Elucidations of the mechanisms for the formation of cholesterol-ozonolysis products in inflamed tissues, their biological activities and involvement in disease development
| Project/Area Number |
21300280
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | University of Shizuoka |
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Principal Investigator |
OHSHIMA Hiroshi 静岡県立大学, 食品栄養科学部, 教授 (80433209)
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| Co-Investigator(Kenkyū-buntansha) |
MIYOSHI Noriyuki 静岡県立大学, 食品栄養科学部, 助教 (70438191)
GODA Toshinao 静岡県立大学, 食品栄養科学部, 教授 (70195923)
HIGASHI Tatsuya 東京理科大学, 薬学部, 教授 (90272963)
NUKAYA Haruo 静岡県立大学, 食品栄養科学部, 客員教授 (00094342)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Keywords | コレステロール / 生活習慣病 / 脂質 / 炎症 / 栄養学 / 分析科学 / オゾン酸化 / 好中球 / ミエロペルオキシダーゼ |
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| Research Abstract |
We have developed a highly sensitive and specific method to analyze atheronals, cholesterol ozonolysis products. Using this method, we have reported that human neutrophils in inflamed tissues can produce an ozone-like oxidant(s) which can oxidize cholesterol to generate atheronals. Because atheronals impair the formation of an important signal molecule, nitric oxide, by inhibiting nitric oxide synthases and also exert potent cytotoxic effects against a variety of cells including neuronal cells, these could be causative agents for Alzheimer's disease and others.
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Report
(4 results)
Research Products
(73 results)
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[Presentation] The myeloperoxidase-H_2O_2-chloride system produces cholesterol ozonolysis products via an ozone free mechanism2009
Author(s)
Susumu Tomono, Noriyuki, Miyoshi, Hidemi, Shiokawa, Megumi, Ito, Yasuaki, Aratani, Hiroshi, Ohshima
Organizer
SFRR Europe meeting Rome 2009
Place of Presentation
Roma, Italy
Related Report
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