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Epidemics and evolution on the commuter network in metropolitan area

Research Project

Project/Area Number 21370009
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Ecology/Environment
Research InstitutionThe Graduate University for Advanced Studies

Principal Investigator

SASAKI Akira  総合研究大学院大学, 先導科学研究科, 教授 (90211937)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2009: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Keywords空間明示的疫学モデル / 交通流動ネットワーク / インフルエンザ / ウイルス強毒株変異 / 伝染病防除政策 / 口蹄疫 / 農場ベースモデル / 分岐過程 / 感染症 / ネットワーク / 交通流動調査 / ハブ / コンパートメントモデル / 空間情報 / 伝染病 / ネットワークトの感染動態 / 病原体の毒性 / 小さな世界 / 大都市交通センサス / 基本増殖率 / 空間構造 / 個体ベースモデル
Research Abstract

Epidemic dynamics of an infectious disease spreading over the commute network in Tokyo metropolitan area is analyzed using a simple mathematical model. The model is formulated based on the meta-population connected by commuter trains where each population is interconnected by commuter flows. Here, the actual data from the Urban Transportation Census(Japanese Ministry of Land, Infrastructure, Transport and Tourism) is used to simulate the movements of commuters. The effect of infectiousness of pathogen and the structure of commute network are investigated and the following results are obtained. The probability of global epidemic and the final size of global epidemic are mainly determined by the joint distribution of home and work population sizes, but is insensitive to the geographical or topological structure of the network.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (52 results)

All 2012 2011 2010 2009 Other

All Journal Article (25 results) (of which Peer Reviewed: 25 results) Presentation (19 results) Book (6 results) Remarks (2 results)

  • [Journal Article] Estimating the risk of re-emergence after stopping polio vaccination2012

    • Author(s)
      Sasaki, A., Haraguchi, Y., and Yoshida, H.
    • Journal Title

      Frontiers in Microbiology 3

      Volume: 178

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Success of a suicidal defense strategy against infection in a structured habitat2012

    • Author(s)
      Fukuyo, M., Sasaki, A., and Kobayashi, I.
    • Journal Title

      Scientific Reports 2

      Volume: 238

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Estimating the risk of re-emergence after stopping polio vaccination2012

    • Author(s)
      Sasaki, A., Haraguchi, Y., Yoshida, H.
    • Journal Title

      Frontiers in Virology

      Volume: 3(Article number:178) Pages: 178-178

    • DOI

      10.3389/fmicb.2012.00178

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Success of a suicidal defense strategy against infection in a structured habitat2012

    • Author(s)
      Masaki Fukuyo, Akira Sasaki, Ichizo Kobayashi
    • Journal Title

      Scientific Reports

      Volume: 2 Issue: 1 Pages: 238-238

    • DOI

      10.1038/srep00238

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Arms race between weevil rostrum length and camellia pericarp thickness : Geographical cline and theory2011

    • Author(s)
      Iseki, N., Sasaki, A., and Toju, H.
    • Journal Title

      Journal of Theoretical Biology

      Volume: 285 Pages: 1-9

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparing the effects of rapid evolution and phenotypic plasticity on predator-prey dynamics2011

    • Author(s)
      Yamamichi, M., Yoshida, T., and Sasaki, A.
    • Journal Title

      American Naturalist

      Volume: 178 Pages: 287-304

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Howdoes the resistance threshold in spatially explicit epidemic dynamics depend on the basic reproductive ratio and spatial correlation of cropgenotypes?2011

    • Author(s)
      Suzuki, S. U., and Sasaki, A.
    • Journal Title

      Journal of Theoretical Biology

      Volume: 276 Pages: 117-125

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oligomorphic dynamics for analyzing the quantitative genetics of adaptive speciation2011

    • Author(s)
      Sasaki, A., and Dieckmann, U.
    • Journal Title

      Journal of Mathematical Biology

      Volume: 63 Pages: 601-635

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A mathematical model of the intracellular replication and within host evolution of hepatitis type Bvirus : Understanding the long time course of the chronic hepatitis2011

