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Formulation of the rare sugar delivery system for functional food and the safety assessment method

Research Project

Project/Area Number 21300282
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionNational Institute for Materials Science

Principal Investigator

SHIRAI Yoko  独立行政法人物質・材料研究機構, 生体機能材料ユニット, 主幹エンジニア (10399404)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Nobuhiro  東北大学, 歯学研究科, 教授 (60183852)
KAMIMURA Wataru  東京大学, 医学部付属病院, 研究員 (80399394)
KANETAKA Hiroyasu  東北大学, 歯学研究科, 准教授 (50292222)
SHIMIZU Yoshinaka  東北大学, 歯学研究科, 助教 (30302152)
Co-Investigator(Renkei-kenkyūsha) MATSUO Tatsuhiro  香川大学, 農学部, 教授 (20270019)
Project Period (FY) 2009-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2010: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Keywords希少糖 / DDS / 安全性評価 / 機能性食品
Research Abstract

Although it has been difficult to supply a large amount of rare sugars, an inexpensive synthetic method on a large scale was recently established, leading to the reports on various physiological functions including regulation of blood glucose level and suppression of body fat accumulation. Meanwhile, it has been pointed out that rare sugars are difficult to utilize as foodstuffs by reason that they are excreted after the gut absorption more rapidly than typical monosaccharide.
Therefore in present study, by applying drug delivery systems (DDS), we tried to bring the physiological functions of rare sugars into action efficiently by means of improving the stability in the body and prolonging the residence time. In addition, safety assessment methods for functional foods containing saccharides such as those exerted in the oral cavity were examined.

Report

(6 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (14 results)

All 2013 2012 2011 2010

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (8 results)

  • [Journal Article] The 90-day oral toxicity study of D-psicose in male wistar rats2012

    • Author(s)
      Ishii R, Matsuo T and Shirai Y
    • Journal Title

      J Clin Biochem Nutri

      Volume: 50(2) Pages: 158-161

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of bacteria in the caries process : ecological perspectives2011

    • Author(s)
      Takahashi N and Nyvad B
    • Journal Title

      J Dent Res

      Volume: 90(3) Pages: 294-303

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Resist ance to acidic environments of carie s-associated bacteria : Bifidobacteri um dentium and Bifidobacterium longu m2010

    • Author(s)
      Nakajo, K, Takahashi N., et al
    • Journal Title

      Caries Res

      Volume: 44(5) Pages: 431-437

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acute and sub-chronic toxicity of D-allose in rats2010

    • Author(s)
      Matsuo T, Shirai Y., et al
    • Journal Title

      Biosci. Biotechnol. Biochem

      Volume: 74(7) Pages: 1476-1478

    • NAID

      10027557521

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Resistance to acidic environments of caries-associated bacteria : Bifidobac terium dentium and Bifidobacterium longum.2010

    • Author(s)
      Nakajo, K, Takahashi N, et al
    • Journal Title

      Caries Res.

      Volume: 44(5) Pages: 431-437

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute and sub-chronic toxicity of D-allose in rats.2010

    • Author(s)
      Matsuo T, Shirai Y, et al
    • Journal Title

      Biosci.Biotechnol.Biochem.

      Volume: 74(7) Pages: 1476-1478

    • NAID

      10027557521

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Formulation of the rare sugar delivery system for functional food2013

    • Author(s)
      Shirai Y, Kamimura W., et al
    • Organizer
      Experimental Biology
    • Place of Presentation
      Boston, USA
    • Year and Date
      2013-04-20
    • Related Report
      2013 Final Research Report
  • [Presentation] Formulation of the Rare-Sugar Delivery System for Functional Food2013

    • Author(s)
      白井暢子
    • Organizer
      Experimental Biology 2013
    • Place of Presentation
      Boston Convention & Exhibition Center
    • Related Report
      2013 Annual Research Report
  • [Presentation] Conjugate of rare sugar with amino acid through the maillard reaction2011

    • Author(s)
      Shirai Y, Kamimura W., et al
    • Organizer
      Experimental Biology
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2011-04-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Conjugate of Rare Sugar with Amino acid through the Maillard Reaction2011

    • Author(s)
      Yoko Shirai, Hitomi Sasaki, Wataru Kamimura
    • Organizer
      Experimental Biology 2011
    • Place of Presentation
      Washington Convention Center, Washington, DC, USA
    • Year and Date
      2011-04-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Acid-tolerance of oral bifidobacteria and its comparison with Streptococcus mutans2010

    • Author(s)
      Nakajo K, Takahashi N., et al
    • Organizer
      The 88th IADR
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-07-17
    • Related Report
      2013 Final Research Report
  • [Presentation] Acid-tolerance of oral bifidobacteria and its comparison with Streptococcus mutans.2010

    • Author(s)
      Nakajo K, Takahashi N, et al
    • Organizer
      The 88^<th> IADR
    • Place of Presentation
      Barcelona(スペイン)
    • Year and Date
      2010-07-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Acute and chronic toxicity of D-allose in rats2010

    • Author(s)
      Matsuo T, Shirai Y., et al
    • Organizer
      Experimental Biology
    • Place of Presentation
      Anaheim, USA
    • Year and Date
      2010-04-24
    • Related Report
      2013 Final Research Report
  • [Presentation] Acute and chronic toxicity of D-allose in rats.2010

    • Author(s)
      Matsuo T, Shirai Y, et al
    • Organizer
      Experimental Biology
    • Place of Presentation
      Anaheim(米国)
    • Year and Date
      2010-04-24
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2019-07-29  

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