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Development of the Functional Molecules for Genome Targeting Chemistry

Research Project

Project/Area Number 21350086
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemistry related to living body
Research InstitutionTohoku University

Principal Investigator

NAGATSUGI Fumi  東北大学, 多元物質科学研究所, 教授 (90208025)

Co-Investigator(Kenkyū-buntansha) HAGIHARA Shinnya  東北大学, 多元物質科学研究所, 助教 (80373348)
井本 修平  東北大学, 多元物質科学研究所, 助教 (20447189)
Co-Investigator(Renkei-kenkyūsha) IMOTO Syuhei  東北大学, 多元物質科学研究所, 助教 (20447189)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2009: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Keywords核酸・蛋白質・糖化学 / クロスリンク反応 / クロスリンク / オリゴDNA / miRNA / In Cell Chemistry / RNA標的 / 遺伝子発現制御 / インテリジェント核酸
Research Abstract

After the human genome project, it is revealed that most of genome has functions without translation to protein. Especially, RNA has a variety of the functions to control the gene expression, for example, rebozyme, riboswich, siRNA and miRNA, so on. In this study, we have developed the novel molecules to recognize strictly the target RNA for regulation of these functions.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (97 results)

All 2012 2011 2010 2009 Other

All Journal Article (17 results) (of which Peer Reviewed: 13 results) Presentation (79 results) Remarks (1 results)

  • [Journal Article] Induced cross-linking reactions to target genes using modified oligonucleotides2011

    • Author(s)
      F. Nagatsugi, and S. Imoto
    • Journal Title

      Organic & Biomolecular Chemistry

      Volume: 9 Pages: 2579-2585

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of the Highly Selective Reactions to Target Gene for the Control of the Gene Expression in Cells2011

    • Author(s)
      F. Nagatsugi
    • Journal Title

      Journal of Synthetic Organic Chemistry Japan

      Volume: 69 Pages: 108-117

    • NAID

      10027916316

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] チミンとの架橋反応性を有する新規人工核酸の開発2011

    • Author(s)
      永次史
    • Journal Title

      化学工業

      Volume: 62 Pages: 137-142

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] 自己活性化インテリジェント人工核酸の創製2011

    • Author(s)
      永次史
    • Journal Title

      化学同人

      Pages: 48-55

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of Reactive Oligonucleotides for Gene Targeting and Their Application to Gene Expression Regulation2010

    • Author(s)
      F. Nagatsugi. and S. Sasaki
    • Journal Title

      Bull. Chem. Soc. Jpn

      Volume: 83 Pages: 744-755

    • NAID

      10027174779

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] インテリジェント核酸を用いた細胞内遺伝子発現制御2010

    • Author(s)
      永次史、佐々木茂貴
    • Journal Title

      Antisense(アンチセンスDNA/RNA研究会)

      Volume: vol14, No1 Pages: 19-30

    • Related Report
      2011 Final Research Report
  • [Journal Article] Alteration of cross-linking selectivity with the 2'-OMe analogue of 2-amino-6-vinylpurine and evaluation of antisense effects2010

    • Author(s)
      S. Imoto, T. Hori, S. Hagihara, Y. Taniguchi, S. Sasaki, F. Nagatsugi
    • Journal Title

      Bioorg. Med. Chem. Lett

      Volume: 20 Pages: 6121-6124

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alteration of cross-linking selectivity with the 2'-OMe analogue of 2-amino-6-vinylpurine and evaluation of antisense effects2010

    • Author(s)
      Imoto, S.; Hori, T.; Hagihara, S.; Taniguchi, Y.; Sasaki, S.; Nagatsugi, F
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 20 Pages: 6121-6124

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The alkyl-connected 2-amino-6-vinylpurine (AVP) crosslinking agent for improved selectivity to the cytosine base in RNA2010

    • Author(s)
      Taniguchi, Y.; Kurose, Y.; Nishioka, T.; Nagatsugi, F.; Sasaki, S.
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 18 Pages: 2894-2901