    • Author(s)
      Nakabayashi, J., and Sasaki, A
    • Journal Title

      Journal of Theoretical Biology

      Volume: 269 Pages: 318-329

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] How does the resistance threshold in spatially explicit epidemic dynamics depend on the basic reproductive ratio and spatial correlation2011

    • Author(s)
      Suzuki, S.U., Sasaki, A.
    • Journal Title

      Journal of Theoretical Biology

      Volume: 276 Issue: 1 Pages: 117-125

    • DOI

      10.1016/j.jtbi.2011.02.002

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oligomorphic dynamics for analyzing the quantitative genetics of adaptive speciation2011

    • Author(s)
      Sasaki, A., Dieckmann, U.
    • Journal Title

      Journal of Mathematical Biology

      Volume: 63 Pages: 601-634

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparing the effects of rapid evolution and phenotypic plasticityon predator-prey dynamics2011

    • Author(s)
      Masato Yamamichi, TakehitoYoshida, Akira Sasaki
    • Journal Title

      American Naturalist

      Volume: 印刷中

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] How does the resistance threshold in spatially explicit epidemic dynamics depend on the basic reproductive ratio and spatial correlation of crop genotypes?2011

    • Author(s)
      Sayaki U.Suzuki, Akira Sasaki
    • Journal Title

      Journal of Theoretical Biology

      Volume: 176 Pages: 117-125

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oligomorphic dynamics for analyzing the quantitative genetics of adaptive speciation2011

    • Author(s)
      Akira Sasaki, UlfDiec kmann
    • Journal Title

      Journal of Mathematical Biology

      Volume: 印刷中

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A mathematical model of the intracellular replication and within host evolution of hepatitis type B virus : Understanding the longtime course of the chronic hepatitis2011

    • Author(s)
      Jun Nakabayashi, AkiraSasaki
    • Journal Title

      Journal of Theoretical Biology

      Volume: 269 Pages: 318-329

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coexistence conditions for strains of influenza with immune cross-reaction2010

    • Author(s)
      Omori, R., Adams, B., and Sasaki, A.
    • Journal Title

      Journal of Theoretical Biology

      Volume: 262 Pages: 48-57

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coexistence conditions for strains of influenza with immune cross-reaction2010

    • Author(s)
      Omori, R.
    • Journal Title

      Journal of Theoretical Biology 262

      Pages: 48-57

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The function of temporally ordered viral gene expression in the intracellular replication of herpes simplex virus type 1(HSV-1)2009

    • Author(s)
      Nakabayashi, J., and Sasaki, A.
    • Journal Title

      Journalof Theoretical Biology

      Volume: 261 Pages: 156-164

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antigenic distance and cross-immunity, invasibility and coexistence of pathogen strains in anepidemiological model with discrete antigenic space2009

    • Author(s)
      Adams, B., and Sasaki, A.
    • Journal Title

      Theoretical Population Biology

      Volume: 76 Pages: 157-167

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evolutionary maintenance of selfish homing endonuclease genes in the absence of horizontal transfer2009

    • Author(s)
      Yahara, K., Fukuyo, M., Sasaki, A., and Kobayashi, I
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America

      Volume: 106 Pages: 18861-18866

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A mathematical model of the stoichiometric control of Smad complex formation in TGF-beta signal transduction pathway2009

    • Author(s)
      Nakabayashi, J., and Sasaki, A.
    • Journal Title

      Journal of Theoretical Biology

      Volume: 259 Pages: 389-403

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The function of temporally ordered viral gene expression in the intracellular replication of herpes simplex virus type 1 (HSV-1)2009

    • Author(s)
      Nakabayashi, J.
    • Journal Title

      Journal of Theoretical Biology 261

      Pages: 156-164

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A mathematical model of the stoichiometric control of Smad complex formation in TGF-<beta> signal transduction pathway.2009

