Role of nucleolus and related proteins for genomic stability
| Project/Area Number |
21310035
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Kyoto University |
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Principal Investigator |
KOBAYASHI Junya 京都大学, 放射線生物研究センター, 准教授 (30301302)
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| Co-Investigator(Kenkyū-buntansha) |
HAYASHI Ikue 広島大学, 医歯薬学総合研究科, 助教 (00346503)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2009: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Keywords | 核小体 / nucleolin / DNA損傷 / チェックポイント / DNA修復 |
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| Research Abstract |
This study was carried out to clarify the roles of nucleolus, which contains multi-copy of ribosomal DNA and forms specific structure compared with other genomic DNA regions, and nucleolus-related protein for genomic stability. As a result, we found that a major nucleolar protein, nucleolin could function for DNA repair and cell cycle checkpoint following irradiation. Furthermore, nucleolus-localizing protein, WRN and its interaction with NBS1 and Rad18/PCNA could participate in the regulation of trans-lesion DNA synthesis. Therefore, nucleolus-related proteins might be important for maintenance of genomic stability against various genomic stresses.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] NBS1 recruits RAD18 via aRAD6-like domain and regulates Polη-dependent translesion DNA synthesis2011
Author(s)
Yanagihara H, Kobayashi J, Tateishi S, Kato A, Matsuura S, Tauchi H, Yamada K, Takezawa J, Sugasawa K, Masutani C, Hanaoka F, Weemaes CM, Mori T, Zou L, Komatsu K.
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Journal Title
Mol Cell
Volume: 43
Issue: 5
Pages: 788-797
DOI
Related Report
Peer Reviewed
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[Journal Article] Regulation of homologous recombination by RNF20-dependent H2Bubiquitination2011
Author(s)
Nakamura K, Kato A, Kobayashi J, Yanagihara H, Sakamoto S, Oliveira D, Shimada S, Tauchi H, Suzuki H, Tashiro S, Zou L, Komatsu K.
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Journal Title
Mol Cell
Volume: 41
Issue: 5
Pages: 515-528
DOI
NAID
Related Report
Peer Reviewed
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