    • NAID

      120005227462

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of Reactive Oligonucleotides for Gene Targeting and Their Application to Gene Expression Regulation2010

    • Author(s)
      Nagatsugi, F.; Sasaki, S.
    • Journal Title

      Bulletin of the Chemical Society of Japan

      Volume: 83 Pages: 744-755

    • NAID

      10027174779

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Formation of highly selective and efficient interstrand cross-linking to thymine without photo-irradiation2009

    • Author(s)
      K. Hattori, T. Hirohama, S. Imoto, S. Kusano, F. Nagatsugi
    • Journal Title

      Chem. Commun

      Volume: 42 Pages: 6463-6465

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Incorporation of an inducible nucleotide analog into DNA by DNA polymerases2009

    • Author(s)
      M. M. Ali, S. Imoto, Y. Li , S. Sasaki and F. Nagatsugi
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 17 Pages: 2859-2863

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Formation of Highly Selective and Efficient Interstrand Cross-Linking to Thymine Without Photo-Irradiation2009

    • Author(s)
      Hattori, K. ; Hirohama, T. ; Imoto, S. ; Kusano, S. ; Nagatsugi, F.
    • Journal Title

      Chem.Comm. 42

      Pages: 6463-6465

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Incorporation of an inducible nucleotide analog into DNA by DNA polymerases2009

    • Author(s)
      M.M.Ali, S.Imoto, Y.Li, S.Sasaki, F.Nagatsugi
    • Journal Title

      Bioorg.Med.Chem. 17

      Pages: 2859-2863

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design and Synthesis of the Novel cross-linking Agent2009

    • Author(s)
      S.Kusano, K.Hattori, S.Imoto, F.Nagatsugi
    • Journal Title

      Nucleic Acids Symp.Ser 53

      Pages: 169-170

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Evaluation of the antisense effect of PEGylated oligodeoxynucleotides containing intelligent nucleoside analogues2009

    • Author(s)
      Y.Taniguchi, Y.Kurose, T, Nishioka, F.Nagatsugi, S.Sasaki
    • Journal Title

      Nucleic Acids Symp.Ser 53

      Pages: 167-168

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Production of truncated protein by the crosslink formation of mRNA with 2'-OMe oligoribonucleotide containing 2-amino-6-vinylpurine

    • Author(s)
      Hagihara, S., Kusano, S., Lin, W. C., Chao, X. G., Hori, T., Imoto, S., Nagatsugi, F.
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] 架橋反応性核酸を用いた効率的蛋白質発現阻害2012

    • Author(s)
      永次史、萩原伸也、草野修平、井本修平
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学、北海道
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 6-ビニルプリンによるシトシンへの極めて早いDNA架橋反応2012

    • Author(s)
      井本修平、永次史、千国友子、寒水壽朗、國枝武久
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学、北海道
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 糖部修飾型架橋反応性ピリミジン誘導体の合成と評価2012

    • Author(s)
      草野修平、萩原伸也、茂木琢磨、永次史
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶應義塾大学、神奈川県
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 機能性オリゴ核酸のRNAへの架橋形成による遺伝子発現制御2012

    • Author(s)
      萩原伸也、草野修平、Chao Xio Guang, 岩本直生、永次史
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶應義塾大学、神奈川県
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Development of Reactive Oligonucleotides with High Selectivity to a Target Base in RNA2012

    • Author(s)
      F. Nagatsugi
    • Organizer
      Asian Chemical Biology Initiative 2012
    • Place of Presentation
      Hanoi, Vietnam
    • Related Report
      2011 Final Research Report
  • [Presentation] Development of Reactive Oligonucleotides with High Selectivity to a Target Base in RNA2012

    • Author(s)
      Fumi Nagatsugi
    • Organizer
      Asian Chemical Biology Initiative
    • Place of Presentation
      Hanoi, Vietnam(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 架橋性塩基を導入したPNAオリゴマーの合成および反応性評価2012

