Measuring force using a magnetic sensor: A novel measurement method for measuring finger tap force and its application to a diagnosis support system for Parkinson's disease

• Project/Area Number: 21360118
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Intelligent mechanics/Mechanical systems
• Research Institution: Hiroshima University
• Principal Investigator: TSUJI Toshio 広島大学, 工学(系)研究科(研究院), 教授 (90179995)
• Co-Investigator(Kenkyū-buntansha): TANAKA Yoshiyuki 長崎大学, 大学院・工学研究科, 准教授 (40336920) ; YOSHIZUMI Masao 広島大学, 大学院・医歯薬保険学研究院, 教授 (20282626)
• Co-Investigator(Renkei-kenkyūsha): SAKODA Saburo 国立病院機構刀根山病院, 院長 (00178625)
• Project Period (FY): 2009-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000); Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2009: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
• Keywords: 指タップ運動 / 血管内皮機能 / 箔状圧電センサ / パーキンソン病 / 指タップ力 / 因子分析 / 自律神経活動評価 / 指タップインピーダンス / 指タップ力計測 / 磁気センサ / 非線形弾性モデル / 自律神経活動 / 指尖容積脈波 / 血圧

Research Abstract

The purpose of this study is to produce a quantitative evaluation for the severity of Parkinson's disease. To this end, we propose a novel simultaneous evaluation method for finger motion properties, muscle forces and autonomic nervous activity during finger tapping movements. As a consequence of this study, we have successfully developed (i) an estimation method of finger motion and forces between two fingers using a magnetic sensor based on fingerpad stiffness characteristics, (ii) an evaluation index of autonomic nervous activity from arterial viscoelastic properties (called a log-linearized arterial viscoelastic index) during finger tapping movements, and (iii) a novel system for evaluating motor function and supporting rehabilitation training of finger tapping movements. The results suggest that the proposed method can evaluate motor function based on muscle forces and nerve activity, and is expected to be applied to other types of movements.

Research Products

• [Journal Article] A novel noninvasive and simple method for assessment of endothelial function: Enclosed zone flow-mediated vasodilation (ezFMD) using an oscillation amplitude measurement (2013)
  • Author(s): Naomi Idei, Teiji Ukawa, Masato Kajikawa, Yumiko Iwamoto, Noritaka Fujimura, Tatsuya Maruhashi, Shinsuke Mikami, Takeshi Matsumoto, Yasuki Kihara, Kazuaki Chayama, Kensuke Noma, Ayumu Nakashima, Tsuneo Takayanagi, Haruka Morimoto, Toshio Tsuji, and Yukihito Higashi
  • Journal Title: Atherosclerosis Volume: 229(2) Issue: 2 Pages: 324-330
  • DOI: 10.1016/j.atherosclerosis.2013.05.016
  • Peer Reviewed
• [Journal Article] 因子分析によるパーキンソン病患者の指タップ運動機能評価と分類 (2013)
  • Author(s): 島 圭介，山口 裕希，芝軒 太郎，辻 敏夫，神鳥 明彦，佐野 佑子，佐古田 三郎
  • Journal Title: 計測自動制御学会論文集 Volume: 49(11) Pages: 1029-1036
  • NAID: 130004549705
  • Peer Reviewed
• [Journal Article] A Log-linearized Arterial Viscoelastic Index and Its Application to Carotid Ultrasonography (2012)
  • Author(s): 堀内 徹也, Abdugheni KUTLUK, 平野 陽豊, 栗田 雄一, 辻 敏夫, 鵜川 貞二, 中村 隆治, 佐伯 昇, 東 幸仁, 河本 昌志, 吉栖 正生
  • Journal Title: Transactions of the Society of Instrument and Control Engineers Volume: 48 Issue: 9 Pages: 563-570
  • DOI: 10.9746/sicetr.48.563
  • NAID: 130004549664
  • ISSN: 0453-4654, 1883-8189
  • Peer Reviewed
