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Structural biology of protein-protein interactions involved in DNA replication under DNA damage

Research Project

Project/Area Number 21370048
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Structural biochemistry
Research InstitutionYokohama City University

Principal Investigator

SATO Mamoru  横浜市立大学, 生命ナノシステム科学研究科, 教授 (60170784)

Co-Investigator(Kenkyū-buntansha) HASHIMOTO Hiroshi  横浜市立大学, 生命ナノシステム科学研究科, 助教 (40336590)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2009: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
KeywordsX線結晶解析 / DNA複製 / DNA損傷応答 / PCNA / ユビキチン化 / 損傷乗り越えDNA合成 / DNAクランプ / 構造解析
Research Abstract

DNA clamp is involved in various cellular events on DNA including DNA replication, repair and replication, and functions as a scaffold protein in those events. DNA clamp forms a ring-shaped trimer that encircles the DNA double helix and slides freely along the DNA axis. PCNA and RAD9/HUS1/RAD1(9-1-1) are DNA clamp in eukaryote. PCNA is a homo-trimer, whereas 9-1-1 is a hetero-trimer. Each subunit of 9-1-1 is composed of PCNA-like domain. However, RAD9 has an additional domain with a molecular weight of 13 kD in the C-terminus. Structure of 9-1-1 trimer of PCNA-like domains is similar to that of PCNA trimer. In this study, we prepared the C-terminal domain of RAD9CTD and performed structural analysis by small angle X-ray scattering(SAXS). Some archaea have heterotrimeric DNA clamp(PCNA1-PCNA2-PCNA3). We reveals that PCNA2-PCNA3 from Sulfolobus tokodaii forms tetrameric ring structure in solution by SAXS.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (123 results)

All 2013 2012 2011 2010 2009

All Journal Article (32 results) (of which Peer Reviewed: 29 results) Presentation (87 results) Book (2 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Mechanistic insights into the activation of Rad51-mediated strand exchange from the structure of a recombination activator, the Swi5-Sfr1 complex2013

    • Author(s)
      N.Kuwabara, Y.Murayama, H.Hashimoto, Y.Kokabu, M.Ikeguchi, M.Sato, K.Mayanagi, Y.Tsutsui, H.Iwasaki,and T.Shimizu
    • Journal Title

      Structure

      Volume: 20 Issue: 3 Pages: 440-449

    • DOI

      10.1016/j.str.2012.01.005

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a small molecule PCNA inhibitor that disrupts interactions with PIP-Box proteins and inhibits DNA replication2012

    • Author(s)
      Chandanamali Punchihewa, Akira Inoue, Asami Hishiki, Yoshihiro Fujikawa, Michele Connelly, Benjamin Evison, Youming Shao, Richard Heath, Isao Kuraoka, Patrick Rodrigues, Hiroshi Hashimoto, Takashi Yagi, & Naoaki Fujii
    • Journal Title

      J. Biol. Chem

      Volume: 287 Pages: 14289-14300

    • Related Report
      2011 Final Research Report
  • [Journal Article] Identification of a small molecule PCNA inhibitor that disrupts interactions with PIP-Box proteins and inhibits DNA replication2012

    • Author(s)
      Chandanamali Punchihewa, Akira Inoue, Asami Hishiki, Yoshihiro Fujikawa, Michele Connelly, Benjamin Evison, Youming Shao, Richard Heath, Isao Kuraoka, Patrick Rodrigues, Hiroshi Hashimoto, Masanobu Kawanishi, Mamoru Sato, Takashi Yagi, Naoaki Fujii
    • Journal Title

      J Biol Chem

      Volume: 287 Issue: 17 Pages: 14289-14300

    • DOI

      10.1074/jbc.m112.353201

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel heterotetameric structure of the crenarchaeal PCNA-2PCNA3 complex2011

    • Author(s)
      Akito Kawai, Hiroshi Hashimoto, Shigesada Higuchi, Masaru Tsunoda, Mamoru Sato, Kazuo T Nakamura, & Shuichi Miyamoto
    • Journal Title

      J. Struct. Biol

      Volume: 174 Pages: 443-450

    • Related Report
      2011 Final Research Report
  • [Journal Article] Crystal structure of the human centromeric nucleosome containing CENP-A2011