    • Author(s)
      石澤悠樹、佐々木要、萩原伸也、永次史
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶應義塾大学、神奈川県
    • Related Report
      2011 Annual Research Report
  • [Presentation] グリコシル化を鍵反応とした架橋反応性を有するピリミジン誘導体の合成と評価2011

    • Author(s)
      草野修平、萩原伸也、永次史
    • Organizer
      第22回万有仙台シンポジウム
    • Place of Presentation
      仙台国際センター,宮城県
    • Year and Date
      2011-12-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 架橋性核酸を用いたmRNAの機能制御2011

    • Author(s)
      萩原伸也、草野修平、岩本直生、Chao Xiao Guang、永次史
    • Organizer
      第11回多元物質科学研究所研究発表会
    • Place of Presentation
      東北大学片平キャンパス・さくらホール、宮城県
    • Year and Date
      2011-12-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 架橋反応性を有する直鎖状ヌクレオシド類縁体の開発2011

    • Author(s)
      草野修平、萩原伸也、茂木琢真、永次史
    • Organizer
      第11回多元物質科学研究所研究発表会
    • Place of Presentation
      東北大学片平キャンパス・さくらホール、宮城県
    • Year and Date
      2011-12-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 遺伝子変異と老化~化学的ピンポイント遺伝子変異誘導方法を目指したアプローチ~2011

    • Author(s)
      永次史
    • Organizer
      第6回老年医学研究会
    • Place of Presentation
      東北大学、宮城県
    • Year and Date
      2011-07-26
    • Related Report
      2011 Final Research Report
  • [Presentation] 遺伝子変異と老化~化学的ピンポイント遺伝子変異誘導方法を目指したアプローチ2011

    • Author(s)
      永次史
    • Organizer
      第6回老年医学研究会
    • Place of Presentation
      東北大学、宮城県(招待講演)
    • Year and Date
      2011-07-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] Evaluation of the Antisense Effects Using the Reactive Oligonucleotides with High Selectivity to the Target Base2011

    • Author(s)
      F. Nagatsugi, T. Hori, S. Kusano, S. Imoto, S. Hagihara, C. H. Guang
    • Organizer
      8th AFMC International Medicinal Chemistry Symposium"Frontier of Medicinal Science"
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] 2'-OMe RNA containing 2-amino-6-vinylpurine as a potent gene regulator2011

    • Author(s)
      S. Hagihara, S. Imoto, C. X. Guang, S. Kusano, F. Nagatsugi
    • Organizer
      The 38th International Symposium on Nucleic Acids Chemistry
    • Place of Presentation
      Sapporo, Japan
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Development of the Reactive Oligonucleotides with high selective reactivity to a Target Base2011

    • Author(s)
      F. Nagatsugi
    • Organizer
      France-Japan workshop Micro- & Nano-Architectures, Materials & Imaging
    • Place of Presentation
      Bordeaux, France
    • Related Report
      2011 Final Research Report
  • [Presentation] 細胞内における遺伝子発現制御を目指した自己活性化架橋反応性核酸の開発2011

    • Author(s)
      永次史、萩原伸也、草野修平、Chao Xiao Guang、茂木琢真
    • Organizer
      第60回高分子討論会
    • Place of Presentation
      岡山大学、岡山県
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 架橋反応性ピリミジン誘導体の合成と評価2011

    • Author(s)
      草野修平、萩原伸也、永次史
    • Organizer
      第5回バイオ関連化学シンポジウム
    • Place of Presentation
      つくば国際会議場「エポカルつくば」、茨城県
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Dependency of the Cross-linking Reactivity with 2-Amino-6-vinylpurine on the Neighboring Bases2011

    • Author(s)
      S. Hagihara, S. Kusano, C. X. Guang, F. Nagatsugi
    • Organizer
      7th Anual Meeting of the oligonucleotides theraputic society
    • Place of Presentation
      Copenhagen, Denmark
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Development of Cross-linking Agents with Highly Selective Reactivity to a Target Base2011

