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Target self-search type micro-bubble manipulation by an ultrasonic wave

Research Project

Project/Area Number 21360195
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Measurement engineering
Research InstitutionGunma University

Principal Investigator

YAMAKOSHI Yoshiki  群馬大学, 大学院・工学研究科, 教授 (10174640)

Co-Investigator(Kenkyū-buntansha) MIWA Takashi  群馬大学, 大学院・工学研究科, 教授 (30313414)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2009: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Keywords超音波 / 微小気泡 / 音響放射圧 / ドラッグデリバリシステム / ターゲッティング / トラッピング / Bjerknes力 / 気泡間相互作用 / 気泡クラウド / キャビテーション / ソノポレーション / 気泡トラッピング / 共焦点レーザー顕微鏡 / 気泡破壊 / 気泡 / アンジュレーション / Bierknes Force / 2次超音波
Research Abstract

Micro-bubble receives two kinds of acoustic radiation forces from ultrasonic wave. If the acoustic radiation forces are used, movement of micro-bubble is controllable from the outside. In this research, micro-bubble trapping methods to the target are newly developed aiming at improvement of drug injection efficiency of drug delivery system. One is the self-trapping method and another is the frequency operating method. Experiments are carried using an ultrasonic contrast agent. Usefulness and the effect of ultrasonic wave irradiation sequence are shown.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (39 results)

All 2012 2011 2010 2009

All Journal Article (15 results) (of which Peer Reviewed: 15 results) Presentation (24 results)

  • [Journal Article] Observation of Micro Hollows produced by Bubble Cloud Cavitation2012

    • Author(s)
      Y. Yamakoshi, T. Miwa
    • Journal Title

      Jpn. J. Appl. Phys.

      Volume: 51(In Press)

    • NAID

      210000141000

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Ultrasonic Wave Irradiation Sequence in Micro Hollow Production Produced by Bubble Cavitation2011

    • Author(s)
      Y. Yamakoshi, T. Miwa
    • Journal Title

      Jpn. J. Appl. Phys.

      Volume: 50

    • NAID

      210000070950

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dynamics simulation of microbubbles in ultrasonic wave field considering the secondary Bjerknes force2011

    • Author(s)
      T. Miwa, Y. Yamakoshi
    • Journal Title

      Key Engineering Materials

      Volume: Vol.459 Pages: 271-276

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dynamics simulation of microbubbles in ultrasonic wave field considering the secondary Bjerknes force2011

    • Author(s)
      T.Miwa, Y.Yamakoshi
    • Journal Title

      Key Engineering Materials

      Volume: 459 Pages: 271-276

    • DOI

      10.4028/www.scientific.net/kem.459.271

    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Ultrasonic Wave Irradiation Sequence in Micro Hollow Production Produced by Bubble Cavitation2011

    • Author(s)
      Y.Yamakoshi, T.Miwa
    • Journal Title

      Jpn.J.Appl.Phys.

      Volume: 50 Issue: 7S Pages: 07HF01-07HF01

    • DOI

      10.1143/jjap.50.07hf01

    • NAID

      210000070950

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optical scattering measurement of microbubble cloud dynamics in ultrasound2010

    • Author(s)
      T. Miwa, Y. Yamakoshi, T. Mashiyama
    • Journal Title

      Jpn. J. Appl. Phys.

      Volume: Vol.49,No.7

    • NAID

      210000068933

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of pre-trapping of microbubbles in sonoporation using N-isopropylacrylamide gel flow channel phantom2010

    • Author(s)
      Y. Yamakoshi, T. Miwa, N. Yoshizawa, H. Inoguchi, D. Zhang
    • Journal Title

      Jpn. J. Appl. Phys.

      Volume: Vol.49,No.7

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of pre-trapping of microbubbles in sonoporation using N-isopropylacrylamide gel flow channel phantom2010

    • Author(s)
      Y.Yamakoshi, T.Miwa, N.Yoshizawa, H.Inoguchi,D.Zhang
    • Journal Title

      Jpn.J.Appl.Phys.

      Volume: 49

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optical scattering measurement of microbubble cloud dynamics in ultrasound2010

    • Author(s)
      T.Miwa, Y.Yamakoshi, T.Mashiyama
    • Journal Title

      Jpn.J.Appl.Phys.

