Structural analysis of A1 protein-telomere-telomerase complex, and development of inhibition of telomerase

• Project/Area Number: 21370047
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Structural biochemistry
• Research Institution: Kyoto University (2010-2011); Yokohama City University (2009)
• Principal Investigator: KATAHIRA Masato 京都大学, エネルギー理工学研究所, 教授 (70211844)
• Co-Investigator(Kenkyū-buntansha): NAGATA Takashi 京都大学, エネルギー理工学研究所, 助教 (10415250)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000); Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2010: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2009: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
• Keywords: テロメア / テロメラーゼ / A1タンパク質 / 癌 / デコイ / 生物物理 / タンパク質 / NMR / 分子認識 / 立体構造 / RNA / 複合体 / テロメレース / DNA

Research Abstract

We have determined the structure of the Musashi-target RNA binary complex with the assist of long-range structural information. With the same assist, the structure of the A1 protein-telomere DNA-telomerase RNA ternary complex has been analyzed. It has been shown that A1 works as a bridge between telomere DNA and telomerase RNA. This suggests that A1 functions to bring telomerase to telomere DNA. The strategy to inhibit telomerase with decoy nucleic acids has also been suggested to be promising.

Research Products

• [Journal Article] Structure of Musashi1 in a complex with target RNA : The role of aromatic stacking interactions (2012)
  • Author(s): Ohyama, T., Nagata, T., Tsuda, K., Kobayashi, N., Imai, T., Okano, H., Yamazaki, T. and Katahira, M
  • Journal Title: Nucleic Acids Res Volume: 10 Issue: 7 Pages: 3218-3231
  • DOI: 10.1093/nar/gkr1139
  • Peer Reviewed
• [Journal Article] Intelligent ribozyme that switches its activity in response to K^+ through quadruplex formation (2012)
  • Author(s): Nagata, T., Sakurai, Y., Hara, Y., Mashima, T., Kodaki, T., Katahira, M.
  • Journal Title: FEBS Journal Volume: (印刷中) Issue: 8 Pages: 1456-1463
  • DOI: 10.1111/j.1742-4658.2012.08538.x
  • Peer Reviewed
• [Journal Article] Presence of alternating glucosaminoglucan in the sheath of Thiothrix nivea (2012)
  • Author(s): Takeda, M., Kondo, K., Ymamada, M., Sumikawa, M., Koizumi, J., Mashima, T., Katahira, M.
  • Journal Title: International journal of biological macromolecules Volume: 50 Issue: 1 Pages: 236-244
  • DOI: 10.1016/j.ijbiomac.2011.10.024
  • Peer Reviewed
• [Journal Article] Structure of Musashil in a complex with target RNA : The role of aromatic stacking interactions (2012)
  • Author(s): Ohyama, et al
  • Journal Title: Nucleic Acids Res Volume: (in press)
  • Peer Reviewed
• [Journal Article] Intelligent ribozyme that switches its activity in response to K+ through quadruplex formation (2012)
  • Author(s): Nagata, et al
  • Journal Title: FEBS J Volume: 279 Pages: 1456-1463
  • Peer Reviewed
• [Journal Article] Heat shock protein 70 inhibitsHIV-1 Vif-mediated ubiquitination and degradation of APOBEC3G (2011)
  • Author(s): Sugiyama, R., Nishitsuji, H., Furukawa, A., Katahira, M., Habu, Y., Takeuchi, H., Ryo, A. and Takaku, H.
  • Journal Title: J. Biol. Chem. Volume: 286 Issue: 12 Pages: 10051-10057
  • DOI: 10.1074/jbc.m110.166108
  • Peer Reviewed
• [Journal Article] Study of a novel glycoconjugate, thiopeptidoglycan, and a novel polysaccharide lyase (2011)
  • Author(s): Kondo, K., Takeda, M., Ejima, W., Kawasaki, Y., Umezu, T., Yamada, M., Koizumi, J., Mashima, T., and Katahira, M.