• [Journal Article] 対数線形化血管粘弾性インデックスの提案と頸動脈超音波検査への応用 (2012)
  • Author(s): 堀内 徹也
  • Journal Title: 計測自動制御学会論文集 Volume: 48 Pages: 563-570
  • Peer Reviewed
• [Journal Article] 対数線形化末梢血管粘弾性インデックスの提案と交感神経遮断術への応用 (2012)
  • Author(s): 平野 博大
  • Journal Title: 計測自動制御学会論文集 Volume: 48 Pages: 731-739
  • Peer Reviewed
• [Journal Article] A Novel Estimation Method of Human Finger Tapping Forces Based on a (2011)
  • Author(s): 島 圭介, 田村 康裕, 辻 敏夫, 神鳥 明彦, 横江 勝, 佐古田 三郎
  • Journal Title: Journal of the Society of Biomechanisms Volume: 35 Issue: 1 Pages: 37-44
  • DOI: 10.3951/sobim.35.37
  • NAID: 10027414940
  • ISSN: 0285-0885
  • Peer Reviewed
• [Journal Article] 箔状圧電センサを利用した血管粘弾性インデックスの非観血モニタリング (2011)
  • Author(s): 丸山大海, 平野陽豊, アブドゲニ・クトゥルク, 辻敏夫, 福田修, 上野直広, 鵜川貞二, 中村隆治, 佐伯昇, 河本昌志, 吉栖正生
  • Journal Title: 電気学会論文誌C部門 Volume: 31 Pages: 1518-1527
  • NAID: 10030527320
  • Peer Reviewed
• [Journal Article] 磁気センサ型指タッピング装置の再現性評価 (2011)
  • Author(s): 佐野佑子, 神鳥明彦, 島圭介, 田村康裕, 高木寛, 辻敏夫, 野田正文, 東川史子, 横江勝, 佐古田三郎
  • Journal Title: 計測自動制御学会論文集 Volume: Vol.47, No.6 Pages: 272-281
  • NAID: 10029250876
  • Peer Reviewed
• [Journal Article] Noninvasive Estimation of Arterial Viscoelastic Indices Using a Foil-type Flexible Pressure Sensor and a Photoplethysmogram (2011)
  • Author(s): Harutoyo Hirano, Hiromi Maruyama, Abdugheni Kutluk, Toshio Tsuji, Osamu Fukuda, Naohiro Ueno, Teiji Ukawa, Ryuji Nakamura, Noboru Saeki, Masashi Kawamoto, Masao Yoshizumi
  • Journal Title: International Journal on Electrical Engineering and Informatics Volume: Vol.3, No.4 Pages: 498-515
  • Peer Reviewed
• [Journal Article] 指腹剛性モデルに基づく指タップ力推定島圭介 田村康裕,辻敏夫,神鳥明彦,横江勝,佐古田三郎 (2011)
  • Author(s): 河野曜暢, アブドゲニ・クトゥルク, 辻敏夫, 鵜川貞二, 中村隆治, 佐伯昇, 吉栖正生, 河本昌志
  • Journal Title: バイオメカニズム学会誌 Volume: Vol.35 Pages: 37-44
  • Peer Reviewed
• [Journal Article] A novel online method to monitor autonomic nervous activity based on arterial wall impedance and heart rate variability (2010)
  • Author(s): Abdugheni Kutluk, Toshio Tsuji, Teiji Ukawa, Ryuji Nakamura, Noboru Saeki, Masao Yoshizumi, Masashi Kawamoto
  • Journal Title: Medical and Biological Engineering and Computing Volume: Vol.48 Pages: 351-359
  • Peer Reviewed
• [Journal Article] Estimation method of finger tapping dynamics using simple magnetic detection system (2010)
  • Author(s): Akihiko Kandori, Yuko Sano, Tsuyoshi Miyashita, Yoshihisa Okada, Masataka Irokawa, Keisuke Shima, Toshio Tsuji, Masaru Yokoe, Saburo Sakoda
  • Journal Title: Review of Scientific Instrument Volume: Vol.81 Pages: 1-6
  • Peer Reviewed
• [Journal Article] 血管粘弾性インデックスの変化を指標とした機械的侵害刺激に対する疼痛の定量的評価 (2010)
  • Author(s): 河野曜暢, アブドゲニ・クトゥルク, 辻敏夫, 鵜川貞二, 中村隆治, 佐伯昇, 吉栖正生, 河本昌志
  • Journal Title: 医療機器学 Volume: Vol.80 Pages: 196-204
  • NAID: 10030687087
  • Peer Reviewed
• [Journal Article] A novel online method to monitor autonomic nervous activity based on arterial wall impedance and heart rate variability (2010)
  • Author(s): Abdugheni Kutluk
  • Journal Title: Medical and Biological Engineering and Computing 48・4 Pages: 351-359
  • Peer Reviewed
• [Journal Article] Measurement and Evaluation of Finger Tapping Movements Using Log-linearized Gaussian Mixture Networks (2009)
  • Author(s): Keisuke Shima
  • Journal Title: Sensors 9・3 Pages: 2187-2201
