Development of Precise-controlled Magnetic Drug Delivery System

• Project/Area Number: 21360133
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Power engineering/Power conversion/Electric machinery
• Research Institution: Osaka University
• Principal Investigator: NISHIJIMA Shigehiro 大阪大学, 工学研究科, 教授 (00156069)
• Co-Investigator(Kenkyū-buntansha): AKIYAMA Yoko 大阪大学, 工学研究科, 講師 (50452470) ; NAKAGAWA Takashi 大阪大学, 工学研究科, 准教授 (70273589) ; HUKUI Satoshi 新潟大学, 自然科学系, 准教授 (70293199)
• Project Period (FY): 2009 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2009: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
• Keywords: 超電気導バルク磁石 / 磁気薬剤配送システム / 強磁性粒子 / 変動磁場 / 粒子軌跡 / シミュレーション / 強磁性針 / 磁気力制御 / 低侵襲治療 / 磁気力 / 薬剤配送システム / 体内深部 / 回転磁場 / 薬剤配送システム(DDS) / 粒子軌跡シミュレーション / 温度感受性リポソーム / 非侵襲治療 / リポソーム / 動物実験

Research Abstract

The objective of this study is to construct the methods of MDDS (magnetic drug delivery system) to accumulate drugs in the local deep part of the body. Two methods; local accumulation of ferromagnetic drug with ferromagnetic needle in the external magnetic field and non-invasive accumulation by rotating MDDS were studied. As a result, the possibility of local accumulation of ferromagnetic drug in the deep part was shown