      Volume: 49

    • NAID

      210000068933

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamics simulation of microbubbles in ultrasonic wave field considering the secondary Bjerknes force2010

    • Author(s)
      Takashi Miwa
    • Journal Title

      Key Engineering Materials (In Press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optical scattering measurement of microbubble cloud dynamics in ultrasound2010

    • Author(s)
      Takashi Miwa
    • Journal Title

      Japanese Journal of Applied Physics (In Press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of pre-trapping of microbubbles in sonoporation using NIPA gel flow channel phantom2010

    • Author(s)
      Yoshiki Yamakoshi
    • Journal Title

      Japanese Journal of Applied Physics (In Press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microbubble Adhesion to Target Wall by Ultrasonic Wave Frequency Sweep Method2009

    • Author(s)
      Yoshiki Yamakoshi
    • Journal Title

      Jpn.J.of Appl.Phys. 48

    • NAID

      210000067153

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Pre-Trapping of Micro Bubbles on Mechanical Damage Enhancement in Bubble Cavitation2009

    • Author(s)
      Yoshiki Yamakoshi
    • Journal Title

      Proc.IEEE Ultrasonic Symposium

      Pages: 1270-1273

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Localization of living-bodies using single-frequency multistatic Doppler radar system2009

    • Author(s)
      Takashi Miwa
    • Journal Title

      IEICE Transactions on Communication Vol.E92-B

      Pages: 2468-2476

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Observation of bubble cloud cavitation by confocal laser microscope2011

    • Author(s)
      Y. Yamakoshi, T. Miwa
    • Organizer
      3rd Int. conf. on Advanced Micro Device Engineering
    • Place of Presentation
      Kiryu,(Japan)
    • Year and Date
      2011-12-08
    • Related Report
      2011 Final Research Report
  • [Presentation] 気泡クラウドキャビテーションにより形成される微小窪みの観察2011

    • Author(s)
      山越芳樹, 郡裕路, 中野宜泰, 山口淳, 三輪空司
    • Organizer
      第32回超音波エレクトロニクスの基礎と応用に関するシンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2011-11-10
    • Related Report
      2011 Final Research Report
  • [Presentation] キャビテーションにおける気泡クラウドの挙動についての実験的検討2011

    • Author(s)
      山口淳, 郡裕路, 中野宜泰, 小澤知享, 山越芳樹, 三輪空司
    • Organizer
      日本超音波医学会関東甲信越地方会23回学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-30
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Evaluation of ultrasonic wave irradiation sequence in bubble cloud cavitation2011

    • Author(s)
      Y. Yamakoshi, T. Miwa
    • Organizer
      Abst. on World Congress of Ultrasoundin Medicine and Biology
    • Place of Presentation
      Vienna,(Austria)
    • Year and Date
      2011-08-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Evaluation of ultrasonic wave irradiation sequence in bubble cloud cavitation2011

    • Author(s)
      Y.Yamakoshi, T.Miwa
    • Organizer
      World Congress of Ultrasound in Medicine and Biology
    • Place of Presentation
      Vienna
    • Year and Date
      2011-08-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 気泡クラウドからのソノポレーションについての実験的検討2011

    • Author(s)
      中野宜泰, 山越芳樹, 三輪空司
    • Organizer
      日本超音波医学会第84回学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-27
    • Related Report
      2011 Final Research Report
  • [Presentation] ソノポレーションにおける超音波照射シーケンスの検討2011

    • Author(s)
      郡裕路, 山越芳樹, 三輪空司
    • Organizer
      日本超音波医学会第84回学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-27
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 気泡クグラウトからのソノポレーションについての実験的検討2011

    • Author(s)
      中野宜泰, 山越芳樹, 三輪空司
    • Organizer
      日本超音波医学会第84回学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Bubble Cavitation Enhancement by Pumping Ultrasonic Wave2010

    • Author(s)
      Y. Yamakoshi, H. Inoguchi, D. Zhang, H. Khori, Y. Nakano, T. Miwa
    • Organizer
      Int. conf. on. Advanced Micro Device Engineering
    • Place of Presentation
      Kiryu
    • Year and Date
      2010-12-10
    • Related Report
      2011 Final Research Report
  • [Presentation] Bubble Cavitation Enhancement by Pumping Ultrasonic Wave2010