    • Author(s)
      Tachiwana H, Kagawa W, Shiga T, Osakabe A, Miya Y, Saito K, Hayashi-Takanaka Y, Oda T, Sato M, Park SY, Kimura H, Kurumizaka H
    • Journal Title

      Nature

      Volume: 476 Issue: 7359 Pages: 232-235

    • DOI

      10.1038/nature10258

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Towards the Structural Characterization of Intrinsically Disordered Proteins by SAXS and MD Simulation2011

    • Author(s)
      T.Oroguchi, M.Ikeguchi, M.Sato
    • Journal Title

      J.Physics : Conference Series

      Volume: 272 Pages: 12005-12005

    • DOI

      10.1088/1742-6596/272/1/012005

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel heterotetrameric structure of the crenarchaeal PCNA2-PCNA3 complex2011

    • Author(s)
      A.Kawai, H.Hashimoto, S.Higuchi, M.Tsunoda c, M.Sato, K.T.Nakamura, S.Miyamoto
    • Journal Title

      J.Struct.Biol.

      Volume: 174 Issue: 1 Pages: 443-450

    • DOI

      10.1111/j.1574-6968.2011.02233.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel heterotetrameric structure of the crenarchaeal PCNA2-PCNA3 complex2011

    • Author(s)
      Akito Kawai, Hiroshi Hashimoto, Shigesada Higuchi, Masaru Tsunoda, Mamoru Sato, Kazuo T Nakamura, Shuichi Miyamoto
    • Journal Title

      J Struct Biol

      Volume: 174 Issue: 3 Pages: 443-450

    • DOI

      10.1016/j.jsb.2011.02.006

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystallization of Bg7S, Purification, crystallization and X-ray diffraction study of basic 7S globulin from soybean2011

    • Author(s)
      T.Yoshizawa, H.Hashimoto, T.Shimizu, M.Yamabe, N.Shichijo, K.Hanada, H.Hirano, M.Sato
    • Journal Title

      Acta Cryst.

      Volume: F67 Issue: 11 Pages: 87-89

    • DOI

      10.1111/j.1742-4658.2011.08111.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Purification, crystallization and X-ray diffraction study of extracellular dermal glycoprotein from carrot and the inhibition complex it forms with an endo-beta-glucanase from Aspergillus aculeatus2011

    • Author(s)
      T.Yoshizawa, T.Shimizu, H.Hirano, M.Sato, H.Hashimoto
    • Journal Title

      Acta Cryst.

      Volume: F67 Issue: 7 Pages: 830-832

    • DOI

      10.1107/s1744309111020045

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis for matrix metalloproteinase-2 (MMP-2)-selective inhibitory action of β-amyloid precursor protein-derived inhibitor2011

    • Author(s)
      H.Hashimoto, T.Takeuchi, K.Komatsu, K.Miyazaki, M.Sato, S.Higashi
    • Journal Title

      J.Biol.Chem.

      Volume: 286 Issue: 38 Pages: 33236-33243

    • DOI

      10.1074/jbc.m111.264176

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Development of N-α-(2-Carboxyl)benzoyl-N5-(2-fluoro-1-iminoethyl)-L-The Development of N-α-(2-Carboxyl)benzoyl-N5-(2-fluoro-1-iminoethyl)-L-ornithine Amide (o-F-amidine) and N-α-(2-Carboxyl)benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine Amide (o-Cl-amidine) As Second Generation Protein Arginine Deiminase (PAD) Inhibitors2011

    • Author(s)
      C.P.Causey, J.E.Jones, J.L.Slack, D.Kamei, L.E.Jones, Jr., V.Subramanian, B.Knuckley, P.Ebrahimi, A.A.Chumanevich, Y.Luo, H.Hashimoto, M.Sato, L.J.Hofseth P.R.Thompson
    • Journal Title

      J.Med.Chem.

