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Study of radiation-induced cluster DNA damage- its structure and repair susceptibility

Research Project

Project/Area Number 21310041
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Risk sciences of radiation/Chemicals
Research InstitutionJapan Atomic Energy Agency

Principal Investigator

YOKOYA Akinari  独立行政法人日本原子力研究開発機構, 原子力科学研究部門先端基礎研究センター, 研究主席 (10354987)

Co-Investigator(Kenkyū-buntansha) SHIKAZONO Naoya  独立行政法人日本原子力研究開発機構・ 原子力科学研究部門, 量子ビーム応用研究センタ ー, 研究主幹 (10354961)
WATANABE Ritsuko  独立行政法人日本原子力研究開発機構・ 原子力科学研究部門, 原子力基礎工学研究センタ ー, 研究副主幹 (10360439)
FUJII Kentaro  独立行政法人日本原子力研究開発機構・ 原子力科学研究部門, 先端基礎研究センター, 研究副主幹 (00360404)
NOGUCHI Miho  独立行政法人日本原子力研究開発機構・ 原子力科学研究部門, 先端基礎研究セ ンター, 研究員 (40455283)
HIGUCHI Mariko  独立行政法人日本原子力研究開発機構・ 原 子力科学研究部門, 原子力基礎工学研究 センタ ー, 任期付研究員 (90370460)
OKA Toshitaka  東北大学, 高等教育開発推進センタ ー, 助教 (70339745)
山下 真一  独立行政法人日本原子力研究開発機構, 量子ビーム応用研究部門, 博士研究員 (20511489)
Project Period (FY) 2009-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2010: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2009: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
KeywordsクラスターDNA損傷 / 放射線 / シンクロトロン放射光 / イオンビーム / DNA修復 / 軟X線 / EPR / DNAラジカル / APサイト / 塩基除去修復酵素 / モンテカルロシミュレーション / 不対電子種 / 突然変異 / 塩基損傷 / 電子常磁性共鳴装置 / トラック構造 / DNA損傷 / クラスターDNA / シンクロトロン放射 / 塩基除去修復 / 分子動力学法
Research Abstract

In order to clarify the induction processes of clustered DNA damage, we have investigated the radiation effect on DNA molecules using both biochemical and spectroscopic techniques. We determined the yields of clustered DNA damage induced by various ion beam exposure. The data were analyzed using a computer simulation method to establish a damage induction model. Further we found a novel radical process involved in the DNA damage induction using an EPR apparatus installed in a high brilliance synchrotron radiation facility. These results have been presented in a number of symposiums or workshops, and also published as 25 peer review papers.

Report

(6 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (167 results)

All 2014 2013 2012 2011 2010 2009 Other

All Journal Article (51 results) (of which Peer Reviewed: 44 results,  Open Access: 1 results) Presentation (110 results) (of which Invited: 7 results) Book (3 results) Remarks (3 results)

  • [Journal Article] Dependence of the yields of AP sites and AP clusters produced in plasmid DNA on scavenging capacity and LET2014

    • Author(s)
      Takuya SHIINA, RitsukoWATANABE, Masao SUZUKI and Akinari YOKOYA
    • Journal Title

      Journal of Radiation Research

      Volume: 55 Issue: suppl 1 Pages: i15-i16

    • DOI

      10.1093/jrr/rrt160

    • NAID

      120006683955

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Order effect of repair processes to clustered DNA damage2014

    • Author(s)
      Iyo SHIRAISHI, Masao SUZUKI, Naoya SHIKAZONO, Kentaro FUJII and Akinari YOKOYA
    • Journal Title

      Journal of Radiation Research

      Volume: 55 Issue: suppl 1 Pages: i92-i93

    • DOI

      10.1093/jrr/rrt152

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 放射線生物学の最前線-DNA損傷機構と損傷修復の分子シミュレーション2014

    • Author(s)
      横谷明徳、高須昌子、石川顕一
    • Journal Title

      日本原子力学会誌ATOMOΣ

      Volume: 56 Pages: 23-27

    • NAID

      130007739582

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 内殻イオン化によるDNA損傷と局在化2014

    • Author(s)
      横谷明徳、鵜飼正敏、岡壽崇、甲斐健師、渡邊立子、藤井健太郎
    • Journal Title

      原子衝突学会誌「しょうとつ」

      Volume: 11 Pages: 33-39

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A. Induction of DNA damage, including abasic sites, in plasmid DNA by carbon ion and X-ray irradiation2013

    • Author(s)
      Shiina, T., Watanabe, R., Shiraishi, I., Suzuki, M., Sugaya, Y., Fujii, K. and Yokoya
    • Journal Title

      Radiat. Environ. Biophys.

      Volume: 52 Pages: 99-112

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] DNA damage by soft X-ray exposure at oxygen K-edge2013

    • Author(s)
      Y. Sugaya, A. Narita, K. Fujii, and A. Yokoya
    • Journal Title

      Journal of Physics:ConferenceSeries

      Volume: 502 Pages: 12040-12040

    • DOI

      10.1088/1742-6596/502/1/012040

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Significance of DNA Polymerase I in in vivo processing of clustered DNA damage2013

    • Author(s)
      Shikazono, N., Akamatsu, K., Takahashi, M., Noguchi, M., Urushibara, A., O’Neill, P. and Yokoya, A.
    • Journal Title

      Mutatation Research

      Volume: 749 Issue: 1-2 Pages: 9-15

    • DOI

      10.1016/j.mrfmmm.2013.07.010

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemical Repair of Base lesions, AP-sites, and Strand Breaks on Plasmid DNA in Dilute Aqueous Solution by Ascorbic Acid2013

    • Author(s)
      Hata, K.
    • Journal Title

      Biochem. Biophys. Res. Comm.

      Volume: 434 Pages: 341-345

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of DNA damage, including abasic sites, in plasmid DNA by carbon ion and X-ray irradiation2013

    • Author(s)
      Shiina, T.
    • Journal Title

      Radiat. Environ. Biophys.

      Volume: 52 Issue: 1 Pages: 99-112

    • DOI

      10.1007/s00411-012-0447-4

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] M. Unpaired electron species in calf thymus DNA thin films induced by nitrogen and oxygen K-shell photoabsorption2012

    • Author(s)
      Oka, T., Yokoya, A., Fujii, K., Fukuda, Y. and Ukai
    • Journal Title

      Phys. Rev. Lett.

      Volume: 109

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The mutagenic potential of 8-oxoG/single strand break-containing clusters depends on their relative positions2012

    • Author(s)
      Noguchi, M., Urushibara, A., Yokoya
    • Journal Title

      Mutat. Res.

