| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2009: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Research Abstract |
Transition-metal-catalyzed allylic substitution reactions with nucleophiles are among the most important transformation methods in modern organic synthesis because of their broad substrate scope under mild reaction conditions and applicability to enantioselective reactions, as well as the versatility of the alkene functionality adjacent to the chiral center for stereoselective derivatization. However, allylic substitution of unsymmetrically substituted allylic substrates occurs competitively at the α-and γ-positions due to formation of a (π-allyl)metal intermediate : the regioselectivity is highly dependent on the substitution pattern of the allylic substrates. In this research, the principle of catalytic γ-selective substitution of allylic systems has been established, and new organic synthetic reactions have been developed.
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