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Spiral Formation of Exc itation Waves Based on Curvature Effect in Culture of Cardiomyocyt

Research Project

Project/Area Number 21340120
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biophysics/Chemical physics
Research InstitutionKyoto University

Principal Investigator

アグラゼ コンスタンチン  京都大学, 物質-細胞統合システム拠点, 教授 (30503651)

Co-Investigator(Kenkyū-buntansha) MAGOME Nobuyuki  京都大学, 物質-細胞統合システム拠点, 助教 (70390052)
MOTOIKE Ikuko  京都大学, 物質-細胞統合システム拠点, 研究員 (70347178)
IMAMURA Hisako  京都大学, 物質-細胞統合システム拠点, 研究員 (30523790)
ORLOVA Yuliya  京都大学, 物質-細胞統合システム拠点, 研究員 (90571901)
Project Period (FY) 2009 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2011: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Keywords非線形振動 / 興奮性 / 曲率効果 / 心筋細胞 / ラセン波 / 反応拡散方程式 / パターン形成 / 光制御
Research Abstract

Behaviors of traveling excitation waves around obstacle region in cultivated cardiomyocytes were investigated in experimentally and numerically. The instability of propagation waves were affected by excitability of the cells and shape of obstacle.Spontaneous formation of spiral wave at edge of sharp corner was also observed.Furthermore, new methods (1) to control activity of cardiomyocytes with the aid of photo-switching molecules, and (2) to construct aligned culture of cells along fabricated microfiber were established

Report

(5 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (31 results)

All 2013 2012 2011 2010 2009 Other

All Journal Article (15 results) (of which Peer Reviewed: 9 results) Presentation (12 results) (of which Invited: 1 results) Remarks (4 results)

  • [Journal Article] Development of a reentrant arrhythmia model in human pluripotent stem cell-derivpd cardiac cell sheets2013

    • Author(s)
      Kadota S, et al.
    • Journal Title

      European Heart Journal

      Volume: VOL.34 Issue: 15 Pages: 1147-1156

    • DOI

      10.1093/eurheartj/ehs418

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Curvature-dependent excitation propagation in cultured cardiac tissue2012

    • Author(s)
      S Kadota, MW Kay, N Magome, K Agladze
    • Journal Title

      JETP letters

      Volume: 94 Pages: 824-830

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Curvature-dependent excitationpropagation in cultured cardiac tissue2011

    • Author(s)
      S. Kadota, M. W. Kay, N. Magome, and K. Agladze,K
    • Journal Title

      J. Exp. Theor. Phys. Lett.

      Volume: vol.94 Pages: 838-844

    • Related Report
      2012 Final Research Report
  • [Journal Article] Digital photo-control of the network of live excitable cell2011

    • Author(s)
      I.S.Erofeev, N. Magome, and K. Agladze
    • Journal Title

      J. Exp. Theor. Phys. Lett

      Volume: vol.94 Pages: 513-516

    • Related Report
      2012 Final Research Report
  • [Journal Article] Photo-Control of Excitation Waves in Cardiomyocyte Tissue Culture2011

    • Author(s)
      N. Magome, G. Kanaporis, N. Moisan, K. Tanaka, and K. Agladze
    • Journal Title

      Tissue Engineering part A

      Volume: vol.17 Pages: 2703-2711

    • Related Report
      2012 Final Research Report
  • [Journal Article] Electronspun nanofibers as a tool for architecture control in engineered cardiac tissue2011

    • Author(s)
      Y. Orlova, N. Magome, L. Liu, Y. Chen, and K. Agladze
    • Journal Title

      Biomaterials

      Volume: vol.32 Pages: 5615-5624

    • Related Report
      2012 Final Research Report
  • [Journal Article] Photo-Control of Excitation Waves in Cardiomyocyte Tissue Culture2011

    • Author(s)
      N.Magome, G.Kanaporis, N.Moisan, K.Tanaka, K.Agladze
    • Journal Title

      Tissue Engineering, part A

      Volume: 17 Issue: 21-22 Pages: 2703-2711

    • DOI

      10.1089/ten.tea.2010.0745

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electronspun nanofibers as a tool for architecture control in engineered cardiac tissue2011

    • Author(s)
      Y.Orlova, N.Magome, L.Liu, Y.Chen, K.Agladze
    • Journal Title

      Biomaterials

      Volume: 32 Issue: 24 Pages: 5615-5624

    • DOI

      10.1016/j.biomaterials.2011.04.042

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Digital photo-control of the network of live excitable cells2011

    • Author(s)
      I.S.Erofeev, N.Magome, K.Agladze
    • Journal Title

      J.Exp.Theor.Phys.Lett.

