| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2009: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
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| Research Abstract |
Functional and physicochemical properties of intrinsically unfolded proteins have been focused. The novel interaction and self-assembly mechanisms have successfully described, based on several physicochemical, structural, and functional analyses. A novel system for handling proteins has been constructed, based on the chemical chaperone-like mechanism of an amino acid and derivatives. For a functionally unknown protein, we elucidated the function from cell-based analyses. A novel target has been used for construction of artificial regulation system of self-assembly process in vitro, showing the potential of proteins used as a tool of a bottom-up process in nano-biotechnology.
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