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ACTN3 genotype and muscle adaptability in Japanese

Research Project

Project/Area Number 21300238
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Sports science
Research InstitutionJuntendo University

Principal Investigator

NAITO Hisashi  順天堂大学, スポーツ健康科学研究科, 教授 (70188861)

Project Period (FY) 2009 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsスポーツ生理学 / 遺伝子 / 骨格筋 / 競技力 / トレーニング / 健康関連体力 / 有酸素能力 / 筋力 / 筋パワー / アルペンスキー / ACTN3 / スピード / パワー / 至適負荷 / 持久力 / 無気的作業閾値 / 筋線維組成
Research Abstract

The purpose of this study was to investigate the association between ACTN3 genotype and muscle function and its adaptability in Japanese. The results indicated that RR genotype might correlate with fast muscle fiber composition. In addition, not only sprinters but also endurance runners could benefit from RR genotype. However, delayed-onset of muscle soreness was not associated with ACTN3 genotype.

Report

(5 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (57 results)

All 2013 2012 2011 2010 2009 Other

All Journal Article (19 results) (of which Peer Reviewed: 17 results) Presentation (38 results) (of which Invited: 1 results)

  • [Journal Article] Heat stress activates the Akt/mTOR signaling pathway in rat skeletal muscle2013

    • Author(s)
      Yoshihara T, Naito H, Kakigi R, Ichinoseki-Sekine N, Ogura Y, Sugiura T, Katamoto S
    • Journal Title

      Acta Physiol

      Volume: 207 Pages: 416-426

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heat stress-induced changes in skeletal muscle: heat shock proteins and cellular signaling transduction2012

    • Author(s)
      Naito H
    • Journal Title

      J Phys Fitness Sports Med

      Volume: 1 Pages: 125-131

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Satellite cell pool enhancement in rat plantaris muscle by endurance training depends on intensity rather than duration2012

    • Author(s)
      Kurosaka M, Naito H, Ogura Y, Machida S, Katamoto S
    • Journal Title

      Acta Physiol

      Volume: 205 Pages: 159-166

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fiber-type specific expression of α-actinin isoforms in rat skeletal muscle2012

    • Author(s)
      Ichinoseki-Sekine N
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 419 Pages: 401-404

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nitric oxide : Is it the cause of muscle soreness?2012

    • Author(s)
      Radak Z
    • Journal Title

      Nitric Oxide

      Volume: 26 Pages: 89-94

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Satellite cell pool enhancement in rat plantaris muscle by endurance training depends on intensity rather than duration.2012

    • Author(s)
      Kurosaka M, Naito H, Ogura Y, Machida S, Katamoto S.
    • Journal Title

      Acta Physiologica,

      Volume: 205(1) Issue: 1 Pages: 159-166

    • DOI

      10.1111/j.1748-1716.2011.02381.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fiber-type specific expression of α-actinin isoforms in rat skeletal muscle2011

    • Author(s)
      Ichinoseki-Sekine N, Yoshihara T, Kakigi R, Ogura Y, Sugiura T, Naito H
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 419 Pages: 401-404

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nitric oxide: Is it the cause of muscle soreness?2011

    • Author(s)
      Radak Z, Naito H, Taylor AW, Goto S
    • Journal Title

      Nitric Oxide

      Volume: 26 Pages: 89-94

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of ageing and endurance exercise training on alpha-actinin isoforms in rat plantaris muscle2011

    • Author(s)
      Ogura Y, Naito H, Kakigi R, Ichinoseki-Sekine N, Kurosaka M, Yoshihara T, Akema T
    • Journal Title

      Acta Physiol

      Volume: 202 Pages: 6836-6836

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Single bout of running exercise changes LC3-II expression in rat cardiac muscle2011

    • Author(s)
      Ogura Y, Iemitsu M, Naito H, Kakigi R, Kakehashi C, Maeda S, Akema T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 414 Pages: 756-760

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heat stress enhances mTOR signaling after resistance exercise in human skeletal muscle2011

    • Author(s)
      Kakigi R, Naito H, Ogura Y, Kobayashi H, Saga N, Ichinoseki-Sekine N, Yoshihara T, Katamoto S
    • Journal Title

      J Physiol Sci

      Volume: 61 Pages: 131-140

    • NAID

      10029049810

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 運動能力を引き出す遺伝と多様性:ACTN3 遺伝子多型と運動能力2011

    • Author(s)
      内藤久士
    • Journal Title

      体育の科学

      Volume: 61 Pages: 691-696

    • Related Report
      2012 Final Research Report
  • [Journal Article] Effects of ageing and endurance exercise training on alpha-actinin isoforms in rat plantaris muscle2011

