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Develo pments of the target cooling and dosimetry systems for the use of the accelerator boron neutron capture therapy

Research Project

Project/Area Number 21310039
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Risk sciences of radiation/Chemicals
Research InstitutionHiroshima University

Principal Investigator

MASAHARU Hoshi  広島大学, 原爆放射線医科学研究所, 教授 (50099090)

Co-Investigator(Kenkyū-buntansha) ZHUMADILOV Kassym  広島大学, 原爆放射線医科学研究所, 特任准教授 (40530770)
ENDO Satoru  広島大学, 大学院・工学研究院, 准教授 (90243609)
ISHIKAWA Masayori  北海道大学, 大学院・医学研究科, 教授 (80314772)
Co-Investigator(Renkei-kenkyūsha) TAKADA Masashi  放射線医学総合研究所, 主任研究員 (50291109)
SATO Hitoshi  茨城県立医療大学, 保健医療学部, 准教授 (90285057)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Keywords放射線 / BNCT / 加速器 / 中性子 / リチウムターゲット / 線量測定 / 冷却システム / Liターゲット / 中性子線量 / ホウ素 / 線量評価
Research Abstract

New target system for the accelerator boron neutron capture therapy by using water cooling system was developed. The target was tested 6 times using the 3MeV proton beam of the accelerator in National Institute for Radiological Sciences with the same power per unit area and was verified to have enough ability to keep the temperature below about 100 degrees. From these results we can manufacture an actual target system. For the dosimetry system we used new plastic including boron and made verified the possibility of the new chamber system to measure necessary neutrons for boron neutron capture therapy system.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (33 results)

All 2011 2010 2009

All Journal Article (25 results) (of which Peer Reviewed: 25 results) Presentation (8 results)

  • [Journal Article] Development of monitoring method of spatial neutron distribution inneutrons. gamma rays mixed field usingimaging plate for NCT-De pression of the field2011

    • Author(s)
      Tanaka, K., Endo, S., Hoshi, M., Takada, J.
    • Journal Title

      Applied Radiation andIsotopes

      Volume: 69 Pages: 1885-1887

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Estimation of Beta-Ray Skin Dose From Exposure to Fission Fall out from The Hiro shima Atomic Bomb2011

    • Author(s)
      Endo, S., Tanaka, K., Shizuma, K., Hoshi, M. and Imanaka, I
    • Journal Title

      Radiation Prote ction Dosimetry

      Pages: 1-7

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of monitoring method of spatial neutron distribution in neutrons-gamma rays mixed field using imaging plate for NCT-Depression of the field2011

    • Author(s)
      Tanaka, K.
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 69 Pages: 1885-1887

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estimation of beta-ray skin dose from exposure tofission fallout from the Hiroshimaa to mic bomb2011

    • Author(s)
      Endo S, Tanaka K, Shizuma K, Hoshi M, Imanaka T
    • Journal Title

      Radiation Protection Dosimetry

      Volume: 143 Issue: 1 Pages: 1-7

    • DOI

      10.1093/rpd/ncr407

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Measurement of microdosimetrics pectra produced from a 290 MeV/ nSpread Out Bragg Peak carbon beam2010

    • Author(s)
      Endo, S., Takada, M., Tanaka, H., Onizuka, Y., Tanaka, K., Miyahara, N., Baba, H., Oishi, A., Ishikawa, M., Hoshi, M., Kimura, S., Minematsu, M., Morimune, Y., Kojima, Y., Shizuma, K.
    • Journal Title

      Radiation and EnvironmentBiophysics

      Volume: 49 Pages: 469-475

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genome-Wide Expression Changes in Saccharo myces cerevisiae in Response to High-LET Ionizing Radiation2010

    • Author(s)
      Mizukami-Murata, S., Iwahashi, H., Kimura, S., Nojima, K., Sakurai, Y., Saitou, T., Fujii, N., Murata, Y., Suga, S., Kitagawa, K., Tanaka, K., Endo, S., Hoshi, M.
    • Journal Title