      Volume: 732 Pages: 34-42

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Unpaired electron species in calf thymus DNA thin films induced by nitrogen and oxygen K-shell photoabsorption2012

    • Author(s)
      Oka, T.
    • Journal Title

      Phys. Rev. Lett.

      Volume: 109 Issue: 21 Pages: 213001-213001

    • DOI

      10.1103/physrevlett.109.213001

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 低線量放射線の微視的エネルギー付与分布 (依頼総説)2012

    • Author(s)
      渡辺立子
    • Journal Title

      放射線生物研究

      Volume: 47 Pages: 335-346

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 分光学的アプローチによる放射線によるゲノム損傷と生体修復の研究 (依頼総説)2012

    • Author(s)
      横谷明徳
    • Journal Title

      応用物理学会分科会誌「放射線」

      Volume: 38 Pages: 55-60

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Observation of Cleavage in DNA and Nucleotides Following Oxygen K-shell Ionization by Measuring X-ray Absorption Near Edge Structure2012

    • Author(s)
      Fujii, K.
    • Journal Title

      Int. J. Radiat. Biol.

      Volume: 38 Pages: 888-894

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lifetime of the Unpaired Electron Species in Calf Thymus DNA Thin Films Induced by Nitrogen and Oxygen K-shell Photoabsorption2012

    • Author(s)
      Oka, T.
    • Journal Title

      Int. J. Radiat. Biol.

      Volume: 38 Pages: 884-887

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a simulation method for dynamics of electrons ejected from DNA molecules irradiated with X-rays2012

    • Author(s)
      Kai, T.
    • Journal Title

      Int. J. Radiat. Biol.

      Volume: 88 Pages: 928-932

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The mutagenic potential of 8-oxoG/single strand break-containing clusters depends on their relative positions2012

    • Author(s)
      Miho Noguchi
    • Journal Title

      Mutation Research

      Volume: 732 Issue: 1-2 Pages: 34-42

    • DOI

      10.1016/j.mrfmmm.2011.12.009

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Yield of single- and double-strand breaks and nucleobase lesions in fully hydrated plasmid DNA films irradiated with high-LET charged particles2012

    • Author(s)
      Ushigome Takeshi
    • Journal Title

      Radiation Research

      Volume: (In press) Issue: 5 Pages: 914-627

    • DOI

      10.1667/rr2701.1

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Applications of the microdosimetric function implemented in the macroscopic partide transport simulation code PHITS2012

    • Author(s)
      Tatsuhiko Sato
    • Journal Title

      International Journal of Radiation Biology

      Volume: 88 Issue: 1-2 Pages: 143-150

    • DOI

      10.3109/09553002.2011.611216

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A. A novel technique using DNA denaturation to detect multiply induced single-strand breaks in a hydrated plasmid DNA molecule by X-ray and 4He2+ ion irradiation2011

    • Author(s)
      Yokoya, A., Shikazono, N., Fujii, K., Noguchi, M. and Urushibara
    • Journal Title

      Radiat. Protect. Dosim

      Volume: 143 Pages: 219-225

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 放射光軟X線を用いた選択的DNA損傷の誘発2011

    • Author(s)
      藤井健太郎
    • Journal Title

      放影協ニュース

      Volume: 4(依頼原稿) Pages: 8-10

    • NAID

      40017410490

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Electron paramagnetic resonance study of unpaired electron species in thin films of pyrimidine bases induced by nitrogen and oxygen K-shell photoabsorption2011

    • Author(s)
      Toshitaka Oka
    • Journal Title

      Applied Physics Letters

      Volume: 98

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel technique using DNA denaturation to detect multiply induced single-strand breaks in a hydrated plasmid DNA molecule by X-ray and ^4He^<2+> ion irradiation2011

    • Author(s)
      Akinari Yokoya
    • Journal Title

      Radiation Protection Dosimetry

      Volume: 143 Pages: 219-225

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A model for analysis of the yield and the level of clustering of radiation-induced DNA strand breaks in hydrated plasmids2011

    • Author(s)
      Naoya Shikazono
    • Journal Title

      Radiation Protection Dosimetry

      Volume: 143 Pages: 181-185

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Monte Carlo simulation of radial distribution of DNA strand breaks along the C and Ne ion paths2011

    • Author(s)
      Ritsuko Watanabe
    • Journal Title

      Radiation Protection Dosimetry

      Volume: 143 Pages: 186-190

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of cell-survival fraction for heavy-ion irradiations based on microdosimetric kinetic model implemented in the particle and heavy ion transport code sysyetm2011

    • Author(s)
      Tatsuhiko Sato
    • Journal Title

      Radiation Protection Dosimetry

      Volume: 143 Pages: 491-496

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced resolution of molecular recognition to distinguish structurally similar molecules by different conformational responses of a protein uponligand binding2011

    • Author(s)
      Mariko Higuchi
    • Journal Title

      Journal of Structural Biology

      Volume: 173 Pages: 20-28

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pulse Radiolysis Study on Free Radical Scavenger Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one). 2 : A Comparative Study on Edaravone Derivatives2011

    • Author(s)
      Kuniki Hata
    • Journal Title

      Journal of Radiation Research

      Volume: 52 Pages: 15-23

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protective effect of silybin and analogues against X-ray radiation-induced damage2010

    • Author(s)
      Haiying Fu
    • Journal Title

      Acta Biochimica et Biophysica Sinica

      Volume: 42 Pages: 489-495

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 軟X線照射によるDNA損傷の光子エネルギーによる選択的な依存性(放射線化学会奨励賞受賞論文)2010

    • Author(s)
      藤井健太郎
    • Journal Title

      放射線化学

      Volume: 90 Pages: 17-22

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 治療用重粒子イオンビームの放射線化学反応(放射線化学会奨励賞受賞論文)2010

    • Author(s)
      山下真一
    • Journal Title

      放射線化学

      Volume: 90 Pages: 11-16

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] X-ray absorption spectra for nucleotides (AMP, GMP, and CMP) in liquid water solutions near the nitrogen K-edge2010

    • Author(s)
      Masatoshi Ukai
    • Journal Title

      Chemical Physics Letters

      Volume: 495 Pages: 90-95

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Studies on Biological Effects of Ion Beams on Lethality, Molecular Nature of Mutation, Mutation Rate, and Spectrum of Mutation Phenotype for Mutation Breeding in Higher Plants2010

