Does pentraxin 3 participate in the mechanism underlying habitual aerobic exercise-induced increase in arterial distensibility?
| Project/Area Number |
21300234
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
MAEDA Seiji 筑波大学, 体育系, 講師 (30282346)
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| Co-Investigator(Kenkyū-buntansha) |
AJISAKA Ryuichi 筑波大学, 体育系, 教授 (70151058)
TANAKA Kiyoji 筑波大学, 体育系, 教授 (50163514)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2009: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Keywords | 有酸素性運動 / 動脈伸展性 / ペントラキシン3 / 抗炎症作用 / 加齢 / 肥満 / 心血管疾患 / 心血管保護作用 / 閉経後中高齢女性 / 運動トレーニング / 大動脈 / 持久鍛錬者 / 生活習慣 |
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| Research Abstract |
Aging and/or obesity induce the decrease in arterial distensibility. Reduction in arterial distensibility is believed to contribute to the pathophysiology of cardiovascular disease and has been identified as a powerful and independent risk factor for cardiovascular disease. On the other hand, habitual aerobic exercise results in a significant increase in arterial distensibility. However, it is unclear the mechanism underlying habitual aerobic exercise-induced enhancement of arterial distensibility. The present study was to investigate whether pentraxin 3 (PTX3), anti-inflammatory protein, is involved in the mechanism underlying the increase in arterial distensibility with aerobic exercise training. We suggest that PTX3 may be an important mechanism underlying the beneficial effect of aerobic exercise training on arterial distensibility.
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Report
(4 results)
Research Products
(14 results)
