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Development of Coherent Raman Spectroscopy for Biological Molecules in Terahertz Frequency Region

Research Project

Project/Area Number 21360031
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied optics/Quantum optical engineering
Research InstitutionUniversity of Fukui

Principal Investigator

TANI Masahiko  福井大学, 遠赤外領域開発研究センター, 教授 (00346181)

Co-Investigator(Kenkyū-buntansha) YAMAGUCHI Mariko  奈良先端科学技術大学院大学, 物質創成科学研究科, 助教 (50521738)
YAMAMOTO Kohji  福井大学, 遠赤外領域開発研究センター, 准教授 (70432507)
Co-Investigator(Renkei-kenkyūsha) HANGYO Masanori  大阪大学, レーザーエネルギー学研究センター, 教授 (10144429)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2010: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Keywords光計測 / テラヘルツ分光 / テラヘルツ / コヒーレントラマン / 生体分子 / 顕微イメージング
Research Abstract

Anharmonic and large-amplitude vibrational modes in biological macro-molecules are thought to be important for their functions and interaction with other molecules, governing the thermo-dynamical the properties. To observe such molecular vibrations in terahertz(THz) frequency region, a novel coherent Raman technique(THz Time-Domain Coherent Raman Spectroscopy), which utilizes THz optical beats created by two frequency-chirped femtosecond pulses and detects the coherent Raman signal in time-domain, has been developed and applied to some non-organic samples for demonstration.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (47 results)

All 2012 2011 2010 2009 Other

All Journal Article (13 results) (of which Peer Reviewed: 8 results) Presentation (31 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Photoconductive emission and detection of terahertz pulsed radiation using semiconductors and semiconductor devices2012

    • Author(s)
      Masahiko Tani, Kohji Yamamoto, Elmer S.Estacio, Christopher T.Que, Hidekazu Nakajima, Masakazu Hibi, Fumiaki Miyamaru, Seizi Nishizawa, Masanori Hangyo
    • Journal Title

      International Journal of Infrared and Millimeter Waves

      Volume: 33 Pages: 393-404

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low-frequency Coherent Raman Spectroscopy Using Spectral-focusing of Chirped Laser Pulses2012

    • Author(s)
      Masahiko Tani, Masakazu Hibi, Kohji Yamamoto, Mariko Yamaguchi, Elmer S.Estacio, Christopher T.Que, Masanori Hangyo
    • Journal Title

      Vibrational Spectroscopy

      Volume: Chapter 7 Pages: 153-168

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electron density measurement of inductively coupled plasmas by terahrtz time-domain spectroscopy (THZ-TDS)2012

    • Author(s)
      Ayumi Ando, Tomoko Kurose, Vivien Reymond, Katsuhisa Kitano, Hideaki Kitahara, Keisuke Takano, Masahiko Tani, Masanori Hangyo, Satoshi Hamaguchi
    • Journal Title

      Journal of Applied Physics

      Volume: 110 Pages: 73303-73303

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Terahertz emission from Indium Oxide films grown on MgO substrates using sub-bandgap photon energy excitation2012

    • Author(s)
      Elmer S.Estacio, Christopher T.Que, Fritz C.B.Awitan, Jan Issac Bugante, Francesca Isabel de Vera, Jonathan Azares, Jessica Afalla, Jeffrey de Vero, Armando S.Somintac, Roland V.Sarmago, Arnel A.Salvador, Kohji Yamamoto, Masahiko Tani
    • Journal Title

      Optics Express

      Volume: 20 Pages: 4518-4524

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] フェムト秒レーザーを励起光源に用いたテラヘルツ帯コヒーレント・ラマン分光手法の開発2011

    • Author(s)
      谷正彦・山本晃司・日比雅和・山口真理子
    • Journal Title

      光学

      Volume: 第40巻第8号

    • NAID

      10029467774

    • Related Report
      2011 Final Research Report
  • [Journal Article] チャープ光パルスを利用したテラヘルツ帯のコヒーレントラマン分光2011

