• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

THE CHEMICAL BIOLOGY OF NEW MICROBIAL ANTI-INFECTIVE AGENTS

Research Project

Project/Area Number 21310146
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Living organism molecular science
Research InstitutionKitasato University

Principal Investigator

TOMODA Hiroshi  北里大学, 薬学部, 教授 (70164043)

Co-Investigator(Renkei-kenkyūsha) INOKOSHI Junji  北里大学, 薬学部, 准教授 (30151640)
UCHIDA Ryuji  北里大学, 薬学部, 講師 (60280632)
KOYAMA Nobuhiro  北里大学, 薬学部, 助教 (60439156)
NAGAMITSU Toru  北里大学, 薬学部, 教授 (90300756)
UMEYAMA Hideaki  北里大学, 薬学部, 教授 (20050619)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2011: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Keywords感染症 / 天然物 / ケミカルバイオロジー / 標的分子 / 結合タンパク質 / ケミカルバイォロジー
Research Abstract

The mechanism of action of three anti-infective agents was studied. Lariatin A showed selective growth inhibition against mycobacteria. The proteins that bind to lariatin A were investigated in the lysate of Mycobacterium smegmatis, which led to the identification of MSMEG1878 protein whose function has not been reported. Cyslabdan potentiated ss-lactam imipenem activity against methicillin-resistant Staphylococcus aureus(MRSA). The proteins that bind to cyslabdan were investigated in the lysate of MRSA, which led to the identification of SAR1388, which is involved in the synthesis of the pentaglycine interpeptide bridge of the MRSA peptidoglycan. Furthermore, the docking model of viridicatumtoxin and UPP synthase was investigated in silico to elucidate the binding mode of spirohexalines.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (64 results)

All 2012 2011 2010 2009

All Journal Article (22 results) (of which Peer Reviewed: 21 results) Presentation (37 results) Patent(Industrial Property Rights) (5 results)

  • [Journal Article] Molecular cloning of the gene cluster for lariatin biosynthesis of Rhodococcus jostii K01-B01712012

    • Author(s)
      Inokoshi J, Matsuhama M, Miyake M, Ikeda H, Tomoda H.
    • Journal Title

      Appl Microbiol Biotechnol

      Volume: (In press) Issue: 2 Pages: 451-460

    • DOI

      10.1007/s00253-012-3973-8

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mode of Action of Microbial Anti-MRSA Agents2012

    • Author(s)
      Tomoda H.
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 132 Issue: 1 Pages: 37-44

    • DOI

      10.1248/yakushi.132.37

    • NAID

      130001871960

    • ISSN
      0031-6903, 1347-5231
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Search Method for Inhibitors of Staphyloxanthin Production by Methicillin-Resistant Staphylococcus aureus2012

    • Author(s)
      Sakai K, et al
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 35 Issue: 1 Pages: 48-53

    • DOI

      10.1248/bpb.35.48

    • NAID

      130001872341

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recent Advance in Research of New Anti-Infectious Agents—Discovery Chemical Biology and Development—2012

    • Author(s)
      Tomoda H, et al
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 132 Issue: 1 Pages: 35-36

    • DOI

      10.1248/yakushi.132.35

    • NAID

      130001871959

    • ISSN
      0031-6903, 1347-5231
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New cyslabdans B and C, potentiators of imipenem activity against methicillin-resistant Staphylococcus aureus produced by Streptomyces sp.K04-01442011

    • Author(s)
      Koyama N, et al
    • Journal Title

      Acta Pharmceutica Sinica B

      Volume: 1 Issue: 4 Pages: 236-239

    • DOI

      10.1016/j.apsb.2011.10.008

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Palmaenones A and B, Two New Antimicrobial Chlorinated Cyclopentenones from Discomycete Lachnum palmae2011

    • Author(s)
      Mastumoto T, et al
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 59 Issue: 12 Pages: 1559-1561

    • DOI

      10.1248/cpb.59.1559

    • NAID

      130001852133

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel postentry inhibitor of human immunodeficiency virus type 1 replication screened by yeast membrane-associated two-hybrid system2011

    • Author(s)
      Urano E, et al
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 55 Issue: 9 Pages: 4251-4260

    • DOI

      10.1128/aac.00299-11

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Total Synthesis of Citridone A2011

    • Author(s)
      Miyagawa, et al
    • Journal Title

      Org Lett

      Volume: 13 Pages: 1158-1161

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Actinohivin : specific amino acid residues essential for anti-HIV activity2010