    • Author(s)
      Atsushi Tanaka
    • Journal Title

      Journal of Radiation Research

      Volume: 51 Pages: 223-233

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 放射線"をピボットとする化学と生物学(特集記事 後書き)2010

    • Author(s)
      横谷明徳
    • Journal Title

      放射線化学 89

      Pages: 36-37

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 重粒子線トラックとDNA損傷2010

    • Author(s)
      渡邊立子
    • Journal Title

      放射線化学 89

      Pages: 13-19

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA変性を利用した分子切断損傷を検出するための新しい方法の開発2010

    • Author(s)
      横谷明徳
    • Journal Title

      基礎科学ノート(原子力機構広報誌) 17

      Pages: 6-9

    • NAID

      40017010633

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 治り難いDNAのケガ(損傷)の実体を解明する2010

    • Author(s)
      横谷明徳
    • Journal Title

      未来へ元気(原子力機構広報誌) 16

      Pages: 10-11

    • Related Report
      2009 Annual Research Report
  • [Journal Article] A. The yield, processing, and biological consequences of clustered DNA2009

    • Author(s)
      Shikazono N., Noguchi, M., Fujii, K., Urushibara, A. and Yokoya
    • Journal Title

      J. Radiat. Res

      Volume: (Invited Review) Pages: 27-36

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A. Nucleobase Lesions and Strand Breaks in Dry DNA Thin Film selectively induced by Monochromatic Soft X-rays2009

    • Author(s)
      Fujii, K., Shikazono, N. and Yokoya
    • Journal Title

      J. Phys. Chem. B

      Volume: 113 Pages: 16007-16015

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A.Nucleobase Lesions and Strand Breaks in Dry DNA Thin Film selectively induced by Monochromatic Soft X-rays2009

    • Author(s)
      Kentaro Fujii
    • Journal Title

      Journal of Physical Chemistry B 113

      Pages: 16007-16015

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] EPR study of radiation damage to DNA irradiated with synchrotron soft X-rays around nitrogen and oxygen K-edge2009

    • Author(s)
      Akinari Yokoya
    • Journal Title

      Radiation Physics and Chemistry 78

      Pages: 1211-1215

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of DNA strand breaks, base lesions and clustered damage sites inhydrated plasmid DNA films by ultrasoft X-rays around the phosphorus Kedge2009

    • Author(s)
      Akinari Yokoya
    • Journal Title

      Radiation Research 172

      Pages: 296-365

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spectral change in X-ray absorption near edge structure of DNA thin films irradiated with monochromatic soft X-rays2009

    • Author(s)
      Kentaro Fujii
    • Journal Title

      Radiation Physics and Chemistry 78

      Pages: 1188-1191

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The yield, processing, and biological consequences of clustered DNA (Invited Review)2009

    • Author(s)
      Naoya Shikazono
    • Journal Title

      Journal of Radiation Research 50

      Pages: 27-36

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biological consequences of potential repair intermediates of clustered base damage site in Escherichia coli2009

    • Author(s)
      Naoya Shikazono
    • Journal Title

      Mutation Research 669

      Pages: 162-168

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Processing of thymine glycol in a clustered DNA damage site : mutagenic orcytotoxic2009

    • Author(s)
      Sophie Bellon
    • Journal Title

      Nucleic Acid Research 37

      Pages: 4430-4440

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Free radical scavenging reactions and antioxidant activities of silybin : mechanistic aspects and pulse radiolytic studies2009

    • Author(s)
      Haiying Fu
    • Journal Title

      Free Radial Reseach 43

      Pages: 887-897

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Free radical scavenging and radioprotective effects of carnosine and anserine2009

    • Author(s)
      Haiying Fu
    • Journal Title

      Radiation Physics and Chemistry 78

      Pages: 1192-1197

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estimation of yields of hydroxyl radicals in water under various energy heavy ions2009

    • Author(s)
      Mitsumasa Taguchi
    • Journal Title

      Radiation Research 171

      Pages: 254-263

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synchrotron radiation photoelectron studies for primary radiation effects using a liquid water jet in vacuum : total and partial photoelectron yields for liquid water near the oxygen K-edge2009

    • Author(s)
      Masatoshi Ukai
    • Journal Title

      Radiation Physics and Chemistry 78

      Pages: 1202-1206

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 放射線被ばく細胞のライブセルイメージング追跡2014

    • Author(s)
      横谷明徳
    • Organizer
      茨城大学公開シンポジウム・第7回Quantum Medicine研究会「がん治療成績向上への取り組みと放射線被ばく影響」
    • Place of Presentation
      水戸
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Dosorbed ion measurement from water doposited deoxyribose film induced by synchrotron soft X-rays2014

    • Author(s)
      K. Fujii, A. Narita, A. Yokoya, M.A. Herve du Penhoat, A. Touati, M.A. Politis
    • Organizer
      The 18th ASRC International Worksho, "Initial processes of radiation effects on genomic stability"
    • Place of Presentation
      Tokai, Ibaraki
    • Related Report
      2013 Annual Research Report
  • [Presentation] 高輝度軟X線を用いた不対電子観測によるDNA損傷の物理化学的プロセス2014

    • Author(s)
      岡壽崇
    • Organizer
      物構研サイエンスフェスタ2013
    • Place of Presentation
      つくば
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 高輝度軟X線を用いた不対電子観測によるDNA損傷の物理学的プロセス2013

    • Author(s)
      岡壽崇
    • Organizer
      物構研サイエンスフェスタ2013
    • Place of Presentation
      つく ば市
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] DNA damage by soft X-ray exposure at oxygen K-edge2013

    • Author(s)
      Sugaya, Y. , Nartita, A. , Fujii, K. and Yokoya, A.
    • Organizer
      1st Conference on Light and Particle Beams in Materials Science
    • Place of Presentation
      Tsukuba, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] Molecular and Cellular Effect of Ionizing Radiation2013

    • Author(s)
      Yokoya, A. , Oka, T. , Fujii, K. , Shiina, T. , Sugaya, Y. , Shiraishi, I. , Urushibara, A. , Narita1, A. , Noguchi, M. and Watanabe, R.
    • Organizer
      The 16th SANKEN International The 11th SANKEN Nanotechnology Symposium
    • Place of Presentation
      saka, Japan
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Dependence of the yields of AP sites and AP clusters produced in plasmid DNA on scavenging capacity and LET2013

    • Author(s)
      Takuya Shiina, Ritsuko Watanabe, Masao Suzuki, Akinari Yokoya
    • Organizer
      Heavy Ion in Therapy and Space Radiation Symposium 2013
    • Place of Presentation
      Chiba
    • Related Report
      2013 Annual Research Report
  • [Presentation] Order effect of base excision processes to repair clustered DNA damage2013