    • Author(s)
      Nakabayashi, J.
    • Journal Title

      Journal of Theoretical Biology 259

      Pages: 389-403

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antigenic distance and cross-immunity, invasibility and coexistence of pathogen strains in an epidemiological model with discrete antigenic space2009

    • Author(s)
      Adams, B.
    • Journal Title

      Theoretical Population Biology 76

      Pages: 157-167

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evolutionary maintenance of selfish homing endonuclease genes in the absence of horizontal transfer2009

    • Author(s)
      Yahara, K.
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America 106

      Pages: 18861-18866

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Forecasting host-parasite arms races : models and time-seriesdata (Invited talk)2011

    • Author(s)
      Akira Sasaki
    • Organizer
      Mathematical Models and ExperimentalMicrobial Systems Workshop, Coevolution : Models and microbial model system
    • Place of Presentation
      Liverpool, UK
    • Year and Date
      2011-04-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] Applying theories of arms races of plants and their parasites : Camellia-weevil system and rice blast disease (Invited talk)2011

    • Author(s)
      Akira Sasaki
    • Organizer
      Mathematical Biosciences Institute Workshop 5 : Coevolution and the Ecological Structure of Plant-insect Communities
    • Place of Presentation
      Ohio State University, Columbus, USA
    • Year and Date
      2011-04-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] インフルエンザウイルスの進化予測:多次元尺度法と宿主・病原体共進化モデルによる融合的アプローチ2011

    • Author(s)
      佐々木顕
    • Organizer
      第64回日本細菌学会関西支部総会特別講演
    • Place of Presentation
      大阪府立大,大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] 宿主寄生生物の共進化におけるモデルの最前線2011

    • Author(s)
      佐々木顕
    • Organizer
      第27回個体群生態学会企画シンポジウム
    • Place of Presentation
      岡山大学,岡山
    • Related Report
      2011 Final Research Report
  • [Presentation] Resistance threshold inspatially explicit epidemic model : Finite size scaling applied to dynamic percolation in epidemic processes with mixed cultivar planting2011

    • Author(s)
      Sasaki A
    • Organizer
      The 8th European Conference on Mathematical Biology(ECMTB 2011)
    • Place of Presentation
      Krakow, Poland
    • Related Report
      2011 Final Research Report
  • [Presentation] Applying theories of arms races of plants and their parasites : Camellia-weevil system and rice blast disease2011

    • Author(s)
      Sasaki A
    • Organizer
      Mathematical Biosciences Institute Workshop 5 : Coevolution and the Ecological Structure of Plant-insect Communities
    • Place of Presentation
      Ohio State University, Columbus, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Theory of Species Packing2011

    • Author(s)
      Sasaki A
    • Organizer
      Lectures in the Winter school on eco-evolutionary modeling of speciation
    • Place of Presentation
      Abisko Science Station, Sweden
    • Related Report
      2011 Final Research Report
  • [Presentation] Theory of Species Packing (Invited lectures)2011

    • Author(s)
      Akira Sasaki
    • Organizer
      Winter school on eco-evolutionary modeling of speciation.An ESF Research Networking Program, Frontiers of Speciation Research
    • Place of Presentation
      Abisko Science Station, Sweden
    • Related Report
      2010 Annual Research Report
  • [Presentation] インフルエンザ新系統の出現時期予測2010

    • Author(s)
      佐々木顕
    • Organizer
      第3回現象数理若手シンポジウム「感染症-実像とモデリング-」-分野の垣根を越えて-
    • Place of Presentation
      明治大学
    • Year and Date
      2010-02-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] A theoretical study for the phylodynamics of influenza A virus2010

    • Author(s)
      Sasaki A
    • Organizer
      Department of Mathematics, Helsinki University
    • Place of Presentation
      Helsinki, Finland
    • Related Report
      2011 Final Research Report
  • [Presentation] 多次元尺度法と個体ベースモデルによるインフルエンザ抗原進化の予測2010

    • Author(s)
      佐々木顕
    • Organizer
      第20回日本数理生物学会年会シンポジウム
    • Place of Presentation
      北海道大学学術交流会館,札幌
    • Related Report
      2011 Final Research Report
  • [Presentation] 口蹄疫流行の空間疫学モデルによる予測2010