    • Author(s)
      F. Nagatsugi, S. Hagihara, S. Kusano, C. X. Guang
    • Organizer
      6th Cambridge Symposium on Nucleic Acids Chemistry and Biology
    • Place of Presentation
      Cambridge, United Kingdom
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 架橋反応性ピリミジン誘導体の合成と評価2011

    • Author(s)
      草野修平、萩原伸也、永次史
    • Organizer
      アンチセンス・遺伝子・デリバリーシンポジウム2011
    • Place of Presentation
      大阪大学、大阪府
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Development of Selective Cross-linking Reactions and Evaluation of Antisense Effects2011

    • Author(s)
      F. Nagatsugi
    • Organizer
      Gordon Conference on Nucleic Acids
    • Place of Presentation
      University of New England, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] 架橋性オリゴ核酸による遺伝子発現制御2011

    • Author(s)
      萩原伸也、井本修平、堀常晃、鈔暁光、永次史
    • Organizer
      第6回日本ケミカルバイオロジー年会
    • Place of Presentation
      東京工業大学大岡山キャンパス、東京都
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] グリコシル化を鍵反応とした架橋反応性を有するピリミジン誘導体の合成2011

    • Author(s)
      草野修平、萩原伸也、永次史
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      神奈川大学、神奈川県
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 架橋反応性の制御因子解明を目指したビニルプリン誘導体の合成2011

    • Author(s)
      櫻庭誠也、Chao Xiao Guang、萩原伸也、永次史
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      神奈川大学、神奈川県
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 2本鎖DNAに結合するペプチド導入型分子モーターの合成と評価2011

    • Author(s)
      高橋佑輔、小林麻衣子、永次史
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      神奈川大学、神奈川県
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 核酸医薬を目指したチミン選択的クロスリンク剤の開発2011

    • Author(s)
      永次史、井本修平、萩原伸也、堀常晃、Cho Xio. Guang
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡大学、静岡県
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 細胞内遺伝子発現制御に向けた架橋性核酸の開発2011

    • Author(s)
      萩原伸也、井本修平、堀常晃、X. Chao、永次史
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      神奈川大学、神奈川県
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Design of the novel artificial molecules for the control of gene expression2011

    • Author(s)
      F. Nagatsugi, S. Hagihara, S. Kusano
    • Organizer
      International Symposium on Engineering Neo-Biomimetics II-Soft Nanomaterials and Soft Robotics-
    • Place of Presentation
      AIST Tsukuba Central, Tsukuba, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Evaluation of the Antisense Effects Using the Reactive Oligonucleotides with High Selectivity to the Target Base2011

    • Author(s)
      F.Nagatsugi, T.Hori, S.Kusano, S.Imoto, S.Hagihara, C.H.Guang
    • Organizer
      AFMC International Medicinal Chemistry Symposium "Frontier of Medicinal Science
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of Acyclic Nucleoside Analogs with Selective Cross-linking to Guanine2011

    • Author(s)
      S.Kusano, S.Hagihara, T.Moki, F.Nagatsugi
    • Organizer
      The 38th International Symposium on Nucleic Acids Chemistry
    • Place of Presentation
      Sapporo, Japan
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of the Reactive Oligonucleotides with high selective reactivity to a Target Base2011

    • Author(s)
      F.Nagatsugi
    • Organizer
      France-Japan workshop Micro- & Nano- Archite ctures, Materials & Imaging
    • Place of Presentation
      Bordeaux, France
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of Selective Cross-linking Reactions and Evaluation of Antisense Effects2011

    • Author(s)
      F.Nagatsugi
    • Organizer
      Gordon Conference on Nucleic Acids
    • Place of Presentation
      University of New England USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] グアニンを標的とした架橋反応性ピリミジン誘導体の開発2011

    • Author(s)
      草野修平、萩原伸也、茂木琢真、永次史
    • Organizer
      グローバルCOEプログラム分子系高次構造体化学国際教育研究拠点シンポジウム2011
    • Place of Presentation
      東北大学片平キャンパス・さくらホール、宮城県
    • Related Report
      2011 Annual Research Report
  • [Presentation] 6-amino-2-vinylpurine誘導体は架橋反応の詳細を明らかにする2011