    • Author(s)
      Iyo Shiraishi, Masao Suzuki, Naoya Shikazono, Kentaro Fujii and Akinari Yokoya
    • Organizer
      Heavy Ion in Therapy and Space Radiation Symposium 2013
    • Place of Presentation
      Chiba
    • Related Report
      2013 Annual Research Report
  • [Presentation] DNA damage by soft X-ray exposure around oxygen K-edge2013

    • Author(s)
      Y. Sugaya, A. Narita, K. Fujii, and A. Yokoya
    • Organizer
      Light and Particle Beams in Material Science 2013
    • Place of Presentation
      Tsukuba
    • Related Report
      2013 Annual Research Report
  • [Presentation] Molecular and cellular effect of ionizing radiation2013

    • Author(s)
      Akinari Yokoya
    • Organizer
      The 16th SANKEN International and The 11th SANKEN Nanotechonology Symposium 2013
    • Place of Presentation
      大阪大学
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 酸素K殻XANES領域の軟X線照射によるDNA損傷の収率変化2013

    • Author(s)
      菅谷雄基
    • Organizer
      第26回日本放射光学会年会・放射光科学合同シンポジウム
    • Place of Presentation
      名古屋大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] X線マイクロビームによる細胞周期を選択した照射効果研究2013

    • Author(s)
      成田あゆみ
    • Organizer
      第26回日本放射光学会年会・放射光科学合同シンポジウム
    • Place of Presentation
      名古屋大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] 放射線によるゲノムDNA損傷の初期過程と生体修復2012

    • Author(s)
      横谷明徳
    • Organizer
      2012年物理学会第67回年次大会領域1シンポジウム放射線が生体に与える影響-原子分子から生物まで-
    • Place of Presentation
      西宮(招待講演)
    • Year and Date
      2012-03-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Dependence of the yields of AP sites and AP clusters produced in plasmid DNA on scavenging capacity and LET2012

    • Author(s)
      Shiina, T. , Sugaya, Y. , Shiraishi, I. , Watanabe, R. , Suzuki, M. , Yokoya, A.
    • Organizer
      The 12th International Workshop on Radiation Damage to DNA
    • Place of Presentation
      Prague, Czech Republic
    • Related Report
      2013 Final Research Report
  • [Presentation] 放射線によるゲノムDNA損傷の初期過程と生体修復2012

    • Author(s)
      横谷明徳
    • Organizer
      日本物理学会第67回年次大会
    • Place of Presentation
      西宮市
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 放射線のトラック構造に依存したクラスターDNA損傷の誘発2012

    • Author(s)
      横谷明徳
    • Organizer
      日本放射線影響学会第55回大会
    • Place of Presentation
      東北大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] タイムラプス法で観測したFucci発現細胞の細胞周期へのX線照射の影響2012

    • Author(s)
      横谷明徳
    • Organizer
      日本放射線影響学会第55回大会
    • Place of Presentation
      東北大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] UV-A照射染色体の移入による遺伝的不安定性の誘発2012

    • Author(s)
      漆原あゆみ
    • Organizer
      日本放射線影響学会第55回大会
    • Place of Presentation
      東北大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] X線照射が細胞に与える影響の放射光マイクロビームを用いた研究2012

    • Author(s)
      成田あゆみ
    • Organizer
      日本放射線影響学会第55回大会
    • Place of Presentation
      東北大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] APサイト及びこれを含むクラスターDNA損傷収率の放射線の線質依存性およびLET依存性2012

    • Author(s)
      椎名卓也
    • Organizer
      日本放射線影響学会第55回大会
    • Place of Presentation
      東北大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] DNA分子上の放射線損傷分布とDNA損傷修復経路干渉の相関2012

    • Author(s)
      白石伊世
    • Organizer
      日本放射線影響学会第55回大会
    • Place of Presentation
      東北大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] 酸素K殻イオン化エネルギー領域の軟X線照射によるDNA損傷の収率変化2012

    • Author(s)
      菅谷雄基
    • Organizer
      日本放射線影響学会第55回大会
    • Place of Presentation
      東北大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] Significance of Pol I in determining the mutagenic potential of clustered DNA damage2012

    • Author(s)
      Naoya Shikazono
    • Organizer
      12th International Workshop on Radiation Damage to DNA
    • Place of Presentation
      Prague, Czech Republic
    • Related Report
      2012 Annual Research Report
  • [Presentation] Soft X-ray absorption spectra of AMP and ATP in solutions2012

    • Author(s)
      Hiroyuki Shimada
    • Organizer
      12th International Workshop on Radiation Damage to DNA
    • Place of Presentation
      Prague, Czech Republic
    • Related Report
      2012 Annual Research Report
  • [Presentation] Dependence of the yields of AP sites and AP clusters produced in plasmid DNA on scavenging capacity and LET2012

    • Author(s)
      Takuya Shiina
    • Organizer
      12th International Workshop on Radiation Damage to DNA
    • Place of Presentation
      Prague, Czech Republic
    • Related Report
      2012 Annual Research Report
  • [Presentation] Order effect of base excision processes to repair clustered DNA damage2012

    • Author(s)
      Iyo Shiraishi
    • Organizer
      12th International Workshop on Radiation Damage to DNA
    • Place of Presentation
      Prague, Czech Republic
    • Related Report
      2012 Annual Research Report
  • [Presentation] Variation in DNA damage induced by monochromatic soft X-rays in the energy region of oxygen K-edge2012

    • Author(s)
      Yuki Sugaya
    • Organizer
      12th International Workshop on Radiation Damage to DNA
    • Place of Presentation
      Prague, Czech Republic
    • Related Report
      2012 Annual Research Report
  • [Presentation] DNA damage caused by UV-A irradiation induces genetic instability2012

    • Author(s)
      Ayumi Urushibara
    • Organizer
      12th International Workshop on Radiation Damage to DNA
    • Place of Presentation
      Prague, Czech Republic
    • Related Report
      2012 Annual Research Report
  • [Presentation] Online Analysis and Yield Determination of H_2 Produced in Water Radiolysis with ^<60>Co γ-rays and C Ion Beams(ポスター賞)2012

    • Author(s)
      Shinichi Yamashita
    • Organizer
      International Workshop on Radiation Effects in Nuclear Technology (RENT-2012)
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2011 Annual Research Report
  • [Presentation] 酸素・窒素のK殼イオン化でDNA薄膜中に生じた不対電子とDNA変異の関係2012