  • Peer Reviewed
• [Presentation] A Log-Linearized Arterial Viscoelastic Model for Evaluation of the Carotid Artery (2013)
  • Author(s): Harutoyo Hirano, Tetsuya Horiuchi, Abdugheni Kutluk, Yuichi Kurita, Teiji Ukawa, Ryuji Nakamura, Noboru Saeki, Yukihito Higashi, Masashi Kawamoto, Masao Yoshizumi, and Toshio Tsuji
  • Organizer: 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC'13)
  • Place of Presentation: Osaka
• [Presentation] Monitoring of Peripheral Vascular Condition Using a Log-Linearized Arterial Viscoelastic index During Endoscopic Thoracic Sympathectomy (2013)
  • Author(s): Hiroki Hirano, Tetsuya Horiuchi, Harutoyo Hirano, Yuichi Kurita, Teiji Ukawa, Ryuji Nakamura, Noboru Saeki, Masao Yoshizumi, Masashi Kawamoto, and Toshio Tsuji
  • Organizer: 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC'13)
  • Place of Presentation: Osaka
• [Presentation] Assessment of pain with mechanical nociceptive stimuli by the change of arterial wall impedance (2012)
  • Author(s): Abdugheni Kutluk
  • Organizer: The 5th International Conference on BioMedical Engineering and Informatics (BMEI 2012)
  • Place of Presentation: Chongqing, China
• [Presentation] Development of a Condition Monitoring System Using an Air-pack Type Pressure Sensor for Bedridden Patients in a Supine Position (2012)
  • Author(s): Harutoyo Hirano
  • Organizer: 2012 IEEE International Conference on Condition Monitoring and Diagnosis
  • Place of Presentation: Bali, Indonesia
• [Presentation] Vascular Impedance, BIS, Heart Rate Variability, and Pulse Wave Velocity During Surgical Stress (2012)
  • Author(s): Noboru Saeki
  • Organizer: ASA2012: American Society of Anesthesiologists Annual Meeting
  • Place of Presentation: Washington, DC., USA
• [Presentation] Severity Estimation of Finger-Tapping Caused by Parkinson's Disease by Using Linear Discriminant Regression Analysis (2012)
  • Author(s): Yuko Sano
  • Organizer: The 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: San Diego, California, USA
• [Presentation] Improvement of Novel Noninvasive Measurement of Endothelial Function : ezFMD (2011)
  • Author(s): Teiji Ukawa, Tsuneo Takayanagi, Haruka Morimoto, Yukihito Higashi, Naomi Idei, Ryosuke Kubo, Masao Yoshizumi, Toshio Tsuji
  • Organizer: 2011 IEEE/SICE International Symposium on System Integration (SII 2011)
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2011-12-20
• [Presentation] 血管粘弾性インデックスによる指タップ運動中の自律神経活動評価 (2011)
  • Author(s): 伊藤雅史, 平野博大, 小松雄亮, 堀内徹也, 平野陽豊, 栗田雄一, 鵜川貞二, 神鳥明彦, 島圭介, 中村隆治, 佐伯昇, 河本昌志, 吉栖正生, 佐古田三郎, 辻敏夫
  • Organizer: 日本人間工学会中国・四国支部九州・沖縄支部合同開催支部大会講演論文集
  • Place of Presentation: 下関市生涯学習プラザ
  • Year and Date: 2011-11-26
• [Presentation] Measurement of Arterial Viscoelastic Properties Using a Foil-type Pressure Sensor and a Photoplethysmography (2011)
  • Author(s): Harutoyo Hirano, Hiromi Maruyama, Abdugheni Kutluk, Toshio Tsuji, Osamu Fukuda, Naohiro Ueno, Teiji Ukawa, Ryuji Nakamura, Noboru Saeki, Masashi Kawamoto, Masao Yoshizumi
  • Organizer: The 3rd International Conference on Electrical Engineering and Informatics
  • Place of Presentation: Bandung, Indonesia
  • Year and Date: 2011-07-18
• [Presentation] 光電容積脈波を利用した対数線形化末梢血管粘弾性インデックスの提案 (2011)