      Applied Bioche mistry and Biote chnology

      Volume: 162 Pages: 855-870

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dosime tricverification of the anisotropic an alytical algo rithm in lunge quivalent heteroge neities with and without bone e quivalen the terogeneities2010

    • Author(s)
      Ono, k., Endo, S., Tanaka, K., Hoshi, M., Hirokawa, Y.
    • Journal Title

      MedicalPhysics

      Volume: 37 Pages: 4456-4463

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Measurements of neutron distributionin neutrons-gamma rays mixed fieldusing imaging plate for neutroncapture the rapy2010

    • Author(s)
      Tanaka, K., Endo, S., Hoshi, M.
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 68 Pages: 207-210

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mixed field dosimetry of accelerator-based neutron source for BNCT2010

    • Author(s)
      中尾稔, 鬼塚昌彦, 馬場大海, 深堀麻衣, 田中憲一, 星正治, 佐々木雅之
    • Journal Title

      Japanese Journal of Medical Physics

      Volume: 30 Pages: 200-201

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Consideration of Biological Effectiveness of Low EnergyProtons Using Biophysical Modeling of the Effects Induced by Exposure of V79Cells2010

    • Author(s)
      Khvostunov, I., Nikjoo, H., Uehara, S., Hoshi, M.
    • Journal Title

      Radiobiology and Radioe cology

      Volume: 55 Pages: 1067-1075

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Consideration of Biological Effectiveness of Low Energy Protons Using Biophysical Modeling of The Effects Induced By Exposure of V79Cells2010

    • Author(s)
      Khvostunov, I., Nikjoo, H., Uehara, S., Hoshi, M.
    • Journal Title

      Russian Journal of Radiation Biology & Radioecology

      Volume: 50 Pages: 81-89

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Measurement of microdosimetric spectra produced from a 290 MeV/n Spread Out Bragg Peak carbon beam2010

    • Author(s)
      Endo, S.
    • Journal Title

      Radiation and Environment Biophysics

      Volume: 49 Pages: 469-475

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-Wide Expression Changes in Saccharomyces cerevisiae in Response to High-LET Ionizing Radiation2010

    • Author(s)
      Mizukami-Murata, S.
    • Journal Title

      Applied Biochemistry and Biotechnology

      Volume: 162(3) Pages: 855-870

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dosimetric verification of the anisotropic analytical algorithm in lung equivalent heterogeneities with and without bone equivalent heterogeneities2010

    • Author(s)
      Ono, K.
    • Journal Title

      Medical Physics

      Volume: 37(8) Pages: 4456-4463

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of monitoring method of spatial neutron distribution in neutrons-gamma rays mixed field using imaging plate2010

    • Author(s)
      Tanaka, K.
    • Journal Title

      Challenges in Neutron Capture Therapy (Proc.of the 14th International Congress on Neutron Capture Therapy)

      Pages: 195-198

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Measurements of neutron distribution in neutrons-gamma rays mixed field using imaging plate for neutron capture therapy2010

    • Author(s)
      Tanaka, K.
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 68 Pages: 207-210

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A study on monitoring method of spatial neutron distribution using imaging plate for NCT2010

    • Author(s)
      田中憲一
    • Journal Title

      Proceedings of 2011 Annual Meeting of AESJ

      Pages: 687-687

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] イメージングプレートを用いた中性子束分布測定法の検討2010

    • Author(s)
      田中憲一
    • Journal Title

      第7回日本中性子捕捉療法学会学術大会抄録集

      Pages: 37-37

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mixed field dosimetry of accelerator-based neutron source for BNCT2010

    • Author(s)
      中尾稔
    • Journal Title

      Japanese Journal of Medical Physics

      Volume: 30(Sup.5) Pages: 200-201

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Consideration of Biological Effectiveness of Low Energy Protons Using Biophysical Modeling of the Effects Induced by Exposure of V79 Cells2010

    • Author(s)
      Khvostunov, I.K.
    • Journal Title

      Biophysics

      Volume: 55(6) Pages: 1067-1075

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Consideration of Biological Effectiveness of Low Energy Protons Using Biophysical Modeling of The Effects Induced By Exposure of V79 Cells2010