    • Author(s)
      岡壽崇
    • Organizer
      第25回日本放射光学会年会,放射光科学合同シンポジウム
    • Place of Presentation
      鳥栖
    • Related Report
      2011 Annual Research Report
  • [Presentation] DNA分子のK殻イオン化閾値領域における光電子再捕獲確率の半古典論的解析2012

    • Author(s)
      横谷明徳
    • Organizer
      第25回日本放射光学会年会,放射光科学合同シンポジウム
    • Place of Presentation
      鳥栖
    • Related Report
      2011 Annual Research Report
  • [Presentation] シンクロトロン軟X線を用いたDNA損傷生成過程の研究2011

    • Author(s)
      藤井健太郎
    • Organizer
      佐賀大学総合分析実験センターセミナー
    • Place of Presentation
      佐賀(招待講演)
    • Year and Date
      2011-12-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 分光学的アプローチによる放射線によるゲノム損傷と生体修復の研究2011

    • Author(s)
      横谷明徳
    • Organizer
      応用物理学会放射線夏の学校
    • Place of Presentation
      仙台(招待講演)
    • Year and Date
      2011-08-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] Study of Unpaired Electron Species in DNA Film Induced by Nitrogen and Oxygen K-shell Photoabsorption2011

    • Author(s)
      Oka, T.
    • Organizer
      The 7th Auger Symposium
    • Place of Presentation
      Julich, Germany
    • Related Report
      2013 Final Research Report
  • [Presentation] Inhibition of binding of Fpg to mviltiple damaged DNA2011

    • Author(s)
      Mariko Higuchi
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] 窒素及び酸素のK殻吸収によってDNA及びDNA核酸塩基中に生じる不対電子種2011

    • Author(s)
      岡壽崇
    • Organizer
      日本放射線影響学会第54回大会
    • Place of Presentation
      神戸
    • Related Report
      2011 Annual Research Report
  • [Presentation] DNA構成原子の内殻イオン化閾値領域における光電子再捕獲確率の半古典論的解析2011

    • Author(s)
      横谷明徳
    • Organizer
      日本放射線影響学会第54回大会
    • Place of Presentation
      神戸
    • Related Report
      2011 Annual Research Report
  • [Presentation] 放射線の飛跡に沿ったDNA損傷生成位置の解析2011

    • Author(s)
      渡邊立子
    • Organizer
      日本放射線影響学会第54回大会
    • Place of Presentation
      神戸
    • Related Report
      2011 Annual Research Report
  • [Presentation] 抗酸化物質エダラボンによるDNA損傷前駆体の化学回復2011

    • Author(s)
      端邦樹
    • Organizer
      日本放射線影響学会第54回大会
    • Place of Presentation
      神戸
    • Related Report
      2011 Annual Research Report
  • [Presentation] 染色体不安定性誘発における紫外線の影響2011

    • Author(s)
      漆原あゆみ
    • Organizer
      日本放射線影響学会第54回大会
    • Place of Presentation
      神戸
    • Related Report
      2011 Annual Research Report
  • [Presentation] 酸素K殼イオン化エネルギー領域の軟X線照射によるDNA損傷収率の変化2011

    • Author(s)
      菅谷雄基
    • Organizer
      日本放射線影響学会第54回大会
    • Place of Presentation
      神戸
    • Related Report
      2011 Annual Research Report
  • [Presentation] クラスターDNA損傷に対する塩基除去修復酵素の作用順序の効果II2011

    • Author(s)
      白石伊世
    • Organizer
      日本放射線影響学会第54回大会
    • Place of Presentation
      神戸
    • Related Report
      2011 Annual Research Report
  • [Presentation] AP site及びこれを含むクラスターDNA損傷収率の放射線の線質及びスキャベンジャー能に対する依存性2011

    • Author(s)
      椎名卓也
    • Organizer
      日本放射線影響学会第54回大会
    • Place of Presentation
      神戸
    • Related Report
      2011 Annual Research Report
  • [Presentation] クラスターDNA損傷の修復におけるPolIの役割2011

    • Author(s)
      鹿園直哉
    • Organizer
      日本放射線影響学会第54回大会
    • Place of Presentation
      神戸
    • Related Report
      2011 Annual Research Report
  • [Presentation] Introduction to Synchrotron Radiation and Radio-biological Studies2011

    • Author(s)
      Akinari Yokoya
    • Organizer
      Surface Electro, Radiation, and Photo Chemistry International Master Course (SERP-Chem), EU Education & Training "ERASUMUS MUNDUS"
    • Place of Presentation
      Orsay, France
    • Related Report
      2011 Annual Research Report
  • [Presentation] 軟X線吸収分光法を用いたDNA損傷の研究2011

    • Author(s)
      藤井健太郎
    • Organizer
      PF研究会「エネルギー付与の不均一性に着目した放射線生物影響研究の展望」
    • Place of Presentation
      つくば(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 放射光照射によるK殻イオン化でDNA関連分子薄膜中に生じた不対電子種2011

    • Author(s)
      岡壽崇
    • Organizer
      PF研究会「エネルギー付与の不均一性に着目した放射線生物影響研究の展望」
    • Place of Presentation
      つくば(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] リンK殼吸収及びこれに続くAuger効果により生成するDNA塩基損傷2011

    • Author(s)
      横谷明徳
    • Organizer
      PF研究会「エネルギー付与の不均一性に着目した放射線生物影響研究の展望」」
    • Place of Presentation
      つくば(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 窒素・酸素のK殻イオン化によるDNA変異と不対電子の関係2011

    • Author(s)
      岡壽崇
    • Organizer
      第54回放射線化学討論会
    • Place of Presentation
      大阪
    • Related Report
      2011 Annual Research Report
  • [Presentation] The affinity of dose-two-damages and repair hOGG12011

    • Author(s)
      Mariko Higuchi
    • Organizer
      第49回日本生物物理学会年会
    • Place of Presentation
      姫路
    • Related Report
      2011 Annual Research Report
  • [Presentation] EPR Study of Unpaired Electron Species in DNA Film Induced by Nitrogen and Oxygen K-shell Photoabsorption2011

    • Author(s)
      Toshitaka Oka
    • Organizer
      14th International Congress of Radiation Research (ICRR2011)
    • Place of Presentation
      Warsaw, Poland
    • Related Report
      2011 Annual Research Report
  • [Presentation] Near Edge X-ray Absorption Spectroscopy of DNA Damage Induced by Soft X-rays2011