  • Journal Title: Internat. J. Biol. Macro mol. Volume: 48 Issue: 2 Pages: 256-262
  • DOI: 10.1016/j.ijbiomac.2010.11.009
  • Peer Reviewed
• [Journal Article] Structural aspects for the recognition of ATP by ribonucleopeptide receptors (2011)
  • Author(s): Nakano, et al
  • Journal Title: J.Am.Chem.Soc. Volume: 133 Pages: 4567-4579
  • Peer Reviewed
• [Journal Article] Heat shock protein 70 inhibits HIV-1 Vif-mediated ubiquitination and degradation of APOBEC3G (2011)
  • Author(s): Sugiyama, et al
  • Journal Title: J.Biol.Chem. Volume: 286 Pages: 10051-10057
  • Peer Reviewed
• [Journal Article] Study of a novel glycoconjugate, thiopeptidoglycan, and a novel polysaccharide lyase, thiopeptidoglycan lyase (2011)
  • Author(s): Kondo, K
  • Journal Title: Internat.J.of Biolog.Macromol. Volume: VOL.48 Pages: 256-262
  • Peer Reviewed
• [Journal Article] Heat shock protein 70 inhibits HIV-1 Vif-mediated ubiquitination and degradation of APOBEC3G (2011)
  • Author(s): Sugiyama, R.
  • Journal Title: J.Biol.Chem Volume: (印刷中 掲載確定)
  • Peer Reviewed
• [Journal Article] Structural aspects for the recognition of ATP by ribonucleopeptide receptors (2011)
  • Author(s): Nakano, S.
  • Journal Title: J.Am.Chem.Soc. Volume: VOL.133 Pages: 4567-4579
  • Peer Reviewed
• [Journal Article] Structural Aspects for the Recognition of ATP by Ribonucleopeptide Receptors (2010)
  • Author(s): T. Morii, et al
  • Journal Title: J. Am. Chem. Soc Volume: Vol.133 Issue: 12 Pages: 4567-4579
  • DOI: 10.1021/ja110725d
  • Peer Reviewed
• [Journal Article] Solution structures of the trihelix DNA-binding domains of the wild-type and a phosphomimetic mutant of Arabidopsis GT-1 (2010)
  • Author(s): Nagata, T., Niyada, E., Fujimoto, N., Nagasaki, Y., Noto, K., Miyanoiri, Y., Murata, J., Hiratsuka, K. and Katahira, M.
  • Journal Title: Proteins Volume: 78 Issue: 14 Pages: 3033-3047
  • DOI: 10.1002/prot.22827
  • Peer Reviewed
• [Journal Article] Solubilization and structural determination of a glycoconjugate which isassembled into the sheath of Leptothrixcholodnii (2010)
  • Author(s): Takeda, M., Kondo, K., Yamada, M., Koizumi, J., Mashima, T., Matsugami, A. and Katahira, M.
  • Journal Title: Int. J. Biol. Macro mol Volume: 46 Issue: 2 Pages: 206-211
  • DOI: 10.1016/j.ijbiomac.2009.12.006
  • Peer Reviewed
• [Journal Article] Solubilization and structural determination of a glycoconjugate which is assembled into the sheath of Leptothrix cholodnii (2010)
  • Author(s): Takeda, M.
  • Journal Title: Int.J.Biol.Macromol Volume: VOL.46 Pages: 206-211
  • Peer Reviewed
• [Journal Article] Solution structures of the trihelix DNA-binding domains of the wild-type and a phosphomimetic mutant of Arabidopsis GT-1, implying a mechanism for an increase in DNA-binding affinity through phosphorylation (2010)
  • Author(s): Nagata, T.
  • Journal Title: Proteins Volume: VOL.78 Pages: 3033-3047
  • Peer Reviewed
• [Journal Article] Solubilization and structural determination of a glycoconjugate which is assembled into the sheath of Leptothrix cholodnii (2010)
  • Author(s): Takeda, M.