    • Author(s)
      草野修平、永次史
    • Organizer
      第14回生命化学研究会
    • Place of Presentation
      南紀白浜、和歌山県
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of the Effective Cross-linking Reaction to Target Gene2010

    • Author(s)
      F.Nagatsugi, T.Hori, S.Kusano, S.Imoto, S.Hagihara
    • Organizer
      Pacifichem 2010
    • Place of Presentation
      Hawaii, USA
    • Year and Date
      2010-12-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 架橋性核酸を用いた遺伝子発現制御2010

    • Author(s)
      萩原伸也、井本修平、堀常晃、永次史
    • Organizer
      第10回多元物質科学研究所研究発表会
    • Place of Presentation
      東北大学片平キャンパス・さくらホール仙台
    • Year and Date
      2010-12-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] チミン選択的クロスリンク剤の合成と評価2010

    • Author(s)
      櫻庭誠也、萩原伸也、永次史
    • Organizer
      第10回多元物質科学研究所研究発表会
    • Place of Presentation
      東北大学片平キャンパス・さくらホール仙台
    • Year and Date
      2010-12-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of the cross-linking reactions activated in duplex formation2010

    • Author(s)
      F. Nagatsugi
    • Place of Presentation
      Pohan University, Korea
    • Year and Date
      2010-07-13
    • Related Report
      2011 Final Research Report
  • [Presentation] Development of the Cross-linking Reactions Activated in Duplex Formation2010

    • Author(s)
      Fumi Nagatsugi
    • Organizer
      Pohan University seminar
    • Place of Presentation
      Pohan University, Korea(招待講演)
    • Year and Date
      2010-07-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] 次世代型核酸医薬を目指した新規人工核酸の開発2010

    • Author(s)
      永次史
    • Organizer
      有機合成化学協会東北支部仙台地区春の講演会
    • Place of Presentation
      東北大学、宮城県
    • Year and Date
      2010-07-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 次世代型核酸医薬を目指した新規人工核酸の開発2010

    • Author(s)
      永次史
    • Organizer
      有機合成化学協会東北支部仙台地区春の講演会
    • Place of Presentation
      東北大学大学院薬学研究科大講義室(招待講演)
    • Year and Date
      2010-07-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 反応性核酸を導入した2'-OMeオリゴRNAを用いたアンチセンス効果及びmiRNAの阻害2010

    • Author(s)
      永次史、萩原伸也、堀常晃、井本修平
    • Organizer
      第20回アンチセンスシンポジウム
    • Place of Presentation
      甲南大学ポートアイランドキャンパス、兵庫県
    • Related Report
      2011 Final Research Report
  • [Presentation] Development of the effective cross-linking reaction to target gene2010

    • Author(s)
      F. Nagatsugi., T. Hori, S. Kusano, S. Imoto, S. Hagihara
    • Place of Presentation
      Hawaii, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Cross-linking reactions with the 2'-OMe analogue of 2-amino-6-vinylpurine and evaluation of antisense effects2010

    • Author(s)
      S. Imoto, T. Hori, C. X. Guang, S. Hagihara, Y. Taniguchi, S. Sasaki., F. Nagatsugi
    • Organizer
      The 37th International Symposium on Nucleic Acids Chemistry
    • Place of Presentation
      Hamagin Hall"VIA MARE", Yokohama, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Crosslink forming oligonucleotide that enhances translation in cells2010

    • Author(s)
      S. Hagihara, W.-C. Lin, S. Imoto, T. Hori, F. Nagatsugi
    • Organizer
      The 37th International Symposium on Nucleic Acids Chemistry
    • Place of Presentation
      Hamagin Hall"VIA MARE", Yokohama, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] 2本鎖形成により活性化されるクロスリンク反応の開発2010

