| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2009: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Research Abstract |
In recent years, a great deal of attention has been focused on siRNA and microRNA as drugs for selective inhibition of gene expression. Toward the practical use of these RNA molecules as therapeutic agents, stabilization of those in vivo is required. In this study, a new method for the stereocontrolled synthesis of phosphorous-modified RNA analogs, which are stable in vivo and expected to be highly effective as drugs, has been developed.
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