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Control of a small amount of molecules in two-dimensional monolayer by local modification

Research Project

Project/Area Number 21350001
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Physical chemistry
Research InstitutionHokkaido University

Principal Investigator

MURAKOSHI Kei  北海道大学, 大学院・理学研究院, 教授 (40241301)

Co-Investigator(Kenkyū-buntansha) NABIKA Hideki  北海道大学, 大学院・理学研究院, 助教 (30372262)
YASUDA Satoshi  北海道大学, 大学院・理学研究院, 講師 (90400639)
池田 勝佳  北海道大学, 大学院・理学研究院, 准教授 (50321899)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2011: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Keywords脂質二分子膜 / 蛍光標識脂質分子 / 全反射顕微鏡 / 分子フィルター / ゲート構造 / 微小ギャップ / 単一分子追跡 / ナノゲート / フィルタ効果 / 透過確率 / 脂質二重膜 / 局所構造制御 / 分子トラッピング / 単一分子分光 / 分子分別場
Research Abstract

We revealed that molecules with distinct sizes and strictures in self-spreading lipid bilayer are selectively filtered when the bilayer spread through the metallic nanogates. In order to make clear the origin of this molecular filtering phenomenon, we have observed molecular diffusion in nano space by single molecular tracking. In this research, metal nanogates with sizes of 100 nm was fabricated on cover slips with using electron beam lithography. The quantitative evaluation by single molecular tracking can reveal that the structural change of lipid bilayer correlates molecular diffusion change in nano space.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (52 results)

All 2012 2011 2010 2009 2007 Other

All Journal Article (25 results) (of which Peer Reviewed: 25 results) Presentation (22 results) Book (3 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Enhanced Brownian Ratchet Molecular Separation Using a Self-Spreading Lipid Bilayer2012

    • Author(s)
      T. Motegi, H. Nabika, K. Murakoshi
    • Journal Title

      Langmuir

      Volume: 28 Pages: 6656-6661

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dynamics of Gold Nanoparticle Assembly and Disassembly Induced by pH Oscillations2012

    • Author(s)
      Nabika, Hideki ; Oikawa, Tetsuro ; Iwasaki, Keisuke ; Murakoshi, Kei ; Unoura, Kei
    • Journal Title

      The Journal of Physical Chemistry

      Volume: 116 Pages: 6153-6158

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polarization Characteristics of Surface-enhanced Raman Scattering from a Small Number of Molecules at the Gap of a Metal Nano-dimer2011

    • Author(s)
      F. Nagasawa, M. Takase, H. Nabika and K. Murakoshi
    • Journal Title

      Chem. Commun

      Volume: 47 Pages: 4514-4516

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection of Adsorption Sites at the Gap of a Hetero-Metal Nano-Dimer at the Single Molecule Level2011

    • Author(s)
      Mai Takase, Yasuhiro Sawai, Hideki Nabika, Kei Murakoshi
    • Journal Title

      Journal of Photochemistry and Photobiology A : Chemistry

      Volume: 221 Pages: 169-174

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphine Sulfides as an Anchor Unit for Single Molecule Junction2011

    • Author(s)
      Aiko Fukazawa, Manabu Kiguchi, Satoshi Tange, Yasunori Ichihashi, Qiang Zhao, Takuya Takahashi, Tatsuya Konishi, Kei Murakoshi, Yuta Tsuji, Alekandar Staykov, Kazunari Yoshizawa, Shigehiro Yamaguchi
    • Journal Title

      Chemistry Letters

      Volume: 2 Pages: 174-174

    • NAID

      10027814812

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polarization Characteristics of Surface-Enhanced Raman Scattering from a Small Number of Molecules at the Gap of a Metal Nano-Dimer2011

    • Author(s)
      Fumika Nagasawa, Mai Takase, Hideki Nabika, Kei Murakoshi
    • Journal Title

      Chemical Communications

      Volume: 47 Pages: 4514-4516

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Control of Dynamics and Molecular Distribution in a Self-Spreading Lipid Bilayer using Surface-Modified Metal Nanoarchitecture2011

