Fate of antibiotics and antivirals in the aquatic environment and contamination by resistant bacteria

• Project/Area Number: 21360256
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Civil and environmental engineering
• Research Institution: Kyoto University
• Principal Investigator: YAMASHITA Naoyuki 京都大学, 大学院・工学研究科, 講師 (90391614)
• Co-Investigator(Kenkyū-buntansha): HIROAKI Tanaka 京都大学, 大学院・工学研究科, 教授 (70344017) ; NAKADA Norihide 京都大学, 大学院・工学研究科, 助教 (00391615)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000); Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2010: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2009: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
• Keywords: 土壌 / 水環境 / 抗生物質 / 薬剤耐性菌 / 多剤耐性菌 / 河川流域 / 下水処理場 / 抗ウイルス剤 / 生態影響

Research Abstract

Survey on the fate of the antibiotics and antivirals in river basin showed that most of pharmaceuticals are entering into the river bodies through wastewater treatment plants. Ecotoxicity tests using aquatic organisms indicated that antibiotics have higher toxicity to algae among aquatic organisms tested. As for the fate of resistant bacteria in the river basin, ampicillin resistant bacteria were detected at high percentages among bacteria isolated from river samples and ampicillin and sulfamethoxazole resistant bacteria were persistent along the river downstream.

Research Products

• [Journal Article] 都市河川における医薬品類の減衰 (2011)
  • Author(s): 花本征也・中田典秀・山下尚之・田中宏明
  • Journal Title: 環境工学研究論文集 Volume: 48 Pages: 179-185
  • Peer Reviewed
• [Journal Article] Detected in Sewage Discharge and River Water in Japan, Environmental Health Perspectives (2010)
  • Author(s): G. C. Ghosh, N. Nakada, N. Yamashita, H. Tanaka
  • Volume: 118
  • Pages: 103-107
• [Journal Article] 淀川水系における医薬品類の存在実態 (2010)
  • Author(s): 花本征也, 中田典秀, 山下尚之, 田中宏明
  • Journal Title: 環境工学研究論文集 Volume: 47 Pages: 423-432
• [Journal Article] Occurrence and Fate of Oseltamivir Carboxylate (Tamiflu) and Amantadine in Sewage Treatment Plants (2010)
  • Author(s): Gopal C.Ghosh, Norihide Nakada, Naoyuki Yamashita, Hiroaki Tanaka
  • Journal Title: Chemosphere Volume: 81 Pages: 13-17
  • Peer Reviewed
• [Journal Article] Oseltamivir Carboxylate-the Active Metabolite of Oseltamivir Phosphate (Tamiflu), Detected in Sewage Discharge and River Water in Japan (2010)
  • Author(s): Gopal Chandra Ghosh, Norihide Nakada, Naoyuki Yamashita, Hiroaki Tanaka
  • Journal Title: Environmental Health Perspectives 118 Pages: 103-107
  • Peer Reviewed
• [Journal Article] 下水処理過程における医薬品類の存在実態と挙動 (2009)
  • Author(s): 成宮正倫, 奥田隆, 中田典秀, 山下尚之, 田中宏明, 佐藤和志, 末岡峯数, 大岩俊雄
  • Journal Title: 環境工学研究論文集 46 Pages: 175-186
  • Peer Reviewed
• [Journal Article] Occurrence and elimination of antibiotics at four sewage treatment plants in Japan and their effects on bacterial ammonia oxidation (2009)
  • Author(s): Gopal Chandra Ghosh, Takashi Okuda, Naoyuki Yamashita, Hiroaki Tanaka
  • Journal Title: Water Science and Technology 59 Pages: 779-786
  • Peer Reviewed
• [Presentation] Detection of Oseltamivir, its active metabolite (Oseltamivir carboxylate), Zanamivir and Amantadine in the Yodo River System, Japan (2011)
  • Author(s): Takashi Azuma, Norihide Nakada, Naoyuki Yamashita, Hiroaki
  • Organizer: GCOE Seminar on Occurrence and Management on Emerging Contaminants in Japan and UK
  • Place of Presentation: 清華大学(China)
  • Year and Date: 2011-12-03
