| Project/Area Number |
21300275
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Wakayama Medical University (2010-2011)
University of Tsukuba (2009) |
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Principal Investigator |
UTSUNOMIYA Hirotoshi (2010-2011) 和歌山県立医科大学, 医学部, 准教授 (60264876)
中原 朗 (2009) University of Tsukuba, 大学院・人間総合科学研究科, 准教授 (90114107)
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| Co-Investigator(Kenkyū-buntansha) |
ISHII Tetsuro 筑波大学, 大学院, 教授 (20111370)
SHODA Junichi 筑波大学, 医学医療系, 教授 (90241827)
TAKAHASHI Hiroshi 筑波大学, 医学医療系, 准教授 (70236313)
宇都宮 洋才 和歌山県立医科大学, 医学部, 講師 (60264876)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAMOTO Masayuki 東北大学, 医学研究科, 教授 (50166823)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2009: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
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| Keywords | 生活習慣病 / 脂肪性肝炎 / 肝発癌 / 機能性食品 / 転写因子 / Nrf2 / 分子標的治療 |
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| Research Abstract |
Nrf2 is a transcription factor that exerts an in vivo defense mechanism against oxidative stress. Therefore, we studied whether Nrf2 inhibits onset and progression of NASH in the animal model of NASH induced by a mechionine-and choline-deficient(MCD) diet. Nrf2 has an inhibitory effect against the onset and progression of MCD-induced NASH through the induction of detoxifying and antioxidative stress gene molecules. It is suggested that Nrf2 is an important target for the treatment of NASH.
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