    • Author(s)
      Takahashi A, et al
    • Journal Title

      J Antibiot

      Volume: 63 Pages: 661-665

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thiolactomycin inhibits D-aspartate oxidase : a novel approach to probing the active site environment2010

    • Author(s)
      Katane M, et al
    • Journal Title

      Biochimie

      Volume: 92 Pages: 1371-1378

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Xanthoradone C, a new potentiator of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Penicillium radicum FKI-3765-22010

    • Author(s)
      Yamazaki H, et al
    • Journal Title

      J Antibiot

      Volume: 63 Pages: 329-330

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Absolute stereochemistry of pentacecilides, new inhibitors of lipid droplet formation in mouse macrophages, produced by Penicillium cecidicola FKI-3765-12010

    • Author(s)
      Yamazaki H, et al
    • Journal Title

      J Antibiot

      Volume: 63 Pages: 315-318

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 6'-Hydroxy-3'-methoxy-mitorubrin, a new potentiator of antifungal miconazole activity, produced by Penicillium radicum FKI-3765-22010

    • Author(s)
      Yamazaki H, et al
    • Journal Title

      Chem Pharm Bull

      Volume: 58 Pages: 829-832

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New rugulosins, anti-MRSA antibiotics, produced by Penicillium radicum FKI-3765-2.2010

    • Author(s)
      Yamazaki H, et al
    • Journal Title

      Org Lett

      Volume: 12 Pages: 1572-1575

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] カイコを感染症モデル動物に利用した抗生物質の探索2010

    • Author(s)
      内田龍児, ら
    • Journal Title

      バイオサイエンスとインダストリー

      Volume: 68 Pages: 314-321

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calpinactam, A New Anti-mycobacterial Agent, Produced by Mortierella alpina FKI-49052010

    • Author(s)
      Koyama N, et al
    • Journal Title

      J Antibiot (in press)

      Pages: 183-186

    • NAID

      10030708126

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nosokomycins, new antibiotics discovered in an in vivo-mimic infection model using silkworm larvae. II.Structure elucidation.2010

    • Author(s)
      Uchida R, et al
    • Journal Title

      J Antibiot (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nosokomycins, new antibiotics discovered in an in vivo-mimic infection model using silkworm larvae. I.Fermentation, isolation and biological properties.2010

    • Author(s)
      Uchida R, et al
    • Journal Title

      J Antibiot (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure and total synthesis of fungal calpinactam, a new antimycobacterial agent2010

    • Author(s)
      Koyama N, et al
    • Journal Title

      Org Lett 12

      Pages: 432-435

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Xanthoradones, new potentiators of imipenem activity against methicill in-resistant Staphylococcus aureus, produced by Penicillium radicum FKI-3765-2. II.Structure elucidation.2009

    • Author(s)
      Yamazaki H, et al
    • Journal Title

      J Antibiot 62

      Pages: 435-437

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Xanthoradones, new potentiators of imipenem activity against methicill in-resistant Staphylococcus aureus, produced by Penicillium radicum FKI-3765-2. I.Taxonomy, fermentation, isolation and biological properties.2009

    • Author(s)
      Yamazaki H, et al
    • Journal Title

      J Antibiot 62

      Pages: 431-434

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lys17 in the 'lasso' peptide lariatin A is responsible for anti-mycobacterial activity.2009

    • Author(s)
      Iwatsuki M, et al
    • Journal Title

      Bioorg Med Chem Lett 15

      Pages: 2888-2890

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 子実体Tylopilus eximius由来MRSAの黄色色素生成阻害物質に関する研究2012

    • Author(s)
      福田隆志, ら
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-31
    • Related Report
      2011 Annual Research Report
  • [Presentation] MRSAの生産する黄色色素生成阻害物質の探索系の構築2012

    • Author(s)
      坂井謙斗, ら
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-31
    • Related Report
      2011 Annual Research Report
  • [Presentation] 真菌FKI-4533株が生産するウンデカプレニル2リン酸合成酵素阻害物質に関する研究2012

    • Author(s)
      猪腰淳嗣, ら
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 真菌由来xanthone類によるMRSAの黄色色素生成阻害活性に関する研究2012

    • Author(s)
      西尾和毅, ら
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 真菌Simplicillium sp.FKI-4981株が生産する新規amphotericin B活性増強物質に関する研究2012

