 中川晴夫、海法康裕、半田康延、荒井陽一
  • Organizer: 第25回日本ニューロモデュレーション学会
  • Place of Presentation: 東京都会長指定シンポジウム
  • Year and Date: 2011-05-21
• [Presentation] 末梢感覚入力によるニューロモデュレーション:泌尿器科分野:排尿障害 (2011)
  • Author(s): 中川晴夫
  • Organizer: 第25回日本ニューロモデュレーション学会
  • Place of Presentation: 東京都
  • Year and Date: 2011-05-21
• [Presentation] Incontinence and the Use of Prosthetics to Enhance Urinary Control (2011)
  • Author(s): Nakagawa H, Kaiho Y, Arai Y.
  • Organizer: American Urological Association Annual Meeting
  • Place of Presentation: (Panelist) Washington D.C. USA, Global Perspectives in Urology Forum, Topic
  • Year and Date: 2011-05-18
• [Presentation] Global Perspectives in Urology Forum, Topic : Incontinence and the Use of Prosthetics to Enhance Urinary Control (2011)
  • Author(s): Haruo Nakagawa
  • Organizer: 米国泌尿器科学会年次総会
  • Place of Presentation: Washington D.C.USA
  • Year and Date: 2011-05-18
• [Presentation] Treatment for post- prostatectomy incontinence (2011)
  • Author(s): Nakagawa H, Kaiho Y, Arai Y.
  • Organizer: 26th Annual EAU Congress (Vienna Austria)
  • Place of Presentation: Joint session of the European Association of Urology (EAU) and the Japanese Urological Association (JUA) (Invited Speaker)
  • Year and Date: 2011-03-18
• [Presentation] 高介護老人保健施設に入所している要介護高齢者の排尿実態 (2010)
  • Author(s): 今西里佳、中川晴夫, 他
  • Organizer: 新潟医療福祉学術集会
  • Place of Presentation: 新潟市
  • Year and Date: 2010-10-30
• [Presentation] 骨盤内手術後の下部尿路機能障害術中電気刺激による神経温存手術 (2010)
  • Author(s): 中川晴夫、新倉仁、海法康裕、荒井陽一
  • Organizer: 第75回泌尿器科学会東部総会
  • Place of Presentation: (宇都宮市)シンポジウム4
  • Year and Date: 2010-09-17
• [Presentation] 脳卒中と排尿障害とその治療 (2010)
  • Author(s): 中川晴夫
  • Organizer: 青森県排尿障害研究会
  • Place of Presentation: 青森市
  • Year and Date: 2010-02-26
• [Presentation] Impact of Sacral surface therapeutic electrical stimulation on early recovery of urinary continence after radical retropubic prostatectomy. (2009)
  • Author(s): 中川晴夫, 他
  • Organizer: 9^<th> World Congress of the International Neuromodulation Society
  • Place of Presentation: Souel Korea
  • Year and Date: 2009-10-03
• [Presentation] Impact of Sacral surface therapeutic electrical stimulation on early recovery of urinary continence after radical retropubic prostatectomy: a pilot study. (2009)
  • Author(s): Nakagawa H, Kaiho Y, Namiki S, Ishidoya S, Saito S and Arai Y.
  • Organizer: 9^<th> World Congress of the International Neuromodulation Society 12-15 September 2009 Seoul
  • Place of Presentation: South Korea, Oral presentation
  • Year and Date: 2009-09-15
• [Presentation] Primary somatosensory evoked magnetic fields by dorsal penile nerve stimulation (2009)
  • Author(s): Matsushita, 中川晴夫, et al
  • Organizer: International Continence Society 38^<th> Annual Meeting
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2009-09-14
• [Presentation] MRIを用いたα1A遮断薬服用後の前立腺部尿道径形態変化の観察 (2009)
  • Author(s): 中川晴夫、平山千惠、佐々木洋介、関和則、小倉隆英、半田康延
  • Organizer: 第16回日本排尿機能学会
  • Place of Presentation: 福岡市
  • Year and Date: 2009-09-10
• [Presentation] Lower urinary tract dysfunction in elderly people staying at a residential facility (2009)
  • Author(s): Imanishi R, Nakagawa H, Matsumoto K, Awaji S, Nabekura M, Tanno O, Arai Y, Kohzuki M.
  • Organizer: The 4th World Congress of the International Society of Physical and Rehabilitation Medicine
  • Place of Presentation: Seoul, South Korea
  • Year and Date: 2009-06-15
• [Presentation] OABを有する女性要介護高齢者における仙骨表面治療的電気刺激終了後の変化について (2009)
  • Author(s): 今西里佳、中川晴夫, 他
  • Organizer: 第22回日本老年泌尿器科学会
  • Place of Presentation: 京都市
  • Year and Date: 2009-05-09
• [Presentation] シンポジウム：どうする日本のデバイスラグ
  • Author(s): 中川晴夫、海法康裕、荒井陽一
  • Organizer: 第２６回日本泌尿器内視鏡学会総会
  • Place of Presentation: 仙台市
  • Invited
• [Presentation] シンポジウム：難治性下部尿路機能障害に挑む 「電気刺激療法」
  • Author(s): 中川晴夫、海法康裕、半田康信、荒井陽一
  • Organizer: 第１００回日本泌尿器科学会総会
  • Place of Presentation: 横浜市
  • Invited
• [Book] 【過活動膀胱診療を考える】Neuromodulation最前線 Progress in Medicine 32 (2012)
  • Author(s): 中川晴夫、海法康裕、泉秀明、荒井陽一
  • Publisher: ライフサイエンス社
• [Book] Progress in Medicine (2012)
  • Author(s): 中川晴夫、海法康裕、泉秀明、荒井陽一
  • Publisher: ライフサイエンス社