      Volume: 54 Issue: 19 Pages: 6919-6935

    • DOI

      10.1021/jm2008985

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fission yeast Swi5-Sfr1 protein complex, an activator of Rad51 recombinase, forms an extremely elongated dogleg-shaped structure2011

    • Author(s)
      Kokabu Y, Murayama Y, Kuwabara N, Oroguchi T, Hashimoto H, Tsutsui Y, Nozaki N, Akashi S, Unzai S, Shimizu T, Iwasaki H, Sato M, Ikeguchi M
    • Journal Title

      J Biol Chem

      Volume: 286 Issue: 50 Pages: 43569-43576

    • DOI

      10.1074/jbc.m111.303339

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] タンパク質の核内輸送の構造基盤2011

    • Author(s)
      佐藤衛
    • Journal Title

      生体の科学

      Volume: 62 Pages: 492-493

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] X線溶液散乱と分子動力学シミュレーションでみるタンパク質の揺らぎ2011

    • Author(s)
      佐藤衛
    • Journal Title

      高分子

      Volume: 60 Pages: 798-800

    • NAID

      10029795616

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural and biochemical analyses of the human PAD4 variant encoded by a functional haplotype gene2011

    • Author(s)
      N.Horikoshi, H.Tachiwana, K.Saito, A.Osakabe, M.Sato, M.Yamada, S.Akashi, Y.Nishimura, W.Kagawa, H.Kurumizaka
    • Journal Title

      Acta Cryst.

      Volume: D67 Pages: 112-118

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 天然変性タンパク質:タンパク質の構造・機能研究の新しいターゲット X線小角散乱と分子動力学シミュレーションによる動的構造解析2011

    • Author(s)
      苙口友隆、池口満徳、佐藤衛
    • Journal Title

      実験医学

      Volume: 29 Pages: 475-480

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystallization of Bg7S, Purification, crystallization and X-ray diffraction study of basic 7S globulin from soybean2011

    • Author(s)
      T.Yoshizawa, H.Hashimoto, T.Shimizu, M.Yamabe, N.Shichijo, K.Hanada, H.Hirano, M.Sato
    • Journal Title

      Acta Cryst.

      Volume: F67 Pages: 87-89

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure and Functional Characterization of Vibrio parahaemolyticus Thermostable Direct Hemolysin2010

    • Author(s)
      I.Yanagihara, K.Nakahira, T.Yamane, S.Kaieda, K.Mayanagi, D.Hamada, T.Fukui, K.Ohnishi, S.Kajiyama, T.Shimizu, M.Sato, T.Ikegami, M.Ikeguchi, T.Honda, H.Hashimoto
    • Journal Title

      J.Biol.Chem.

      Volume: 285 Pages: 16267-16274

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deimination stabilizes histone H2A/H2B dimers as revealed by electrospray ionization mass spectrometry2010

    • Author(s)
      Shimoyama, S., Nagadoi, A., Tachiwana, H., Yamada, M., Sato, M., Kurumizaka, H., Nishimura, Y., Akashi, S.
    • Journal Title

      J.Mass.Spectrom.

      Volume: 45 Pages: 900-908

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure of zinc-finger domain of Nanos and its functional implications2010

    • Author(s)
      H.Hashimoto, K.Hara, A.Hishiki, S.Kawaguchi, N.Shichijo, K.Nakamura, S.Unzai, Y.Tamaru, T. Shimizu, M.Sato
    • Journal Title

      EMBO Rep.

      Volume: 11 Pages: 848-853

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 中性子溶液散乱法による生体高分子の構造解析2010

    • Author(s)
      佐藤衛
    • Journal Title

      RADIOISOTOPES

      Volume: 59 Pages: 367-378

    • NAID

      10026384220

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystallization and X-ray diffraction studies of DNA-free and DNA-bound forms of EcoO 109I DNA methyltransferase2010

    • Author(s)
      M.Iwamoto, A.Hishiki, T.Shimada, T.Imasaki, J.Tsuda, K.Kita, T.Shimizu, M.Sato, H.Hashimoto
    • Journal Title

      Acta Cryst.

      Volume: F66 Pages: 1528-1530

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression, purification and crystallization of Swi5 and the Swi5-Sfr1 complex from fission yeast2010

    • Author(s)
      N.Kuwabara, H.Hashimoto, N.Yamada, S.Unzai, M.Ikeguchi, M.Sato, Y.Murayama, H.Iwasaki, T.Shimizu
    • Journal Title

      Acta Cryst.