      Volume: 94 Issue: 6 Pages: 513-516

    • DOI

      10.1134/s0021364011180056

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Curvature-dependent excitation propagation in cultured cardiac tissue2011

    • Author(s)
      Kadota S, et al
    • Journal Title

      J Exp Theor Phys Lett

      Volume: 94 Issue: 11 Pages: 904-910

    • DOI

      10.1134/s0021364011230044

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Patterning and excitability control in cardiomyocyte tissue culture2010

    • Author(s)
      N. Magome and K. Agladze
    • Journal Title

      Physica D

      Volume: vol.239 Pages: 1560-1566

    • Related Report
      2012 Final Research Report
  • [Journal Article] Patterning and excitability control in cardiomyocyte tissue culture2010

    • Author(s)
      N.Magome, K.Agladze
    • Journal Title

      Physica D

      Volume: 239 Pages: 1560-1569

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unpinning of a spiral wave anchored around a circular obstacle by an external wave train : Common aspects of a chemical reaction and cardiomyocyte tissue2009

    • Author(s)
      Tanaka M., 他5名
    • Journal Title

      CHAOS 19

      Pages: 43114-43114

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Liberation of a pinned spiral wave by a single stimulus in excitable media2009

    • Author(s)
      Horning M., 他3名
    • Journal Title

      Physical Review E 79

      Pages: 26218-26218

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multi-electrode monitoring of guided excitation in patterned cardiomyocytes

    • Author(s)
      L. Wang, L. Liu, X. Li, N. Magome, K. Agladze, and Y. Chen
    • Journal Title

      Microelectron.Eng

      Volume: (in press)

    • Related Report
      2012 Final Research Report
  • [Presentation] Photo-controlled engineered cardiac tissue2012

    • Author(s)
      K. Agladze
    • Organizer
      International Conference "Instabilities and Control of Excitable Networks: From macro- to nano-systems"
    • Place of Presentation
      Dolgoprudny, Russia
    • Related Report
      2012 Final Research Report
  • [Presentation] Photo-controlled engineered cardiac tissue2012

    • Author(s)
      K. Agladze
    • Organizer
      International Conference "Instabilities and Control of Excitable Networks: From macro- to nano-systems"
    • Place of Presentation
      Dolgoprudny, Russia
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Digital photo-control of cardiac tissue2011

    • Author(s)
      アグラゼ コンスタンチン
    • Organizer
      European Conference on Artificial Life
    • Place of Presentation
      パリ、フランス(招待講演)
    • Year and Date
      2011-08-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] 光感受性を有する心筋細胞系の構築2011

    • Author(s)
      馬籠信之、Nicolas MOISAN, 田中耕一郎、Bamien BAIGL、吉川研一、Konstantin AGLADZE
    • Organizer
      第91回日本化学会春季年会
    • Place of Presentation
      神奈川大学(神奈川県)
    • Year and Date
      2011-03-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Light Mediated Control of Cardiac Excitability2011

    • Author(s)
      N.Magome, L.Swift, H.Asfour, M.Kay, N.Sarvazyan, K.Agladze
    • Organizer
      55th Annual Meeting of the Biophysical Society
    • Place of Presentation
      Convention Center (Maryland, USA)
    • Year and Date
      2011-03-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Control of Structure and Excitability of Cardiomyocyte Culture2011

    • Author(s)
      N.Magome, Y.Orlova, L.Liu, Y.Chen, K.Agladze
    • Organizer
      International Symposium on Engineering Neo-Biomimetics II
    • Place of Presentation
      産業技術総合研究所(茨城県)(招待講演)
    • Year and Date
      2011-02-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Control of Structure and Excitability of Cardiomyocyte Culture2011

    • Author(s)
      N. Magome, Y. Orlova, L. Liu, Y. Chen, and K. Agladze
    • Organizer
      International Symposium on Engineering Neo-Biomimetics II - Soft nanomaterials and Soft Robotics -
    • Place of Presentation
      Tsukuba.
    • Related Report
      2012 Final Research Report
  • [Presentation] Light Mediated Control of Cardiac Excitability2011

    • Author(s)
      N. Magome, L. Swift, H. Asfour, M. Kay, N.Sarvazyan, and K. Agladze
    • Organizer
      55th Annual Meeting of the Biophysical Society
    • Place of Presentation
      Maryland, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Switching of Cell Activity Induced by Photo-Switching Molecules2010

    • Author(s)
      N.Magome, K.Agladze
    • Organizer
      9^<th> iCeMS International Symposium
    • Place of Presentation
      京都大学(京都府)
    • Year and Date
      2010-12-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Optical Control of Excitation Waves in Cardiomyocyte Culture2010

    • Author(s)
      N. Magome and K. Agladze
    • Organizer
      Gordon Research Conference; Oscillation & Dynamic Instabilities in Chemical Systems
    • Place of Presentation
      Lucca, Italy.
    • Related Report
      2012 Final Research Report
  • [Presentation] Optical Control of Excitation Waves in Cardiomyocyte Culture2010

    • Author(s)
      N.Magome, K.Agladze
    • Organizer
      Gordon Research Conference : Oscillations & Dynamic Instabilities in Chemical Systems
    • Place of Presentation
      II Ciocco Hotel and Resort (Lucca, Italy)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Light Control of Cardiac Tissue2009

    • Author(s)
      Magome N., Agladze K.
    • Organizer
      4th iCeMS International Symposium
    • Place of Presentation
      京都
    • Year and Date
      2009-05-28
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.agladze.icems.kyoto-u.ac.jp/

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.agladze.icems.kyoto-u.ac.jp/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.agladze.icems.kyoto-u.ac.jp/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.agladze.icems.kyoto-u.ac.jp/index.html

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2019-07-29  

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