    • Author(s)
      谷正彦
    • Journal Title

      「分光研究」トピックス

      Volume: Vol.60, No.5 Pages: 191-192

    • NAID

      10029483424

    • Related Report
      2011 Final Research Report
  • [Journal Article] Efficient electro-optic sampling detection of terahertz radiation via Cherenkov phase Matching2011

    • Author(s)
      Masahiko Tani, Kazuki Horita, Tetsuya Kinoshita, Christopher T.Que, Elmer Estacio, Kohji Yamamoto, Michael I.Bakuno V
    • Journal Title

      Opt.Express

      Volume: 19 Pages: 19901-19906

    • NAID

      110009552864

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Terahertz Emission Enhancement in InAs Thin Films Using a Silicon Lens Coupler2011

    • Author(s)
      Christopher T. Que, Tadataka Edamura, Makoto Nakajima, Masahiko Tani, Masanori Hangyo
    • Journal Title

      Jpn.J.Appl.Phys

      Volume: 50

    • NAID

      40018960969

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 電気光学結晶を用いたテラヘルツパルス波検出技術2011

    • Author(s)
      谷正彦, 山本晃司
    • Journal Title

      月刊オプトロニクス

      Volume: 2011年8号 Pages: 93-96

    • Related Report
      2011 Annual Research Report
  • [Journal Article] フェムト秒レーザーを励起光源に用いたテラヘルツ帯コヒーレント・ラマン分光手法の開発2011

    • Author(s)
      谷正彦, 山本晃司, 日比雅和, 山口真理子
    • Journal Title

      光学

      Volume: 第40巻 Pages: 402-408

    • NAID

      10029467774

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] チャープ光パルスを利用したテラヘルツ帯のコヒーレントラマン分光2011

    • Author(s)
      谷正彦
    • Journal Title

      分光研究,トピックス

      Volume: 第60巻 Pages: 191-192

    • NAID

      10029483424

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Time-Domain Coherent Anti-Stokes Raman Scattering Signal Detection for Terahertz Vibrational Spectroscopy Using Chirped Femtosecond Pulses2010

    • Author(s)
      Masahiko Tani, Toshiyuki Koizumi, Hisashi Sumikura, Mariko Yamaguchi, Kohji Yamamoto, and Masanori Hangyo
    • Journal Title

      Applied Physics Express

      Volume: Vol.3, No.7 Issue: 7 Pages: 72401-72401

    • DOI

      10.1143/apex.3.072401

    • NAID

      10026495288

    • Related Report
      2011 Final Research Report
  • [Journal Article] Time-Domain Coherent Anti-Stokes Raman Scattering Signal Detection for Terahertz Vibrational Spectroscopy Using Chirped Femtosecond Pulses2010

    • Author(s)
      Masahiko Tani, Toshiyuki Koizumi, Hisashi Sumikura, Mariko Yamaguchi, Kohji Yamamoto, Masanori Hangyo
    • Journal Title

      Applied physics Express

      Volume: Vol.3

    • NAID

      10026495288

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Development of devices and techniques for high-performance THz time-domain spectroscopy for material analyses2012

    • Author(s)
      Masahiko Tani, Kohji Yamamoto, Elmer S.Estacio, Christopher T.Que, Kazutoshi Fukui, Kazuyoshi Kurihara, Fumiyosi Kuwashima
    • Organizer
      The 4th International Workshop on Far-Infrared Technologies 2012 (IW-FIRT 2012)
    • Place of Presentation
      University of Fukui, Fukui, Japan(Invited)
    • Year and Date
      2012-03-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] THz TDS of weak intermolecular hydrogen bonds ; Observations of C-H…O=C in self-associated complexes of propionaldehyde2012

    • Author(s)
      K.Mizuno, T.Kikuchi, K.Murakami, H.Nagaoka, K Fukui, K.Yamamoto, M.Tani
    • Organizer
      The 4th International Workshop on Far-Infrared Technologies 2012 (IW-FIRT 2012)
    • Place of Presentation
      University of Fukui, Fukui, Japan(Poster)
    • Year and Date
      2012-03-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] テラヘルツ電磁波の特徴,分光・計測応用,および最近の話題2012

