Selfish DNases at a diverging point to survival, death and evolution
Project/Area Number |
21370001
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Genetics/Genome dynamics
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Research Institution | The University of Tokyo |
Principal Investigator |
KOBAYASHI Ichizo 東京大学, 大学院・新領域創成科学研究科, 教授 (30126057)
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Co-Investigator(Renkei-kenkyūsha) |
HANDA Naofumi 東京大学, 大学院・新領域創成科学研究科, 特任助教 (00396855)
TAKAHASHI Noriko 東京大学, 大学院・新領域創成科学研究科, 特任助教 (70466829)
MIKIHIKO Kawai 東京大学, 大学院・新領域創成科学研究科, 特任研究員 (80451904)
FURUTA Yoshikazu 東京大学, 大学院・新領域創成科学研究科, 特任助教 (40613667)
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Research Collaborator |
UCHIYAMA Ikuo 基礎生物学研究所, ゲノム情報研究室, 助教 (90243089)
JANUSZ Bujnicki IIMCB, Poland
KOJI Yahara 学振, 特別研究員(PD)
MASAKI Fukuyo 学振, 特別研究員(PD)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2009: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
|
Keywords | ゲノム構築 / ゲノム再編 / ゲノム維持 / ゲノム進化 |
Research Abstract |
Our experimental analyses and genome comparisons revealed how DNAases distinguishing self and non-self genome acted on genomes and drove their evolution.1. We revealed role of antisense RNA in their gene regulation and life cycle.2. We showed several restriction enzymes cleave a DNA replication fork.3. With restriction enzyme attacking the chromosome, we demonstrated success of suicidal defense strategy against infection.4. Genome comparison of H. pylori revealed novel mechanisms of genome rearrangements and suggested that restriction modification systems frequently switch their recognition sequence.
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Report
(4 results)
Research Products
(181 results)
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[Presentation] Why do we die from infection?2012
Author(s)
M Fukuyo, A Sasaki, I Kobayashi
Organizer
SESJ2012 (進化学会第14回大会), Symposium 3: Experimental evolution and conflicts
Place of Presentation
Tokyo Metropolitan University, Tokyo
Year and Date
2012-08-23
Related Report
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[Presentation] 遺伝子内ドメイン移動2011
Author(s)
古田芳一、河合幹彦、内山郁夫、小林一三
Organizer
日本遺伝学会第83回大会
Place of Presentation
京都大学、京都
Year and Date
2011-09-21
Related Report
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[Presentation] 遺伝子内ドメイン移動2011
Author(s)
古田芳一、河合幹彦、内山郁夫、小林一三
Organizer
日本遺伝学会第83回大会、2B-06
Place of Presentation
京都市京都大学
Year and Date
2011-09-21
Related Report
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[Presentation] Novel genome rearrangement mechanisms detected by Helicobacter pylori genome comparison2011
Author(s)
Y Furuta, M Kawai, K Yahara, T Tsuru, N Takahashi, N Handa, K Oshiaa, M Hat tori, M Yoshida, T Azuma, I Uchiyama, I Kobayashi
Organizer
International Union of Microbiological Societies 2011 Congress (IUMS2011)
Place of Presentation
Sapporo Convention Center, Sapporo, Japan
Year and Date
2011-09-09
Related Report
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[Presentation] Novel genome rearrangement mechanisms detected by Helicobacter pylorigenome comparison2011
Author(s)
Yoshikazu Furuta, Mikihiko Kawai, Koji Yahara, Takeshi Tsuru, Noriko Takahashi, Naofumi Handa, Kenshiro Oshima, Masahira Hattori, Masaru Yoshida, Takeshi Azuma, Ikuo Uchiyama, Ichizo Kobayashi
Organizer
International Union of Microbiological Societies 2011 Congress, BR30-3
Place of Presentation
Sapporo Convention Center, Sapporo
Year and Date
2011-09-09
Related Report
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[Presentation] Evolutionary Genome Engineering2011
Author(s)
Yoko Asakura, Hiroyuki Kojima, Ichizo Kobayashi
Organizer
International Union of Microbiological Societies 2011 Congress
Place of Presentation
Sapporo Convention Center, Sapporo, Japan(招待講演)
Year and Date
2011-09-06
Related Report
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[Presentation] 遺伝子内ドメイン移動2011
Author(s)
古田芳一、河合幹彦、内山郁夫、小林一三
Organizer
日本進化学会第13回大会
Place of Presentation
京都大学、京都
Year and Date
2011-07-31
Related Report
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[Presentation] 遺伝子内ドメイン移動2011
Author(s)
古田芳一、河合幹彦、内山郁夫、小林一三
Organizer
日本進化学会第13回大会、O-E19
Place of Presentation
京都市京都大学
Year and Date
2011-07-31
Related Report
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[Presentation] DNA duplication associated with inversion (DDAI)and domain movement (DoMo) : two novel genome rearrangement mechanisms discovered through genome comparison2011
Author(s)
Yoshikazu Furuta, Mikihiko Kawai, Koji Yahara, Takeshi Tsuru, Noriko Takahashi, Naofumi Handa, Kenshiro Oshima, Masahira Hattori, Masaru Yoshida, Takeshi Azuma, Ikuo Uchiyama, Ichizo Kobayashi