      Volume: F66 Pages: 1124-1126

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 腸炎ビブリオが産生する耐熱性溶血毒TDHの構造と機能2010

    • Author(s)
      橋本博, 山根努, 池口満徳, 中平久美子, 柳原格
    • Journal Title

      日本結晶学会誌

      Volume: 52 Pages: 285-289

    • NAID

      10027673136

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase ζ and REV12010

    • Author(s)
      Kodai Hara, Hiroshi Hashimoto, Yoshiki Murakumo, Shunsuke Kobayashi, Toshiaki Kogame, Satoru Unzai, Satoko Akashi, Shunichi Takeda, Toshiyuki Shimizu, Mamoru Sato
    • Journal Title

      J Biol Chem 285

      Pages: 12299-307

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Purification, crystallization and initial X-ray diffraction study of human REV7 in complex with REV3 fragment2009

    • Author(s)
      Kodai Hara, Toshiyuki Shimizu, Satoru Unzai, Satoko Akashi, Mamoru Sato, Hiroshi Hashimoto
    • Journal Title

      Acta Crystallogr Sect F Struct Biol Cryst Commun 65

      Pages: 1302-5

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The structure of the N-terminal regulatory domain of a plant NADPH oxidase and its functional implications2009

    • Author(s)
      Takashi Oda, Hiroshi Hashimoto, Naoyuki Kuwabara, Satoko Akashi, Kokoro Hayashi, Chojiro Kojima, Wong Hann Ling, Tsutomu Kawasaki, Ko Shimamoto, Mamoru Sato, Toshiyuki Shimizu
    • Journal Title

      J Biol Chem 285

      Pages: 1435-45

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Purification, crystallization and initial X-ray diffraction study of the zinc-finger domain of zebrafish Nanos2009

    • Author(s)
      Hiroshi Hashimoto, Shigeta Kawaguchi, Kodai Hara, Keishi Nakamura, Toshiyuki Shimizu, Yutaka Tamaru, Mamoru Sato
    • Journal Title

      Acta Crystallogr Sect F Struct Biol Cryst Commun 65

      Pages: 959-61

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conserved aromatic and basic amino acid residues in the pore region of Caenorhabditis elegans spastin play critical roles in microtubule severing2009

    • Author(s)
      Yuka Matsushita-Ishiodori, Kunitoshi Yamanaka, Hiroshi Hashimoto, Masatoshi Esaki, Teru Ogura
    • Journal Title

      Genes Cells 14

      Pages: 925-40

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intrinsic Dynamics of Restriction Endonuclease EcoO109I Studied by Molecular Dynamics Simulations and X-Ray Scattering Data Analysis2009

    • Author(s)
      Tomotaka Oroguchi, Hiroshi Hashimoto, Toshiyuki Shimizu, Mamoru Sato, Mitsunori Ikeguchi
    • Journal Title

      Biophys J 96

      Pages: 2808-22

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 損傷乗り越え型DNAポリメラーゼとPCNAの相互作用2009

    • Author(s)
      菱木麻美, 橋本博
    • Journal Title

      日本結晶学会誌 51

      Pages: 286-91

    • NAID

      10026107483

    • Related Report
      2009 Annual Research Report
  • [Presentation] ニンジンEDGPの麹菌キシログルカン特異的エンドグルカナーゼ阻害機構2012

    • Author(s)
      吉澤拓也、清水敏之、平野久、橋本博、佐藤衛
    • Organizer
      第29回PFシンポジウム
    • Place of Presentation
      つくば国際会議場
    • Related Report
      2011 Annual Research Report
  • [Presentation] Structure of REV7 in complex with a REV3 fragment and structural implication of the interaction between DNA polymerase ζ and REV12011

    • Author(s)
      Hiroshi Hashimoto
    • Organizer
      SNY-YCU Bilateral Symposium on Structural Biology
    • Place of Presentation
      SNY-YCU Bilateral Symposium on Structural Biology
    • Year and Date
      2011-11-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 天然変性タンパク質をターゲットとした新しい構造生物学2011

    • Author(s)
      佐藤衛
    • Organizer
      京都大学大学院理学研究科講演会
    • Place of Presentation
      京都大学大学院理学研究科セミナーハウス(大セミナー室)(招待講演)
    • Year and Date
      2011-07-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 生殖細胞の形成に関わるゼブラフィッシュ由来Nanosタンパク質の構造 生物学的研究2011

    • Author(s)
      橋本博
    • Organizer
      三重大学大学院生物資源学研究科生物圏生命科学専攻博士後期課程 重点シンポジウム
    • Place of Presentation
      三重大学
    • Year and Date
      2011-02-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Protonation & Deprotonation of Protein Revealed by X-ray & Neutron Crystallography2011