    • Author(s)
      永次史、井本修平、堀常晃、萩原伸也、谷口陽祐、佐々木茂貴
    • Organizer
      第59回高分子討論会
    • Place of Presentation
      北海道大学高等教育機能開発総合センター、北海道
    • Related Report
      2011 Final Research Report
  • [Presentation] Development of the cross-linking reactions to thymine with high selectivity2010

    • Author(s)
      S. Imoto, T. Hori, K. Hattori, S. Kusano, S. Hagihara, Y. Taniguchi, S. Sasaki, F. Nagatsugi
    • Organizer
      IRT 2010-XIX International Round Table on Nucleosides, Nucleotides and Nucleic Acids
    • Place of Presentation
      Lyon, France
    • Related Report
      2011 Final Research Report
  • [Presentation] Development of the novel artificial molecules for the control of gene expression2010

    • Author(s)
      F. Nagatsugi
    • Organizer
      1^<st> Asian Chemical Biology Conference
    • Place of Presentation
      Seoul National University, Seoul, Korea
    • Related Report
      2011 Final Research Report
  • [Presentation] 新規反応性核酸の開発及びmiRNA阻害に向けた検討2010

    • Author(s)
      永次史、堀常晃、井本修平、草野修平、萩原伸也
    • Organizer
      第10回遺伝子デリバリー研究会シンポジウム
    • Place of Presentation
      北海道大学学術交流会館、北海道
    • Related Report
      2011 Final Research Report
  • [Presentation] チミンとの架橋反応性を有する新規人工核酸の開発2010

    • Author(s)
      井本修平、服部恵一、草野修平、廣濱智哉、萩原伸也、永次史
    • Organizer
      第5回日本ケミカルバイオロジー年会
    • Place of Presentation
      慶應義塾大学日吉キャンパス、神奈川県
    • Related Report
      2011 Final Research Report
  • [Presentation] チミジンを標的とした新規クロスリンク剤の合成と評価2010

    • Author(s)
      草野修平、服部恵一、井本修平、永次史
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      近畿大学本部キャンパス、大阪府
    • Related Report
      2011 Final Research Report
  • [Presentation] Development of the Novel Artificial Molecules for the Control of Gene Expression2010

    • Author(s)
      Fumi Nagatsugi
    • Organizer
      1^<st> Asian Chemical Biology Conference
    • Place of Presentation
      Seoul National University, Seoul, Korea(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] チミンとの架橋反応性を有する新規人工核酸の開発2010

    • Author(s)
      井本修平、服部恵一、草野修平、廣濱智哉、萩原伸也、永次史
    • Organizer
      第5回日本ケミカルバイオロジー年会
    • Place of Presentation
      慶應義塾大学日吉キャンパス協生館
    • Related Report
      2010 Annual Research Report
  • [Presentation] 2本鎖形成により活性化されるクロスリンク反応の開発2010

    • Author(s)
      永次史、井本修平、堀常晃、萩原伸也、谷口陽祐、佐々木茂貴
    • Organizer
      第59回高分子討論会
    • Place of Presentation
      北海道大学高等教育機能開発総合センター
    • Related Report
      2010 Annual Research Report
  • [Presentation] Crosslink forming oligonucleotide that enhances translation in cells (The 37th International Symposium on Nucleic Acids Chemistry2010

    • Author(s)
      S.Hagihara, W.-C.Lin, S.Imoto, T.Hori, F.Nagatsugi
    • Organizer
      The 37th International Symposium on Nucleic Acids Chemistry
    • Place of Presentation
      Hamagin Hall "VIA MARE", Yokohama, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cross-linking Reactions with the 2'-OMe Analogue of 2-Amino-6-Vinylpurine and Evaluation of Antisense Effects2010

    • Author(s)
      S.Imoto, T.Hori, C.X.Guang, S.Hagihara, Y.Taniguchi, S.Sasaki, F.Nagatsug
    • Organizer
      The 37th International Symposium on Nucleic Acids Chemistry
    • Place of Presentation
      Hamagin Hall "VIA MARE", Yokohama, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規反応性核酸の開発及びmiRNA阻害に向けた検討2010