    • Author(s)
      谷正彦
    • Organizer
      第22回光・ナノサイエンスフォーマルセミナー
    • Place of Presentation
      京都大学宇治キャンパス,宇治市(招待講演)
    • Year and Date
      2012-03-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] Elements of terahertz time-domain spectroscopy (THz-TDS) and applications of THz-TDS to material research2012

    • Author(s)
      Masahiko Tani
    • Organizer
      Symposium on Materials for Ultrafast and Terahertz Spectroscopy
    • Place of Presentation
      University of Philippines, Philippines(Invited)
    • Year and Date
      2012-02-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] テラヘルツ帯振動分光で探る有機・生体分子のダイナミクス2012

    • Author(s)
      谷正彦
    • Organizer
      ナノ・バイオICTシンポジウム~バイオに学ぶ未来ICT型センシングテクノロジー~
    • Place of Presentation
      東京ビッグサイト
    • Year and Date
      2012-02-15
    • Related Report
      2011 Final Research Report
  • [Presentation] テラヘルツ帯振動分光で探る有機・生体分子のダイナミクス2012

    • Author(s)
      谷正彦
    • Organizer
      NICT未来ICT研究所主催 ナノ・バイオICTシンポジウム~バイオに学ぶ未来ICT型センシングテクノロジー~
    • Place of Presentation
      東京ビッグサイト,東京(招待講演)
    • Year and Date
      2012-02-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of Emitters and Detectors for THz Time-Domain Spectroscopy System with a 1.55μm fs Fiber Laser2011

    • Author(s)
      M.Tani, H.Nakajima, K.Horita, T.Kinoshita, T.Nagase, M.Hibi, K.Saito, C.T.Que, E.Estacio, K.Yamamoto, F.Miyamaru, S.Nishizawa
    • Organizer
      International Photonics Conference 2011 (IPC2011)
    • Place of Presentation
      Tainan, Taiwan(Invited)
    • Year and Date
      2011-12-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] テラヘルツ時間領域コヒーレントラマン分光2011

    • Author(s)
      斉藤勝哉, 日比雅和, 山本晃司, 谷正彦
    • Organizer
      2011年度日本物理学会北陸支部定例学術講演会,講演番号D-a4
    • Place of Presentation
      福井大学文京キャンパス,福井市
    • Year and Date
      2011-11-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] プロピオンアルデヒド会合体中に形成される水素結合CH…Oのテラヘルツ時間領域分光法による検出2011

    • Author(s)
      水野和子, 菊地巧也, 村上公祐介, 永岡一, 山本晃司, 福井一俊, 谷正彦
    • Organizer
      溶液化学研究会第34回溶液化学シンポジウム,講演番号O20
    • Place of Presentation
      名古屋大学ES総合館ESホール,名古屋市
    • Year and Date
      2011-11-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Efficient THz emitters and detectors for 1.55-μm fs laser excitation2011

    • Author(s)
      M.Tani, H.Nakajima, K.Horita, T.Kinoshita, T.Nagase, M.Hibi, K.Saito, C.T.Que, E.Estacio, K.Yamamoto, F.Miyamaru, S.Nishizawa
    • Organizer
      The International Photonics and OptoElectronics Meetings (POEM) 2011
    • Place of Presentation
      Wuhan, China(Invited)
    • Year and Date
      2011-11-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] テラヘルツ分光技術概論2011

    • Author(s)
      谷正彦
    • Organizer
      日本分光学会第47回夏期セミナー「テラヘルツ時間領域分光入門」
    • Place of Presentation
      幕張メッセ国際会議場,千葉市(招待講演)
    • Year and Date
      2011-09-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] テラヘルツフォトニクスの最前線基礎講座2011

    • Author(s)
      谷正彦
    • Organizer
      電気学会北陸支部フロンティアセミナー
    • Place of Presentation
      福井工業大学福井キャンパス,福井市(招待講演)
    • Year and Date
      2011-08-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] テラヘルツ波応用の基礎と将来展望2011

    • Author(s)
      谷正彦
    • Organizer
      富士フィルム解析講演会
    • Place of Presentation
      富士フィルム株式会社R&D統括本部解析技術センター,足柄市(招待講演)
    • Year and Date
      2011-08-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] テラヘルツ波分光2011

