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The Study on Human Genome diversity

Research Project

Project/Area Number 21310126
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 基礎ゲノム科学
Research InstitutionNational Institute of Genetics

Principal Investigator

TOYODA Atsushi  国立遺伝学研究所, 生命情報研究センター, 特任准教授 (10267495)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2009: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Keywords個人ゲノム / 多様性 / 次世代シーケンサー / 第二世代シーケンサー
Research Abstract

Next generation sequencing offers lower cost and higher throughput than Sanger sequencing for human personal genome. To understand all genetic variants within personal genome, we carried out re-sequencing of two chromosomes(HSA21 and HSAY) separated from a human cell line and a sample from the HapMap JPT(Japanese) sets using the GAIIx sequencers. In a Japanese male genome, we identified over 3 million sequence variants(SNVs) at an average of 30-fold coverage. In addition, not only SNVs but also structural variants, such as indels and copy number variants, were detected.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (7 results)

All 2012 2011 2010

All Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (2 results)

  • [Journal Article] Genome analysis of the domestic dog(korean jindo) by massively parallel sequencing2012

    • Author(s)
      Kim RN, Kim DS, Choi SH, Yoon BH, Kang A, Nam SH, Kim DW, Kim JJ, Ha JH, Toyoda A, Fujiyama A, Kim A, Kim MY, Park KH, Lee KS, Park HS.
    • Journal Title

      DNA Res

      Volume: 19(3) Pages: 275-288

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genome features of "Dark-fly", a Drosophila line reared long-term in a dark environment2012

    • Author(s)
      Izutsu M, Zhou J, Sugiyama Y, Nishimura O, Aizu T, Toyoda A, Fujiyama A, Agata K, Fuse N.
    • Journal Title

      PLoS One

      Volume: 7(3)

    • NAID

      120003892186

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Centromere-targeted de novo ntegrations of an LTR retrotransposon of Arabidopsis lyrata2012

    • Author(s)
      Tsukahara S, Kawabe A, Kobayashi A, Ito T, Aizu T, Shin-i T, Toyoda A, Fujiyama A, Tarutani Y, Kakutani T.
    • Journal Title

      Genes Dev

      Volume: 26(7) Pages: 705-713

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 1000ゲノムプロジェクトの目標と展開2011

    • Author(s)
      水口洋平・豊田敦
    • Journal Title

      医学のあゆみ

      Volume: 236 Pages: 616-622

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] Whole genome assembly of a natto production strain Bacillus subtilis natto from very short read data2010

    • Author(s)
      Nishito Y, Osana Y, Hachiya T, Popendorf K, Toyoda A, Fujiyama A, Itaya M, Sakakibara Y.
    • Journal Title

      BMC Genomics

      Volume: 11 Pages: 243-243

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] 次世代シークエンサーを用いた全ゲノム解析2010

    • Author(s)
      豊田敦
    • Organizer
      日本人類遺伝学会第55回大会
    • Place of Presentation
      大宮ソニックシティホール
    • Year and Date
      2010-10-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 次世代シークエンサーを用いた全ゲノム解析2010

    • Author(s)
      豊田敦
    • Organizer
      日本人類遺伝学会第55回大会
    • Place of Presentation
      大宮ソニックシティホール大ホール
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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