  • Journal Title: Int.J.Biol.Macromol. 46 Pages: 206-211
  • Peer Reviewed
• [Journal Article] Solution structures of the trihelix DNA-binding domains of the wild-type and a phosphomimetic mutant of Arabidopsis GT-1, implying a mechanism for an increase in DNA-binding affinity through phosphorylation (2010)
  • Author(s): Nagata, T.
  • Journal Title: Proteins (in press)
  • Peer Reviewed
• [Journal Article] Structure, interaction, and real-time monitoring of the enzymatic reaction of wild-type APOBEC3G (2009)
  • Author(s): Furukawa, A., Nagata, T., Matsugami, A., Habu, Y., Sugiyama, R., Hayashi, F., Yokoyama, S., Takaku, H. and Katahira, M.
  • Journal Title: EMBO J. Volume: 28 Issue: 4 Pages: 440-451
  • DOI: 10.1038/emboj.2008.290
  • Peer Reviewed
• [Journal Article] Uniquequadruplex structure and interaction of anRNA aptamer against bovine prion protein (2009)
  • Author(s): Mashima, T., Matsugami, A., Nishikawa, F., Nishikawa, S. and Katahira, M.
  • Journal Title: Nucleic Acids Res. Volume: 37 Issue: 18 Pages: 6249-6258
  • DOI: 10.1093/nar/gkp647
  • Peer Reviewed
• [Journal Article] The orientation of the ends of G-quadruplex structures investigated using end-extended oligonucleotides (2009)
  • Author(s): Sannohe, Y., Sato, K., Matsugami, A., Shinohara, K., Mashimo, T., Katahira, M. and Sugiyama, H.
  • Journal Title: Bioorg. Medici. Chem. Volume: 17 Issue: 5 Pages: 1870-1875
  • DOI: 10.1016/j.bmc.2009.01.051
  • Peer Reviewed
• [Journal Article] Structural studies of an RNA aptamer containing GGArepeats under ionic conditions using microchip electrophoresis (2009)
  • Author(s): Nishikawa, F., Murakami, K., Matsugami, A., Katahira, M. and Nishikawa, S.
  • Journal Title: Oligonucleotides Volume: 19 Issue: 2 Pages: 179-190
  • DOI: 10.1089/oli.2008.0167
  • Peer Reviewed
• [Journal Article] Structure, interaction, and real-time monitoring of the enzymatic reaction of wild-type APOBEC3G (2009)
  • Author(s): Furukawa, A.
  • Journal Title: EMBO J. 28 Pages: 440-451
  • Peer Reviewed
• [Journal Article] The orientation of the ends of G-quadruplex structures investigated using end-extended oligonucleotides (2009)
  • Author(s): Sannohe, Y.
  • Journal Title: Bioorg.Medici.Chem. 17 Pages: 1870-1875
  • Peer Reviewed
• [Journal Article] Structural studies of an RNA aptamer containing GGA repeats under ionic conditions using microchip electrophoresis, circular dichroism and 1D-NMR (2009)
  • Author(s): Nishikawa, F.
  • Journal Title: Oligonucleotides 19 Pages: 179-190
  • Peer Reviewed
• [Journal Article] Unique quadruplex structure and interaction of an RNA aptamer against bovine prion protein (2009)
  • Author(s): Mashima, T.
  • Journal Title: Nucleic Acids Res. 37 Pages: 6249-6258
  • Peer Reviewed
• [Journal Article] Structural analysis of ribonucleopeptide aptamer against ATP (2009)
  • Author(s): Mashima, T
  • Journal Title: Nucleic Acids Symp. 53 Pages: 267-268
  • Peer Reviewed
• [Journal Article] Structure and real-time monitoring of the enzymatic reaction of APOBE C3G which is involved in anti-HIV activity (2009)
  • Author(s): Furukawa, A.