Research Products

• [Journal Article] Study on Magnetic Drug Delivery System Using HTS Bulk Magnet (2012)
  • Author(s): K. Nakagawa, F. Mishima, Y. Akiyama, S. Nishijima
  • Journal Title: IEEE TRANS.APPL.SUPERCOND, reviewed Volume: VOL. 22, NO. 3 Pages: 4903804-4903804
• [Journal Article] Study on Magnetic Drug Delivery System Using HTS Bulk Magnet (2012)
  • Author(s): K. Nakagawa
  • Journal Title: IEEE TRANS.APPL.SUPERCOND Volume: VOL. 22, NO. 3
• [Journal Article] Drug accumulation by means of noninvasive magnetic drug delivery system (2011)
  • Author(s): M. Chuzawa, F. Mishima, Y. Akiyama, S. Nishijima
  • Journal Title: Physica C: Superconductivity, reviewed Volume: Vol.471, Issue 21-22 Pages: 1538-1542
• [Journal Article] Drug accumulation by means of noninvasive magnetic drug delivery system (2011)
  • Author(s): M.Chuzawa, F.Mishima, Y.Akiyama, S.Nishijima
  • Journal Title: Physica C, Superconductivity Volume: 471 Issue: 21-22 Pages: 1538-1542
  • DOI: 10.1016/j.physc.2011.05.233
  • Peer Reviewed
• [Journal Article] A study on accumulation of magnetic drug in the capillary vessel of target organ using superconducting MDDS (2010)
  • Author(s): F. Mishima, Y. Akiyama, S. Nishijima
  • Journal Title: Physica C: Superconductivity, reviewed Volume: Volume 470, Issue 20 Pages: 1837-1840
• [Journal Article] Drug Delivery Using an Embedded Ferromagnetic Needle and External Magnets (2010)
  • Author(s): Y. Hirota, F. Mishima, Y. Akiyama, and S. Nishijima
  • Journal Title: IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY, reviewed Volume: VOL. 20, NO.3 Pages: 826-828
• [Journal Article] 超電導バルク磁石を用いた磁気薬剤配送システムに関する研究 (2010)
  • Author(s): 廣田友佳、忠澤充高、三島史人、秋山庸子、西嶋茂宏
  • Journal Title: 低温工学 Volume: Vo . l4 5、No Pages: 298-303
  • NAID: 10026452707
  • Peer Reviewed
• [Journal Article] 磁気力薬剤配送システムの開発 (2010)
  • Author(s): 三島史人、西嶋茂宏
  • Journal Title: 日本AEM学会誌 Volume: Vol. 18、No.1 Pages: 21-28
  • NAID: 110007619823
  • Peer Reviewed
• [Journal Article] Drug Delivery Using an Embedded Ferromagnetic Needle and External Magnets (2010)
  • Author(s): Y.Hirota, F.Mishima, Y.Akiyama, S.Nishijima
  • Journal Title: IEEE Transactions on applied Superconductivity Volume: 20(3) Pages: 826-828
  • Peer Reviewed
• [Journal Article] A study on accumulation of magnetic drug in the capillary vessel of target organ using superconducting MDDS (2010)
  • Author(s): F.Mishima, Y.Akiyama, S.Nishijima
  • Journal Title: Physica C : Superconductivity Volume: 470(20) Pages: 1837-1840
  • Peer Reviewed
• [Journal Article] Research and Development of Magnetic Drug Delivery System Using Bulk High Temperature Superconducting Magnet (2009)
  • Author(s): S. NishijimaF. Mishima, Y. Tabata, H. Iseki, Y.Muragaki, A. Sasaki, N. Saho
  • Journal Title: IEEE Transactions on applied Superconductivity, reviewed Volume: Vol.19,No.3 Pages: 2257-2260
• [Journal Article] Fundamental study for development magnetic drug delivery system (2009)
  • Author(s): Y. Hirota , Y.Akiyama , Y. Izumi, S . Nishijima
  • Journal Title: Physica C: Superconductivity, reviewed Volume: Vol.469, 15-20 Pages: 1853-1856
  • NAID: 10024469086
• [Journal Article] 磁気力誘導薬剤配送システム (2009)
  • Author(s): 西嶋茂宏、三島史人
  • Journal Title: まぐね/Magnetics Japan Volume: Vol. 4、No.11 Pages: 535-543
  • NAID: 10025570571
• [Journal Article] Research and Development of Magnetic Drug Delivery System Using Bulk High Temperature (2009)
  • Author(s): S.Nishijima, F.Mishima, Y.Tabata, H.Iseki, Y.Muragaki, A.Sasaki, N.Saho
  • Journal Title: IEEE Transactions on applied Superconductivity Vol19, No.3 Pages: 2257-2260
  • Peer Reviewed
• [Journal Article] Fundamental study for development magnetic drug delivery system (2009)
  • Author(s): Y.Hirota, Y.Akiyamaa, Y.Izumi, S.Nishijima,
  • Journal Title: Physica C : Superconductivity, Vol.469, 15-20 Pages: 1853-1856
  • NAID: 10024469086
  • Peer Reviewed
• [Journal Article] Study on magnetic separation of nanosized ferromagnetic particles (2009)
  • Author(s): R Nakao, Y Matuo, F Mishima, T Taquchi S Nishijima
  • Journal Title: Phys.:Conf.Ser. 156 Pages: 1-5
  • NAID: 10019981673
  • Peer Reviewed
• [Journal Article] 磁気力誘導薬剤配送システム (2009)
  • Author(s): 西嶋茂宏、三島史人