    • Author(s)
      Kentaro Fujii
    • Organizer
      14th International Congress of Radiation Research (ICRR2011)
    • Place of Presentation
      Warsaw, Poland
    • Related Report
      2011 Annual Research Report
  • [Presentation] Significance of the repair synthesis in determining the biological consequences of clustered DNA damage2011

    • Author(s)
      Naoya Shikazono
    • Organizer
      14th International Congress of Radiation Research (ICRR2011)
    • Place of Presentation
      Warsaw, Poland
    • Related Report
      2011 Annual Research Report
  • [Presentation] Study of Unpaired Electron Species in DNA Film Induced by Nitrogen and Oxygen K-shell Photoabsorption2011

    • Author(s)
      Toshitaka Oka
    • Organizer
      7th Auger Symposium
    • Place of Presentation
      Julich, Germany
    • Related Report
      2011 Annual Research Report
  • [Presentation] X-ray Absorption Spectroscopic Analysis of DNA Damage Induced by Soft X-rays2011

    • Author(s)
      Kentaro Fujii
    • Organizer
      7th Auger Symposium
    • Place of Presentation
      Julich, Germany
    • Related Report
      2011 Annual Research Report
  • [Presentation] AP sites in Plasmid DNA Caused by Auger Effect of Oxygen2011

    • Author(s)
      Akinari Yokoya
    • Organizer
      7th Auger Symposium
    • Place of Presentation
      Julich, Cermany
    • Related Report
      2011 Annual Research Report
  • [Presentation] Biological Assessment of Radiation Damage of ATP by Soft X-rays2011

    • Author(s)
      Kentaro Fujii
    • Organizer
      7th Auger Symposium
    • Place of Presentation
      Julich, Germany
    • Related Report
      2011 Annual Research Report
  • [Presentation] 水の放射線分解で生じる水素のオンライン収率測定2011

    • Author(s)
      山下真一
    • Organizer
      第48回アイソトープ放射線研究発表会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] 修復酵素hOGG1によるクラスターDNA損傷の修復阻害に関するシミュレーション2011

    • Author(s)
      樋口真理子
    • Organizer
      第11回日本蛋白質科学会年会
    • Place of Presentation
      大阪
    • Related Report
      2011 Annual Research Report
  • [Presentation] Online Analysis of H2 Produced in γ-radiolysis of Water2011

    • Author(s)
      Shinichi Yamashita
    • Organizer
      Intemational Workshop on Radiation Effects in Nuclear Technology (RENT-2011)
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2011 Annual Research Report
  • [Presentation] ESR study of unpaired electron species in nucleobase films induced by nitrogen and oxygen K-shell photoabsorption2011

    • Author(s)
      Toshitaka Oka
    • Organizer
      International Workshop on Radiation Effects in Nuclear Technology
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 軟X線照射したDNA薄膜のXANESスペクトル変化2011

    • Author(s)
      藤井健太郎
    • Organizer
      第24回日本放射光学会年会・放射光科学合同シンポジウム
    • Place of Presentation
      つくば
    • Related Report
      2010 Annual Research Report
  • [Presentation] 酸素・窒素のK殻イオン化でDNA関連分子薄膜中に生じた不対電子種のESRによる測定2011

    • Author(s)
      岡壽崇
    • Organizer
      第24回日本放射光学会年会・放射光科学合同シンポジウム
    • Place of Presentation
      つくば
    • Related Report
      2010 Annual Research Report
  • [Presentation] 酸素K殻共鳴励起によりプラスミドDNA中に生成する鎖切断、塩基変異及びAPサイト2011

    • Author(s)
      菅谷雄基
    • Organizer
      第24回日本放射光学会年会・放射光科学合同シンポジウム
    • Place of Presentation
      つくば
    • Related Report
      2010 Annual Research Report
  • [Presentation] 放射線の直接作用による様々なDNA損傷生成モード2010

    • Author(s)
      横谷明徳
    • Organizer
      平成22年度第2回量子ビーム科学研究施設研究会~量子ビームの医学・生物学への応用~(大阪大学産業科学研究所)
    • Place of Presentation
      大阪(招待講演)
    • Year and Date
      2010-11-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 難修復性のDNA損傷に関する物理学的及び生物学的アプローチによる研究2010

    • Author(s)
      横谷明徳
    • Organizer
      東北大学医学部加齢研究所研究員会セミナー
    • Place of Presentation
      仙台(招待講演)
    • Year and Date
      2010-08-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] Various modes of DNA damage formation by the direct effect of radiation2010

    • Author(s)
      Yokoya, A.
    • Organizer
      The 56th Annual Meeting of Radiation Research Society
    • Place of Presentation
      Hawaii, USA
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Measurement of unpaired electron species in dry DNA thin films irradiated with synchrotron soft X-rays around oxygen and nitrogen K-edge studied by EPR2010

    • Author(s)
      Toshitaka Oka
    • Organizer
      The 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010)
    • Place of Presentation
      Hawaii, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] CYPMPOによるガンマ線照射水分解ラジカル捕捉と安定性評価2010

    • Author(s)
      岡壽崇
    • Organizer
      第49回電子スピンサイエンス学会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Annual Research Report
  • [Presentation] 酸素及び窒素のK殻イオン化でDNA関連分子薄膜中に生じた不対電子種の測定2010

    • Author(s)
      岡壽崇
    • Organizer
      第49回電子スピンサイエンス学会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development and applications of the microdosimetric function imolemented in the macroscopic particle transport simulation code PHITS2010

    • Author(s)
      Tatsuhiko Sato
    • Organizer
      Monte Carlo computational methods in radiation track simulation and applications in physical, biological and medical sciences
    • Place of Presentation
      Stockholm, Sweden
    • Related Report
      2010 Annual Research Report
  • [Presentation] スピントラップ剤CYTPMPOによるガンマ線照射水分解生成物補足とその安定性2010

    • Author(s)
      岡壽崇
    • Organizer
      日本放射線影響学会第53回大会
    • Place of Presentation
      京都
    • Related Report
      2010 Annual Research Report
  • [Presentation] 重粒子による水の放射線分解:水分解ラジカルの空間分布とダイナミクス2010

    • Author(s)
      山下真一
    • Organizer
      日本放射線影響学会第53回大会
    • Place of Presentation
      京都
    • Related Report
      2010 Annual Research Report
  • [Presentation] プラスミドDNAの変性-アニーリングを利用した多重塩基損傷検出のための新しい方法の開発2010

