Molecular Genetics of Sleep in Drosophila
| Project/Area Number |
21370003
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Keywords | ショウジョウバエ / 睡眠 / アデノシン受容体 / 行動解析 / サーカディアンリズム / ウルトラディアンリズム / 時計突然変異体 / ショウジョウバェ |
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| Research Abstract |
Sleep research is important for people in modern world as we are faced with many problems associated with good sleep and sleep disorders. Recent studies indicate that Drosophila can be used as an excellent model organism to study on sleep. We have developed an CCD camera-PC system to track movement of a single fly. We found that Drosophila have an endogenous ultradian oscillator, which is masked by circadian rhythmic behaviors. The pdf clock mutant shows robust and precise ultradian rhythm with period length about 55 minutes. The ultradian rhythm of pdf mutant flies was not temperature compensated. We also studied the neural mechanism of sleep regulation by caffeine to reveal the possible role of the adenosine receptor.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Identification of a novel gene, Anorexia, regulating feeding activity via insulin signaling in Drosophila melanogaster2011
Author(s)
Ryuda, M. Tsuzuki, S., Matsumoto, H., Oda, O., Tanimura T. and Hayakawa, Y.
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Journal Title
J. Biol. Chem
Volume: 286
Pages: 38417-38426
Related Report
Peer Reviewed
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[Journal Article] The clock gene cryptochrome of Bactrocera cucurbitae(Diptera : Tephritidae) in strains with different mating times2009
Author(s)
Fuchikawa, T., Sanada, S., Nishio, R., Matsumoto, A., Matsuyama, T., Yamagishi, M., Tomioka, K., Tanimura, T. and Miyatake T.
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Journal Title
Heredity
Volume: 104
Pages: 387-392
Related Report
Peer Reviewed
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