    • Author(s)
      Mamoru Sato
    • Organizer
      The First International Symposium on Structural Epigenomics
    • Place of Presentation
      Hamagin Hall Viamare
    • Year and Date
      2011-01-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Towards the structural characterization of intrinsically disordered proteins by SAXS and MD simulation2011

    • Author(s)
      Mamoru Sato
    • Organizer
      第34回日本分子生物学会大会
    • Place of Presentation
      パシフィコ横浜(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Biochemical and structural analyses of the nucleosome in transcriptionally active region2011

    • Author(s)
      Yusuhiro Arimura, Hiroaki Tachibana, Takashi Oda, Mamoru Sato, Hitoshi Kurumizaka
    • Organizer
      第34回日本分子生物学会大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] Crystal structure and biochemical property of the human centromere specific nucleosome2011

    • Author(s)
      Hiroaki Tachibana, Wataru Kagawa, Tatsuya Shiga, Ryohei Matsumoto, Yuta Miya, Akihisa Osakabe, Yoko Hayashi-Takanaka, Takashi Oda, Mamoru Sato, Sam-Yong Park, Hiroshi Kimura, Hitoshi Kurumizaka
    • Organizer
      第34回日本分子生物学会大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] Structure of REV7 in complex with a REV3 fragment and structural implication of the interaction between DNA polymerase F Nf and REV12011

    • Author(s)
      Hiroshi Hashimoto, Kodai Hara, Yoshiki Murakumo, Shunsuke Kobayashi, Toshiaki Kogame, Satoru Unzai, Satoko Akashi, Shunichi Takeda, Toshiyuki Shimizu, Mamoru Sato
    • Organizer
      Current Opinion in Structural Biology & DNA Repair, A Current Opinion in Structural Biology conference
    • Place of Presentation
      NH Grand Hotel Krasnapolsky, Amsterdam, Netherlands
    • Related Report
      2011 Annual Research Report
  • [Presentation] ニンジンEDGPによる麹菌XEGの阻害複合体構造2011

    • Author(s)
      吉澤拓也, 橋本博, 清水敏之, 平野久, 佐藤衛
    • Organizer
      平成23年度日本結晶学会年会
    • Place of Presentation
      北海道大学学術交流会館(札幌市)
    • Related Report
      2011 Annual Research Report
  • [Presentation] APP由来インヒビターペプチドによるMMP-2選択的阻害機構の解明2011

    • Author(s)
      竹内友香、橋本博、宮崎香、佐藤衛、東昌市
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      京都国際会館
    • Related Report
      2011 Annual Research Report
  • [Presentation] SAXS to Investigate Protein Flexibility and Intrinsic Disorder in Solution2011

    • Author(s)
      Mamoru Sato
    • Organizer
      The 3th Asian Symposium on Advance Materials : Chemistry & Physics of Functional Materials (ASAM-3)
    • Place of Presentation
      Kyushu University (Chikushi-campus)(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Analysis on dynamical structure of intrinsically disordered protein Hef, using MD-SAXS method2011

    • Author(s)
      T.Oroguchi, T.Oda, H.Hashimoto, Y.Ishino, M.Ikeguchi, M.Sato
    • Organizer
      第49回日本生物物理学会年会
    • Place of Presentation
      兵庫県立大学・姫路書写キャンパス
    • Related Report
      2011 Annual Research Report
  • [Presentation] MMP-2とAPP由来インヒビターペプチドとの複合体の結晶構造解析2011

    • Author(s)
      竹内友香、橋本博、宮崎香、佐藤衛、東昌市
    • Organizer
      第16回日本病態プロテアーゼ学会学術集会2011
    • Place of Presentation
      千里ライフサイエンスセンター
    • Related Report
      2011 Annual Research Report
  • [Presentation] Structural basis of inhibition mechanism by carrot EDGP against GH12. The inhibitory structure of carrot EDGP against endoglucanase from A.aculeatus2011