    • Author(s)
      Hideki Nabika, Masahiro Oowada, Kei Murakoshi
    • Journal Title

      Physical Chemistry Chemical Physics

      Volume: 13 Pages: 5561-5564

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acceleration of Photochromicring-Opening Reaction of Diarylethenederivatives by Excitation of Localized Surface Plasmon2011

    • Author(s)
      Yasuyuki Tsuboi, Ryosuke Shimizu, Tatsuya Shoji, Noboru kitamura, Mai Takase, Kei Murakoshi
    • Journal Title

      Journal of Photochemistry and Photobiology A : Chemistry

      Volume: 221 Pages: 250-255

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of an Isolated Individual Single-walled Carbon Nanotube using Electrochemical STM2011

    • Author(s)
      S.Yasuda, K.Ikeda, L.Yu, K.Murakoshi
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: (印刷中)(accepted)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Control of dynamics and molecular distribution in a self-spreading lipid bilayer using surface-modified metal nanoarchitecture2011

    • Author(s)
      Hideki Nabika
    • Journal Title

      Phys.Chem.Chem.Phys

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 細胞膜に学ぶ分子操作2011

    • Author(s)
      並河英紀
    • Journal Title

      化学

      Volume: 66 Pages: 47-50

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Toward Plasmon-Induced Photoexcitation of Molecules2010

    • Author(s)
      H. Nabika, M. Takase, F. Nagasawa and K. Murakoshi
    • Journal Title

      J. Phys. Chem. Lett.

      Volume: 1 (16) Pages: 2470-2487

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Force applied to a single molecule at a single nano-gate molecule filter2010

    • Author(s)
      Baku Takimoto
    • Journal Title

      Nanoscale

      Volume: 2 Pages: 2591-2595

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FRET observation of nano-gate molecular filter2010

    • Author(s)
      Hideki Nabika
    • Journal Title

      Trans.Mater.Res.Soc.Jpn.

      Volume: 35 Pages: 283-286

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 固液界面上の脂質二重膜を用いた分子操作2010

    • Author(s)
      並河英紀
    • Journal Title

      Colloid and Interface Communication

      Volume: 35 Pages: 20-21

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Toward Plasmon-Induced Photoexcitation of Molecules2010

    • Author(s)
      Hideki Nabika
    • Journal Title

      J.Phys.Chem.Lett.

      Volume: 1 Pages: 2470-2487

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristic surface-enhanced Raman scattering from a small number of molecules in an anisotropic electromagnetic field at metal nano-gap2010

    • Author(s)
      F.Nagasawa
    • Journal Title

      Trans.Mater.Res.Soc.Jpn. (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fluorescence resonant energy transfer observation of nano-gate molecular filter2010

    • Author(s)
      T.Sumida
    • Journal Title

      Trans.Mater.Res.Soc.Jpn. (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced Emission from Photo-Activated Silver Clusters Coupled with Localized Surface Plasmon Resonance2009

    • Author(s)
      B. Takimoto, H. Nabika and K. Murakoshi
    • Journal Title

      J. Phys. Chem.

      Volume: C113(27) Pages: 11751-11755

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced emission from photoactivated silver clusters coupled with localized surface plasmon resonance2009

    • Author(s)
      B.Takimoto
    • Journal Title

      J.Phys.Chem.C 113

      Pages: 11751-11755

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single Molecule Tracking of Cholera-toxin Subunit B on GM1-ganlioside Containing Lipid Bilayer2009

    • Author(s)
      H.Nabika
    • Journal Title

      e-J.Surf.Sci.Nanotechnol 7

      Pages: 74-77

    • NAID

      130004439119

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Segregation of Molecules in Lipid Bilayer Spreading through Metal Nano-gates2009

    • Author(s)
      H.Nabika
    • Journal Title

      Anal.Chem. 81

      Pages: 699-704

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single Molecular Observation of Hop Diffusion in a Lipid Bilayer at Metallic Nanogates2009

    • Author(s)
      B.Takimoto
    • Journal Title

      J.Phys.Chem.C 113

      Pages: 3127-3132

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Bending Energy on the Self-spreading Lipid Bilayer2009