    • Author(s)
      Y.Yamakoshi, H.Inoguchi, D.Zhang, H.Khori, Y.Nakano, T.Miwa
    • Organizer
      Int.conf.on.Advanced Micro Device Engineering
    • Place of Presentation
      桐生
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 気泡キャビテーションにおけるポンピング超音波の周波数変調の効果2010

    • Author(s)
      山越芳樹, 三輪空司
    • Organizer
      第31回超音波エレクトロニクスの基礎と応用に関するシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2010-12-06
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 気泡キャビテーションにより生じるゲル流路内面の微小窪みの評価2010

    • Author(s)
      山越芳樹
    • Organizer
      日本超音波医学会関東甲信越地方会22回学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-30
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 生体模擬流路でのキャビテーション観察による微小気泡プリトラッピングの検討2010

    • Author(s)
      山越芳樹, 吉澤伸幸, 井野口博輝, 郡裕路, ノルスリアナファティハ, 三輪空司
    • Organizer
      日本超音波医学会第83回学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-05-31
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 超音波気泡マニピュレーションによるキャビテーション増強2009

    • Author(s)
      山越芳樹
    • Organizer
      第2回超音波とマイクロバブルの相互作用に関するシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2009-12-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Novelmethod of sonoporation in drugdelivery system using frequency modulation of pumping ultrasonic wave2009

    • Author(s)
      Y. Yamakoshi, T. Miwa
    • Organizer
      Int. conf. on. Advanced Micro Device Engineering
    • Place of Presentation
      Kiryu
    • Year and Date
      2009-12-11
    • Related Report
      2011 Final Research Report
  • [Presentation] Novel method of sonoporation in drug delivery system using frequency modulation of pumping ultrasonic wave2009

    • Author(s)
      Y.Yamakoshi
    • Organizer
      Int.conf. on. Advanced Micro Device Engineering
    • Place of Presentation
      桐生
    • Year and Date
      2009-12-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 超音波中の微小気泡群ダイナミクスの光散乱計測2009

    • Author(s)
      三輪空司, 山越芳樹, 増山知東
    • Organizer
      Ultra Sonic Electronics Symposium
    • Place of Presentation
      京都
    • Year and Date
      2009-11-20
    • Related Report
      2011 Final Research Report
  • [Presentation] NIPAゲル流路を用いたソノポレーションの評価2009

    • Author(s)
      山越芳樹
    • Organizer
      第30回超音波エレクトロニクスの基礎と応用に関するシンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2009-11-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 超音波中の微小気泡群ダイナミクスの光散乱計測2009

    • Author(s)
      三輪空司
    • Organizer
      第30回超音波エレクトロニクスの基礎と応用に関するシンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2009-11-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effect of Pre-trapping of Micro Bubbles on Mechanical Damage Enhancement in Bubble Cavitation2009

    • Author(s)
      Y. Yamakoshi, T. Miwa, Y. Takahashi, H. Inoguchi
    • Organizer
      2009 IEEE Int. Ultrasonic Symp
    • Place of Presentation
      Roma, Italy
    • Year and Date
      2009-09-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Effect of Pre-Trapping of Micro Bubbles on Mechanical Damage Enhancement in Bubble Cavitation2009

    • Author(s)
      Y.Yamakoshi
    • Organizer
      IEEE Ultrasonic Symposium
    • Place of Presentation
      Roma Itary
    • Year and Date
      2009-09-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] 音響放射圧場中での気泡群ダイナミクスの三次元シミュレーション2009

    • Author(s)
      三輪空司, 山越芳樹, 高橋悠二
    • Organizer
      日本超音波医学会
    • Place of Presentation
      東京
    • Year and Date
      2009-05-22
    • Related Report
      2011 Final Research Report
  • [Presentation] NIPAゲルによるキャビテーション評価のための血管模擬ファントム2009

    • Author(s)
      高橋悠二
    • Organizer
      日本超音波医学会第82回学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-05-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 音響放射圧場中での気泡群ダイナミクスの三次元シミュレーション2009

    • Author(s)
      三輪空司
    • Organizer
      日本超音波医学会第82回学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-05-22
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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