Statistical Analysis of Single Cell Mechanics by Atomic Force Microscopy
Project/Area Number |
21310079
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Nanomaterials/Nanobioscience
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Research Institution | Hokkaido University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
KAWAHARA Koichi 北海道大学, 情報科学研究科, 特任教授 (20125397)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2009: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
|
Keywords | 原子間力顕微鏡 / 多数細胞 / 細胞レオロジー / ナノ計測 / 細胞周期 / 細胞分化 / 細胞診断 / 統計解析 / 細胞力学 / 多変量解析 / レオロジー / 細胞アレイ |
Research Abstract |
We investigated the number distribution of single cell rheology by atomic force microscopy (AFM) and discuss the statistical data in connection with a modern model of cell rheology such as power-law rheology. (1) The number distribution of single cell rheology was measured as a function of external frequency. (2) The rheological behavior of cells was measured as cells were synchronized using serum starvation. (3) We succeeded to measure the ensemble-and time-averaged cell rheology and found differences between them. (4) We investigated the number distribution of power-law rheology of cells transformed from normal cells to immortalized cells.
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Report
(4 results)
Research Products
(59 results)