    • Author(s)
      H.Nabika
    • Journal Title

      ECS Trans. 19

      Pages: 79-85

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Observation of a Small Number of Molecules at a Metal Nanogap Arrayed on a Solid Surface Using Surface-Enhanced Raman Scattering2007

    • Author(s)
      Y. Sawai, B. Takimoto, H. Nabika, K. Ajitoand K. Murakoshi
    • Journal Title

      J. Am. Chem. Soc

      Volume: 129 Pages: 1658-1662

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] 局所光電場による固液界面での化学反応制御に向けて2012

    • Author(s)
      村越敬
    • Organizer
      電気化学会第79回大会
    • Place of Presentation
      アクトシティ浜松(静岡)(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Monitoring Plasmon-Assisted Photochemical Reaction at Metal Nanogap by Surface-Enhanced Raman Scattering2011

    • Author(s)
      K. Murakoshi
    • Organizer
      SeminaireSOLEIL
    • Place of Presentation
      France, invited
    • Year and Date
      2011-06-20
    • Related Report
      2011 Final Research Report
  • [Presentation] Monitorine Plasmon-Assisted Photochemical Reaction at Metal Nanogap by Surface-Enhanced Raman Scattering2011

    • Author(s)
      Murakoshi Kei
    • Organizer
      Seminaire SOLEIL
    • Place of Presentation
      Soleil synchrotron (France)(招待講演)
    • Year and Date
      2011-05-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Plasmon-Assisted Nano-Processing of an Individual Single-Walled Carbon Nanotube2011

    • Author(s)
      K. Murakoshi
    • Organizer
      219th Electrochemical Society Meeting (ECS)
    • Place of Presentation
      Montreal, Canada, invited
    • Year and Date
      2011-05-02
    • Related Report
      2011 Final Research Report
  • [Presentation] Depolarization Behavior of Raman Scattering Photons from a Gap of Metal Nanodimer2011

    • Author(s)
      K. Murakoshi, F. Nagasawa, M. Takase, H. Nabika
    • Organizer
      XXV International Conference on Photochemistry ICP2011
    • Place of Presentation
      Beijing, China, invited
    • Related Report
      2011 Final Research Report
  • [Presentation] Anisotropic Polarization of a Single Molecule at Metal Nanogap under Illumination2011

    • Author(s)
      Murakoshi Kei
    • Organizer
      The Third Asian Spectroscopy Conference
    • Place of Presentation
      Xiamen univ.(China)(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Depolarization Behavior of Raman Scattering Photons from a Gap of Metal Nanodimer2011

    • Author(s)
      Murakoshi Kei, Nagasawa Fumika, Takase Mai, Nabika Hideki
    • Organizer
      X X V International Conference on Photochemistry ICP2011
    • Place of Presentation
      Beijing univ.(China)(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Molecular Separation in the Self-spreading Lipid Bilayer based on Brownian Ratchet Mechanism2010

    • Author(s)
      Toshinori Motegi
    • Organizer
      61st Annual Meeting of ISE
    • Place of Presentation
      Trade exhibition center (France)
    • Year and Date
      2010-09-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Molecular Filtering Effect at Nano-Space by Using Self-Spreading Lipid Bilayer as Molecular Transport Medium2010

    • Author(s)
      Tomoki Sumida
    • Organizer
      NCSS2010
    • Place of Presentation
      幕張メッセ国際会議場(千葉市)
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Molecular Filtering on Self-Spreading Lipid Bilayer by Curvature Modulation2010

    • Author(s)
      Takafumi Ogawa
    • Organizer
      NCSS2010
    • Place of Presentation
      幕張メッセ国際会議場(千葉市)
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Single molecule tracking study on the self-spreading lipid bilayer in confined space2010

    • Author(s)
      Hideki Nabika
    • Organizer
      NCSS2010
    • Place of Presentation
      幕張メッセ国際会議場(千葉市)
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Molecular Separation of CTB/GM1 in Self-Spreading Bilayer Using Brownian Rachet2010

    • Author(s)
      Toshinori Motegi
    • Organizer
      NCSS2010
    • Place of Presentation
      幕張メッセ国際会議場(千葉市)
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Self-spreading lipid bilayer through metallic nano channels2010