    • Author(s)
      内田龍児, ら
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cyslabdanの合成研究2012

    • Author(s)
      菱沼裕介, ら
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Analysis of essential amino acids in lasso peptide lariatins for anti-mycobacterial activity by single amino acid substitution2012

    • Author(s)
      Inokoshi J, et al
    • Organizer
      The 6th Korea-Japan Chemical Biology Symposium
    • Place of Presentation
      Sapporo
    • Year and Date
      2012-01-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Inhibition of MRSA yellow pigment production by citridone A2012

    • Author(s)
      Sakai K, et al
    • Organizer
      The 6th Korea-Japan Chemical Biology Symposium
    • Place of Presentation
      Sapporo
    • Year and Date
      2012-01-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mechanism of action of cyslabdan, a potentiator of β-lactam drug activity against MRSA2012

    • Author(s)
      Koyama N, et al
    • Organizer
      The 6th Korea-Japan Chemical Biology Symposium
    • Place of Presentation
      Sapporo
    • Year and Date
      2012-01-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 投げ縄構造を有するペプチドlariatinの生合成に関する研究-LarCの構造解析-2011

    • Author(s)
      猪腰淳嗣, ら
    • Organizer
      第14回北里微生物アカデミー研究集会
    • Place of Presentation
      相模原
    • Year and Date
      2011-08-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 真菌の生産する新しい抗結核ペプチドcalpinactamの研究2011

    • Author(s)
      小山信裕, ら
    • Organizer
      第14回北里微生物アカデミー研究集会
    • Place of Presentation
      相模原
    • Year and Date
      2011-08-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mechanism of action of new anti-infectious agents from microorganisms2011

    • Author(s)
      Tomoda H.
    • Organizer
      The Uehara Memorial Foundation Symposium
    • Place of Presentation
      Tokyo
    • Year and Date
      2011-06-08
    • Related Report
      2011 Final Research Report
  • [Presentation] Mechanism of action of new anti-infectious agents from microorganisms2011

    • Author(s)
      Tomoda H
    • Organizer
      The uehara memorial foundation symposium 2011
    • Place of Presentation
      Tokyo
    • Year and Date
      2011-06-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mechanism of action of cyslabdan, a potentiator of imipenem activity against MRSA2011

    • Author(s)
      Tomoda H
    • Organizer
      Inaugural Metting of Bergey's International Society for Microbial Systematics
    • Place of Presentation
      Beijing, China
    • Year and Date
      2011-05-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] Microbial anthraquinones inhibit staphyloxanthin production by MRSA2011

    • Author(s)
      Sakai kent, et al
    • Organizer
      Inaugural Metting of Bergey's International Society for Microbial Systematics
    • Place of Presentation
      Beijing, China
    • Year and Date
      2011-05-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] カイコ感染評価系で抗真菌活性を示すトリコセテン類に関する研究2011

    • Author(s)
      浪口慎吾, ら
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] Anthraquinone類によるMRSA由来黄色色素形成阻害作用2011

    • Author(s)
      坂井謙斗, ら
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] 真菌由来抗結核ペプチドcalpinactamの作用機序解析2011

    • Author(s)
      柳澤千聡, ら
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] イミペネム活性増強剤cyslabdanの標的分子と作用機構2011

    • Author(s)
      土倉友梨子, ら
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] 微生物由来の抗MRSA剤の作用機構の解析2011

    • Author(s)
      供田洋
    • Organizer
      日本薬学会第131年会一般シンポジウム
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] 微生物由来の抗MRSA剤の作用機構の解析2011

    • Author(s)
      供田洋
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡(一般シンポジウム)
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Selective anti-mycobacterial activity of fungal calpinactam, new aminoca prolactam peptide2011

    • Author(s)
      Koyama N, et al
    • Organizer
      ICDDT2011
    • Place of Presentation
      Dubai, UAE
    • Year and Date
      2011-02-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 投げ縄構造を有するペプチドlariatinの生合成に関わるLarCの機能解析に関する研究2010

    • Author(s)
      三宅緑, ら
    • Organizer
      第33回日本分子生物学会年会、第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] New anti-mycobacterial peptide antibiotics, lariatin and calpinactam2010

    • Author(s)
      Tomoda H
    • Organizer
      FIP2010
    • Place of Presentation
      Lisbon, Portugal
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 投げ縄構造を有する抗結核ペプチドlariatinの構造活性相関に関する研究2010