  • Journal Title: Nucleic Acids Symp. 53 Pages: 87-88
  • Peer Reviewed
• [Journal Article] Structural aspects for the function of ATP-binding ribonucleopeptide receptors (2009)
  • Author(s): Nakano, S.
  • Journal Title: Nucleic Acids Symp.Ser. 53 Pages: 259-260
  • Peer Reviewed
• [Presentation] Sliding-direction-dependent activity of anti-HIV enzyme, and structural basis of anti-prion activity of RNA aptamer (2012)
  • Author(s): Furukawa, A., Mashima, T., Sugase, K., Fujiwara, H., Nagata, T., Morishita, R., Ryo, A., Nishikawa, F., Nishikawa, S., Kamatari, Y., Kuwata, K. and Katahira, M.
  • Organizer: Korea-Japan Bilateral NMR Symposium
  • Place of Presentation: Sapporo
  • Year and Date: 2012-03-16
• [Presentation] Towards evaluation of wood cell wall structures and those biodegradation using solution NMR (2012)
  • Author(s): Nishimura, H., Kozawa, Y., Okamura, H., Watanabe, T. and Katahira, M.
  • Organizer: Korea-Japan Bilateral NMR Symposium
  • Place of Presentation: Sapporo
  • Year and Date: 2012-03-16
• [Presentation] Recognition of prion protein by the RNA aptamer (2012)
  • Author(s): Mashima, T., Fujiwara, H., Nishikawa, F., Saimura, M., Kamatari, Y., Kuwata, K., Imamura, M., Yokoyama, T., Nishikawa, S. and Katahira, M.
  • Organizer: Korea-Japan Bilateral NMR Symposium
  • Place of Presentation: Sapporo
  • Year and Date: 2012-03-16
• [Presentation] Sliding-direction-dependent activity of anti-HIV enzyme, and structural basis of anti-prion activity of RNA aptamer (2012)
  • Author(s): Furukawa, et al
  • Organizer: Korea-Japan Bilateral NMR Symposium
  • Place of Presentation: 北海道大学(招待講演)
  • Year and Date: 2012-03-16
• [Presentation] Base-deamination rate dependent on the direction of sliding of an enzyme along DNA as revealed by numerical analysis of NMR data, and wood biomass studied by solution NMR (2011)
  • Author(s): Nishimura, et al
  • Organizer: The International Symposium on Nuclear Magnetic Resonance 2011
  • Place of Presentation: 大桟橋ホール(神奈川県)
  • Year and Date: 2011-11-17
• [Presentation] Real-time monitoring of the cytidine deamination along single-stranded DNA by an anti-HIV factor, APOBEC3G (2011)
  • Author(s): Furukawa, et al
  • Organizer: The International Symposium on Nuclear Magnetic Resonance 2011
  • Place of Presentation: 大桟橋ホール(神奈川県)
  • Year and Date: 2011-11-16
• [Presentation] r (GGA)4 chimeric ribozyme switches its activity in response to K+ via quadruplex formation (2011)
  • Author(s): Nagata, et al
  • Organizer: The 38th International Symposium on Nucleic Acids Chemistry
  • Place of Presentation: 北海道大学
  • Year and Date: 2011-11-11
• [Presentation] Structural basis of the high affinity of the RNA aptamer against prion protein (2011)
  • Author(s): Mashima, et al
  • Organizer: The 16th annual meeting of the RNA society
  • Place of Presentation: プリンスホテル(京都府)
  • Year and Date: 2011-06-15
• [Presentation] Structural basis of the high affinity of the RNA aptamer against prion protein (2011)
  • Author(s): Mashima, T., Fujiwara, H., Koshida, T., Saimura, M., Imamura, M., Yokoyama, T., Nishikawa, F., Nishikawa, S. and Katahira, M.
  • Organizer: The 16th annual meeting of the RNA society
  • Place of Presentation: Kyoto
• [Presentation] Elucidation of functions on APOBEC3DE and APOBEC3F based on structure-oriented analysis (2011)
  • Author(s): Iwaoka, R., Furukawa, A., Okamura, H. and Katahira, M.
