| Project/Area Number |
21300253
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
WAKI Hidefumi 和歌山県立医科大学, 医学部, 講師 (50274957)
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| Co-Investigator(Kenkyū-buntansha) |
MAEDA Masanobu 和歌山県立医科大学, 医学部, 教授 (80181593)
KOHSAKA Akira 和歌山県立医科大学, 医学部, 講師 (00458051)
GOURAUD Sabine 和歌山県立医科大学, 医学部, 学内助教 (30453179)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Keywords | 孤束核 / 高血圧 / 有酸素運動 / 循環調節中枢 / 遺伝子発現 / ヒスタミン / セロトニン / 神経科学 |
|---|
| Research Abstract |
Daily exercise has been associated with antihypertensive benefits ; however, its mechanisms remain unclear. To explore this, we have investigated the effects of daily exercise on an important brain area in regulating blood pressure, the nucleus of the solitary tract(NTS), in spontaneously hypertensive rats(SHR). We have revealed that daily exercise alters gene expression profiles and neuronal functions in the NTS of SHR. These results suggest that the plastic changes in the NTS may be involved in the antihypertensive effects of daily exercise. Moreover, we have concluded that the serotoninergic system may have an important role in the functional changes in the NTS induced by daily exercise.
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