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Mechanisms of increase in exercise induced energy expenditure

Research Project

Project/Area Number 21300240
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Sports science
Research InstitutionNational Institute of Health and Nutrition

Principal Investigator

MIURA Shinji  独立行政法人国立健康・栄養研究所, 基礎栄養研究部脂質・糖代謝研究室, 室長 (10342932)

Co-Investigator(Renkei-kenkyūsha) EZAKI Osamu  独立行政法人国立健康・栄養研究所, 基礎栄養研究部, 部長 (90191923)
KAMEI Yasutomi  東京医科歯科大学, 難治疾患研究所, 特任教授 (70300829)
KANO Yutaka  電気通信大学, 情報理工学部, 准教授 (90293133)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Keywordsエネルギー代謝 / AMPK / LKB1 / 横隔膜 / 筋線維 / PGC-1 / 運動 / ミトコンドリア / fuel sensor
Research Abstract

Trained subjects have a high VO2max due to a high cardiac output and high metabolic capacity of skeletal muscles. Because exercise training increases peroxisome proliferator-activated receptorγcoactivator 1α(PGC-1α) in skeletal muscle, PGC-1α-mediated changes may contribute to the improvement of exercise capacity and VO2max. There are three isoforms of PGC-1αmRNA. PGC-1α-b protein is a predominant PGC-1αisoform in response to exercise. In this study, we showed that PGC-1α-b induced increased mitochondrial biogenesis, capillaries, and fatty acid transporters in skeletal muscles may contribute to improved exercise capacity via an increase in fatty acid utilization.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (40 results)

All 2011 2010 2009 Other

All Journal Article (12 results) (of which Peer Reviewed: 7 results) Presentation (18 results) Book (9 results) Remarks (1 results)

  • [Journal Article] Skeletal muscle-specific expression of PGC-1α-b, an exercise-responsive isoform, increases exercise capacity and peak oxygen uptake2011

    • Author(s)
      Tadaishi, M., Miura, S., Kai, Y., Kano, Y., Oishi, Y., and Ezaki, O.
    • Journal Title

      PLoS ONE

      Volume: 6(12)

    • URL

      http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0028290

    • Related Report
      2011 Final Research Report
  • [Journal Article] Control of microvascular PO2 kinetics following onset of muscle contractions : Role for AMPK2011

    • Author(s)
      Kano, Y., Poole, D. C., Sudo, M., Hirachi, T., Miura, S., and Ezaki, O.
    • Journal Title

      Am. J. Physiol. Regul. Integr. Comp. Physiol

      Volume: 301

    • Related Report
      2011 Final Research Report
  • [Journal Article] Effect of exercise intensity and AICAR on isoform-specific expressions of murine skeletal muscle PGC-1αmRNA : a role ofβ2-adrenergic receptor activation2011

    • Author(s)
      Tadaishi, M., Miura, S., Kai, Y., Kawasaki, E., Koshinaka, K., Kawanaka, K., Nagata, J., Oishi, Y., and Ezaki, O.
    • Journal Title

      Am. J. Physiol. Endocrinol. Metab

      Volume: 300

    • Related Report
      2011 Final Research Report
  • [Journal Article] Skeletal muscle-specific expression of PGC-1α-b, an exercise-responsive isoform, increases exercise capacity and peak oxygen uptake2011

    • Author(s)
      Tadaishi, M., Miura, S., Kai, Y., Kano, Y., Oishi, Y., Ezaki, O.
    • Journal Title

      PLoS ONE

      Volume: 6

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Control of microvascular PO2 kinetics following onset of muscle contractions : Role for AMPK2011

    • Author(s)
      Kano, Y., Poole, D.C., Sudo, M., Hirachi, T., Miura, S., Ezaki, O.
    • Journal Title

      Am.J.Physiol.Regul.Integr.Comp.Physiol.

      Volume: 301

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of exercise intensity and AICAR on isoform-specific expressions of murine skeletal muscle PGC-la mRNA : a role of f32-adrenergic receptor activation.2011

    • Author(s)
      Tadaishi, M., Miura, S., Kai, Y., Kawasaki, E., Koshinaka, K., Kawanaka, K., Nagata, J., Oishi, Y., Ezaki, O.
    • Journal Title

      Am.J.Physiol.Endocrinol.Metab.