    • Author(s)
      Takuya Yoshizawa, Toshiyuki Shimizu, Hisashi Hirano, Mamoru Sato, Hiroshi Hashimoto
    • Organizer
      XXII Congress of the International Union of Crystallography
    • Place of Presentation
      Palacio Municipal de Congresos de Madrid/Municipal Conference Centre
    • Related Report
      2011 Annual Research Report
  • [Presentation] Crystal structure of zinc-finger domain of Nanos and its functional implications2011

    • Author(s)
      Hiroshi Hashimoto, Kodai Hara, Asami Hishiki, Shigeta Kawaguchi, Takuya Yoshizawa, Satoru Unzai, Yutaka Tamaru, Toshiyuki Shimizu, Mamoru Sato
    • Organizer
      XXII Congress of the International Union of Crystallography
    • Place of Presentation
      Palacio Municipal de Congresos de Madrid/Municipal Conference Centre
    • Related Report
      2011 Annual Research Report
  • [Presentation] 制限酵素EcoO109IのDNA結合に関する構造研究2011

    • Author(s)
      渡部みなみ、橋本博、喜多恵子、清水敏之、佐藤衛
    • Organizer
      第28回PFシンポジウム
    • Place of Presentation
      つくば国際会議場(エポカルつくば)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 腸炎ビブリオ由来耐熱性溶血毒TDHの構造2011

    • Author(s)
      橋本博、中平久美子、山根努、福井貴史、大西紀陽久、清水敏之、本田武司、佐藤衛、池口満徳、柳原格
    • Organizer
      第28回PFシンポジウム
    • Place of Presentation
      つくば国際会議場(エポカルつくば)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 始原生殖細胞の形成に関わるNanosの構造生物学的研究2011

    • Author(s)
      橋本博、原幸大、菱木麻美、川口茂太、七條直記、中村敬至、雲財悟、田丸浩、清水敏之、佐藤衛
    • Organizer
      第28回PFシンポジウム
    • Place of Presentation
      つくば国際会議場(エポカルつくば)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 始原生殖細胞の維持に関わるNanosの構造生物学的研究2011

    • Author(s)
      橋本博、原幸大、菱木麻美、川口茂太、吉澤拓也、雲財悟、田丸浩、清水敏之、佐藤衛
    • Organizer
      第11回日本蛋白質科学会
    • Place of Presentation
      ホテル阪急エキスポパーク
    • Related Report
      2011 Annual Research Report
  • [Presentation] 分子動力学シミュレーションによるK48およびK63結合型ジユビキチンの動的構造解析2011

    • Author(s)
      渕上壮太郎、笠口友隆、池口満徳、佐藤衛、木寺詔紀
    • Organizer
      第11回日本蛋白質科学会
    • Place of Presentation
      ホテル阪急エキスポパーク
    • Related Report
      2011 Annual Research Report
  • [Presentation] 天然変性タンパク質をターゲットとした新しい構造生物学-将来光源を用いた1分子解析を目指して-2011

    • Author(s)
      佐藤衛
    • Organizer
      PF研究会「ERLサイエンスワークショップII」
    • Place of Presentation
      高エネルギー加速器研究機構「小林ホール」(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 制限酵素EcoO109IのDNA結合メカニズムの構造学的解明2011

    • Author(s)
      渡部みなみ、橋本博、喜多恵子 、清水敏之、佐藤衛
    • Organizer
      第24回日本放射光学会年会
    • Place of Presentation
      つくば国際会議場(エポカルつくば)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腸炎ビブリオが産生する耐熱性溶血毒TDHの構造解析2011

    • Author(s)
      橋本博、中平久美子、山根努、福井貴史、大西紀陽久、清水敏之、本田武司、佐藤衛、池口満徳、柳原格
    • Organizer
      第24回日本放射光学会年会
    • Place of Presentation
      つくば国際会議場(エポカルつくば)
    • Related Report
      2010 Annual Research Report
  • [Presentation] ニンジン由来Extra cellular dermal glycoproteinの結晶構造解析2011

    • Author(s)
      吉澤拓也、橋本博、清水敏之、平野久、佐藤衛
    • Organizer
      第24回日本放射光学会年会
    • Place of Presentation
      つくば国際会議場(エポカルつくば)
    • Related Report
      2010 Annual Research Report
  • [Presentation] タンパク質の動的構造解析-MD-SAXSからX-FELを用いた1分子解析へ-2011

