| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2009: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Research Abstract |
Aging and/or obesity induce the decrease in arterial distensibility. Reduction in arterial distensibility is believed to contribute to the pathophysiology of cardiovascular disease and has been identified as a powerful and independent risk factor for cardiovascular disease. On the other hand, habitual aerobic exercise results in a significant increase in arterial distensibility. However, it is unclear the mechanism underlying habitual aerobic exercise-induced enhancement of arterial distensibility. The present study was to investigate whether pentraxin 3 (PTX3), anti-inflammatory protein, is involved in the mechanism underlying the increase in arterial distensibility with aerobic exercise training. We suggest that PTX3 may be an important mechanism underlying the beneficial effect of aerobic exercise training on arterial distensibility.
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