  • Organizer: 3^<rd> G-COE International Symposium Zero Carbon Energy 2011
  • Place of Presentation: 水原
• [Presentation] r(GGA) 4 chimeric ribozyme switches its activity in response to K+ via quadruplex formation (2011)
  • Author(s): Nagata, T., Sakurai, Y., Mashima, T. and Katahira, M.
  • Organizer: The 38th International Symposium on Nucleic Acids Chemistry
  • Place of Presentation: Sapporo
• [Presentation] Base-deamination rate dependent on the direction of sliding of an enzyme along DNA as revealed by numerical analysis of NMR data, and wood biomass studied by solution NMR (2011)
  • Author(s): Nishimura, H., Furukawa, A., Okamura, H., Kozawa, Y., Morishita, R., Ryo, A., Sugase, K., Watanabe, T. and Katahira, M.
  • Organizer: The International Symposium on Nuclear Magnetic Resonance 2011
  • Place of Presentation: Yokohama
• [Presentation] Linkage analysis of lignin for lignocellulosic biorefinery (2010)
  • Author(s): Yoshioka, K.
  • Organizer: The International Chemical Congress of Pacific Basin Societies
  • Place of Presentation: ハワイコンベンションセンター(米国)
  • Year and Date: 2010-12-17
• [Presentation] Unique quadruplex structure and interaction of r(GGAGGAGGAGGA) with protein (2010)
  • Author(s): Mashima, T.
  • Organizer: The International Chemical Congress of Pacific Basin Societies
  • Place of Presentation: ハワイコンベンションセンター(米国)(招待講演)
  • Year and Date: 2010-12-16
• [Presentation] Structure and interaction of an RNA aptamer with potential therapeutic use (2010)
  • Author(s): Mashima, T.
  • Organizer: The International Chemical Congress of Pacific Basin Societies
  • Place of Presentation: ハワイコンベンションセンター(米国)(招待講演)
  • Year and Date: 2010-12-15
• [Presentation] The real-time monitoring of the enzymatic reaction of an anti-HIV factor APOBEC3G (2010)
  • Author(s): Furukawa, A.
  • Organizer: Korea-Japan Bilateral NMR Symposium
  • Place of Presentation: ソウル大学(韓国)(招待講演)
  • Year and Date: 2010-11-26
• [Presentation] A mechanism for a increase in DNA-binding affinity of the trihelix DNA-binding domain via its phosphrylation (2010)
  • Author(s): Nagata, T.
  • Organizer: The 37^<th> International Symposium on Nucleic Acids Chemistry 2010
  • Place of Presentation: はまぎんホール(横浜市)
  • Year and Date: 2010-11-11
• [Presentation] Structural aspects of the fluorescence intensity changes of the ATP-binding ribonucleopeptide sensor (2010)
  • Author(s): Nakano, S.
  • Organizer: The 37^<th> International Symposium on Nucleic Acids Chemistry 2010
  • Place of Presentation: はまぎんホール(横浜市)
  • Year and Date: 2010-11-11
• [Presentation] Structure and interaction of RNA aptamer against prion protein in complex with the partial binding peptide (2010)
  • Author(s): Mashima, T.
  • Organizer: The 37^<th> International Symposium on Nucleic Acids Chemistry 2010
  • Place of Presentation: はまぎんホール(横浜市)
  • Year and Date: 2010-11-10
• [Presentation] Real-time monitoring of the enzymatic reaction of APOBEC3G possessing anti-HIV activity, and the structure and interaction of the RNA aptamer against prion protein (2010)
  • Author(s): Furukawa, A.
  • Organizer: The 10^<th> KIAS Conference on Protein Structure and Function
  • Place of Presentation: International Conference Hall(韓国)(招待講演)
  • Year and Date: 2010-10-01
• [Presentation] The real-time monitoring of the enzymatic reaction of an anti-HIV factor APOBEC3G (2010)
  • Author(s): Furukawa, A.