      Volume: 300

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The cathepsin L gene is a direct taret of FOXO1 in the skeletal muscle.2010

    • Author(s)
      Yamazaki, Y., Kamei, Y., Sugita, S., Akaike, F., Kanai, S., Miura, S., Hirata, Y., Troen, B.R., Kitamura, T., Nishino, I., Suganami, T., Ezaki, O., Ogawa, Y.
    • Journal Title

      Biochem.J. 427

      Pages: 171-178

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased expression of DNA methyltransferase 3a in obese adipose tissue : studies with transgenic mice.2010

    • Author(s)
      Kamei, Y., Suganami, T., Ehara, T., Kanai, S., Hayashi, K., Yamamoto, Y., Miura, S., Ezaki, O., Okano, M., Ogawa, Y.
    • Journal Title

      Obesity 18

      Pages: 314-321

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ubiquitin C-terminal hydrolase-L3-knockout mice are resistant to diet-induced obesity and show increased activation of AMP-activated protein kinase in skeletal muscle2009

    • Author(s)
      Setsuie, R., Suzuki, M., Kabuta, T., Fujita, H., Miura, S., Ichihara, N., Yamada, D., Wang, YL., Ezaki, O., Suzuki, Y., and Wada, K.
    • Journal Title

      FASEB J

      Volume: 23 Pages: 4148-4157

    • Related Report
      2011 Final Research Report
  • [Journal Article] α2-AMPK activity is not essential for an increase in fatty acid oxidation during low-intensity exercise2009

    • Author(s)
      Miura, S., Kai, Y., Kamei, Y., Bruce, C. R., Kubota, N., Febbraio, M. A., Kadowaki, T., and Ezaki, O.
    • Journal Title

      Am. J. Physiol. Endocrinol. Metab

      Volume: 296

    • Related Report
      2011 Final Research Report
  • [Journal Article] Ubiquitin C-terminal hydrolase-L3-knockout mice are resistant to diet-induced obesity and show increased activation of AMP-activated protein kinase in skeletal muscle.2009

    • Author(s)
      Setsuie, R., Suzuki, M., Kabuta, T., Fujita, H., Miura, S., Ichihara, N., Yamada, D., Wang, YL., Ezaki, O., Suzuki, Y., Wada, K.
    • Journal Title

      FASEB J. 23

      Pages: 4148-4157

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of FOXO1 in skeletal muscle does not alter longevity in mice.2009

    • Author(s)
      Chiba, T., Kamei, Y., Shimizu, T., Shirasawa, T., Katsumata, A., Shiraishi, L., Sugita, S., Ogawa, Y., Miura, S., Ezaki, O.
    • Journal Title

      Mech.Ageing Dev. 130

      Pages: 420-428

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] NEATの測定意義と脂肪燃焼の分子機序2011

    • Author(s)
      江崎治、三浦進司、野田光彦
    • Organizer
      第32回日本肥満学会
    • Place of Presentation
      淡路夢舞台国際会議場(兵庫)
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 骨格筋特異的PGC-1α-b過剰発現による脂肪燃焼効率の向上2011

    • Author(s)
      只石幹、三浦進司、江崎治
    • Organizer
      第32回日本肥満学会
    • Place of Presentation
      淡路夢舞台国際会議場(兵庫)
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 運動による脂肪酸酸化亢進メカニズム:骨格筋LKB1-AMPK情報伝達系の関与2011

    • Author(s)
      三浦進司、只石幹、江崎治
    • Organizer
      第32回日本肥満学会
    • Place of Presentation
      淡路夢舞台国際会議場(兵庫)
    • Year and Date
      2011-09-23
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 運動による脂肪酸酸化亢進メカニズム2011

    • Author(s)
      三浦進司、只石幹、江崎治
    • Organizer
      第66回日本体力医学会大会
    • Place of Presentation
      海峡メッセ下関(山口)
    • Year and Date
      2011-09-17
    • Related Report
      2011 Final Research Report
  • [Presentation] 運動による脂肪酸酸化亢進メカニズム2011

    • Author(s)
      三浦進司、只石幹、江崎治
    • Organizer
      第65回日本体力医学会大会
    • Place of Presentation
      海峡メッセ下関(山口)
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 骨格筋PGC-1α-b過剰発現が運動継続能力、VO2maxに及ぼす影響2011

    • Author(s)
      只石幹、三浦進司、江崎治
    • Organizer
      第66回日本体力医学会大会
    • Place of Presentation
      海峡メッセ下関(山口)
    • Year and Date
      2011-09-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 骨格筋PGC-1α-b過剰発現が運動継続能力、VO_2maxに及ぼす影響2011

    • Author(s)
      只石幹、三浦進司、江崎治
    • Organizer
      第66回日本体力医学会大会
    • Place of Presentation
      海峡メッセ下関(山口)
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 骨格筋LKB1活性は低強度運動時の脂肪酸酸化亢進に必須である2010

    • Author(s)
      三浦進司、只石幹、江崎治
    • Organizer
      第65回日本体力医学会大会
    • Place of Presentation
      千葉商科大学(千葉)
    • Year and Date
      2010-09-17
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 運動強度の違いがPGC-1αisoform mRNA発現に及ぼす影響2010

    • Author(s)
      只石幹、三浦進司、川中健太郎、江崎治
    • Organizer
      第65回日本体力医学会大会
    • Place of Presentation
      千葉商科大学(千葉)
    • Year and Date
      2010-09-16
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] LKB1 activity in skeletal muscle is essential for an increase in fatty acid oxidation during low-intensity exercise2010