    • Author(s)
      横谷明徳
    • Organizer
      日本放射線影響学会第53回大会
    • Place of Presentation
      京都
    • Related Report
      2010 Annual Research Report
  • [Presentation] DNA損傷の空間分布と難修復性を考慮した生存率曲線の解析2010

    • Author(s)
      渡邊立子
    • Organizer
      日本放射線影響学会第53回大会
    • Place of Presentation
      京都
    • Related Report
      2010 Annual Research Report
  • [Presentation] 8-oxoGを含むクラスターDNA損傷の誘発突然変異2010

    • Author(s)
      野口実穂
    • Organizer
      日本放射線影響学会第53回大会
    • Place of Presentation
      京都
    • Related Report
      2010 Annual Research Report
  • [Presentation] 希薄プラスミドDNA水溶液へのガンマ線照射:放射線誘起損傷の抗酸化剤エダラボンによる化学回復2010

    • Author(s)
      端邦樹
    • Organizer
      日本放射線影響学会第53回大会
    • Place of Presentation
      京都
    • Related Report
      2010 Annual Research Report
  • [Presentation] 非二重鎖切断型損傷による遺伝的不安定性の誘発2010

    • Author(s)
      漆原あゆみ
    • Organizer
      日本放射線影響学会第53回大会
    • Place of Presentation
      京都
    • Related Report
      2010 Annual Research Report
  • [Presentation] 軟X線及び電子線照射によりプラスミドDNA中に生成する塩基損傷及びAPサイト2010

    • Author(s)
      菅谷雄基
    • Organizer
      日本放射線影響学会第53回大会
    • Place of Presentation
      京都
    • Related Report
      2010 Annual Research Report
  • [Presentation] クラスターDNA損傷に対する塩基除去修復酵素の作用順序の効果2010

    • Author(s)
      白石伊世
    • Organizer
      日本放射線影響学会第53回大会
    • Place of Presentation
      京都
    • Related Report
      2010 Annual Research Report
  • [Presentation] AP site及びこれを含むクラスターDNA損傷収率の放射線の線質及びスキャベンジャー能に対する依存性2010

    • Author(s)
      椎名卓也
    • Organizer
      日本放射線影響学会第53回大会
    • Place of Presentation
      京都
    • Related Report
      2010 Annual Research Report
  • [Presentation] Various modes of DNA damage formation by the direct effect of radiation2010

    • Author(s)
      Akinari Yokoya
    • Organizer
      The 56th Annual Meeting of Radiation Research Society
    • Place of Presentation
      Hawaii, USA(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Water radiolysis with high-energy heavy ions : conversion of transient water radicals into stable product inside heavy-ion tracks2010

    • Author(s)
      Shinichi Yamashita
    • Organizer
      The 56th Annual Meeting of Radiation Research Society
    • Place of Presentation
      Hawaii, USA(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Processing and biological consequences of clustered DNA damage containing a single strand break and an AP site2010

    • Author(s)
      Naoya Shikazono
    • Organizer
      The 56th Annual Meeting of Radiation Research Society
    • Place of Presentation
      Hawaii, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] ガンマ線照射により生成した水分解ラジカルのCYPMPOによる捕捉2010

    • Author(s)
      岡壽崇
    • Organizer
      第53回放射線化学討論会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Annual Research Report
  • [Presentation] 軟X線照射によるDNA損傷の光子エネルギーによる選択的な依存性(日本放射線化学会奨励賞受賞講演)2010

    • Author(s)
      藤井健太郎
    • Organizer
      第53回放射線化学討論会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Annual Research Report
  • [Presentation] 治療用重粒子イオンビームの放射線化学反応(日本放射線化学会奨励賞受賞講演)2010

    • Author(s)
      山下真一
    • Organizer
      第53回放射線化学討論会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Annual Research Report
  • [Presentation] Water radiolysis with heavy ions of energies up to 28GeV2010

    • Author(s)
      Shinichi Yamashita
    • Organizer
      3rd Asia-Pacific Symposium on Radiation Chemistry (APSRC-2010)/DAE-BRNS 10th Biennial Trombay Symposium on Radiation & Photochemistry (TSRP-2010)
    • Place of Presentation
      Lonavala, India(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] スピントラップ剤CYPMPOによる水分解ラジカル捕捉-1-2010

    • Author(s)
      岡壽崇
    • Organizer
      第47回アイソトープ・放射線研究発表会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] スピントラップ剤CYPMPOによる水分解ラジカル捕捉-2-2010

    • Author(s)
      岡壽崇
    • Organizer
      第47回アイソトープ・放射線研究発表会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] Near Edge X-ray Absorption Fine Structure of DNA Thin Film Irradiated with Soft X-rays2010

    • Author(s)
      Kentaro Fujii
    • Organizer
      The 37th International conference on Vacuum Ultraviolet and X-ray Physics
    • Place of Presentation
      Vancouver, Canada
    • Related Report
      2010 Annual Research Report
  • [Presentation] Water radiolysis with steady-state heavy-ion beams from HIMAC2010

    • Author(s)
      Shinichi Yamashita
    • Organizer
      15emes Journees d'Etudes de la Chimie sous Rayonnement (JECR-2010)
    • Place of Presentation
      Bordeaux, France(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cell-type and ion-species depdendence of the biological doses for charged-particle theapy2010

    • Author(s)
      Tatsuhiko Sato
    • Organizer
      49th Annual meeting on the particle therapy co-operative group
    • Place of Presentation
      前橋
    • Related Report
      2010 Annual Research Report
  • [Presentation] A novel technique using DNA denaturation-annealing to detect multiply induced base lesions in plasmid DNA molecules by X-ray irradiation2010

    • Author(s)
      Akinari Yokoya
    • Organizer
      The 11th International Workshop on Radiation Damage to DNA
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] 軟X線により乾燥DNA試料中に生じる分子変化の照射エネルギー依存性2010

    • Author(s)
      藤井健太郎
    • Organizer
      第23回日本放射光学会年会・放射光科学合同シンポジウム
    • Place of Presentation
      姫路
    • Related Report
      2009 Annual Research Report
  • [Presentation] 酸素及び窒素のK殻イオン化によりDNA関連分子薄膜中に生じた不対電子種のEPR観測2010

    • Author(s)
      横谷明徳
    • Organizer
      第23回日本放射光学会年会・放射光科学合同シンポジウム
    • Place of Presentation
      姫路
    • Related Report
      2009 Annual Research Report
  • [Presentation] Near Edge X-ray Absorption Fine Structure of DNA Thin Film Irradiated with Soft X-rays2009