• [Presentation] 下水処理場に流入するタミフル及びその活性代謝物,リレンザ,アマンタジンの濃度推移 (2011)
  • Author(s): 東剛志, 中田典秀, 山下尚之, 田中宏明
  • Organizer: 第48回環境工学研究フォーラム
  • Place of Presentation: 大同大学(名古屋市)
  • Year and Date: 2011-11-25
• [Presentation] The fate and distribution of pharmaceuticals and personal care products in sewage treatment plants (2011)
  • Author(s): Masanori Narumiya, Norihide Nakada, Naoyuki Yamashita
  • Organizer: 4th IWA-ASPIRE Conference and Exhibition
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-10-04
• [Presentation] 淀川水系における抗インフルエンザ薬タミフル及びその活性代謝物,リレンザ,アマンタジンの存在実態と環境動態の解明 (2011)
  • Author(s): 東剛志, 中田典秀, 山下尚之, 田中宏明
  • Organizer: 第14回日本水環境学会シンポジウム
  • Place of Presentation: 東北工業大学(仙台市)
  • Year and Date: 2011-09-10
• [Presentation] 淀川河川中における抗インフルエンザ薬タミフル及びその活性代謝物,リレンザ,アマンタジンの濃度推移 (2011)
  • Author(s): 東剛志, 中田典秀, 山下尚之, 田中宏明
  • Organizer: 環境科学会2011年年会
  • Place of Presentation: 関西学院大学(西宮市)
  • Year and Date: 2011-09-08
• [Presentation] インフルエンザ流行期での淀川水系における抗インフルエンザ薬タミフル及びその活性代謝物,リレンザ,アマンタジンの存在実態 (2011)
  • Author(s): 東剛志, 中田典秀, 山下尚之, 田中宏明
  • Organizer: 京都大学環境衛生工学研究会第33回シンポジウム
  • Place of Presentation: 京都大学桂キャンパス(京都市)
  • Year and Date: 2011-07-29
• [Presentation] 下水処理場における汚泥処理を含めた医薬品類の存在実態 (2011)
  • Author(s): 成宮正倫, 中田典秀, 山下尚之, 田中宏明
  • Organizer: 第48回下水道研究発表会
  • Place of Presentation: 東京ビックサイト(東京都)
  • Year and Date: 2011-07-28
• [Presentation] Initial Ecological Risk Assessment of Pharmaceuticals and Personal Care Products Found in the Japanese Water Environment using Algae, Daphnia (2011)
  • Author(s): Tsukasa KAWAKAMI, Naoyuki YAMASHITA, Norihide NAKADA
  • Organizer: Micropol & Ecohazard 2011
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2011-07-12
• [Presentation] Natural Attenuation of Pharmaceuticals and Personal Care Products in a River (2011)
  • Author(s): Seiya Hanamoto, Norihide Nakada, Naoyuki Yamashita, Hiroaki
  • Organizer: Micropol & Ecohazard 2011
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2011-07-12
• [Presentation] Pandemic influenza and the proposed widespread use of anti-influenza drugs-an emerging pharmaceutical group of environmental concern, and end-of-pipe treatment options (2011)
  • Author(s): Gopal C.GHOSH, Hiroaki TANAKA, Naoyuki YAMASHITA, Norihide NAKADA
  • Organizer: Micropol & Ecohazard 2011
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2011-07-12
• [Presentation] Investigations on the fate of pharmaceuticals and personal care products during activated sludge treatment (2011)
  • Author(s): Masanori Narumiya, Kazushi Sato, Takashi Okuda, Norihide Nakada
  • Organizer: Micropol & Ecohazard 2011
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2011-07-12
• [Presentation] 水環境中における医薬品類の光分解に関する検討 (2011)
  • Author(s): 花本征也, 中田典秀, 山下尚之, 田中宏明
  • Organizer: 第45回水環境学会年会
  • Place of Presentation: 札幌市
  • Year and Date: 2011-03-20
• [Presentation] LC-MS/MSを用いた水環境中の医薬品代謝物成分の同時分析法 (2011)
  • Author(s): 東剛志, 中田典秀, 山下尚之, 田中宏明
  • Organizer: 第45回水環境学会年会
  • Place of Presentation: 札幌市
  • Year and Date: 2011-03-20
• [Presentation] 水環境中における医薬品類の光分解に関する検討 (2011)
  • Author(s): 花本征也, 中田典秀, 山下尚之, 田中宏明
  • Organizer: 第45回水環境学会年会
  • Place of Presentation: 札幌
• [Presentation] 下水処理場に流入するタミフル及びその活性代謝物,リレンザ,アマンタジンの濃度推移 (2011)
  • Author(s): 東剛志, 中田典秀, 山下尚之, 田中宏明
  • Organizer: 第48回環境工学研究フォーラム
  • Place of Presentation: 東京
• [Presentation] Natural Attenuation of Pharmaceuticals and Personal Care Products in a River (2011)
  • Author(s): S. Hanamoto, N. Nakada, N. Yamashita, H. Tanaka
