Development of the Functional Molecules for Genome Targeting Chemistry
| Project/Area Number |
21350086
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemistry related to living body
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| Research Institution | Tohoku University |
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Principal Investigator |
NAGATSUGI Fumi 東北大学, 多元物質科学研究所, 教授 (90208025)
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| Co-Investigator(Kenkyū-buntansha) |
HAGIHARA Shinnya 東北大学, 多元物質科学研究所, 助教 (80373348)
井本 修平 東北大学, 多元物質科学研究所, 助教 (20447189)
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| Co-Investigator(Renkei-kenkyūsha) |
IMOTO Syuhei 東北大学, 多元物質科学研究所, 助教 (20447189)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2009: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Keywords | 核酸・蛋白質・糖化学 / クロスリンク反応 / クロスリンク / オリゴDNA / miRNA / In Cell Chemistry / RNA標的 / 遺伝子発現制御 / インテリジェント核酸 |
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| Research Abstract |
After the human genome project, it is revealed that most of genome has functions without translation to protein. Especially, RNA has a variety of the functions to control the gene expression, for example, rebozyme, riboswich, siRNA and miRNA, so on. In this study, we have developed the novel molecules to recognize strictly the target RNA for regulation of these functions.
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Report
(4 results)
Research Products
(97 results)
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[Journal Article] Production of truncated protein by the crosslink formation of mRNA with 2'-OMe oligoribonucleotide containing 2-amino-6-vinylpurine
Author(s)
Hagihara, S., Kusano, S., Lin, W. C., Chao, X. G., Hori, T., Imoto, S., Nagatsugi, F.
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Journal Title
Bioorg. Med. Chem. Lett.
Volume: (in press)
Related Report
Peer Reviewed
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[Presentation] 2'修飾型反応性核酸の合成2009
Author(s)
堀常晃、井本修平、萩原伸也、永次史
Organizer
第9回 多元物質科学研究所 研究発表会
Place of Presentation
東北大学片平キャンパス・さくらホール(仙台)
Year and Date
2009-12-11
Related Report
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