| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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| Research Abstract |
Using a gene expression database of mesenchymal stem cells and various cells differentiated from them, we have invented two informatics methods to select candidates of cell differentiation induction factors. In one method we have shown that there are two out of top five candidates actually promote the adipocyte differentiation. In another method we have shown that we use only a few hundreds known data out of about 20, 000 human genes and predict cell differentiation factors with high accuracy. Furthermore, we have established an experimental method to use proteins as combinatorial induction system of multiple factors.
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