  • Journal Title: まぐね/Magnetics Jpan. Vol.4, No.11 Pages: 535-543
  • NAID: 10025570571
  • Peer Reviewed
• [Presentation] 超電導バルク磁石を用いた磁気力制御遺伝子導入のための研究 (2012)
  • Author(s): 中川公太、大阿久佳宏、玉田順也、三島史人、秋山庸子、大窄マリアナ今日美、中神啓徳、西嶋茂宏
  • Organizer: 第86回秋季低温工学・超電導学会
  • Place of Presentation: いわて県民情報交流センター
• [Presentation] Precise control of the drug kinetics by non-invasive magnetic drug delivery system (2012)
  • Author(s): F. Mishima, M. Chuzawa, Y. Akiyama, S. Nishijima
  • Organizer: 2012 Applied Superconductivity Conference
  • Place of Presentation: Portland,U.S.A
• [Presentation] 超電導バルク磁石を用いた磁気力制御遺伝子導入のための研究 (2012)
  • Author(s): 中川公太
  • Organizer: 第86回 秋季低温工学・超電導学会
  • Place of Presentation: いわて県民情報交流センター
• [Presentation] Study on Magnetic Drug Delivery System Using HTS Bulk Magnet (2011)
  • Author(s): K. Nakagawa, F. Mishima, Y. Akiyama, S. Nishijima
  • Organizer: 22nd International Conference on Magnet Technology
  • Place of Presentation: Marseille, Franc
• [Presentation] 非侵襲磁気力制御薬剤配送システムのための基礎的研究 (2011)
  • Author(s): 忠澤充高、三島史人、秋山庸子、西嶋茂宏
  • Organizer: 第10回2011年度磁気力制御・磁場応用夏の学校
  • Place of Presentation: 大阪市立長居ユースホステル
• [Presentation] 温度感受性リポソームを用いた磁気力制御薬剤配送システムの基礎的研究 (2011)
  • Author(s): 中川公太、三島史人、秋山庸子、西嶋茂宏
  • Organizer: 第84回2011年度春季低温工学・超電導学会
  • Place of Presentation: 筑波NIMS
• [Presentation] 温度感受性リポソームを用いた磁気力制御薬剤配送システムの基礎的研究 (2011)
  • Author(s): 中川公太、三島史人、秋山庸子、西嶋茂宏
  • Organizer: 平成23年電気学会全国大会
  • Place of Presentation: 大阪大学
• [Presentation] Drug Accumulation by Means of Noninvasive Magnet Drug Delivery System (2011)
  • Author(s): M. Chuzawa, F. Mishima, Y. Akiyama, S. Nishijima
  • Organizer: 23rd Interantioanl Symoposium on Superconductivity
  • Place of Presentation: Tsukuba, Japan
• [Presentation] Study on Magnetic Drug Delivery System Using HTS Bulk Magnet (2011)
  • Author(s): K.Nakagawa, F.Mishima, Y.Akiyama, S.Nishijima
  • Organizer: (MT-22) 22nd International Conference on Magnet Technology
  • Place of Presentation: Marseille, France
• [Presentation] Precise Control of the Drug Kinetics by Means of Noninvasive Drug Delivery System (2011)
  • Author(s): M.Chuzawa, F.Mishima, Y.Akiyama, S.Nishijima
  • Organizer: (ISS2011) 24rd International Symposium on Superconductivity
  • Place of Presentation: タワーホール船堀(東京)
• [Presentation] 温度感受性リポソームを用いた磁気力制御薬剤配送システムの基礎的研究 (2011)
  • Author(s): 中川公太、三島史人、秋山庸子、西嶋茂宏
  • Organizer: 第84回2011年度春季低温工学・超電導学会
  • Place of Presentation: 物質・材料機構(筑波)
• [Presentation] Drug accumulation by means of noninvasive magnetic drug delivery system (2010)
  • Author(s): M.Chuzawa, F.Mishima, Y.Akiyama, S.Nishijima
  • Organizer: 23^<rd> International Symposium on Superconductivity (ISS2010)
  • Place of Presentation: Epochal Tsukuba, Tsukuba
  • Year and Date: 2010-11-03
• [Presentation] 磁気力制御薬剤配送システムによる精密集積制御の検討(1)-モデル系での検討- (2010)
  • Author(s): 忠澤充高, 廣田友佳, 三島史人, 秋山庸子, 西嶋茂宏
  • Organizer: 2010年度春季低温工学・超電導学会
  • Place of Presentation: 川崎市産業振興会館, 川崎市
  • Year and Date: 2010-05-13
• [Presentation] 磁気力制御薬剤配送システムによる精密集積制御の検討(2)-生体内での検討- (2010)
  • Author(s): 三島史人, 忠澤充高, 廣田友佳, 秋山庸子, 西嶋茂宏
  • Organizer: 2010年度春季低温工学・超電導学会
  • Place of Presentation: 川崎市産業振興会館, 川崎市
  • Year and Date: 2010-05-13
• [Presentation] 非侵襲の磁気分離薬剤配送システムの研究 (2010)
  • Author(s): 忠澤充高、三島史人、秋山庸子、西嶋茂宏
  • Organizer: 第9回2010 磁気力制御・磁場夏の学校
  • Place of Presentation: 国立オリンピック記念青少年総合センター
• [Presentation] 磁気力制御薬剤配送システムによる精密集積制御の検討(1)～モデル系での検討～ (2010)
  • Author(s): 忠澤充高、廣田友佳、三島史人、秋山庸子、西嶋茂宏
  • Organizer: 第82回2010年度低温工学・超伝導学会
  • Place of Presentation: 川崎市産業振興会館
• [Presentation] 磁気力制御薬剤配送システムによる精密集積制御の検討(2)～生体内での検討～ (2010)
  • Author(s): 三島史人、忠澤充高、廣田友佳、秋山庸子、西嶋茂宏
  • Organizer: 第82回2010年度低温工学・超伝導学会
  • Place of Presentation: 川崎市産業振興会館
• [Presentation] 磁気薬剤配送システム(MDDS)に関する基礎的研究 (2009)
  • Author(s): 廣田友佳、三島史人、秋山庸子、西嶋茂宏
  • Organizer: 第81回2009年度低温工学・超伝導学
  • Place of Presentation: 岡山大学
• [Presentation] Development of Magnetic Drug Delivery System (2009)
  • Author(s): Y. Hirota, F. Mishima, Y. Akiyama, S. Nishijima
  • Organizer: 21st International Conference on Magnet Technology
  • Place of Presentation: Heifei, China
• [Remarks]
  • URL: http://www.see.eng.osaka-u.ac.jp/seeqb/seeqb/main/import/mdds.html
• [Remarks]
  • URL: http://www.see.eng.osaka-u.ac.jp/seeqb/seeqb/main/import/dds.html