    • Author(s)
      佐々木顕
    • Organizer
      日本応用数理学会ミニシンポジウム
    • Place of Presentation
      明治大学,東京
    • Related Report
      2011 Final Research Report
  • [Presentation] 空間疫学モデルと毒性の進化2010

    • Author(s)
      佐々木顕
    • Organizer
      第37回日本マイコプラズマ学会学術集会基調講演
    • Place of Presentation
      国立感染症研究所,東京
    • Related Report
      2011 Final Research Report
  • [Presentation] Forecasting host-parasite arms races : models and time-series data2010

    • Author(s)
      Sasaki A
    • Organizer
      Mathematical Models and Experimental Microbial Systems Workshop, Coevolution : Models and microbial model system
    • Place of Presentation
      Liverpool, UK
    • Related Report
      2011 Final Research Report
  • [Presentation] インフルエンザ新系統の出現時期2010

    • Author(s)
      佐々木顕
    • Organizer
      予測第3回現象数理若手シンポジウム
    • Place of Presentation
      明治大学,東京
    • Related Report
      2011 Final Research Report
  • [Presentation] 多次元尺度法と個体ベースモデルによるインフルエンザ抗原進化の予測2010

    • Author(s)
      佐々木顕
    • Organizer
      日本生態学会第57回年会
    • Place of Presentation
      東大駒場キャンパス
    • Related Report
      2009 Annual Research Report
  • [Presentation] Emergence probability of new flu escape variants : Be aware of early stage mutants and of spring outbreak2009

    • Author(s)
      Sasaki A
    • Organizer
      BICS Conference Multiply Structured Populations in Biology
    • Place of Presentation
      University of Bath, Bath, UK
    • Related Report
      2011 Final Research Report
  • [Presentation] Emergence probability of new flu escape variants : Be aware of early stage mutants and of spring outbreak2009

    • Author(s)
      佐々木顕
    • Organizer
      BICS Conference. Multiply Structured Populations in Biology
    • Place of Presentation
      University of Bath
    • Related Report
      2009 Annual Research Report
  • [Presentation] Immune-driven phylodynamics of influenza A evolution2009

    • Author(s)
      佐々木顕
    • Organizer
      The 6th SOKENDAI Student Seminar for Biological Science
    • Place of Presentation
      YAMAHA Resort Tsumagoi
    • Related Report
      2009 Annual Research Report
  • [Book] 伝染病の数理2012

    • Author(s)
      佐々木顕
    • Publisher
      岩波書店(印刷中)
    • Related Report
      2011 Final Research Report
  • [Book] ゾウムシの矛とツバキの盾の軍拡競争2012

    • Author(s)
      佐々木顕
    • Publisher
      岩波書店
    • Related Report
      2011 Final Research Report
  • [Book] 軍拡競争・共進化・種分化2010

    • Author(s)
      佐々木顕
    • Publisher
      共立出版
    • Related Report
      2011 Final Research Report
  • [Book] 軍拡競争・共進化・種分化「行動・進化」の数理生物学2010

    • Author(s)
      佐々木顕(分担執筆)
    • Publisher
      共立出版
    • Related Report
      2010 Annual Research Report
  • [Book] 軍拡競争・共進化・種分化.「行動・進化」の数理生物学.(日本数理生物学会編).2010

    • Author(s)
      佐々木顕
    • Total Pages
      208
    • Publisher
      共立出版
    • Related Report
      2009 Annual Research Report
  • [Book] 群集生態モデルと進化動態 : 資源分割理論を例に. 群集生態学2-進化生物学からせまる(大串隆之・近藤倫生・吉田丈人 (編))2009

    • Author(s)
      佐々木顕
    • Total Pages
      327
    • Publisher
      京都大学出版会
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://sites.google.com/site/sokendaisasaki/home/members/a_sasaki

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://researchmap.jp/AkiraSasaki

    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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