    • Author(s)
      谷正彦
    • Organizer
      応用物理学会テラヘルツ電磁波技術研究会若手研究者サマースクール
    • Place of Presentation
      湯郷温泉湯郷グランドホテル,美作市(招待講演)
    • Year and Date
      2011-08-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of High-Performance Terahertz Time-domain Spectrometer and its applications2011

    • Author(s)
      Masahiko Tani, Kohji Yamamoto, Christopher T.Que, Elmer S.Estacio, Takashi Furuya, Fumiaki Miyamaru, Seizi Nishizawa, Masaya Kawase
    • Organizer
      12th International Balkan Workshop on Applied Physics
    • Place of Presentation
      Constanta, Romania(Invited)
    • Year and Date
      2011-07-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] テラヘルツテクノロジーの現状と展望2011

    • Author(s)
      谷正彦
    • Organizer
      近畿総合通信局産学官連携セミナー、テラヘルツテクノロジーフォーラム共催研究会「テラヘルツテクノロジーと超ブロードバンド情報通信の展望」
    • Place of Presentation
      大阪大学豊中キャンパスΣ(シグマ)ホール,豊中市(招待講演)
    • Year and Date
      2011-06-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] THz Time-Domain Spectroscopy and Its Applications in Material Analysis2011

    • Author(s)
      Masahiko Tani, Kohji Yamamoto, Masaya Kawase, Mariko Yamaguchi, Seizi Nishizawa, Masanori Hangyo
    • Organizer
      International Congress on Analytical Science 2011 (ICAS2011)
    • Place of Presentation
      Kyoto, Japan(Invited)
    • Year and Date
      2011-05-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] テラヘルツ帯時間領域コヒーレントラマン分光装置の広帯域化と安定化2011

    • Author(s)
      日比雅和, 山本晃司, 谷正彦
    • Organizer
      2011年春季第58回応用物理学関係連合講演会
    • Place of Presentation
      神奈川工科大学
    • Year and Date
      2011-03-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Recognition of Sound-alike Medicine and Dynamics Study of Saturated Hydrocarbon by Terahertz-Time-Domain Spectroscopy (Invited)2011

    • Author(s)
      Kohji Yamamoto, Keita Takagi, Ryouhei Yasuda, Hirokatsu Itoh, Itaru Torii, Kazutoshi Fukui, Masahiko Tani, Seizi Nishizawa, Masava Kawase
    • Organizer
      The 2nd THz-Bio International Workshop
    • Place of Presentation
      Center for THz-Bio Applic ation Systems, Seoul National University, Korea
    • Year and Date
      2011-01-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Coherent Raman spectroscopy in THz region by using high-repetition rate femtosecond laser2010

    • Author(s)
      Masakazu Hibi, Christopher T.Que, Takashi Furuya, Kohji Yamamoto, Masahiko Tani
    • Organizer
      International Symposium on Frontier of Terahertz Spectroscopy IV : Innovations in THz Spectroscopy and THz-Wave Wireless Communications
    • Place of Presentation
      Matsumoto Campus, Shinshu University, Matsumoto, Japan
    • Year and Date
      2010-10-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Time-domain coherent Raman spectroscopy in THz frequency region2010

    • Author(s)
      M.Hibi, T.Furuya, Ch.T.Que, M.Tani
    • Organizer
      The 35th International Conference on Infrared, Millimeter and THz Waves (IRMMW-THz 2010)
    • Place of Presentation
      Angelicum, Rome.Italy
    • Year and Date
      2010-10-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Terahertz Spectroscopy of Ascorbic Acid Oxidase in Aqueous Solutions2010

    • Author(s)
      Ch.T.Que, A.Ramundo-Orlando, K.Yamamoto, M.Tani
    • Organizer
      The 35th International Conference on Infrared, Millimeter and THz Waves (IRMMW-THz 2010)
    • Place of Presentation
      Angelicum, Rome.Italy
    • Year and Date
      2010-10-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] テラヘルツ時間領域分光法による水溶液中アスコルビン酸化酵素測定2010

