| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2009: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Research Abstract |
To explore new medicinal leads for Tuberculosis, we succeeded in establishment of the screening systems focusing on the environments of Mycobacterium tuberculosis-infected region. Then, we searched the active substances from the extracts of marine organisms and the culture of marine microbe by established bioassay-guided separation. As a result, we isolated halicyclamins, trichoderins and nybomysin as anti-dormant mycobacterial substances. In addition, we succeeded in choosing the candidates of their target molecules by using genomic DNA library and/ or next-generation sequencer. On the other hand, desferrioxamine E was identified as an inhibitor of biofilm formation of Mycobacterium species. We also clarified the action-mechanism of desferrioxamine E as an inhibitor of biofilm formation.
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