    • Author(s)
      Ogura Y
    • Journal Title

      Acta Physiol

      Volume: 202 Pages: 683-690

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single bout of running exercise changes LC3-II expression in rat cardiac muscle2011

    • Author(s)
      Ogura Y
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 414 Pages: 131-140

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 運動能力を引き出す遺伝と多様性:ACTN3遺伝子多型と運動能力2011

    • Author(s)
      内藤久士
    • Journal Title

      体育の科学

      Volume: 61 Pages: 691-696

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Effects of home-based resistance training among elderly Japanese women with different ACTN3 (R577X) genotypes2010

    • Author(s)
      Ichinoseki-Sekine N, Naito H, Harima H, Nakagawa K, Katamoto S
    • Journal Title

      J Health Sports Sci Juntendo

      Volume: 1 Pages: 486-493

    • NAID

      40017239047

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of home-based resistance training among elderly Japanese women with different ACTN3 (R577X) genotypes.2010

    • Author(s)
      Ichinoseki-Sekine N, Naito H, Harima H, Nakagawa K, Katamoto S.
    • Journal Title

      Journal of Health and Sports Science

      Volume: 1 Pages: 486-493

    • NAID

      40017239047

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Different adaptations of alpha-actinin isoforms to exercise training in rat skeletal muscles2009

    • Author(s)
      Ogura Y, Naito H, Kakigi R, Akema T, Sugiura T, Katamoto S, Aoki J
    • Journal Title

      Acta Physiol

      Volume: 196 Pages: 341-349

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Different adaptations of alpha-actinin isoforms to exercise training in rat skeletal muscles2009

    • Author(s)
      Ogura Y, Naito H, Kakigi R, Akema T, Sugiura T, Katamoto S, Aoki J.
    • Journal Title

      Acta Physiol 196

      Pages: 341-349

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Why does skeletal muscle have fast and slow muscle fibers?2013

    • Author(s)
      Naito H
    • Organizer
      第90回日本生理学会大会シンポジウム
    • Place of Presentation
      タワーホール船堀(東京都)
    • Year and Date
      2013-03-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 次世代のトレーニングを考える~トレーニングにおける温故知新~2012

    • Author(s)
      内藤久士
    • Organizer
      第25回日本トレーニング科学会大会
    • Place of Presentation
      立命館大学(草津)
    • Year and Date
      2012-12-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 子どもにおける下肢スティフネスとアクチニン 3 遺伝子の関連性2011

    • Author(s)
      渡辺圭佑,他 2 名
    • Organizer
      第62回日本体育学会大会
    • Place of Presentation
      鹿屋体育大学(鹿児島)
    • Year and Date
      2011-09-25
    • Related Report
      2012 Final Research Report
  • [Presentation] ラット横隔膜におけるαアクチニン 3 タンパク質の筋線維特異的発現2011

    • Author(s)
      関根紀子,他 5 名
    • Organizer
      第66回日本体力医学会大会
    • Place of Presentation
      下関 (山口)
    • Year and Date
      2011-09-16
    • Related Report
      2012 Final Research Report
  • [Presentation] ACTN3 遺伝子型は子どもの疾走能力を決定するか?2011

    • Author(s)
      柳谷登志雄,他 5 名
    • Organizer
      第66回日本体力医学会大会
    • Place of Presentation
      下関 (山口)
    • Year and Date
      2011-09-16
    • Related Report
      2012 Final Research Report
  • [Presentation] 加齢および持久性トレーニングがラット足底筋のαアクチニンアイソフォームに及ぼす影響2011

    • Author(s)
      小倉裕司,他 5 名
    • Organizer
      第66回日本体力医学会大会
    • Place of Presentation
      下関 (山口)
    • Year and Date
      2011-09-16
    • Related Report
      2012 Final Research Report
  • [Presentation] ACTN3 遺伝子型と骨格筋(遺伝子からみた骨格筋の運動能力の関わり)2011

    • Author(s)
      内藤久士
    • Organizer
      日本運動生理学会 第19回大会
    • Place of Presentation
      徳島大学(徳島)
    • Year and Date
      2011-08-25
    • Related Report
      2012 Final Research Report
  • [Presentation] 12 時間の機械的人工換気がラット横隔膜におけるαアクチニン 3 タンパク質の筋線維特異的発現に及ぼす影響2011

    • Author(s)
      関根紀子,他 3 名
    • Organizer
      日本運動生理学会第19回大会
    • Place of Presentation
      徳島大学(徳島)
    • Year and Date
      2011-08-25
    • Related Report
      2012 Final Research Report
  • [Presentation] サイクリング愛好者の ACTN3 遺伝子型に関する研究2011

    • Author(s)
      佐賀典生,他 4 名
    • Organizer
      日本運動生理学会第19回大会
    • Place of Presentation
      徳島大学 (徳島)
    • Year and Date
      2011-08-25
    • Related Report
      2012 Final Research Report
  • [Presentation] ACTN3遺伝子型と骨格筋(遺伝子からみた骨格筋の運動能力の関わり)2011