    • Author(s)
      Miura S、Kai Y、Tadaishi M、Ezaki O
    • Organizer
      70th Scientific Sessions, American Diabetes Association
    • Place of Presentation
      Orland, Florida, USA
    • Year and Date
      2010-06-26
    • Related Report
      2011 Final Research Report
  • [Presentation] LKBI activity in skeletal muscle is essential for an increase in fatty acid oxidation during low-intensity exercise.2010

    • Author(s)
      Miura S., Kai Y., Tadaishi M., Ezaki O.
    • Organizer
      70th Scientific Sessions, American Diabetes Association
    • Place of Presentation
      Orland, Florida, USA
    • Year and Date
      2010-06-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 運動はどのようにして脂肪酸酸化を亢進するのか2010

    • Author(s)
      三浦進司
    • Organizer
      日本農芸化学会2010年度大会シンポジウム(骨格筋機能と生活習慣病)
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2010-03-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 運動はどのようにして脂肪酸酸化を亢進するのか2010

    • Author(s)
      三浦進司
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京大学、東京
    • Year and Date
      2010-03-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] The role of AMPK in skeletal muscle on microvascular PO_2 kinetics following onset of muscle contraction2010

    • Author(s)
      Kano Y、Poole DC、Sudo M、Miura S、Ezaki O
    • Organizer
      Integrative Phyisiology of Exercise
    • Place of Presentation
      Miami Beach, Florida, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] 低強度運動による脂質代謝亢進に骨格筋AMPKの活性化は必須ではない2009

    • Author(s)
      三浦進司
    • Organizer
      第64回日本体力医学会
    • Place of Presentation
      朱鷺メッセ(新潟市)
    • Year and Date
      2009-09-18
    • Related Report
      2011 Final Research Report
  • [Presentation] 低強度運動による脂質代謝亢進に骨格筋AMPKの活性化は必須ではない2009

    • Author(s)
      三浦進司
    • Organizer
      第64回日本体力医学会
    • Place of Presentation
      朱鷺メッセ、新潟
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Fibrate treatment causes muscle atrophy with increased FOXO1 mRNA in a PPAR α-dependent manner in mice.2009

    • Author(s)
      Miura, S., Kai, Y., Ezaki, O
    • Organizer
      The 69th American Diabetes Association Scientific Sessions
    • Place of Presentation
      New Orleans, LA, USA
    • Year and Date
      2009-06-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 運動による骨格筋PGC-1α新規アイソフォームの発現2009

    • Author(s)
      三浦進司
    • Organizer
      第1回分子骨格筋代謝研究会
    • Place of Presentation
      京都大学(京都)
    • Year and Date
      2009-03-28
    • Related Report
      2011 Final Research Report
  • [Book] 運動療法-運動療法の理論,すべてがわかる最新・糖尿病2011

    • Author(s)
      江崎治、三浦進司
    • Publisher
      照林社
    • Related Report
      2011 Final Research Report
  • [Book] 生活習慣病の栄養管理「糖分摂取過剰と生活習慣病」、成人病と生活習慣病2011

    • Author(s)
      三浦進司、只石幹、江崎治
    • Related Report
      2011 Final Research Report
  • [Book] AMPキナーゼによる糖の取り込み制御、内分泌・糖尿病・代謝内科2011

    • Author(s)
      江崎治、三浦進司
    • Related Report
      2011 Final Research Report
  • [Book] すべてがわかる最新・糖尿病(運動療法-運動療法の理論)2011

    • Author(s)
      江崎治、三浦進司
    • Total Pages
      5
    • Publisher
      照林社
    • Related Report
      2011 Annual Research Report
  • [Book] PGC-1αとミトコンドリア機能、エネルギー代謝、Adiposcience2010

    • Author(s)
      江崎治、三浦進司
    • Related Report
      2011 Final Research Report
  • [Book] 肥満症(2) PGC-1、日本臨床増刊号2010

    • Author(s)
      三浦進司、只石幹、江崎治
    • Related Report
      2011 Final Research Report
  • [Book] 肥満症(2)筋肉などでの代謝調節、日本臨床増刊号2010

    • Author(s)
      江崎治、千葉剛、三浦進司
    • Related Report
      2011 Final Research Report
  • [Book] PGC-1の多彩な機能と糖・脂質代謝制御における意義-糖・脂質代謝制御におけるPGC-1αアイソフォームa, b, cの意義、内分泌・糖尿病科2009

    • Author(s)
      江崎治、三浦進司
    • Related Report
      2011 Final Research Report
  • [Book] 運動の抗肥満効果、ILSI JAPAN2009

    • Author(s)
      三浦進司、江崎治
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.nih.go.jp/eiken/info/pdf/kenkoeiyonews31.pdf

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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