| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2011: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2009: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Research Abstract |
A new trichostatin analog and a new aurelic acid analog were isolated from Streptomyces hygroscopicus and Streptomyces sp. as an innate immune inhibitor inhibitory and a transcription/translation inhibitory compound, respectively. In addition, a stereostructure of gonytolide A, an innate immune activator, was determined, and its analogs were isolated from Gonytrichum sp. Structure-activity relationship study based on celastramycin A and gonytolide A was also carried out.
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