    • Author(s)
      内藤久士
    • Organizer
      日本運動生理学会第19回大会
    • Place of Presentation
      徳島大学(徳島)
    • Year and Date
      2011-08-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] 12時間の機械的人工換気がラット横隔膜におけるαアクチニン3タンパク質の筋線維特異的発現に及ぼす影響2011

    • Author(s)
      関根紀子
    • Organizer
      日本運動生理学会第19回大会
    • Place of Presentation
      徳島大学(徳島)
    • Year and Date
      2011-08-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] サイクリング愛好者のACTN3遺伝子型に関する研究2011

    • Author(s)
      佐賀典生
    • Organizer
      日本運動生理学会第19回大会
    • Place of Presentation
      徳島大学(徳島)
    • Year and Date
      2011-08-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effects of 12-h mechanical ventilation on fibre-specific expression of alpha-actinin-3 protein in rat diaphragm2011

    • Author(s)
      Ichinoseki-Sekine N, 他 5 名
    • Organizer
      The 16th Annual Congress of the European College of Sport Science
    • Place of Presentation
      Liverpool (UK)
    • Related Report
      2012 Final Research Report
  • [Presentation] Adaptation of alpha-actinin isoforms to endurance exercise training in adult and old rat plantaris muscle2011

    • Author(s)
      Ogura Y, 他 4 名
    • Organizer
      The American College of Sports Medicine 58th Annual Meeting
    • Place of Presentation
      Denver(USA).
    • Related Report
      2012 Final Research Report
  • [Presentation] Fiber-specific expression of alpha-actinin-3 protein in rat diaphragm2011

    • Author(s)
      Ichinoseki-Sekine N, 他 5 名
    • Organizer
      Experimental Biology 2011
    • Place of Presentation
      Washington DC (USA).
    • Related Report
      2012 Final Research Report
  • [Presentation] Fiber-specific expression of alpha-actinin-3 protein in rat diaphragm2011

    • Author(s)
      Ichinoseki-Sekine N
    • Organizer
      Experimental Biology 2011
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] Adaptation of alpha-actinin isoforms to endurance exercise training in adult and old rat plantaris muscle2011

    • Author(s)
      Ogura Y
    • Organizer
      The American College of Sports Medicine 58th Annual Meeting
    • Place of Presentation
      Denver, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effects of 12-h mechanical ventilation on fibre-specific expression of alpha-actinin-3 protein in rat diaphragm2011

    • Author(s)
      Ichinoseki-Sekine N
    • Organizer
      The 16th Annual Congress of the European College of Sport Science
    • Place of Presentation
      Liverpool, UK
    • Related Report
      2011 Annual Research Report
  • [Presentation] ラット横隔膜におけるαアクチニン3タンパク質の筋線維特異的発現2011

    • Author(s)
      関根紀子
    • Organizer
      第66回日本体力医学会大会
    • Place of Presentation
      下関(山口)
    • Related Report
      2011 Annual Research Report
  • [Presentation] ACTN3遺伝子型は子どもの疾走能力を決定するか?2011

    • Author(s)
      柳谷登志雄
    • Organizer
      第66回日本体力医学会大会
    • Place of Presentation
      下関(山口)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 加齢および持久性トレーニングがラット足底筋のαアクチニンアイソフォームに及ぼす影響2011

    • Author(s)
      小倉裕司
    • Organizer
      第66回日本体力医学会大会
    • Place of Presentation
      下関(山口)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 子どもにおける下肢スティフネスとアクチニン3遺伝子の関連性2011

    • Author(s)
      渡辺圭佑
    • Organizer
      第62回日本体育学会大会
    • Place of Presentation
      鹿屋体育大学(鹿児島)
    • Related Report
      2011 Annual Research Report
  • [Presentation] esponse of alpha-actinin isoforms to mechanical ventilation-induced diaphragmatic atrophy2010

    • Author(s)
      Ichinoseki-Sekine N, 他 5 名
    • Organizer
      ACSM Conference on Integrative Physiology of Exercise
    • Place of Presentation
      Miami(USA)
    • Year and Date
      2010-09-25
    • Related Report
      2012 Final Research Report
  • [Presentation] Response of alpha-actinin isoforms to mechanical ventilation-induced diaphragmatic atrophy.2010

    • Author(s)
      Ichinoseki-Sekine N, Naito H, Yoshihara T, Ogura Y, Sugiura T, SK Powers.
    • Organizer
      ACSM Conference on Integrative Physiology of Exercise
    • Place of Presentation
      Miami, USA
    • Year and Date
      2010-09-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] ACTN3 遺伝子多型と高齢日本人女性のトレーニング効果2010

