| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2009: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
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| Research Abstract |
An artificial nucleic acid bearing a switching function controlling structural properties, a useful nucleic acid unit for conjugation chemistry, and a couple of bridged nucleic acid guanine analogs were synthesized. Non-natural oligonucleotides that can form cytosine quadruplex structure at physiological conditions were synthesized as well. Moreover, invasive technique for evaluating gene expression change was established, and it was shown that artificial oligonucleotide could induce a change in gene expression pattern. These results indicate that our developing artificial nucleic acids are effective to gene expression regulation.
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