    • Author(s)
      佐藤衛、苙口友隆
    • Organizer
      第2回中性子小角散乱解析法研究会
    • Place of Presentation
      京都大学原子炉実験所
    • Related Report
      2010 Annual Research Report
  • [Presentation] Towards the structural characterization of IDPs by SAXS and MD simulation2011

    • Author(s)
      Mamoru Sato
    • Organizer
      The First International Symposium on Intrinsically Disordered Proteins
    • Place of Presentation
      Hamagin Hall Viamare
    • Related Report
      2010 Annual Research Report
  • [Presentation] 損傷乗り越えDNA合成におけるタンパク質間相互作用の構造生物学2010

    • Author(s)
      橋本博
    • Organizer
      第18回大阪府立母子保健総合医療センターシンポジウム(母と子のすこやか基金)
    • Place of Presentation
      大阪府立母子保健総合医療センター研究所
    • Year and Date
      2010-12-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 天然変性タンパク質の動的構造に基づく創薬2010

    • Author(s)
      佐藤衛
    • Organizer
      武田薬品工業株式会社セミナー
    • Place of Presentation
      武田薬品工業株式会社医薬品研究本部探索研究センター
    • Year and Date
      2010-12-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] X線小角散乱と天然変性タンパク質:タンパク質の動的構造解析の 新しいパラダイム2010

    • Author(s)
      佐藤衛
    • Organizer
      日本学術振興会回折構造生物第169委員会第32回研究会
    • Place of Presentation
      ゆうぽうと(東京都品川区 )
    • Year and Date
      2010-11-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 天然変性タンパク質の動的構造解析への挑戦2010

    • Author(s)
      佐藤衛
    • Organizer
      文科省「新学術領域研究(天然変性蛋白質)」第1回公開シンポジウム
    • Place of Presentation
      理化学研究所横浜研究所
    • Year and Date
      2010-01-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 生体内におけるマウスPAD4の細胞内局在性2010

    • Author(s)
      奈良拓也、佐藤友美、佐藤衛、山田道之、仁科行雄
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会(合同大会)
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2010 Annual Research Report
  • [Presentation] Crystal structure of xyloglucan specific endo-β-1, 4-glucanase from Aspergillus aculeatus2010

    • Author(s)
      T.Yoshizawa, H.Hashimoto, T.Shimizu, H.Hirano, M.Sato
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会(合同大会)
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2010 Annual Research Report
  • [Presentation] Crystal structure of Nanos zinc-finger domain reveals functional implication of RNA binding2010

    • Author(s)
      H.Hashimoto, K.Hara, A.Hishiki, S.Kawaguchi, N.Shichijo, K.Nakamura, S.Unzai, Y.Tamaru, T. Shimizu, M.Sato
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会(合同大会)
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2010 Annual Research Report
  • [Presentation] 質量分析を用いたヒストンH2A-H2Bのシトルリン化の解析2010

    • Author(s)
      浅野裕輝、下山真吾、長土居有隆、立和名博昭、山田道之、佐藤衛、胡桃沢仁志、西村善文、明石知子
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会(合同大会)
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2010 Annual Research Report
  • [Presentation] 相同組換えに関わるSwi5-Sfr1複合体の構造機能解析2010

    • Author(s)
      桑原直之、橋本博、小甲裕一、池口満徳、佐藤衛、真柳浩太、村山泰斗、岩崎博史、清水敏之
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会(合同大会)
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2010 Annual Research Report
  • [Presentation] GH12に属するキシログルカン特異的エンドグルカナーゼXEGの結晶構造解析2010

    • Author(s)
      吉澤拓也、橋本博、清水敏之、佐藤衛
    • Organizer
      日本結晶学会2010年度年会
    • Place of Presentation
      大阪大学コンベンションセンター
    • Related Report
      2010 Annual Research Report
  • [Presentation] Sulfolobus tokodaii由来PCNA2-PCNA3複合体の立体構造2010

    • Author(s)
      河合聡人、橋本博、樋口成定、角田大、佐藤衛、中村和郎、宮本秀
    • Organizer
      日本結晶学会2010年度年会
    • Place of Presentation
      大阪大学コンベンションセンター
    • Related Report
      2010 Annual Research Report
  • [Presentation] 制限酵素EcoO109IのDNA結合に関する構造基盤2010