  • Author(s): 平野博大, 堀内徹也, 丸山大海, 平野陽豊, Kutluk Abdugheni, 辻敏夫, 鵜川貞二, 中村隆治, 佐伯昇, 吉栖正生, 河本昌志
  • Organizer: 日本機械学会ロボティクス・メカトロニクス講演会2011講演論文集
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2011-05-28
• [Presentation] 箔状圧電センサを利用した血圧脈波の計測-足背動脈波計測と血管粘弾性インデックスの推定- (2011)
  • Author(s): 平野陽豊, 丸山大海, Kutluk Abdugheni, 辻敏夫, 福田修, 上野直広, 鵜川貞二, 中村隆治, 佐伯昇, 河本昌志, 吉栖正生
  • Organizer: 日本機械学会ロボティクス・メカトロニクス講演会2011講演論文集
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2011-05-28
• [Presentation] 再現性評価に基づく指タップ運動の特徴抽出 (2010)
  • Author(s): 山口裕希, 田村康裕, 島圭介, 辻敏夫, 佐野佑子, 神鳥明彦, 佐古田三郎
  • Organizer: 日本人間工学会第43回中国・四国支部大会
  • Place of Presentation: 広島大学医学部
  • Year and Date: 2010-10-30
• [Presentation] 対数線形化血管粘弾性インデックスの提案と頚動脈超音波検査への応用 (2010)
  • Author(s): 堀内徹也, Abdugheni Kutluk, 辻敏夫, 鵜川貞二, 中村隆治, 佐伯昇, 東幸仁, 河本昌志, 吉栖正生
  • Organizer: 第6回西日本血管・機能研究会
  • Place of Presentation: 福岡サンパレス(福岡)
  • Year and Date: 2010-08-07
• [Presentation] Estimation of Vascular Impedance Using a Log-linearized Viscoelastic Model (2009)
  • Author(s): Abdugheni Kutluk
  • Organizer: Proceedings of the International Symposium on Early Detection and Rehabilitation Technology of Dementia
  • Place of Presentation: 岡山市
  • Year and Date: 2009-12-11
• [Presentation] Estimation of Human Finger Tapping Forces Based on a Fingerpad-Stiffness Model (2009)
  • Author(s): Keisuke Shima, Yasuhiro Tamura, Toshio Tsuji, Akihiko Kandori, Masaru Yokoe, and Saburo Sakoda
  • Organizer: Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: Minnesota, USA
  • Year and Date: 2009-09-04
• [Book] A Log-linearized Viscoelastic Model for Measuring Changes in Vascular Impedance (2011)
  • Author(s): Abdugheni Kutluk, Ryuji Nakamura, Toshio Tsuji, Teiji Ukawa, Noboru Saeki, Masao Yoshizumi, Masashi Kawamoto
  • Total Pages: 8
  • Publisher: Early Detection and Rehabilitation Technologies for Dementia : Neuroscience and Biomedical Applications
• [Book] Evaluation and Training of Human Finger Tapping Movements (2010)
  • Author(s): Keisuke Shima, Toshio Tsuji, Akihiko Kandori, Masaru Yokoe and Saburo Sakoda
  • Publisher: INTECH
• [Remarks]
  • URL: http://www.bsys.hiroshima-u.ac.jp/
• [Remarks] http://www.bsys.hiroshima-u.ac.jp/
• [Remarks] 生体システム論研究室
  • URL: http://www.bsys.hiroshima-u.ac.jp/
• [Remarks]
  • URL: http://www.bsys.hiroshima-u.ac.jp/
• [Remarks]
  • URL: http://www.bsys.hiroshima-u.ac.jp/index.phtml
• [Patent(Industrial Property Rights)] 血圧計測システム (2013)
  • Inventor(s): 神鳥 明彦, 佐野 佑子, 辻 敏夫, 平野 陽豊
  • Industrial Property Rights Holder: 神鳥 明彦, 佐野 佑子, 辻 敏夫, 平野 陽豊
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-07-10
• [Patent(Industrial Property Rights)] Method of Estimating Finger-Tapping Force (2009)
  • Inventor(s): Toshio Tsuji, Keisuke Shima, Yasuhiro Tamura, Akihiko Kandori, Yuko Sano, Tsuyoshi Miyashita
  • Industrial Property Rights Holder: Toshio Tsuji, Keisuke Shima, Yasuhiro Tamura, Akihiko Kandori, Yuko Sano, Tsuyoshi Miyashita
  • Industrial Property Rights Type: 特許
  • Filing Date: 2009-10-23
  • Overseas
• [Patent(Industrial Property Rights)] 血管内皮機能評価装置 (2009)
  • Inventor(s): 辻敏夫, 吉栖正生, 東幸仁, 河本昌志, 小澤秀夫, 鵜川貞二, 高柳恒夫
  • Industrial Property Rights Holder: 辻敏夫, 吉栖正生, 東幸仁, 河本昌志, 小澤秀夫, 鵜川貞二, 高柳恒夫
  • Industrial Property Rights Type: 特許
  • Filing Date: 2009-09-14