    • Author(s)
      Kazuya Fukagawa
    • Organizer
      NCSS2010
    • Place of Presentation
      幕張メッセ国際会議場(千葉市)
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Catalytic Activity of An Individual Single-Walled Carbon Nanotube using Surface-Enhanced Raman Scattering2010

    • Author(s)
      K. Murakoshi
    • Organizer
      Novel Nanostructures and Catalysis -Seeking for Breakthrough-
    • Place of Presentation
      Lake Toya, invited
    • Year and Date
      2010-07-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Segregation of a Small Amount of Molecule in Self-Spreading Lipid Bilayer Through Metallic Nanogate2010

    • Author(s)
      Hideki Nabika
    • Organizer
      217th ECS Meeting
    • Place of Presentation
      The Hyatt Regency Vancouver and The Fairmont Hotel Vancouver (Canada)
    • Year and Date
      2010-04-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 固液界面における少数原子・分子系の構造制御と機能化2010

    • Author(s)
      村越敬
    • Organizer
      日本化学会第90春季年会日本化学会第27回日学術賞受賞講
    • Place of Presentation
      近畿大学
    • Year and Date
      2010-03-28
    • Related Report
      2011 Final Research Report
  • [Presentation] Structural Dependence on the Molecular Segregation at Metal Nanogate2009

    • Author(s)
      K.Murakoshi
    • Organizer
      12th SNU and Hokkaido University Joint Symposium On Nano Green Chemistry for Sustainable Society
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2009-11-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] Measurements on Single-Molecule Surface-Enhanced Raman Scattering from Controlled Metal Nanogap2009

    • Author(s)
      K.Murakoshi
    • Organizer
      216th Meeting of the Electrochemical Society
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2009-10-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Observation of a Single Molecule in Strong Photon-Molecule Coupling Field at Metal Nano-Gap2009

    • Author(s)
      K.Murakoshi
    • Organizer
      International Meeting on Interdiciplinary Chemistry 2009 at Ikaho
    • Place of Presentation
      Ikaho
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Observation of Single-Molecule at Metal Nano-gap2009

    • Author(s)
      K.Murakoshi
    • Organizer
      KJF International Conference on Organic Materials for Electronics and Photonics
    • Place of Presentation
      JEJU, Korea
    • Year and Date
      2009-08-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Observation and Manipulation of a Small Number of Molecules at Plasmon Active Ultra-Small Nanostructure2009

    • Author(s)
      K.Murakoshi
    • Organizer
      5th Kurt Schwabe Symposium
    • Place of Presentation
      Erlangen, Germany
    • Year and Date
      2009-05-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Nano-gate Molecular Filter by using of a Self-spreading Lipid Bilayer as a Molecular Transporter2009

    • Author(s)
      H.Nabika
    • Organizer
      215th Meeting of the Electrochemical Society
    • Place of Presentation
      San Francisco, U.S.A.
    • Year and Date
      2009-05-26
    • Related Report
      2009 Annual Research Report
  • [Book] Molecular Nano Dynamics "Molecular segregation at periodic metalnano-architectures on solid surface"2009

    • Author(s)
      H. Nabika and K. Murakoshi John Wileyand Sons Ltd
    • Total Pages
      1200
    • Related Report
      2011 Final Research Report
  • [Book] 金属ナノ・マイクロ粒子の形状・構造制御技術2009

    • Author(s)
      並河英紀、村越敬
    • Publisher
      第8章米澤徹、シーエムシー出版
    • Related Report
      2011 Final Research Report
  • [Book] "Molecular segregation at periodic metal nano-architectures on solid surface" in Molecular Nano Dynamics2009

    • Author(s)
      H.Nabika
    • Total Pages
      1200
    • Publisher
      John Wiley and Sons Ltd.
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://wwwchem.sci.hokudai.ac.jp/pc/

    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] カーボンナノチューブの製造方法2011

    • Inventor(s)
      村越敬、保田諭、アハマドシャウキィ
    • Industrial Property Rights Holder
      北海道大学
    • Filing Date
      2011-03-10
    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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