| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Research Abstract |
Maintenance of centrosome numbers is required for correct chromosome segregation, and radiation induces its aberrations. In order to understand their mechanisms, we investigated roles of the DNA damage response in maintenance of centrosome integrity. We found that activation of the signaling pathway mediated by ATR and Chk1 causes supernumerary centrosomes when homologous recombination repair is inhibited. Supernumerary centrosomes are frequently observed in cancer. We also found that activation of ATM is involved in centrosome aberrations when SYCE2, a cancer testis antigen, is expressed. Additionally, aneuploidy is induced by centrosome-independent mechanisms in cells defective in homologous recombination repair, indicating that multiple pathways are involved in regulation of chromosome integrity.
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