Organizer
Annual Meeting of the Society for Molecular Biology and Evolution 2011 (SMBE2011)
Place of Presentation
Kyoto Univ., Kyoto(poster presentation)
Year and Date
2011-07-28
Related Report
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[Presentation] Genome dynamics and evolution.2011
Author(s)
Ichizo Kobayashi
Organizer
OIST Summer School on Quantitative Evolutionary and Comparative Genomics
Place of Presentation
OIST, Okinawa, Japan.(招待講演)
Year and Date
2011-05-28
Related Report
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[Presentation] 遺伝子内ドメイン移動2011
Author(s)
古田芳一、河合幹彦、内山郁夫、小林一三
Organizer
第5回日本ゲノム微生物学会年会
Place of Presentation
仙台市東北学院大学(口頭およびポスター発表)
Year and Date
2011-03-16
Related Report
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[Presentation] ゲノムDNAの逆位に伴った遺伝子の重複と崩壊2011
Author(s)
古田芳一*, 河合幹彦*, 矢原耕史, 高橋規子, 半田直史, 鶴剛史, 大島健志朗, 吉田優, 東健, 服部正平, 内山郁夫, 小林一三(*:equalcontribution)
Organizer
ゲノム微生物学会ワークショップ-ゲノムで繋がる微生物研究の新展開-
Place of Presentation
仙台市東北大学(ポスター発表)
Related Report
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[Presentation] H.pylori evolution : clues from Japanese isolates' genomesSelfish restriction systems switching on bacterial death program2010
Author(s)
Mikihiko Kawai, Koji Yahara, Yoshikazu Furuta, Takeshi Tsuru, Naofumi Handa, Noriko Takahashi, Kenshiro Oshima, Masaru Yoshida, Takeshi Azuma, Masahira Hattori, Ikuo Uchiyama, Ichizo Kobayashi
Organizer
Hannover Medical School
Place of Presentation
Hannover, Germany
Year and Date
2010-08-06
Related Report
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[Presentation] Complete genome sequences of multiple East Asian Helicobacter pylori strains reveals their co-evolution with human populations.2010
Author(s)
Ichizo Kobayashi, Mikihiko Kawai, Koji Yahara, Yoshikazu Furuta, Takeshi Tsuru, Naofumi Handa, Noriko Takahashi, Kenshiro Oshima, Masaru Yoshida, Takeshi Azuma, Masahira Hattori, Ikuo Uchiyama.
Organizer
The 10th Japan-Korea International Symposium on Microbiology
Place of Presentation
Yokohama, JAPAN(ポスター発表)
Year and Date
2010-03-26
Related Report
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[Presentation] Genome rearrangements revealed through comparison of four complete genomes of Japanese Helicobacter pylori2010
Author(s)
Yoshikazu Furuta, Mikihiko Kawai, Koji Yahara, Takeshi Tsuru, Noriko Takahashi, Naofumi Handa, Kenshiro Oshima, Masahira Hattori, Masaru Yoshida, Takeshi Azuma, Ikuo Uchiyama, Ichizo Kobayashi
Organizer
XXIIIrd International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer, W7.2
Place of Presentation
Rotterdam, The Netherlands
Related Report
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[Presentation] Comparison of four complete genomes of Japanese Helicobacter pylori : Genome rearrangements and genomic islands2010
Author(s)
Yoshikazu Furuta, Mikihiko Kawai, Koji Yahara, Takeshi Tsuru, Noriko Takahashi, Naofumi Handa, Kenshiro Oshima, Masahira Hattori, Masaru Yoshida, Takeshi Azuma, Ikuo Uchiyama, Ichizo Kobayashi
Organizer
Infectious Disease Genomics & Global Health 2010, 32
Place of Presentation
Hinxton, UK(ポスター発表)
Related Report
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[Presentation] East Asian Helicobacter pylori Genomes : Co-evolution with their Human Host.2009
Author(s)
Mikihiko Kawai, Koji Yahara, Yoshikazu Furuta, Takeshi Tsuru, Naofumi Handa, Noriko Takahashi, Kenshiro Oshima, Masaru Yoshida, Takeshi Azuma, Masahira Hattori, Ikuo Uchiyama, Ichizo Kobayashi
Organizer
Global COE Workshop on Bioinforxnatics in the Era of "Genome Information Big Bang"
Place of Presentation
Shenzhen, China
Related Report
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[Presentation] Complete genome sequences of multiple Japanese Helicobacter pylori strains : a progress report.2009
Author(s)
Ichizo Kobayashi, Mikihiko Kawai, Koji Yahara, Yoshikazu Furuta, Takeshi Tsuru, Naofumi Handa, Noriko Takahashi, Kenshiro Oshima, Masaru Yoshida, Takeshi Azuma, Masahira Hattori, Ikuo Uchiyama
Organizer
CHRO 2009 : 15th International Workshop on Campylobacter, Helicobacter and Related Organisms
Place of Presentation
Toki Messe, Niigata, Japan
Related Report
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[Presentation] Complete genome sequences of four Japanese H.pylori strains and their comparative analyses.2009
Author(s)
Ichizo Kobayashi, Mikihiko Kawai, Koji Yahara, Yoshikazu Furuta, Takeshi Tsuru, Naofumi Handa, Noriko Takahashi, Kenshiro Oshima, Masaru Yoshida, Takeshi Azuma, Masahira Hattori, Ikuo Uchiyama.
Organizer
Sapporo Cancer Seminar 2009 (SCS2009)
Place of Presentation
Sapporo(ポスター発表)
Related Report
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