    • Author(s)
      関根紀子,他 4 名
    • Organizer
      65回日本体力医学会大会
    • Place of Presentation
      千葉商大 (千葉)
    • Year and Date
      2010-09-17
    • Related Report
      2012 Final Research Report
  • [Presentation] ACTN3遺伝子多型と高齢日本人女性のトレーニング効果2010

    • Author(s)
      関根紀子, 内藤久士, 張間裕子, 佐賀典生, 形本静夫
    • Organizer
      第65回日本体力医学会大会
    • Place of Presentation
      千葉商大(千葉)
    • Year and Date
      2010-09-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラット損傷筋におけるαアクチニンアイソフォーム発現2010

    • Author(s)
      柿木亮、他 4 名
    • Organizer
      第18回日本運動生理学会大会
    • Place of Presentation
      鹿児島大(鹿児島)
    • Year and Date
      2010-08-01
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] Different response of alpha-actinin isoforms to muscle injury in rat skeletal muscle2010

    • Author(s)
      Kakigi R, 他 6 名
    • Organizer
      The American College of Sports Medicine 57th Annual Meeting
    • Place of Presentation
      Baltimore (USA)
    • Year and Date
      2010-06-01
    • Related Report
      2012 Final Research Report
  • [Presentation] Effects of home-based fall prevention training in Japanese elderly women with different ACTN3 (R577X) genotypes2010

    • Author(s)
      Ichinoseki-Sekine N, 他 4 名
    • Organizer
      The American College of Sports Medicine 57th Annual Meeting
    • Place of Presentation
      Baltimore (USA)
    • Year and Date
      2010-06-01
    • Related Report
      2012 Final Research Report
  • [Presentation] Different response of alpha-actinin isoforms to muscle injury in rat skeletal muscle.2010

    • Author(s)
      Kakigi R, Naito H, Ogura Y, Fukai Y, Yoshihara T, Ichinoseki-Sekine N, Katamoto S.
    • Organizer
      The American College of Sports Medicine 57th Annual Meeting
    • Place of Presentation
      Baltimore, USA
    • Year and Date
      2010-06-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effects of home-based fall prevention training in Japanese elderly women with different ACTN3 (R577X) genotypes.2010

    • Author(s)
      Ichinoseki-Sekine N, Harima H, Nakagawa K, Naito H, Katamoto S.
    • Organizer
      The American College of Sports Medicine 57th Annual Meeting
    • Place of Presentation
      Baltimore, USA
    • Year and Date
      2010-06-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Different response of alpha-actinin isoforms to muscle damage in rat skeletal muscle2010

    • Author(s)
      Kakigi R, 他 6 名
    • Organizer
      19th International Conference on Sport Sciences
    • Place of Presentation
      Budapest(Hungary)
    • Year and Date
      2010-04-09
    • Related Report
      2012 Final Research Report
  • [Presentation] Different response of alpha-actinin isoforms to muscle damage in rat skeletal muscle.2010

    • Author(s)
      Kakigi R, Naito H, Ogura Y, Fukai Y, Yoshihara T, Ichinoseki-Sekine N, Katamoto S.
    • Organizer
      19th International Conference on Sport Sciences
    • Place of Presentation
      Budapest, Hungary
    • Year and Date
      2010-04-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] ACTN3 遺伝子多型と中高年女性のトレーニング効果2009

    • Author(s)
      関根紀子,他 4 名
    • Organizer
      第64回日本体力医学会大会
    • Place of Presentation
      朱鷺メッセ (新潟)
    • Year and Date
      2009-09-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 運動トレーニングに伴うラット骨格筋αアクチニンアイソフォームの適応2009

    • Author(s)
      小倉裕司,他 3 名
    • Organizer
      第64回日本体力医学会大会
    • Place of Presentation
      朱鷺メッセ(新潟)
    • Year and Date
      2009-09-18
    • Related Report
      2012 Final Research Report 2009 Annual Research Report
  • [Presentation] ACTN3遺伝子多型と中高年女性のトレーニング効果2009

    • Author(s)
      関根紀子, 内藤久士, 張間裕子, 佐賀典生, 形本静夫
    • Organizer
      第64回日本体力医学会大会
    • Place of Presentation
      朱鷺メッセ(新潟)
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 次世代のトレーニングを考える~トレーニングにおける温故知新~

    • Author(s)
      内藤久士
    • Organizer
      第25回日本トレーニング科学会大会
    • Place of Presentation
      立命館大学(滋賀県)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Why does skeletal muscle have fast and slow muscle fiber?

    • Author(s)
      Hisashi Naito
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Related Report
      2012 Annual Research Report

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Published: 2009-04-01   Modified: 2019-07-29  

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