    • Author(s)
      Christopher Que, Alfonsina Ramundo-Orlando, 山本晃司, 谷正彦
    • Organizer
      第71回応用物理学会学術講演会
    • Place of Presentation
      長崎大学文教キャンパス
    • Year and Date
      2010-09-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] テラヘルツ時間領域分光とテラヘルツ帯時間領域コヒーレントラマン分光待講演)2010

    • Author(s)
      谷正彦
    • Organizer
      「テラヘルツ分光計測とイメージング」研究討論会(耳成22年度第一回テラヘルツ電磁波技術研究会,平成22年度第1回テラヘルツ応用システム研究会共催研究討論会)
    • Place of Presentation
      三国観光ホテル,福井県坂井市
    • Year and Date
      2010-08-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] テラヘルツ時間領域分光法による炭化水素のテラヘルツ領域のスペクトル研究2010

    • Author(s)
      山本晃司, 伊藤浩克, 鳥居航, 福井一俊, 谷正彦, 山口真理子, 萩行正憲
    • Organizer
      「テラヘルツ分光計測とイメージング」研究討論会(耳成22年度第一回テラヘルツ電磁波技術研究会,平成22年度第1回テラヘルツ応用システム研究会共催研究討論会)
    • Place of Presentation
      三国観光ホテル,福井県坂井古市
    • Year and Date
      2010-08-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] Terahertz time-domain spectroscopy of ascorbic acid oxidase in aqueous solutions2010

    • Author(s)
      Christopher Que, Alfonsina Ramundo-Orlando, Kohji Yamamoto, Masahiko Tani
    • Organizer
      「テラヘルツ分光計測とイメージング」研究討論会(耳成22年度第一回テラヘルツ電磁波技術研究会,平成22年度第1回テラヘルツ応用システム研究会共催研究討論会)
    • Place of Presentation
      三国観光ホテル,福井県坂井古市
    • Year and Date
      2010-08-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] Coherent Raman spectroscopy in THz region by using chirped femtosecond laser pulses2010

    • Author(s)
      Masakazu Hibi, Takashi Furuya, Christopher T.Que, Masahiko Tani
    • Organizer
      The 3rd International Workshop on Far-Infrared Technologies 2010 (IW-FIRT2010)
    • Place of Presentation
      Univ. of Fukui
    • Year and Date
      2010-03-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Attempts for observation of low-frequency modes in biological macro-molecules by using terahertz vibrational spectroscopy2010

    • Author(s)
      谷正彦
    • Organizer
      THz-Bio Workshop in Korea
    • Place of Presentation
      Seoul National University
    • Year and Date
      2010-03-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] フェムト秒レーザーによるテラヘルツ帯コヒーレントラマン散乱分光法2010

    • Author(s)
      谷正彦, 山本晃司, 古屋岳, ケクリストファー, 山口真理子, 萩行正憲
    • Organizer
      レーザー学会学術講演会第30回年次大会
    • Place of Presentation
      千里ライフサイエンスセンター
    • Year and Date
      2010-02-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Attempts for observation of low-frequency modes in biological macro-molecules by using terahertz vibrational spectroscopy2010

    • Author(s)
      Masahiko Tani
    • Organizer
      THz-Bio Workshop
    • Place of Presentation
      Seoul National University
    • Related Report
      2011 Final Research Report
  • [Presentation] テラヘルツ電磁波による分光と計測応用2009

    • Author(s)
      谷正彦
    • Organizer
      2009年度第2回TMS研究会講演会
    • Place of Presentation
      福井大学文京キャンパス
    • Year and Date
      2009-07-31
    • Related Report
      2009 Annual Research Report
  • [Book] Low-frequency Coherent Raman Spectroscopy Using Spectral-focusing of Chirped Laser Pulses2012

    • Author(s)
      Masahiko Tani, Masakazu Hibi, Kohji Yamamoto, Mariko Yamaguchi, Elmer S. Estacio, Christopher T. Que, and Masanori Hangyo
    • Publisher
      InTech
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://fir.u-fukui.ac.jp/thzlab/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://fir.u-fukui.ac.jp/thzlab/seika2011FY.html

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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