Metallomics of cells and organisms at different stages of development
Project/Area Number |
21350041
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Analytical chemistry
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Research Institution | Nagoya University |
Principal Investigator |
UMEMURA Tomonari 名古屋大学, エコトピア科学研究所, 准教授 (10312901)
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Co-Investigator(Kenkyū-buntansha) |
INAGAKI Kazumi 独立行政法人産業技術総合研究所, 計測標準研究部門 (50356490)
SYU Yanbei 独立行政法人産業技術総合研究所, 計測標準研究部門 (90422790)
BAN Masatoshi 独立行政法人水産総合研究センター, さけますセンター (80425462)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2011: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2009: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
|
Keywords | メタロミクス / オミックス / 1細胞分解 / 受精卵 / 必須微量元素 / 金属タンパク質 / 高速分離 / モノリス / 1細胞分析 |
Research Abstract |
In the" omics" era, there is a great need for comprehensive genome-wide multi-element analysis of a single cell and organism, because the combination of different metals and metalloids may exhibit an additive, synergistic, or antagonistic effect on cellular functions. Thus, we have had an intense interest in determining what kind of and how many elements are involved in cells, organs and organisms. In this paper, we have carried out multielement analysis of single celled bacteria(Escherichia coli) and organism(euglena) as well as embryos of chum salmon at different stages of development. The experimental results revealed that trace elements were to some extent selectively transferred from the culture media(or yolk sac) to the cell(or embryonic body) at an appropriate timing.
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Report
(4 results)
Research Products
(83 results)
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[Journal Article] Estimation of the Distribution of Intravenously Injected Adipose Tissue-Derived Stem Cells Labeled with Quantum Dots in Mice Organs through the Determination of their Metallic Components by ICP-MS2011
Author(s)
Y. Takasaki, M. Watanabe, H. Yukawa, A. Sabarudin, K. Inagaki, N. Kaji, Y. Okamoto, M. Tokeshi, Y. Miyamoto, H. Noguchi, T. Umemura, S. Hayashi, Y. Baba, H. Haraguchi
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Journal Title
Anal. Chem
Volume: 83
Pages: 8252-8258
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Peer Reviewed
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[Journal Article] Estimation of the Distribution of Intravenously Injected Adipose Tissue-Derived Stem Cells Labeled with Quantum Dots in Mice Organs through the Determination of their Metallic Components by ICP-MS2011
Author(s)
Y.Takasaki, M.Watanabe, H.Yukawa, A.Sabarudin, K.Inagaki, N.Kaji, Y.Okamoto, M.Tokeshi, Y.Miyamoto, H.Noguchi, T.Umemura, S.Hayashi, Y.Baba, H.Haraguchi
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Journal Title
Anal.Chem.
Volume: 83
Issue: 21
Pages: 8252-8258
DOI
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Peer Reviewed
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[Presentation] Highly Precise Measurement of Adipose Tissue-Derived Stem Cells Labeled with Quantum Dots in Mice by ICP-MS2011
Author(s)
Y.Takasaki, A.Sabarudin, M.Watanabe, H.Yukawa, Noritada Kaji, Yukihiro Okamoto, Y.Miyamoto, H.Noguchi, M.Tokeshi, T.Umemura, S.Hayashi, Y.Baba
Organizer
IUPAC International Congress on Analytical Sciences 2011 (ICAS2011)
Place of Presentation
Kobe, Japan
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[Presentation] ICP-MSによるマウスに静注した量子ドット標識化脂肪組織由来幹細胞の体内動態の精密測定2010
Author(s)
高崎裕加, 渡辺将生, 湯川博, 梅村知也, 加地範匡, 岡本行広, 宮本義孝, 野口洋文, 渡慶次学, 林衆治, 馬場嘉信
Organizer
日本分析化学会第59年会
Place of Presentation
仙台
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[Patent(Industrial Property Rights)] 噴霧器および分析装置2009
Inventor(s)
稲垣和三, 藤井紳一郎, 高津章子, 千葉光一, 朱彦北, 黒岩貴芳, 中川孝郎, 阿部正昭, 高崎裕加, 梅村知也
Industrial Property Rights Holder
(独) 産業技術総合研究所, (株) エス・ティ・ジャパン, 名古屋大学
Industrial Property Number
2009-211317
Filing Date
2009-09-14
Related Report