  • Organizer: XXIV International Conference on Magnetic Resonance in Biological Systems
  • Place of Presentation: Cairns Convention Centre Cairns(オーストラリア)
  • Year and Date: 2010-08-24
• [Presentation] Real-time monitoring of the enzymatic reaction of APOBEC3G possessing anti-HIV activity, and the structure and interaction of the RNA aptamer against prion protein (2010)
  • Author(s): Mashima, T.
  • Organizer: XXIV International Conference on Magnetic Resonance in Biological Systems
  • Place of Presentation: Cairns Convention Centre Cairns(オーストラリア)(招待講演)
  • Year and Date: 2010-08-23
• [Presentation] The analysis of the mechanism of an enzyme reaction toward the development of new energy systems (2010)
  • Author(s): Iwaoka, R.
  • Organizer: The 2^<nd> International Symposium of Kyoto University Global COE Program-Zero Carbon Energy Kyoto 2010
  • Place of Presentation: 京都大学おうばくプラザ(宇治市)
  • Year and Date: 2010-08-19
• [Presentation] Real-time monitoring of the enzymatic reaction of APOBEC3G possessing anti-HIV activity, and the structure of the RNA aptamer against prion protein (2010)
  • Author(s): Furukawa, A.
  • Organizer: International Symposium of Korean Society of Biochemistry and Molecular Biology-Structural Biology and Drug Discovery-
  • Place of Presentation: ソウル大学(韓国)(招待講演)
  • Year and Date: 2010-05-18
• [Presentation] Real-time monitoring of the cytidine deamination along single-stranded DNA by an anti-HIV factor (2010)
  • Author(s): Furukawa, A., Mashima, T., Matsugami, A., Nagata. T., Sugiyama, R., Takaku, H., Nishikawa, F., Nishikawa, S. and Katahira, M.
  • Organizer: The International Symposium on Nuclear Magnetic Resonance 2011
  • Place of Presentation: Seoul
• [Presentation] Real-time monitoring of the enzymatic reaction of APOBEC3G possessing anti-HIV activity, and the structure of the RNA aptamer against prion protein (2010)
  • Author(s): Mashima, T., Furukawa, A., Nagata, T., Nishikawa, F., Nishikawa, S. and Katahira, M.
  • Organizer: XXIV International Conference on Magnetic Resonance in Biological Systems
  • Place of Presentation: Cairns
• [Presentation] Structure and interaction of an RNA aptamer with potential therapeutic use (2010)
  • Author(s): Mashima, T., Matsugami, A., Nishikawa, F., Nishikawa, S. and Katahira, M.
  • Organizer: The International Chemical Congress of Pacific Basin Societies
  • Place of Presentation: Hawaii
• [Presentation] Unique quadruplex structure and interaction of r(GGAGGAGGAGGA) with protein (2010)
  • Author(s): Mashima, T., Matsugami, A., Nishikawa, F., Nishikawa, S. and Katahira, M.
  • Organizer: The International Chemical Congress of Pacific Basin Societies
  • Place of Presentation: Hawaii
• [Presentation] Real-time monitoring of the enzymatic reaction of APOBEC3G possessing anti-HIV activity, and the structure and interaction of the RNA aptamer against prion protein (2010)
  • Author(s): Furukawa, A., Mashima, T., Nagata, T., Nishikawa, F., Nishikawa, S. and Katahira, M.
  • Organizer: The 10th KIAS Conference on Protein Structure and Function
  • Place of Presentation: Seoul
• [Presentation] The real-time monitoring of the enzymatic reaction of an anti-HIV factor APOBEC3G (2010)
  • Author(s): Furukawa, A., Nagata, T., Morishita, R., Iwaoka, R. and Katahira, M.
  • Organizer: Korea-Japan Bilateral NMR Symposium
• [Presentation] The real-time monitoring of the enzymatic reaction of an anti-HIV factor APOBEC3G (2010)
  • Author(s): Furukawa, A., Nagata, T., Morishita, R., Iwaoka, R. and Katahira, M.
