| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
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| Research Abstract |
New absolute asymmetric synthesis using the property of organic crystals were developed. Crystallization under various conditions was examined and was clarified a change of molecular structure, polymorphism and the crystal structure. Furthermore, I succeeded in controlling the rate of racemization of the apparent chiral molecules in the chiral crystals, and leading it effectively to the optically active products. I also developed the highly diastereoselective reaction using chiral memory controlled by crystallization induced diastereomer transformation (CIDT).
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