    • Author(s)
      Khvostunov, K.
    • Journal Title

      Russian Journal of Radiation Biology & Radioecology 50(1)

      Pages: 81-89

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The microdosimentric consideration of RBE of low-energy protons on V79 cells2010

    • Author(s)
      Khvostunov, K.
    • Journal Title

      III International Symposium under the auspices of UNESCO dedicated to the centenary of Academician N.M.Sisakian's birth, Moscow, Dubna, January 24-28, 2007, Book of abstracts

      Pages: 152-153

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The microdosimetric consideration of RBE of low-energy protons on V79 cells2010

    • Author(s)
      Khvostunov, K.
    • Journal Title

      III International Symposium under the auspices of UNESCO dedicated to the centenary of Academician N.M.Sisakian's birth, Moscow, Dubna, January 24-28, 2007, Book of abstracts

      Pages: 336-338

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microdosimetry on a Mini-Reactor UTR-KINKI for Educational Uses and Biological Researches2009

    • Author(s)
      Endo, S., Tanaka, K., Fujikawa, K., Horiguchi, T., Itoh, T., Onizuka, Y., Hoshi, M., Murataka, A., Kojima, Y. andShizuma, K.
    • Journal Title

      Journal of Radiation Research

      Volume: 50 Pages: 83-87

    • NAID

      110007042072

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Microdosimetry on a Mini-Reactor UTR-KINKI for Educational Uses and Biological Researches2009

    • Author(s)
      Endo, S.
    • Journal Title

      Journal of Radiation Research 50

      Pages: 83-87

    • NAID

      110007042072

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 加速器Liターゲット中性子源のための4重電離箱システムの開発2011

    • Author(s)
      中尾稔, 鬼塚昌彦, 馬場大海, 深堀麻衣, 田中憲一, 星正治, 佐々木雅之
    • Organizer
      平成22年度京都大学原子炉実験所専門研究会
    • Place of Presentation
      大阪府熊取町
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] イメージングプレートによるNCT用中性子束分布測定法の検討2011

    • Author(s)
      田中憲一, 遠藤暁, 星正治, 高田純
    • Organizer
      日本原子力学会2011年春の年会
    • Place of Presentation
      福井市
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] イメージングプレートを用いた線量分布測定法の検討2010

    • Author(s)
      田中憲一, 遠藤暁, 星正治, 高田純
    • Organizer
      第7回日本中性子捕捉療法学会学術大会
    • Place of Presentation
      東京都
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 加速器硼素中性子捕捉療法の混合場における線量評価2010

    • Author(s)
      中尾稔, 鬼塚昌彦, 馬場大海, 深堀麻衣, 田中憲一, 星正治, 佐々木雅之
    • Organizer
      第100回日本医学物理学会学術大会
    • Place of Presentation
      東京都
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Development of monitoring method of spatial neutron distribution in neutrons-gamma rays mixed field using imaging plate2010

    • Author(s)
      Tanaka, K., Endo, S., Hoshi, M. andTakada, J.
    • Organizer
      14thInternational Congress on Neutron Capture Therapy
    • Place of Presentation
      Buenos Aires, Argentina
    • Related Report
      2011 Final Research Report
  • [Presentation] Mixed field do simetry of accelerator-based neutron source for BNCT2010

    • Author(s)
      Nakao, M., Onitsuka, M., Baba, T., Fukahori, M., Tanaka, K., Hoshi, M., Sasaki, N.
    • Organizer
      The 6th International Workshop on Personnel Monitoring
    • Place of Presentation
      Ibaraki
    • Related Report
      2011 Final Research Report
  • [Presentation] Development of monitoring method of spatial neutron distribution in neutrons-gamma rays mixed field using imaging plate2010

    • Author(s)
      Tanaka, K.
    • Organizer
      14th International Congress on Neutron Capture Therapy
    • Place of Presentation
      Buenos Aires, Argentina
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mixed field dosimetry of accelerator-based neutron source for BNCT2010

    • Author(s)
      Nakao, M.
    • Organizer
      The 6th International Workshop on Personnel Monitoring
    • Place of Presentation
      Ibaraki
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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