  • Organizer: XXIV International Conference on Magnetic Resonance in Biological Systems
  • Place of Presentation: Cairns
• [Presentation] The analysis of the mechanism of an enzyme reaction toward the development of new energy systems (2010)
  • Author(s): Iwaoka, R., Furukawa, A. and Katahira, M.
  • Organizer: The 2nd International Symposium of Kyoto University Global COE Program Zero Carbon Energy Kyoto 2010
  • Place of Presentation: Kyoto
• [Presentation] Structure and interaction of RNA aptamer againstprion protein in complex with the partial binding peptide (2010)
  • Author(s): Mashima, T., Koshida, T., Saimura, M., Nishikawa, F., Nishikawa, S. and Katahira, M.
  • Organizer: The 37th International Symposium on Nucleic Acids Chemistry 2010
  • Place of Presentation: Yokohama
• [Presentation] Structure and interaction of RNA aptamer against prion protein in complex with the partial binding peptide (2010)
  • Author(s): Nagata, T., Niyada, E., Fujimoto, N., Nagasaki, Y., Noto, K., Miyanoiri, Y., Murata, J., Hiratsuka, K. and Katahira, M.
  • Organizer: The 37th International Symposium on Nucleic Acids Chemistry 2010
  • Place of Presentation: Yokohama
• [Presentation] A mechanism for a increase in DNA-binding affinity of the trihelix DNA-binding domain via its phosphrylation (2010)
  • Author(s): Nakano, S., Mashima, T., Tainaka, K., Katahira, M. and Morii, T.
  • Organizer: The 37th International Symposium on Nucleic Acids Chemistry 2010
  • Place of Presentation: Yokohama
• [Presentation] Structural aspects of the fluorescence intensity changes of the ATP-binding ribonucleopeptide sensor (2010)
  • Author(s): Yoshioka, K., Daidai, M., Katahira, M. and Watanabe, T.
  • Organizer: The International Chemical Congress of Pacific Basin Societies
  • Place of Presentation: Hawaii
• [Presentation] Unique quadruplex structure and interaction of the RNA aptamer against bovine prion protein (2009)
  • Author(s): Mashima, T.
  • Organizer: Joint Symposium of the 5^<th> annual Meeting of the Oligonucleotide Therapeutics Society and the 19^<th> Antisense Symposium
  • Place of Presentation: 福岡
  • Year and Date: 2009-11-05
• [Presentation] Structure, interaction and real-time monitoring of the enzymatic reaction of APOBEC3G which possesses anti-HIV activity (2009)
  • Author(s): Furukawa, A.
  • Organizer: The 3^<rd> Asia-Pacific NMR Symposium
  • Place of Presentation: 済州島
  • Year and Date: 2009-10-27
• [Presentation] Real-time monitoring of the enzymatic reaction of APOPBEC3G possessing anti-HIV activity, and the structure of the RNA aptamer against prion (2009)
  • Author(s): Furukawa, A.
  • Organizer: The 3^<rd> Asia-Pacific NMR Symposium
  • Place of Presentation: 済州島
  • Year and Date: 2009-10-26
• [Presentation] Structure and real-time monitoring of the enzymatic reaction of APOBEC3G which is involved in anti-HIV activity (2009)
  • Author(s): Furukawa, A.
  • Organizer: The 6^<th> International Symposium on Nucleic Acids Chemistry
  • Place of Presentation: 高山
  • Year and Date: 2009-10-01
• [Presentation] Structural analysis of ribonucleopeptide aptamer against ATP (2009)
  • Author(s): Mashima, T
  • Organizer: The 6^<th> International Symposium on Nucleic Acids Chemistry
  • Place of Presentation: 高山
  • Year and Date: 2009-09-29
• [Presentation] Structural aspects for the function of ATP-binding ribonucleopeptide receptors (2009)
  • Author(s): Nakano, S.
