| Project/Area Number |
21300254
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Teikyo Heisei University |
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Principal Investigator |
MESAKI Noboru 帝京平成大学, 地域医療学部, 教授 (30010408)
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| Co-Investigator(Kenkyū-buntansha) |
AKIMOTO Takayuki 東京大学, 医学系研究科, 講師 (00323460)
EMITSU Motoyuki 立命館大学, スポーツ健康科学部, 准教授 (90375460)
AIZAWA Katsuji 専修大学, 文学部, 講師 (80375477)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2009: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Keywords | 加齢 / 老化 / 自己分泌 / 運動 / 性ホルモン / 骨格筋 / 閉経 |
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| Research Abstract |
Sex steroid hormones are mainly produced and secreted by the ovary, testis, and adrenal cortex and affect diverse physiological processes of target organs or tissues, such as reproductive organs, bones, liver, heart, vasculature, brain, and skeletal muscles. Previously, we demonstrated that skeletal muscles are capable of locally synthesizing circulating DHEA to testosterone and estrogen. This study examined association of life-style related diseases and sarcopenia in local skeletal and cardiac muscles and intended to apply it to exercise therapy for anti-aging. Our data demonstrated that local steroidogenesis is involved in age-related life-style related diseases and sarcopenia, suggesting that this mechanism provides beneficial information as a basic finding of the exercise therapy for anti-aging prevention.
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