    • Author(s)
      Kentaro Fujii
    • Organizer
      International Coference on Electronic Spectroscopy and Structure
    • Place of Presentation
      Nara, Japan
    • Related Report
      2009 Annual Research Report
  • [Presentation] Synchrotron radiation photoelectron studies for primary radiation effects in bio-solutions : Two dimensional electron spectra for liquid water in the soft X-ray region2009

    • Author(s)
      Masatoshi Ukai
    • Organizer
      International Coference on Electronic Spectroscopy and Structure
    • Place of Presentation
      Nara, Japan
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mutagenic potential of clustered DNA damage containing single strand break and 8-oxoGs2009

    • Author(s)
      Miho Noguchi
    • Organizer
      15th International Symposium on Microdosimetry : An International Meeting on Ionizing Radiation Quality, Molecular Mechanisms, Cellular Effects, an Their Consequences for Low Level Risk Assessment and Radiation Therapy
    • Place of Presentation
      Verona, Italy
    • Related Report
      2009 Annual Research Report
  • [Presentation] Analysis on the Yield and the Level of Clustering of Radiation-induced DNA Strand Breaks in Hydrated Plasmids2009

    • Author(s)
      Naoya Shikazono
    • Organizer
      15th International Symposium on Microdosimetry : An International Meeting on Ionizing Radiation Quality, Molecular Mechanisms, Cellular Effects, an Their Consequences for Low Level Risk Assessment and Radiation Therapy
    • Place of Presentation
      Verona, Italy
    • Related Report
      2009 Annual Research Report
  • [Presentation] Simulation of Intra-track Spatial Distribution of Simple and Complex DNA damage Induced by Heavy Ions2009

    • Author(s)
      Ritsuko Watanabe
    • Organizer
      15th International Symposium on Microdosimetry : An International Meeting on Ionizing Radiation Quality, Molecular Mechanisms, Cellular Effects, an Their Consequences for Low Level Risk Assessment and Radiation Therapy
    • Place of Presentation
      Verona, Italy
    • Related Report
      2009 Annual Research Report
  • [Presentation] A Novel Technique Using DNA Denaturation to Detect Multiply Induced Single-strand Breaks in a Hydrated Plasmid DNA Molecule by X-ray and He^<2+> Ion Irradiation2009

    • Author(s)
      Akinari Yokoya
    • Organizer
      15th International Symposium on Microdosimetry : An International Meeting on Ionizing Radiation Quality, Molecular Mechanisms, Cellular Effects, an Their Consequences for Low Level Risk Assessment and Radiation Therapy
    • Place of Presentation
      Verona, Italy
    • Related Report
      2009 Annual Research Report
  • [Presentation] DNA二本鎖切断はLET増加に伴い増加するのか?減少するのか?:(1)増加するという立場からの考察(ワークショップ依頼講演)2009

    • Author(s)
      横谷明徳
    • Organizer
      第52回日本放射線影響学会
    • Place of Presentation
      広島
    • Related Report
      2009 Annual Research Report
  • [Presentation] 微視的線量分布からみたDNA二本鎖切断のLET依存性2009

    • Author(s)
      渡邊立子
    • Organizer
      第52回日本放射線影響学会
    • Place of Presentation
      広島
    • Related Report
      2009 Annual Research Report
  • [Presentation] イオンビーム照射により高水和DNAフィルム中に誘発されるDNA鎖切断及び塩基損傷収率のLET依存性2009

    • Author(s)
      横谷明徳
    • Organizer
      第52回日本放射線影響学会
    • Place of Presentation
      広島
    • Related Report
      2009 Annual Research Report
  • [Presentation] 大腸菌におけるクラスターDNA損傷誘発突然変異2009

    • Author(s)
      鹿園直哉
    • Organizer
      第52回日本放射線影響学会
    • Place of Presentation
      広島
    • Related Report
      2009 Annual Research Report
  • [Presentation] 単色軟X線によるDNAの鎖切断及び塩基損傷の選択的誘発2009

    • Author(s)
      藤井健太郎
    • Organizer
      第52回日本放射線影響学会
    • Place of Presentation
      広島
    • Related Report
      2009 Annual Research Report
  • [Presentation] 同一鎖上に配置されたクラスターDNA損傷のプロセシングについて2009

    • Author(s)
      野口実穂
    • Organizer
      第52回日本放射線影響学会
    • Place of Presentation
      広島
    • Related Report
      2009 Annual Research Report
  • [Presentation] 鎖切断とAP部位を含むクラスターDNA損傷のプロセシングと生物効果2009

    • Author(s)
      鹿園直哉
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] 生体溶液試料に対する二次イオン質量分析法の開発2009

    • Author(s)
      住谷亮輔
    • Organizer
      原子衝突研究協会第34回年会
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report
  • [Book] Spectroscopic study of radiation-induced DNA lesions and their susceptibility to enzymatic repair. In: Charged particle and photon interactions with matter-recent advances, applications and interfaces(Eds. , Y. Hatano, Y. Katsumura, and A. Mozumder)2011

    • Author(s)
      Yokoya, A. , Fujii, K. , Shikazono, N. and Ukai
    • Publisher
      CRC/Taylor & Francis Group
    • Related Report
      2013 Final Research Report
  • [Book] Charged particle and photon interactions with matter-recent advances, applications and interfaces, Chapter 20 : Spectroscopic study of radiation-induced DNA lesions and their susceptibility to enzymatic repair(Eds., Y.Hatano, Y.Katsumura, and A.Mozumder)2011

    • Author(s)
      Akinari Yokoya
    • Publisher
      CRC/Taylor & Francis Group
    • Related Report
      2010 Annual Research Report
  • [Book] Charged particle and photon interactions with matter-recent advances, applications and interfaces, Chapter 13 : Radiation chemistry of liquid water with heavy ions : steady-state and pulse radiolysis studies(Eds., Y.Hatano, Y.Katsumura, and A.Mozumder)2011

    • Author(s)
      Shinichi Yamashita
    • Publisher
      CRC/Taylor & Francis Group
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://asrc.jaea.go.jp/soshiki/gr/yokoya-gr/

    • Related Report
      2013 Final Research Report
  • [Remarks] 放射場生体分子科学研究グループ

    • URL

      http://asrc.jaea.go.jp/soshiki/gr/yokoya-gr/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 放射場生体分子科学研究グループ

    • URL

      http://asrc.jaea.go.jp/soshiki/gr/yokoya-gr/

    • Related Report
      2012 Annual Research Report

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Published: 2009-04-01   Modified: 2019-07-29  

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