|Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2009: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
In this study, we first developed a high-throughput screening method to identify microRNA (miRNA) which maturation is inhibited at the processing steps, and found several candidate miRNAs. Second, we examined the effects of adenosine deaminases acting on RNAs (ADARs) on miRNA processing, and identified novel 48 editing sites in 24 miRNAs. Each ADAR isoform was considered to inhibit the processing of different miRNAs.