  • Organizer: Micropol & Ecohazard
  • Place of Presentation: Sydney, Australia
• [Presentation] Initial Ecological Risk Assessment of Pharmaceuticals and Personal Care Products Found in the Japanese Water Environment using Algae (2011)
  • Author(s): T. Kawakami, N. Yamashita, N. Nakada, H. Tanaka
  • Organizer: Daphnia and Bacteria, Micropol & Ecohazard
  • Place of Presentation: Sydney, Australia
• [Presentation] 藻類・ミジンコ・細菌を用いた医薬品及び日用品由来化学物質の生態毒性評価 (2010)
  • Author(s): 川上都香彩, 山下尚之, 中田典秀, 田中宏明
  • Organizer: 第47回環境工学研究フォーラム
  • Place of Presentation: 高知市
  • Year and Date: 2010-11-13
• [Presentation] 栄養段階が異なる水生生物を用いた医薬品及び日用品由来化学物質の生態毒性評価 (2010)
  • Author(s): 川上都香彩, 山下尚之, 中田典秀, 田中宏明
  • Organizer: 第32回京都大学環境衛生工学研究会シンポジウム
  • Place of Presentation: 京都市
  • Year and Date: 2010-07-30
• [Presentation] 下水に含まれる医薬品類に関する研究 (2010)
  • Author(s): 花本征也, 中田典秀, 山下尚之, 田中宏明
  • Organizer: 第32回京都大学環境衛生工学研究会シンポジウム
  • Place of Presentation: 京都市
  • Year and Date: 2010-07-30
• [Presentation] Development of multiresidue analytical method for anti-influenza drugs by LC-MS/MS (2010)
  • Author(s): Takashi Azuma, Norihide Nakada, Naoyuki Yamashita, Hiroaki Taknaka
  • Organizer: 32st Symposium on Environmental & Sanitary Engineering Research
  • Place of Presentation: 京都市
  • Year and Date: 2010-07-30
• [Presentation] 淀川水系における医薬品類の雨天時存在実態の把握 (2010)
  • Author(s): 花本征也, 中田典秀, 山下尚之, 田中宏明
  • Organizer: 第46回下水道研究発表会
  • Place of Presentation: 名古屋市
  • Year and Date: 2010-07-29
• [Presentation] Distribution of Antiviral Drugs in the Water Environment During the Outbreak of a Novel Influenza A virus-Swine flu (2010)
  • Author(s): Takashi Azuma, Gopal Chandra Ghosh, Norihide Nakada, Naoyuki Yamashita, Hiroaki Taknaka
  • Organizer: 第47回下水道研究発表会
  • Place of Presentation: 名古屋市
  • Year and Date: 2010-07-29
• [Presentation] 藻類・ミジンコ・細菌を用いた医薬品及び日用品由来化学物質の生態毒性評価 (2010)
  • Author(s): 川上都香彩, 山下尚之, 中田典秀, 田中宏明
  • Organizer: 第47回環境工学研究フォーラム
  • Place of Presentation: 高知
• [Presentation] Behavior of pharmaceutical active compounds during sewage treatment process : occurrence, removal and distribution in the dissolved and suspended phases (2009)
  • Author(s): Masanori NARUMIYA, Takashi OKUDA, Norihide NAKADA, Naoyuki YAMASHITA, Hiroaki TANAKA, Kazushi SATO, Minekazu SUEOKA, Toshio OIWA
  • Organizer: UK-JAPAN Workshop on endocrine disrupting chemicals
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2009-11-13
• [Presentation] Persistence of Pharmaceuticals and Personal Care Products in Reclaimed Wastewater (2009)
  • Author(s): Masanori NARUMIYA, Takashi OKUDA, Norihide NAKADA, Naoyuki YAMASHITA, Hiroaki TANAKA, Kazushi SATO, Minekazu SUEOKA, Toshio OIWA
  • Organizer: The 7th IWA World Congress on Water Reclamation and Reuse
  • Place of Presentation: Brisbane, Australia
  • Year and Date: 2009-09-21
• [Presentation] 下水汚泥中に含まれる医薬品類の分析に関する検討 (2009)
  • Author(s): 成宮正倫, 中田典秀, 山下尚之, 田中宏明, 佐藤和志, 末岡峯数, 大岩俊雄
  • Organizer: 土木学会平成21年度全国大会
  • Place of Presentation: 福岡市
  • Year and Date: 2009-09-03
• [Presentation] 淀川水系における医薬品類の動態に関する検討 (2009)
  • Author(s): 花本征也, 杉下寛樹, 中田典秀, 山下尚之, 田中宏明, 宝輪勲, 小西千絵
  • Organizer: 第31回京都大学環境衛生工学研究会シンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2009-07-31
• [Presentation] 下水処理場における懸濁態を含めた医薬品類の存在実態 (2009)
  • Author(s): 成宮正倫, 中田典秀, 山下尚之, 田中宏明, 佐藤和志, 末岡峯数, 大岩俊雄
  • Organizer: 第46回下水道研究発表会
  • Place of Presentation: 東京都
  • Year and Date: 2009-07-29