Creations of Dynamical Guiding Principle of Selectivity and Stochasticity across Spatiotemporal Hierarchy in Biological Functions
Project/Area Number |
21340117
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Biophysics/Chemical physics
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Research Institution | Hokkaido University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
LI Chun-biu 北海道大学, 電子科学研究所, 准教授 (90397795)
TERAMOTO Hiroshi 北海道大学, 電子科学研究所, 助教 (90463728)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2009: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
|
Keywords | 1分子計測(SMD) / 化学物理 / 生物物理 / ネットワーク / 生体分子 / 化学反応ダイナミクス / 法双曲的不変多様体 / カオス力学系 / 遷移状態 / 複雑ネットワーク / 一分子計測 / 化学反応ダイナミックス / エネルギー地形 / 非平衡定常状態 |
Research Abstract |
To the fundamental question of how molecular functions persist its selectivity under influence of thermal fluctuation, we revealed that one can predict analytically the reaction fate or structural change by a nonlinear coordinate transformation involving the velocities of the system and the friction and random force exerted by thermal degrees of freedom, transition state can change dynamically at high energy/temperature regimes, and developed a new theory that enables us to derive an effective energy landscape from hierarchical state space transition network derived from single molecule time series.
|
Report
(4 results)
Research Products
(206 results)
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[Book] Non-Brownian Phase Space Dynamics of Molecules, the Nature of their Vibrational States, and non-RRKM Kinetics in Advancing Theory for Kinetics and Dynamics of Complex, Many-Dimensional Systems : Clusters and Proteins Advances in Chemical Physics, 1452011
Author(s)
David M.Leitner, Yasuhiro Matsunaga, Akira Shojiguchi, Chun-Biu Li, Tamiki Komatsuzaki, Mikito Toda
Total Pages
40
Publisher
John-Wiley & Sons, Inc.
Related Report
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