  • Organizer: The 6^<th> International Symposium on Nucleic Acids Chemistry
  • Place of Presentation: 高山
  • Year and Date: 2009-09-29
• [Presentation] Real-time monitoring of the enzymatic reaction of APOPBEC3G possessing anti-HIV activity, and the structure of the RNA aptamer against prion (2009)
  • Author(s): Furukawa, A., Mashima, T., Nagata, T., Takaku, H., Matsugami, A., Nishikawa, F., Nishikawa, S. and Katahira, M.
  • Organizer: The 3rd Asia-Pacific NMR Symposium
  • Place of Presentation: Cheju
• [Presentation] Structure, interaction and real-time monitoring of the enzymatic reaction of APOBEC3G which possesses anti-HIV activity (2009)
  • Author(s): Furukawa, A., Nagata, T., Sugiyama, R., Takaku, H. and Katahira, M.
  • Organizer: The 3rd Asia-Pacific NMR Symposium
  • Place of Presentation: Cheju
• [Presentation] Structural analysis of ribonucleopeptide aptamer against ATP (2009)
  • Author(s): Mashima, T., Matsugami, A., Nakano, S., Inoue, M., Fukuda, M., Morii, T. and Katahira, M.
  • Organizer: The 6^<th> International Symposium on Nucleic Acids Chemistry
  • Place of Presentation: Gifu
• [Presentation] Structure and real-time monitoring of the enzymatic reaction of APOBEC3G which is involved in anti-HIV activity (2009)
  • Author(s): Furukawa, A., Nagata, T., Matsugami, A., Habu, Y., Sugiyama, R., Hayashi, F., Kobayashi, N., Yokoyama, S., Takaku, H. and Katahira, M.
  • Organizer: The 6th International Symposium on Nucleic Acids Chemistry
  • Place of Presentation: Gifu
• [Presentation] Structural aspects for the function of ATP-binding ribonucleopeptide receptors (2009)
  • Author(s): Nakano, S., Fukuda, M., Mashima, T., Katahira, M. and Morii, T.
  • Organizer: The 6^<th> International Symposium on Nucleic Acids Chemistry
  • Place of Presentation: Gifu
• [Presentation] Unique quadruplex structure and interaction of the RNA aptamer against bovine prion protein (2009)
  • Author(s): Mashima, T., Matsugami, A., Nishikawa, F., Nishikawa, S. and Katahira, M.
  • Organizer: Joint Symposium of the 5^<th> annual Meeting of the Oligonucleotide Therapeutics Society and the 19^<th> Antisense Symposium
  • Place of Presentation: Fukuoka
• [Book] Encyclopedia of Biophysics,"Introduction to Nucleic Acids NMR" (2012)
  • Author(s): Katahira, M. and Mashima, T.
  • Publisher: Springer
• [Book] 日本化学会編・CSJカレントレビュー"核酸化学のニュートレンド-DNA・RNAの新たな可能性を開く""論文にみる最重要概念と革新実験データ" (2011)
  • Author(s): 片平正人
  • Publisher: 化学同人
• [Book] 日本化学会編・CSJカレントレビュー核酸化学のニュートレンドーDNA・RNAの新たな可能性を開く (2011)
  • Author(s): 片平正人
  • Total Pages: 5
  • Publisher: 化学同人
• [Remarks]
  • URL: http://www.iae.kyoto-u.ac.jp/bio/a-13_j.html
• [Remarks]
  • URL: http://www.iae.kyoto-u.ac.jp/bio/
• [Remarks]
  • URL: http://www.iae.kyoto-u.ac.jp/bio/a-13_j.html
• [Patent(Industrial Property Rights)] Nucleic Acid-Enzyme Complex (2011)
  • Inventor(s): 片平正人
  • Industrial Property Rights Holder: 横浜国立大学長飯田嘉宏
  • Acquisition Date: 2011-03-10
  • Overseas