    • Author(s)
      永次史、堀常晃、井本修平、草野修平、萩原伸也
    • Organizer
      第10回遺伝子デリバリー研究会シンポジウム
    • Place of Presentation
      北海道大学学術交流会館
    • Related Report
      2010 Annual Research Report
  • [Presentation] 反応性核酸を導入した2'-OMeオリゴRNAを用いたアンチセンス効果及びmiRNAの阻害2010

    • Author(s)
      永次史、萩原伸也、堀常晃、井本修平
    • Organizer
      第20回アンチセンスシンポジウム
    • Place of Presentation
      甲南大学ポートアイランドキャンパス
    • Related Report
      2010 Annual Research Report
  • [Presentation] DNA結合型分子モーターの回転挙動2010

    • Author(s)
      櫻庭誠也・永谷直人・桑原俊介・原田宣之・永次史
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      近畿大学本部キャンパス(大阪)
    • Related Report
      2009 Annual Research Report
  • [Presentation] チミジンを標的とした新規クロスリンク剤の合成と評価2010

    • Author(s)
      草野修平・服部恵一・井本修平・永次史
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      近畿大学本部キャンパス(大阪)
    • Related Report
      2009 Annual Research Report
  • [Presentation] チミジン選択的クロスリンク剤の開発2010

    • Author(s)
      永次史、服部恵一、廣濱智哉、草野修平、井本修平
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山大学津島キャンパス他(岡山)
    • Related Report
      2009 Annual Research Report
  • [Presentation] チミジン選択的クロスリンク剤の開発2009

    • Author(s)
      草野修平、服部恵一、井本修平、永次史
    • Organizer
      第9回 多元物質科学研究所 研究発表会
    • Place of Presentation
      東北大学片平キャンパス・さくらホール(仙台)
    • Year and Date
      2009-12-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 2'修飾型反応性核酸の合成2009

    • Author(s)
      堀常晃、井本修平、萩原伸也、永次史
    • Organizer
      第9回 多元物質科学研究所 研究発表会
    • Place of Presentation
      東北大学片平キャンパス・さくらホール(仙台)
    • Year and Date
      2009-12-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 細胞内遺伝子発現制御に向けた新規人工分子の創製2009

    • Author(s)
      永次史
    • Organizer
      第31回東北薬学セミナー
    • Place of Presentation
      江陽グランドホテル、宮城県
    • Year and Date
      2009-12-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 細胞内遺伝子発現制御に向けた新規人工分子の創製2009

    • Author(s)
      永次史
    • Organizer
      第31回東北薬学セミナー
    • Place of Presentation
      江陽グランドホテル(仙台)
    • Year and Date
      2009-12-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Development of the Novel Artificial Molecules for the Control of Gene Expression2009

    • Author(s)
      F.Nagatsugi
    • Organizer
      The 11th International Kyoto Conference on New Aspects of Organic Chemistry
    • Place of Presentation
      リーガロイヤルホテル(京都)
    • Year and Date
      2009-11-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] Development of the novel cross-linking reaction to thymine with high selectivity2009

    • Author(s)
      F. Nagatsugi, T. Hirohama, S. Kusano, Hattori, S. Imoto
    • Organizer
      The 4th International Conference on Cutting-Edge Organic Chemistry in Asia
    • Place of Presentation
      Convention Center, Chulabhorn Research Institute, Bangkok, Thailand
    • Related Report
      2011 Final Research Report
  • [Presentation] Development of the novel artificial molecules for the control of gene expression2009

    • Author(s)
      F. Nagatsugi
    • Organizer
      ICOK 9
    • Place of Presentation
      Rihga Royal Hotel, Kyoto, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Development of the novel cross-linking agent with high selectivity to thymine2009