    • Author(s)
      三宅緑, ら
    • Organizer
      2010年度日本放線菌学会大会
    • Place of Presentation
      船堀
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 放線菌Streptomyces sp.K04-0144株の生産するβ-ラクタム薬活性増強物質2010

    • Author(s)
      土倉友梨子, ら
    • Organizer
      2010年度日本放線菌学会大会
    • Place of Presentation
      船堀
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 投げ縄構造を有する抗結核ペプチドlariatinのアミノ酸置換体についての検討2010

    • Author(s)
      三宅緑, ら
    • Organizer
      第23回北里大学バイオサイエンスフォーラム研究会
    • Place of Presentation
      十和田
    • Year and Date
      2010-08-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] 真菌Mortierella alpina FKI-4905株が生産する抗結核活性物質2010

    • Author(s)
      小山信裕
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] β-ラクタム薬の抗MRSA活性増強剤cyslabdanの標的タンパク質の解析2010

    • Author(s)
      土倉友梨子
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 投げ縄構造を有する抗結核ペプチドlariatinの構造活性相関に関する研究2010

    • Author(s)
      三宅緑
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Discovery of Fungal Calpinactam, A New Anti-mycobacterial Agent2010

    • Author(s)
      Koyama N
    • Organizer
      The 5th Japan-Korea Chemical Biology Symposium
    • Place of Presentation
      Busan, Korea
    • Year and Date
      2010-01-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] カイコ感染症モデルを利用した治療効果を示す抗生物質の探索2009

    • Author(s)
      供田洋
    • Organizer
      医学・創薬研究を支えるヒトと昆虫の生物資源-病理と病態モデル-
    • Place of Presentation
      東京
    • Year and Date
      2009-11-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] Cloning and characterization of the lariatin biosynthetic gene cluster from Rhodococcus jostii K01-B0171.2009

    • Author(s)
      Inokoshi J
    • Organizer
      3th Asia-Pacific International Peptide Symposium
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2009-11-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Discovery for New Anti-Mycobacterial Agents from Microorganisms.2009

    • Author(s)
      Tomoda H
    • Organizer
      Australia-Japan Workshop on Biodiversity
    • Place of Presentation
      Canberra, Australia
    • Year and Date
      2009-10-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Calpinactam, a New Anti-mycobacterial Agent, Produced by Mortierella alpina FKI-49052009

    • Author(s)
      Koyama N
    • Organizer
      49th ICAAC
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2009-09-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] イミペネムの抗MRSA活性増強物質cyslabdanの作用機構に関する研究2009

    • Author(s)
      土倉友梨子
    • Organizer
      第22回バイオサイエンスフォーラム
    • Place of Presentation
      東京
    • Year and Date
      2009-08-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] イミペネムの抗MRSA活性増強剤cyslabdanの標的分子の解析2009

    • Author(s)
      小山信裕
    • Organizer
      第24回日本放線菌学会大会
    • Place of Presentation
      秋田
    • Year and Date
      2009-07-16
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] MRSA産生黄色色素の生成阻害能を示す新規化合物とその製造方法2011

    • Inventor(s)
      供田洋、福田隆志、小山信裕
    • Industrial Property Rights Holder
      学校法人北里研究所
    • Filing Date
      2011-07-15
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] MRSA産生黄色色素の生成阻害能を示す新規化合物とその用途2011

    • Inventor(s)
      供田洋、長光亨、福田隆志、小山信裕
    • Industrial Property Rights Holder
      学校法人北里研究所
    • Filing Date
      2011-10-12
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] MRSA産生黄色色素の生成阻害能を示す新規化合物とその製造方法2011

    • Inventor(s)
      供田洋, ら
    • Industrial Property Rights Holder
      北里大学
    • Industrial Property Number
      2011-156720
    • Filing Date
      2011-07-15
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] MRSA産生黄色色素の生成阻害能を示す新規化合物とその用途2011

    • Inventor(s)
      供田洋, ら
    • Industrial Property Rights Holder
      北里大学
    • Industrial Property Number
      2011-224968
    • Filing Date
      2011-10-12
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 抗真菌剤の活性増強作用を有する新規物質およびその製造方法と用途2011

    • Inventor(s)
      供田洋, 内田龍児, 野中健一, 増間碌郎, 大村智
    • Industrial Property Rights Holder
      学校法人 北里研究所
    • Industrial Property Number
      2011-041894
    • Filing Date
      2011-02-28
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi