Structural and Functional Analyses of Intrinsically Unfolded Proteins for Engineering

• Project/Area Number: 21360398
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biofunction/Bioprocess
• Research Institution: The University of Tokyo
• Principal Investigator: TSUMOTO Kouhei 東京大学, 医科学研究所, 教授 (90271866)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2009: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
• Keywords: 蛋白質 / 分子認識 / 生物・生体工学 / ナノバイオ / 天然変性 / 蛋白質間相互作用 / スクリーニング

Research Abstract

Functional and physicochemical properties of intrinsically unfolded proteins have been focused. The novel interaction and self-assembly mechanisms have successfully described, based on several physicochemical, structural, and functional analyses. A novel system for handling proteins has been constructed, based on the chemical chaperone-like mechanism of an amino acid and derivatives. For a functionally unknown protein, we elucidated the function from cell-based analyses. A novel target has been used for construction of artificial regulation system of self-assembly process in vitro, showing the potential of proteins used as a tool of a bottom-up process in nano-biotechnology.

Research Products

• [Journal Article] Mapping the ultra-weak protein-protein interactions between heme transporters of Staphylococcus aureus (2012)
  • Author(s): Ryota Abe, Jose M.M.Caaveiro, Hiroko Kozuka-Hata, Masaaki Oyama, Kouhei Tsumoto
  • Journal Title: Journal of biological chemistry Volume: (印刷中) Issue: 20 Pages: 16477-16487
  • DOI: 10.1074/jbc.m112.346700
  • Peer Reviewed
• [Journal Article] Interleukin-11 Links Oxidative Stress and Compensatory Proliferation (2012)
  • Author(s): Nishina T, Komazawa-Sakon S, Yanaka S, Zheng X, Palo J, Kojima Y, Yamashina S, Sano E, Putoczki T, Doi T, Ueno T, Ezaki J, Ushio H, Ernst M, Kouhei T, Okamura K, Nakano H
  • Journal Title: Science Signal Volume: 5 Issue: 207
  • DOI: 10.1126/scisignal.2002056
  • Peer Reviewed
• [Journal Article] Crystal Structure of Enzyme CapF of Staphylococcus aureus Reveals a Unique A rchitecture Composed of Two Functional Domains (2012)
  • Author(s): Miyafusa T, Caaveiro JM, Tanaka Y, Tsumoto K
  • Journal Title: Biochemical journal Volume: (印刷中) Issue: 3 Pages: 671-680
  • DOI: 10.1042/bj20112049
  • Peer Reviewed
• [Journal Article] Establishment of a microcarrier culture system with serial sub-cultivation for functionally active human endothelial cells (2012)
  • Author(s): Tashiro S, Tsumoto K, Sano E
  • Journal Title: J.Biotechnol. Volume: (印刷中) Issue: 3-4 Pages: 202-213
  • DOI: 10.1016/j.jbiotec.2012.02.022
  • Peer Reviewed
• [Journal Article] Catalytic activity of MsbA reconstituted in nanodisc particles is modulated by remote interactions with the bilayer (2011)
  • Author(s): Kawai T, Caaveiro JM, Abe R, Katagiri T, Tsumoto K
  • Journal Title: FEBS Lett Volume: 585 Issue: 22 Pages: 3533-3537
  • DOI: 10.1016/j.febslet.2011.10.015
• [Journal Article] Molecular Basis of Recognition of Antibacterial Porphyrins by Heme-Transporter IsdH-NEAT3 of Staphylococcus aureus (2011)
  • Author(s): Moriwaki Y, Caaveiro JM, Tanaka Y, Tsutsumi H, Hamachi I, Tsumoto K
  • Journal Title: Biochemistry Volume: 50 Issue: 34 Pages: 7311-7320
  • DOI: 10.1021/bi200493h
• [Journal Article] Stepwise Characterization of the Thermodynamics of Trichocyte Intermediate Filament Protein Supramolecular Assembly (2011)
  • Author(s): Ishii D, Abe R, Watanabe SI, Tsuchiya M, Nocker B, Tsumoto K
  • Journal Title: J. Mol. Biol Volume: 408 Issue: 5 Pages: 832-838
  • DOI: 10.1016/j.jmb.2011.03.034
• [Journal Article] Refolding single-chain antibody(scFv) using lauroyl-L-glutamate as a solubilization detergent and arginine as a refolding additive (2011)
  • Author(s): Motonori Kudou ; Daisuke Ejima ; Haruna Sato ; Ryosuke Yumioka ; Tsutomu Arakawa ; and Kouhei Tsumoto
  • Journal Title: Protein Exp. Purif Volume: 77 Issue: 1 Pages: 68-74
  • DOI: 10.1016/j.pep.2010.12.007
  • Peer Reviewed
• [Journal Article] Non-core region modulates interleukin-11 signaling activity : Generation of agonist and antagonist variants (2011)
  • Author(s): Yanaka S, Sano E, Naruse N, Miura KI, Futatsumori-Sugai M, Caaveiro JM, Tsumoto K
  • Journal Title: J. Biol. Chem Volume: 286 Issue: 10 Pages: 8085-8093
  • DOI: 10.1074/jbc.m110.152561
• [Journal Article] Monoubiquitination of Tob/BTG family proteins competes with degradation-targeting polyubiquitination. (2011)
  • Author(s): Suzuki T
  • Journal Title: Biochem Biophys Res Commun Volume: 409 Issue: 1 Pages: 70-4
  • DOI: 10.1016/j.bbrc.2011.04.107
  • Peer Reviewed
• [Journal Article] Structural and Energetic Hot-Spots for the Interaction between a Ladder-like Polycyclic Ether and the Anti-Ciguatoxin Antibody 10C9Fab (2011)
  • Author(s): Mihoko Ui, Yoshikazu Tanaka, Takeshi Tsumuraya, Ikuo Fujii, Masayuki Inoue, Masahiro Hirama, and Kouhei Tsumoto
  • Journal Title: Molecular Bio Systems Volume: 7 Pages: 793-798
• [Journal Article] A novel protein refolding system using lauroyl-l-glutamate as a solubilizing detergent and arginine as a folding assisting agent (2011)
  • Author(s): Kudou M, Yumioka R, Ejima D, Arakawa T, Tsumoto K
  • Journal Title: Protein Expr Purif Volume: 75 Issue: 1 Pages: 46-54
  • DOI: 10.1016/j.pep.2010.08.011
  • Peer Reviewed
• [Journal Article] Chemical and Pharmacological Chaperones : Application for Recombinant Protein Production and Protein Folding Diseases (2011)
  • Author(s): Rahul S. Rajan, Kouhei Tsumoto, Masao Tokunaga, Hiroko Tokunaga, Yoshiko Kita and Tsutomu Arakawa
  • Journal Title: Current Medicinal Chemistry Volume: 18 Issue: 1 Pages: 1-15
  • DOI: 10.2174/092986711793979698
• [Journal Article] Gene expression profiles predicting the response to IFN-β and a combination of temozolomide and IFN-β in malignant gliomas (2011)
  • Author(s): Yoshino A, Tashiro S, Ogino A, Yachi K, Ohta T, Fukushima T, Watanabe T, Katayama Y, Okamoto Y, Sano E, Tsumoto K
  • Journal Title: Int J Oncol. Volume: 39 Pages: 529-542
  • DOI: 10.3892/ijo.2011.1068
  • Peer Reviewed
• [Journal Article] Hydration is Required in DNA G-Quadruplex-Protein Binding (2011)
  • Author(s): Nagatoishi S, Isono N, Tsumoto K, Sugimoto N
  • Journal Title: Chembiochem. Volume: 12 Issue: 12 Pages: 1822-1826
  • DOI: 10.1002/cbic.201100264
  • Peer Reviewed
• [Journal Article] Structural and Energetic Hot-Spots for the Interaction between a Ladder-like Polycyclic Ether and the Anti-Ciguatoxin Antibody 10C9Fab (2011)
  • Author(s): Mihoko Ui, Yoshikazu Tanaka, Takeshi Tsumuraya, Ikuo Fujii, Masayuki Inoue, Masahiro Hirama, Kouhei Tsumoto
  • Journal Title: Molecular BioSystems Volume: 7 Issue: 3 Pages: 793-798
  • DOI: 10.1039/c0mb00162g
  • Peer Reviewed
• [Journal Article] Molecular basis of recognition of antibacterial porphyrions by heme-transoprter IsdH-NEAT3 of Staphylococcus aureus Biochemistry (2011)
  • Author(s): Moriwaki, Y., Caaveiro, J.M.M., Tanaka, Y., Tsutsumi, H., Hamachi, I., Tsumoto, K.
  • Journal Title: Biochemistry Volume: 50 Pages: 7211-7320
  • Peer Reviewed
• [Journal Article] Refolding single-chain antibody (scFv) using lauroyl-L-glutamate as a solubilization detergent and arginine as a refolding additive. (2011)
  • Author(s): Kudou M, Ejima D, Sato H, Yumioka R, Arakawa T, Tsumoto K
  • Journal Title: Protein Exp.Purif. Volume: 印刷中掲載確定
  • Peer Reviewed
• [Journal Article] Non-core region modulates interleukin-11 signaling activity : Generation of agonist and antagonist variants. (2011)
  • Author(s): Yanaka S, Sano E, Naruse N, More KI, Futatsumori-Sugai M, Caaveiro JM, Tsumoto K
  • Journal Title: J.Biol.Chem. Volume: 印刷中掲載確定
  • Peer Reviewed
• [Journal Article] Structural and Energetic Hot-Spots for the Interaction between a Ladde r-like Polycychc Ether and the Anti-Ciguatoxin Antibody 10C9Fab. (2011)
  • Author(s): Ui M, Tanaka Y, Tsumuraya T, Fujii I, Inoue M, Hirama M, Tsumoto K
  • Journal Title: Mol.BioSyst. Volume: 印刷中掲載確定
  • Peer Reviewed
• [Journal Article] A novel protein refolding system using lauroy1-1-glutamate as a solubilizing detergent and arginine as a folding assisting agent. (2011)
  • Author(s): Kudou M, Yumioka R, Ejima D, Arakawa T, Tsumoto K.
  • Journal Title: Protein Exp.Purif. Volume: 印刷中掲載確定
  • Peer Reviewed
• [Journal Article] Chemical and Pharmacological Chaperones : Application for Recombinant Protein Production and Protein Folding Diseases. (2011)
  • Author(s): Rajan R S, Tsumoto K, Tokunaga M, Tokunaga H, Kita Y, Arakawa T
  • Journal Title: Current Medicinal Chemistry Volume: 18(1) Pages: 11-15
  • Peer Reviewed
• [Journal Article] Gene expression profiling predicts response to temozolomide in malignant gliomas. (2011)
  • Author(s): Yoshino A, Ogino A, Yachi K, Ohta T, Fukushima T, Watanabe T, Katayama Y, Okamoto Y, Naruse N, Sano E, Tsumoto K.
  • Journal Title: Int J Oncol. Volume: 36(6) Pages: 1367-1377
  • Peer Reviewed
• [Journal Article] An approach to rational ligand-design based on a thermodynamic analysis (2010)
  • Author(s): Ui M, Tsumoto K
  • Journal Title: Recent Pat Biotechnol Volume: 4 Issue: 3 Pages: 183-188
  • DOI: 10.2174/187220810793611482
• [Journal Article] Solubilization of Membrane Proteins with Novel N-Acylamino Acid Detergents (2010)
  • Author(s): Ryota Abe, Jose M. M. Caaveiro, Motonori Kudou and Kouhei Tsumoto
  • Journal Title: Mol. Bio Syst Volume: 6 Issue: 4 Pages: 677-679
  • DOI: 10.1039/b925791h
• [Journal Article] Contribution of the flexible loop region to the function of Staphylococcal enterotoxin B(SEB) (2010)
  • Author(s): Saeko Yanaka, Motonori Kudou, Yoshikazu Tanaka, Takumi Sasaki, Sumiyo Takemoto, Atsuko Sakata Yukio Hattori, Tomoyuki Koshi, Shiro Futaki, Kouhei Tsumoto, and Toshihiro Nakashima
  • Journal Title: Protein Eng. Des. Select Volume: 23 Issue: 5 Pages: 415-421
  • DOI: 10.1093/protein/gzq006
• [Journal Article] Contribution of asparagine residues to the stabilization of a proteinaceous antigen-antibody complex : HyHEL-10-HEL (2010)
  • Author(s): Yokota A., Tsumoto K., Shiroishi M., Nakanishi T., Kondo H., Kumagai I
  • Journal Title: J. Biol. Chem Volume: 285 Issue: 10 Pages: 7686-7696
  • DOI: 10.1074/jbc.m109.089623
• [Journal Article] Reactive oxygen species induced by Streptococcus pyogenes invasion trigger apoptotic cell death in infected epithelial cells (2010)
  • Author(s): Aikawa C, Nozawa T, Maruyama F, Tsumoto K, Hamada S, Nakagawa I
  • Journal Title: Cell Microbiol Volume: 12 Issue: 6 Pages: 814-830
  • DOI: 10.1111/j.1462-5822.2010.01435.x
• [Journal Article] Temperature and salt concentration alter base-sequence selectivity of a duplex DNA-binding protein (2010)
  • Author(s): Nagatoishi S, Tanaka Y, Kudou M and Tsumoto K
  • Journal Title: Mol. Biosyst Volume: 6 Issue: 1 Pages: 98-101
  • DOI: 10.1039/b914828k
• [Journal Article] Signal peptide design for improving recombinant protein secretion in the baculovirus expression vector system (2010)
  • Author(s): Futatsumori-Sugai M and Tsumoto K
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 391 Issue: 1 Pages: 931-935
  • DOI: 10.1016/j.bbrc.2009.11.167
• [Journal Article] Salicylate restores transport function and anion exchanger activity of missense pendrin mutations. (2010)
  • Author(s): Ishihara K, Okuyama S, Kumano S, Iida K, Hamana H, Murakoshi M, Kobayashi T, Usami S, Ikeda K, Haga Y, Tsumoto K Nakamura H, Hirasawa N, Wada H.
  • Journal Title: Hear Res. Volume: 270(1-2) Pages: 110-118
  • Peer Reviewed
• [Journal Article] The structural mechanism of the inhibition of archaeal Re1E toxin by its cognate Re1B antitoxin. (2010)
  • Author(s): Shinohara M, Guo JX, Mori M, Nakashima T, Takagi H, Nishimoto E, Yamashita S, Tsumoto K, Kakuta Y, Kimura M.
  • Journal Title: Biochem Biophys Res Commun. Volume: 400(3) Pages: 346-351
  • Peer Reviewed
• [Journal Article] Expression of antibody variable region-human alkaline pbosphatase fusion proteins in mammalian cells. (2010)
  • Author(s): Sasajima Y, Iwasaki R, Tsumoto K, Kumagai I, Ihara M, Ueda H.
  • Journal Title: J Immunol Methods. Volume: 361(1-2) Pages: 57-63
  • Peer Reviewed
• [Journal Article] Salicylate-induced translocation of prestin having mutation in the GTSRH sequence to the plasma membrane. (2010)
  • Author(s): Kumano S, Iida K, Ishihara K, Murakoshi M, Tsumoto K, Ikeda K, Kumagai I, Kobayashi T, Wada H.
  • Journal Title: FEBS Lett. Volume: 584(11) Pages: 2327-2332
  • Peer Reviewed
• [Journal Article] Reactive oxygen species induced by Streptococcus pyogenes invasion trigger apoptotic cell death in infected epithelial cells. (2010)
  • Author(s): Aikawa C, Nozawa T, Maruyama F, Tsumoto K, Hamada S, Nakagawa I.
  • Journal Title: Cell Microbiol. Volume: 12(6) Pages: 814-830
  • Peer Reviewed
• [Journal Article] Step-Wise Refolding of Recombinant Proteins. (2010)
  • Author(s): Tsumoto K, Arakawa T, Chen L.
  • Journal Title: Curr Pharm Biotechnol. Volume: 11(3) Pages: 285-288
  • Peer Reviewed
• [Journal Article] Non-Denaturing Solubilization of Inclusion Bodies. (2010)
  • Author(s): Tsumoto K, Abe R, Ejima D, Arakawa T.Non-Denaturing Solubilization of Inclusion Bodies.
  • Journal Title: Curr Pharm Biotechnol. Volume: 11(3) Pages: 309-310
  • Peer Reviewed
• [Journal Article] Solubilization of Membrane Proteins with Novel N-Acylamino Acid Detergents. (2010)
  • Author(s): Ryota Abe, Jose M.M.Caaveiro, Motonori Kudou, Kouhei Tsumoto
  • Journal Title: Mol.BioSyst. Volume: 6 Pages: 677-679
  • Peer Reviewed
• [Journal Article] Contribution of the flexible loop region to the function of Staphylococcal enterotoxin B (SEB) (2010)
  • Author(s): Yanaka S, Kudou M, Tanaka Y, Sasaki T, Takemoto S, Sakata A, Hattori Y, Koshi T, Futaki S, Tsumoto K, Nakashima T
  • Journal Title: Protein Eng.Des.Select. Volume: 23(5) Pages: 415-421
  • Peer Reviewed
• [Journal Article] Direct and Selective Immobilization of Proteins by Means of an Inorgan is Material-Binding Peptide : Discussion on Functionalization in the Elongation to Material-Binding Peptide. (2010)
  • Author(s): Yokoo N, Thgashi T, Umetsu M, Tsumoto K, Hattori T, Nakanishi T, Ohera S, Takami S, Naka T, Abe H, Kumagai I, Adschiri T.
  • Journal Title: J.Phys.Chem.B. Volume: 114(1) Pages: 480-486
  • Peer Reviewed
• [Journal Article] Signal peptide design for improving recombinant protein secretion in the baculovirus expression vector system (2010)
  • Author(s): Futatsumori-Sugai M, Tsumoto K
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 391(1) Pages: 931-935
  • Peer Reviewed
• [Journal Article] Contribution of asparagine residues to the stabilization of a proteinaceous antigen-antibody complex : HyHEL-10-HEL (2010)
  • Author(s): Yokota A., Tsumoto K., Shiroishi M., Nakanishi T., Kondo H., Kumagai I
  • Journal Title: J.Biol.Chem. Volume: 285 Pages: 7686-7696
  • Peer Reviewed
• [Journal Article] Screening of effective column rinse solvent for Protein-A chromatography. (2010)
  • Author(s): Yumioka R
  • Journal Title: Protein Exp.Purif. 70 Pages: 218-223
  • Peer Reviewed
• [Journal Article] Temperature and salt concentration alter base-sequence selectivity of a duplex DNA-binding protein. (2010)
  • Author(s): Nagatoishi S
  • Journal Title: Mol.Biosyst. 6 Pages: 98-101
  • Peer Reviewed
• [Journal Article] MEP HyperCel chromatography II : Binding, washing and elution. (2010)
  • Author(s): Arakawa T
  • Journal Title: Protein Expr Purif. 71 Pages: 168-173
  • Peer Reviewed
• [Journal Article] Antigen-antibody Binding (2010)
  • Author(s): Kumagai I., 津本浩平
  • Journal Title: Encyclopedia of Life Sciences (掲載確定, 印刷中)
  • Peer Reviewed
• [Journal Article] Contribution of asparagine residues to the stabilization of a proteinaceous antigen-antibody complex : HyHEL-10-HEL (2010)
  • Author(s): Yokota A.
  • Journal Title: J.Biol.Chem. 285 Pages: 7686-7696
  • Peer Reviewed
• [Journal Article] Signal peptide design for improving recombinant protein secretion in the baculovirus expression vector system (2010)
  • Author(s): Futatsumori-Sugai M
  • Journal Title: Biochem.Biophys.Res.Commun. 391 Pages: 931-935
  • Peer Reviewed
• [Journal Article] Direct and Selective Immobilization of Proteins by Means of an Inorganic Material-Binding Peptide : (2010)
  • Author(s): Yokoo N
  • Journal Title: J.Phys.Chem.B. 114 Pages: 480-486
  • Peer Reviewed
• [Journal Article] Contribution of the flexible loop region to the function of Staphylococcal enterotoxin B(SEB) (2010)
  • Author(s): Yanaka S
  • Journal Title: Protein Eng.Des.Select. (掲載確定, 印刷中)
  • Peer Reviewed
• [Journal Article] Solubilization of Membrane Proteins with Novel N-Acylamino Acid Detergents. (2010)
  • Author(s): Abe R
  • Journal Title: Mol.BioSyst. 6 Pages: 677-679
  • Peer Reviewed
• [Journal Article] Non-Denaturing Solubilization of Inclusion Bodies. (2010)
  • Author(s): 津本浩平
  • Journal Title: Curr Pharm Biotechnol. (掲載確定, 印刷中)
  • Peer Reviewed
• [Journal Article] Step-Wise Refolding of Recombinant Proteins. (2010)
  • Author(s): 津本浩平
  • Journal Title: Curr Pharm Biotechnol. (掲載確定, 印刷中)
  • Peer Reviewed
• [Journal Article] Reactive oxygen species induced by Streptococcus pyogenes invasion trigger apoptotic cell death in infected epithelial cells. (2010)
  • Author(s): Aikawa C
  • Journal Title: Cell Microbiol. (掲載確定, 印刷中)
  • Peer Reviewed
• [Journal Article] Contributions of interfacial residues of human Interleukin15 to the specificity and affinity for its private alpha-receptor (2009)
  • Author(s): Sakamoto S, Jose M. M. Caaveiro, Sano E, Tanaka Y, Kudou M and Tsumoto K
  • Journal Title: J. Mol. Biol Volume: 389 Issue: 5 Pages: 880-894
  • DOI: 10.1016/j.jmb.2009.04.050
• [Journal Article] To be excluded or to bind, that is the question : Arginine effects on proteins (2009)
  • Author(s): Nakakido M, Kudou M, Arakawa T, and Tsumoto K
  • Journal Title: Curr. Pharm. Biotechnol Volume: 10 Pages: 415-420
  • URL: http://www.benthamdirect.org/pages/content.php?CPB/2009/00000010/00000004/0010G.SGM
• [Journal Article] Immobilized metal affinity chromatography in the presence of arginine (2009)
  • Author(s): Abe R, Kudou M, Tanaka Y, Arakawa T and Tsumoto K
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 381 Issue: 3 Pages: 306-310
  • DOI: 10.1016/j.bbrc.2009.01.054
• [Journal Article] Utilization of an arginine-elution method for FLAG-tag chromatography (2009)
  • Author(s): Futatsumori-Sugai M, Abe R, Watanabe M, Kudou M, Yamamoto T, Ejima D, Arakawa T, and Tsumoto K
  • Journal Title: Protein Expr Purif Volume: 67 Issue: 2 Pages: 148-155
  • DOI: 10.1016/j.pep.2009.03.012
• [Journal Article] Molecular Glues Carrying Multiple Guanidinium Ion Pendants via an Oligoether Spacer : Stabilization of Microtubules against Depolymerization. (2009)
  • Author(s): Okuro K.
  • Journal Title: J.Am.Chem.Soc. 131 Pages: 1626-1627
  • Peer Reviewed
• [Journal Article] Immobilized metal affinity chromatography in the presence of arginine. (2009)
  • Author(s): Abe R
  • Journal Title: Biochem.Biophys.Res.Commun. 381 Pages: 306-310
  • Peer Reviewed
• [Journal Article] Contributions of interfacial residues of human Interleukin15 to the specificity and affinity for its private alpha-receptor. (2009)
  • Author(s): Sakamoto S
  • Journal Title: J.Mol.Biol. 389 Pages: 880-894
  • Peer Reviewed
• [Journal Article] Impact of intrinsic cooperative thermodynamics of peptide-MHC complexes on antiviral activity of HIV-specific cytotoxic T lymphocytes (2009)
  • Author(s): Motozono C
  • Journal Title: J.Immunol. 182 Pages: 5528-5536
  • Peer Reviewed
• [Journal Article] The interaction of hyperthermophilic TATA-box binding protein with single-stranded DNA is entropically favorable and exhibits a large negative heat capacity change at high salt concentration. (2009)
  • Author(s): Nagatoishi S
  • Journal Title: Mol.BioSyst. 5 Pages: 957-961
  • Peer Reviewed
• [Journal Article] Utilization of an arginine-elution method for FLAG-tag chromatography (2009)
  • Author(s): Futatsumori-Sugai M
  • Journal Title: Protein Expr Purif. 67 Pages: 148-155
  • Peer Reviewed
• [Journal Article] To be excluded or to bind, that is the question : Arginine effects on proteins (2009)
  • Author(s): Nakakido M
  • Journal Title: Curr.Pharm.Biotechnol. 10 Pages: 415-420
  • Peer Reviewed
• [Journal Article] Observation of the membrane-binding activity and domain structure of gpV, which comprises the tail spike of bacteriophage P2. (2009)
  • Author(s): Kageyama Y
  • Journal Title: Biochemistry 48 Pages: 10129-10135
  • Peer Reviewed
• [Journal Article] Manipulation of protein-complex function by using an engineered heterotrimeric coiled-coil switch. (2009)
  • Author(s): Mizuno T
  • Journal Title: Org.Biomol.Chem. 7 Pages: 3102-3111
  • Peer Reviewed
• [Journal Article] アルギニンによる蛋白質ハンドリング (2009)
  • Author(s): 工藤基徳
  • Journal Title: ペプチドニュースレター 72 Pages: 9-11
  • Peer Reviewed
• [Journal Article] 抗体による環状ポリエーテル系毒素シガトキシンの認識と識別 (2009)
  • Author(s): 宇井美穂子
  • Journal Title: 蛋白質核酸酵素 54 Pages: 1182-1189
• [Journal Article] 抗原抗体相互作用の熱力学的解析:特異性と親和性 (2009)
  • Author(s): 津本浩平
  • Journal Title: 熱測定 36 Pages: 205-215
  • NAID: 10025613091
• [Journal Article] 相互作用の熱力学情報に基づく低分子リガンド設計 (2009)
  • Author(s): 津本浩平
  • Journal Title: 薬学雑誌 (掲載確定, 印刷中)
  • NAID: 130000136119
• [Presentation] Tob1-CNOT7間相互作用阻害剤の合理的探索 (2012)
  • Author(s): 田代晋也, 他
  • Organizer: 日本化学会第92春季年会
  • Place of Presentation: 慶応義塾大学日吉キャンパス
• [Presentation] 還元環境下で自発的な共有結合形成により重合する蛋白質の開発 (2012)
  • Author(s): 松長遼, 他
  • Organizer: 日本化学会第92春季年会
  • Place of Presentation: 慶応義塾大学日吉キャンパス
• [Presentation] プレターゲティング法を用いた薬剤輸送のためのコアストレプトアビジン融合抗体 (2012)
  • Author(s): 湯村恭平, 他
  • Organizer: 日本化学会第92春季年会
  • Place of Presentation: 慶応義塾大学日吉キャンパス
• [Presentation] Affinity improvement of an engineered scFv antibody through rational design (2012)
  • Author(s): 木吉真人, 他
  • Organizer: 日本-インド医学シンポジウム
  • Place of Presentation: 東京女子医科大学
• [Presentation] Affinity improvement of an engineered scFv antibody through rational design (2012)
  • Author(s): 木吉真人, 他
  • Organizer: 日本化学会第92春季年会
  • Place of Presentation: 慶応義塾大学日吉キャンパス
• [Presentation] Structure-based analysis reveals hydration changes of Lysozyme and Glucose isomerase induced by Arginine hydrochloride (2012)
  • Author(s): 中木戸誠, 他
  • Organizer: 日本-インド医学シンポジウム
  • Place of Presentation: 東京女子医科大学
• [Presentation] Tob1-CNOT7間相互作用阻害剤の合理的探索 (2012)
  • Author(s): 田代晋也, 他
  • Organizer: 日本化学会第92回春季年会
  • Place of Presentation: 慶應義塾大学日吉キャンパス
• [Presentation] 悪性神経膠腫に対するテモゾロミドとインターフェロンベークによる相乗効果 (2011)
  • Author(s): 吉野篤緒, 他
  • Organizer: 第70回日本脳神経外科学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-10-13
• [Presentation] Thermodynamic Analyses of Binding and Transfer of Heme : Isd System (2011)
  • Author(s): Tsumoto K, Caaveiro J. M. M., Abe R, Moriwaki Y, Vu N, Watanabe M, Tanaka Y
  • Organizer: 14th Asian Chemical Congress 2011(14ACC)
• [Presentation] Structural and functional analysis of Capsular polysaccharide synthesizing enzyme CapF from Staphylococcus aureus (2011)
  • Author(s): Miyafusa T, Tanaka Y, Caaveiro J. M. M., Kuroda M, Yao M, Ohta T, Tanaka I, Tsumoto K
  • Organizer: The IXth European Symposium of The Protein Society
  • Place of Presentation: Stockholm-Stockholm University, Aula Magna
• [Presentation] Targeted glycosylation of "non-core region" of Interleukin 11 modulates its biological function (2011)
  • Author(s): Yanaka S, Sano E, Naruse N, Caaveiro J. M. M., Tsumoto K
  • Organizer: Immunology 2011
  • Place of Presentation: Moscone Center(San Francisco・USA)
• [Presentation] Advancing Fragment-Based Drug Discovery with Efficient Use of Thermodynamic and Kinetic Analysis (2011)
  • Author(s): 岡本未央, 他
  • Organizer: The 2011 Joint Conference of CBI & JSB
  • Place of Presentation: 神戸国際会議場
• [Presentation] Analysis of iron and other metalloporphyrins recognition and transport mechanism among IsdH, IsdA, IsdC from Staphylococcus aureus (2011)
  • Author(s): 森脇由隆, 他
  • Organizer: The 49^<th> Annual Meeting of the Biophysical Society of Japan
  • Place of Presentation: 兵庫県立大学姫路書写キャンパス
• [Presentation] Nanodiscを用いたABCトランスポーターMsbAのATPとの相互作用解析 (2011)
  • Author(s): 河合武揚, 他
  • Organizer: 第26回生体機能関連化学シンポジウム
  • Place of Presentation: つくば国際会議場
• [Presentation] アミノ酸界面活性剤による膜蛋白質の可溶化 (2011)
  • Author(s): 安部良太, 他
  • Organizer: 第26回生体機能関連化学シンポジウム
  • Place of Presentation: つくば国際会議場
• [Presentation] 黄色ブドウ球菌由来ヘム鉄取り込み蛋白質のヘム輸送機能解析 (2011)
  • Author(s): 安部良太, 他
  • Organizer: 第11回日本蛋白質科学会年会
  • Place of Presentation: ホテル阪急エキスポパーク
• [Presentation] Structural and functional analysis of Capsular polysaccharide synthesizing enzyme CapF from Staphylococcus aureus (2011)
  • Author(s): 宮房孝光, 他
  • Organizer: The IXth European Symposium of The Protein Society
  • Place of Presentation: Stockholm University(ストックホルム、スウェーデン)
• [Presentation] 化膿レンサ球菌由来ヒアルロン酸分解酵素の物理化学的解析 (2011)
  • Author(s): 宮房孝光, 他
  • Organizer: 第11回日本蛋白質科学会年会
  • Place of Presentation: ホテル阪急エキスポパーク
• [Presentation] 黄色ブドウ球菌由来莢膜合成酵素CapE、CapF間相互作用による活性制御機構の解明 (2011)
  • Author(s): 宮房孝光, 他
  • Organizer: 第26回生体機能関連化学シンポジウム
  • Place of Presentation: つくば国際会議場
• [Presentation] Structural and functional analysis of bifunctional enzyme CapF (2011)
  • Author(s): 宮房孝光, 他
  • Organizer: The 2011 Joint Conference of CBI & JSB
  • Place of Presentation: 神戸国際会議場
• [Presentation] Targeted glycosylation of "non-core region" of Interleukin 11 modulates its biological function (2011)
  • Author(s): 谷中冴子, 他
  • Organizer: Immunology 2011
  • Place of Presentation: Moscone Center (San FranCisco, U.S.A.)
• [Presentation] ヒト主要組織適合複合体(HLA)の揺らぎが傷害性T細胞(CTL)に与える影響について (2011)
  • Author(s): 谷中冴子, 他
  • Organizer: 第11回日本蛋白質科学会年会
  • Place of Presentation: ホテル阪急エキスポパーク
• [Presentation] Protein-Ligand Interactions in the Hydrophobic Pocket of an Enzyme Studied with a Fragment Library (2011)
  • Author(s): 河邉昭博, 他
  • Organizer: The 2011 Joint Conference of CBI & JSB
  • Place of Presentation: 神戸国際会議場
• [Presentation] ケトステロイド異性化酵素の親和性・特異性創出機構精密解析 (2011)
  • Author(s): 河邉昭博, 他
  • Organizer: 第26回生体機能関連化学シンポジウム
  • Place of Presentation: つくば国際会議場
• [Presentation] 親和性向上を目指したscFv抗体の合理的改変 (2011)
  • Author(s): 三浦恵梨, 他
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 化膿連鎖球菌由来ヘム取り込み関連蛋白質Shrの機能解析 (2011)
  • Author(s): 下村拓矢, 他
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 大腸菌由来ガラクトース異性化酵素の基質認識における芳香環の役割 (2011)
  • Author(s): 工藤翔太, 他
  • Organizer: 第5回バイオ関連化学シンポジウム
  • Place of Presentation: つくば国際会議場
• [Presentation] 大腸菌由来ガラクトース異性化酵素の基質認識におけるTyr284の役割 (2011)
  • Author(s): 工藤翔太, 他
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館
• [Presentation] 放射線免疫療法を指向した抗P-cadherin抗体の物理化学的解析 (2011)
  • Author(s): 工藤翔太, 他
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 膠芽腫に対するテモゾロミドとIFN-betaの相乗効果 (2011)
  • Author(s): 吉野篤緒, 他
  • Organizer: 第29回日本脳腫瘍学会学術集会
  • Place of Presentation: 下呂温泉「水明館」岐阜県
• [Presentation] Design and preparation of core-streptavidin-fusion antibody for pretargeting drug delivery (2011)
  • Author(s): 湯村恭平, 他
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 黄色ブドウ球菌細胞表面蛋白質EbpSの機能解析 (2011)
  • Author(s): 中木戸誠, 他
  • Organizer: 第11回日本蛋白質科学会年会
  • Place of Presentation: ホテル阪急エキスポパーク
• [Presentation] 黄色ブドウ球菌細胞表面蛋白質EbpSの機能解析 (2011)
  • Author(s): 中木戸誠, 他
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館
• [Presentation] Structural analysis of fragaceatoxin C, a pore-forming toxin (2011)
  • Author(s): 田中耕路, 他
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
• [Presentation] プレターゲティング法によるドラッグデリバリーを目指したコアストレプトアビジン融合抗体の構築 (2011)
  • Author(s): 湯村恭平, 他
  • Organizer: 日本化学会第91春季年会(2011)
  • Place of Presentation: 神奈川大学横浜キャンパス
• [Presentation] Nanodiscを用いたABCトランスポーターMsbAの機能解析 (2011)
  • Author(s): 河合武揚, 他
  • Organizer: 本化学会第91春季年会(2011)
  • Place of Presentation: 神奈川大学横浜キャンパス
• [Presentation] 黄色ブドウ球菌由来鉄取り込み蛋白質群IsdH, IsdA, IsdCと種々の金属ポルフィリン認識機構解析 (2011)
  • Author(s): 森脇由隆, 他
  • Organizer: 日本化学会第91春季年会(2011)
  • Place of Presentation: 神奈川大学横浜キャンパス
• [Presentation] Structural and functional analysis of capsular polysaccharide synthesizing enzyme CapF (2010)
  • Author(s): T. Miyafusa ; Y. Tanaka ; J. Martinez Caaveiro ; M. Kuroda ; M. Yao ; T. Ohta ; I. Tanaka ; K. Tsumoto
  • Organizer: 2010環太平洋国際化学会
  • Place of Presentation: ハワイコンベンションセンター
• [Presentation] Hawaii Convention Centor Solubilization of Membrane Proteins with Novel N-Acylamino Acid Detergents (2010)
  • Author(s): 安部良太・ホセマルチネスカアベイロ・津本浩平
  • Organizer: Pacific Chem 2010
  • Place of Presentation: 米国ハワイ州
• [Presentation] Aromatic Interactions are Essential for Carbohydrate Recognition by an Enzyme (2010)
  • Author(s): Caaveiro, J. M. M., Kobe, A., Clifton, J. G., Ringe, D., Petsko, G. A. and Tsumoto, K
  • Organizer: DiPiA2010
  • Place of Presentation: Skipper Hotel. Barcelona,スペイン
• [Presentation] プレターゲティング法による薬物輸送を指向したコアストレプトアビジン融合抗体の構築 (2010)
  • Author(s): 湯村恭平, 他
  • Organizer: 第4回バイオ関連化学シンポジウム
  • Place of Presentation: 大阪大学豊中キャンパス
• [Presentation] プレターゲティングドラッグデリバリーを目指したコアストレプトアビジン融合抗体 (2010)
  • Author(s): 湯村恭平, 他
  • Organizer: BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] Nanodiscを用いたABCトランスポーターのATPとの結合の解析 (2010)
  • Author(s): 河合武揚, 他
  • Organizer: 第4回バイオ関連化学シンポジウム
  • Place of Presentation: 大阪大学豊中キャンパス
• [Presentation] Nanodiscを用いたABCトランスポーターの機能解析 (2010)
  • Author(s): 河合武揚, 他
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] 黄色ブドウ球菌由来莢膜合成酵素CapFのRmlc様ドメインの機能解析 (2010)
  • Author(s): 宮房孝光, 他
  • Organizer: 第10回日本蛋白質科学会
  • Place of Presentation: 札幌コンベンションセンター
• [Presentation] Structural and functional analysis of capsular polysaccharide synthesizing enzyme CapF. (2010)
  • Author(s): T.Miyafusa, 他
  • Organizer: 2010環平洋国際化学会
  • Place of Presentation: ハワイコンベンションセンターアメリカ、ハワイ
• [Presentation] Expression and in vitro characterization of anti-Epiregulin scFv-Fc (2010)
  • Author(s): 田代晋也, 他
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] Protein Carbohydrate Interaction in the Active site of Galactose Mutarotase (2010)
  • Author(s): Caaveiro, J.M.M., 他
  • Organizer: 25 International Carbohydrate Conference
  • Place of Presentation: Makuhari Messe千葉市
• [Presentation] Aromatic Interactions are Essential for Carbohydrate Recognition by an Enzyme (2010)
  • Author(s): Caaveiro, J.M.M., 他
  • Organizer: DiPiA (Developments in Protein Interaction Analysis 2010)
  • Place of Presentation: Skipper Hotel. Barcelona, スペイン
• [Presentation] Aromatic Interactions are Essential for the Binding of Galactose to a Sugar Processing Enzyme (2010)
  • Author(s): Caaveiro, J.M.M., 他
  • Organizer: 2010 International Chemical Congress of Pacific Basin Societies
  • Place of Presentation: Hawaii Convention Center, Honolulu, ハワイ,アメリカ
• [Presentation] 生体内・生体外の実験系を用いた黄色ブドウ球菌膜表面由来天然変性蛋白質EbpSの機能解析 (2010)
  • Author(s): 中木戸誠, 他
  • Organizer: 第10回日本蛋白質科学会年会
  • Place of Presentation: 札幌コンベンションセンター
• [Presentation] The effect of structural dynamics of the Human Leucocyte Antigen on the function of cytotoxic T Lymphocyte (2010)
  • Author(s): 谷中冴子, 他
  • Organizer: 第48回日本生物物理学会
  • Place of Presentation: 東北大学川内キャンパス
• [Presentation] ヒト主要組織適合複合体の動的構造と傷害性T細胞の活性の関連について (2010)
  • Author(s): 谷中冴子, 他
  • Organizer: 第10回日本蛋白質科学会年会
  • Place of Presentation: 北海道コンベンションセンター
• [Presentation] 黄色ブドウ球菌由来鉄取り込み蛋白質IsdH-金属ポルフィリン間相互作用解析 (2010)
  • Author(s): 森脇由隆, 他
  • Organizer: 第10回日本蛋白質科学会年会
  • Place of Presentation: 札幌コンベンションセンター
• [Presentation] 黄色ブドウ球菌由来鉄取り込み蛋白質IsdH-NEAT3と金属ポルフィリン間相互作用解析 (2010)
  • Author(s): 森脇由隆, 他
  • Organizer: 第4回バイオ関連化学シンポジウム
  • Place of Presentation: 大阪大学豊中ぎヤンパス
• [Presentation] 黄色ブドウ球菌由来鉄取り込み蛋白質IsdH-NEAT3、IsdAと金属ポルフィリン間相互作用解析 (2010)
  • Author(s): 森脇由隆, 他
  • Organizer: BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] レンサ球菌由来線毛構成蛋白質のin vitro重合 (2010)
  • Author(s): 松長遼, 他
  • Organizer: 第10回日本蛋白質科学会年会
  • Place of Presentation: 札幌コンベンションセンター
• [Presentation] CH/II相互作用が決定する特異性:ガラクトース異性化酵素の構造・機能解析 (2010)
  • Author(s): 河邉昭博, 他
  • Organizer: 第25回生体機能関連化学シンポジウム
  • Place of Presentation: 大阪大学豊中キャンパス
• [Presentation] Transmission electron microscopy and thermal analysis of the trichocyte intermediate filament assembly in vitro. (2010)
  • Author(s): 安部良太, 他
  • Organizer: Gordon Research Conference -Intermediate Filament-
  • Place of Presentation: Tilton School, ティルトン,アメリカ
• [Presentation] Solubilization of Membrane Proteins with Novel N-Acylamino Acid Detergents (2010)
  • Author(s): 安部良太, 他
  • Organizer: Pacific Chem 2010
  • Place of Presentation: Hawaii Convention Centorハワイ,アメリカ
• [Presentation] Three Hot-Spot Regions Define the High Affinity of Human Interleukin 15 for its Private alpha-Receptor (2009)
  • Author(s): Caaveiro, J. M. M., Sakamoto, S., Sano, E., Kudou, M. and Tsumoto, K
  • Organizer: The 23rd Symposium of the Protein Society
  • Place of Presentation: Boston, Massachusetts, USA
• [Presentation] 黄色ブドウ球菌膜表面由来機能未知蛋白質EbpSの機能解析 (2009)
  • Author(s): 中木戸誠
  • Organizer: 第9回 日本蛋白質科学会年会
  • Place of Presentation: 熊本全日空ホテルニュースカイ
• [Presentation] HLA-HIV由来抗原ペプチド複合体の熱安定性と抗原性 (2009)
  • Author(s): 谷中冴子
  • Organizer: 第9回 日本蛋白質科学会年会
  • Place of Presentation: 熊本全日空ホテルニュースカイ
• [Presentation] 創薬開発を目指したインターロイキン11改変体の物性解析 (2009)
  • Author(s): 谷中冴子
  • Organizer: 第74回 日本インターフェロン・サイトカイン学会
  • Place of Presentation: 芝覧会館(京都大学)
• [Presentation] Structure-based analysis reveals hydration changes of Lysozyme and Glucose isomerase induced by Arginine hydrochloride (2009)
  • Author(s): 中木戸誠
  • Organizer: Protein Society 23^<rd> annual symposium
  • Place of Presentation: Boston Marriott Copley Place
• [Presentation] Structural Basis for Multimeric Heme Complexation through a Specific Protein-Heme Interaction (2009)
  • Author(s): Masato Watanabe
  • Organizer: Protein Society 23^<rd> annual symposium
  • Place of Presentation: Boston Marriott Copley Place
• [Presentation] Characterization of Interleukin 11 agonist & antagonist (2009)
  • Author(s): 谷中冴子
  • Organizer: Protein Society 23^<rd> annual symposium
  • Place of Presentation: Boston Marriott Copley Place
• [Presentation] Three Hot-Spot Regions Define the High Affinity of Human Interleukin 15 for its Private alpha-Receptor (2009)
  • Author(s): Caaveiro, J.M.M.
  • Organizer: Protein Society 23^<rd> annual symposium
  • Place of Presentation: Boston Marriott Copley Place
• [Presentation] 黄色ブドウ球菌膜表面由来天然変性蛋白質EbpSの物性解析 (2009)
  • Author(s): 中木戸誠
  • Organizer: 第24回 生体機能関連化学シンポジウム
  • Place of Presentation: 九州大学医系キャンパス・百年記念講堂
• [Presentation] 化膿レンサ球菌由来ヒアルロン酸分解酵素群の構造特性評価 (2009)
  • Author(s): 宮房孝光
  • Organizer: 第24回 生体機能関連化学シンポジウム
  • Place of Presentation: 九州大学医系キャンパス・百年記念講堂
• [Presentation] 黄色ブドウ球菌由来膜表面蛋白質EbpSの物性・機能解析 (2009)
  • Author(s): 中木戸誠
  • Organizer: 第82回 日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] 構造情報を基盤とした黄色ブドウ球菌由来莢膜合成蛋白質の機能解析 (2009)
  • Author(s): 宮房孝光
  • Organizer: 第82回 日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] 高機能化IL11改変体の特性解析 (2009)
  • Author(s): 谷中冴子
  • Organizer: 第82回 日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] 黄色ブドウ球菌由来鉄取り込み蛋白質におけるヘム輸送機構解析 (2009)
  • Author(s): 安部良太
  • Organizer: 第82回 日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] ヒト主要組織適合複合体の安定性が細胞障害性T細胞活性に及ぼす影響 (2009)
  • Author(s): 谷中冴子
  • Organizer: 第47回 日本生物物理学会年会
  • Place of Presentation: 徳島文理大学
• [Book] 生化学事典「クロマトグラフィー」「界面活性剤」 (2012)
  • Author(s): 中木戸誠、津本浩平
  • Publisher: 朝倉書店(印刷中)
• [Book] BIOINDUSTRY (2011)
  • Author(s): 津本浩平
• [Book] 生物工学 (2011)
  • Author(s): 津本浩平
• [Book] 遺伝子工学 (2011)
  • Author(s): 津本浩平
  • Publisher: 化学同人
• [Book] Amino Acids, Peptides and Proteins in Organic Chemistry Volume 5-Analysis and Function of Amino Acids and Peptides (2011)
  • Author(s): Satoshi Ohtake, Yoshiko Kita, Kouhei Tsumoto, Tsutomu Arakawa
  • Publisher: Wiley
• [Book] 生化学事典 (2011)
  • Author(s): 中木戸誠、津本浩平
  • Publisher: 朝倉書店
• [Book] 抗体の安定性向上技術 (2011)
  • Author(s): 津本浩平
  • Publisher: BIOINDUSTRY
• [Book] タンパク質相互作用解析:等温滴定型熱量測定と表面プラズモン共鳴 (2011)
  • Author(s): 津本浩平
  • Publisher: 生物工学
• [Book] Encyclopedia of Life Sciences (2010)
  • Author(s): Kumagai I. and Tsumoto K.
• [Book] 抗体会合体の定量的評価の課題抗体医薬のための細胞構築と培養技術 (2010)
  • Author(s): 津本浩平、江島大輔、荒川力
• [Book] 酵素利用技術大系 (2010)
  • Author(s): 津本浩平
• [Book] ファインケミカルシリーズ抗体医薬のための細胞構築と培養技術 (2010)
  • Author(s): 津本浩平、江島大輔、荒川力
  • Publisher: シーエムシー出版
• [Book] 酵素:一般論「酵素利用技術大系」 (2010)
  • Author(s): 津本浩平
  • Publisher: 株式会社エヌ・ティーエス
• [Book] リフォールディング「酵素利用技術大系」 (2010)
  • Author(s): 工藤基徳、津本浩平
  • Publisher: 株式会社エヌ・ティーエス
• [Book] 抗原抗体相互作用の熱力学的制御生体機能関連化学部会ニュースレター (2010)
  • Author(s): 津本浩平
  • Publisher: 社団法人日本化学会
• [Book] 酵素利用技術体系 (2010)
  • Author(s): 小宮山眞監修
  • Total Pages: 1500
  • Publisher: エヌティーエス
• [Book] 薬学雑誌 (2009)
  • Author(s): 津本浩平、宇井美穂子
• [Book] 熱測定 (2009)
  • Author(s): 津本浩平、宇井美穂子
• [Remarks]
  • URL: http://park.itc.u-tokyo.ac.jp/phys-biochem
• [Remarks]
  • URL: http://park.itc.u-tokyo.ac.jp/phys-biochem
• [Remarks]
  • URL: http://park.itc.u-tokyo.ac.jp/phys-biochem
• [Remarks]
  • URL: http://park.itc.u-tokyo.ac.jp/phys-biochem
• [Patent(Industrial Property Rights)] 抗体改変による疾患部位特異的な診断薬・治療薬の集積法 (2009)
  • Inventor(s): 浜窪隆雄、津本浩平, 他
  • Industrial Property Rights Holder: 東大TLO
  • Filing Date: 2009-04-09
• [Patent(Industrial Property Rights)] 抗体改変による疾患部位特異的な診断薬・治療薬の集積法 (2009)
  • Inventor(s): 浜窪隆雄、津本浩平, 他
  • Industrial Property Rights Holder: 東大TLO
  • Filing Date: 2009-04-09
  • Overseas