    • Author(s)
      F. Nagatsugi, K. Hattori, T. Hirohama, S. Kusano, S. Imoto
    • Organizer
      Joint Symposium of the 5^<th> Annual Meeting of the Oligonucleotide Therapeutics Society and the 19^<th> Antisense Symposium
    • Place of Presentation
      Centennial Hall, Kyushu University Hospital Campus Fukuoka, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Design and synthesis of the novel cross-linking agent2009

    • Author(s)
      S. Kusano, K. Hattori, S. Imoto, F. Nagatsugi
    • Organizer
      35th International Symposium on Nucleic Acids Chemistry
    • Place of Presentation
      Takayama, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Development of the novel cross-linking reagents to react to the target genes with high selectivity2009

    • Author(s)
      F. Nagatsugi, T. Hirohama, S. Kusano, K. Hattori, S. Imoto
    • Organizer
      2^<nd> Switzerland-Japan Biomolecular Chemistry Symposium
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] 2本鎖DNA上におけるクリックケミストリーを応用したDNA結合分子探索手法の開発2009

    • Author(s)
      永次史、廣濱智哉、井本修平
    • Organizer
      日本ケミカルバイオロジー学会第4回年会
    • Place of Presentation
      神戸市産業進行センター、兵庫県
    • Related Report
      2011 Final Research Report
  • [Presentation] 2本鎖DNA上におけるクリックケミストリーを応用したDNA結合分子探索手法の開発2009

    • Author(s)
      永次史、廣濱智哉、井本修平
    • Organizer
      日本ケミカルバイオロジー学会 第4回年会
    • Place of Presentation
      神戸市産業進行センター神戸
    • Related Report
      2009 Annual Research Report
  • [Presentation] Development of the Novel Cross-linking Reagents to React to the Target Genes with High Selectivity2009

    • Author(s)
      F.Nagatsugi, T.Hirohama, S.Kusano, K.Hattori, S.Imoto
    • Organizer
      2^<nd> Switzerland-Japan Biomolecular Chemistry Symposium
    • Place of Presentation
      東京大学駒場リサーチキャンパス・コンベンションホール(東京)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Design and Synthesis of the Novel cross-linking Agent, (35th Intemational Symposium on Nucleic Acids Chemistry2009

    • Author(s)
      S.Kusano, K.Hattori, S.Imoto, F.Nagatsugi
    • Organizer
      35th International Symposium on Nucleic Acids Chemistry
    • Place of Presentation
      高山市民文化会館(高山)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Evaluation of the antisense effect of PEGylated oligodeoxynucleotides containing intelligent nucleoside analogues2009

    • Author(s)
      Y.Taniguchi, Y.Kurose, T.Nishioka, F.Nagatsugi, Sasaki, S.
    • Organizer
      35th International Symposium on Nucleic Acids Chemistry
    • Place of Presentation
      高山市民文化会館(高山)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Development of the Novel Cross-linking Agent with High Selectivity to Thymine2009

    • Author(s)
      F.Nagatsugi, K.Hattori, T.Hirohama, S.Kusano, S.Imoto
    • Organizer
      Joint Symposium of the 5^<th> Annual Meeting of the Oligonucleotide Therapeutics Society and the 19^<th> Antisense Symposium
    • Place of Presentation
      Kyushu University Hospital Campus(福岡)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Development of the Novel Cross-linking Reaction to Thymine with High Selectivity2009

    • Author(s)
      F.Nagatsugi, T.Hirohama, S.Kusano, K.Hattori, S.Imoto
    • Organizer
      The 4th International Conference on Cutting-Edge Organic Chemistry in Asia, Convention Center, 2009/11/29-12/3)
    • Place of Presentation
      Chulabhorn Research Institue、Bangkok, Thailand
    • Related Report
      2009 Annual Research Report
  • [Presentation] DNAの構造制御を目指した分子モーターの創製2009

    • Author(s)
      永次史、小林麻衣子、櫻庭誠也、桑原俊介
    • Organizer
      第24回生体機能関連化学シンポジウム
    • Place of Presentation
      九州大学医学部百年講堂(福岡)
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.tagen.tohoku.ac.jp/labo/nagatsugi/index.html

    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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