    • Author(s)
      渡部みなみ、橋本博、喜多恵子、清水敏之、佐藤衛
    • Organizer
      日本結晶学会2010年度年会
    • Place of Presentation
      大阪大学コンベンションセンター
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腸炎ビブリオの産出する耐熱性溶血毒TDHの構造研究2010

    • Author(s)
      橋本博、中平久美子、山根努、福井貴史、大西紀陽久、清水敏之、本武司、佐藤衛、池口満徳、柳原格
    • Organizer
      日本結晶学会2010年度年会
    • Place of Presentation
      大阪大学コンベンションセンター
    • Related Report
      2010 Annual Research Report
  • [Presentation] Crystal structure of thermostable direct hemolysin from Vibrio parahaemolyticus2010

    • Author(s)
      Hiroshi Hashimoto, Kumiko Nakahira, Tsutomu Yamane, Takashi Fukui, Kiyohisa Ohnishi, Toshiyuki Shimizu, TakeshiHonda, Mamoru Sato, Mitsunori Ikeguchi, Itaru Yanagihara
    • Organizer
      The 10th Conference of the Asian Crystallographic Association (AsCA2010)
    • Place of Presentation
      BEXCO, Busan, Korea
    • Related Report
      2010 Annual Research Report
  • [Presentation] Crystal structure of extra cellular dermal glycoprotein from carrot and xyloglucan specific endo-β-1, 4-glucanase from Aspergillus aculeatue2010

    • Author(s)
      Takuya, Yoshizawa, Hiroshi Hashimoto, Toshiyuki Shimizu, Hisashi Hirano, Mamoru Sato
    • Organizer
      The 10th Conference of the Asian Crystallographic Association (AsCA2010)
    • Place of Presentation
      BEXCO, Busan, Korea
    • Related Report
      2010 Annual Research Report
  • [Presentation] Solution structure of S.pombe Swi5-Sfr1 studied by small-angle X-ray scattering2010

    • Author(s)
      S.Kokabu, Y.Murayama, N. Kuwabara, T.Oroguchi, H.Hashimoto, T.Shimizu, H.Iwasaki, M.Sato, M.Ikeguchi
    • Organizer
      第48回日本生物物理学会年会
    • Place of Presentation
      東北大学川内キャンパス
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dynamic structure analysis of diubiquitins with different linkages studied by MD-SAXS method2010

    • Author(s)
      S.Fuchigami, T.Oroguchi, M.Ikeguchi, M.Sato, A.Kidera
    • Organizer
      第48回日本生物物理学会年会
    • Place of Presentation
      東北大学川内キャンパス
    • Related Report
      2010 Annual Research Report
  • [Presentation] Structural modeling for protein complexes using small-angle X-ray scattering2010

    • Author(s)
      K.Oshima, D.Standley, E. Kanamori, Y.Murakami, T.Oroguchi, M.Ikeguchi, M.Sato, H. Nakamura
    • Organizer
      第48回日本生物物理学会年会
    • Place of Presentation
      東北大学川内キャンパス
    • Related Report
      2010 Annual Research Report
  • [Presentation] X線小角散乱法による分裂酵母Swi-Sfr1の溶液構造解析2010

    • Author(s)
      小甲裕一、村山泰斗、桑原直之、苙口友隆、橋本博、清水敏之、岩崎博史、佐藤衛、池口満徳
    • Organizer
      第10回日本蛋白質科学会年会
    • Place of Presentation
      札幌コンベンションセンター
    • Related Report
      2010 Annual Research Report
  • [Presentation] X線小角散乱法を用いたタンパク質複合体の構造モデリングを目指して2010

    • Author(s)
      大島勘二、S.Daron、金森英司、村上洋一、苙口友隆、池口満徳、佐藤衛、中村春木
    • Organizer
      第10回日本蛋白質科学会年会
    • Place of Presentation
      札幌コンベンションセンター
    • Related Report
      2010 Annual Research Report
  • [Presentation] 天然変性タンパク質研究:タンパク質の構造・機能研究の新しいパラダイム2010

    • Author(s)
      佐藤衛
    • Organizer
      第10回日本蛋白質科学会年会
    • Place of Presentation
      札幌コンベンションセンター
    • Related Report
      2010 Annual Research Report
  • [Presentation] 翻訳語修飾にともなうタンパク質の構造変化-H2A/H2Bのシトルリン化-2010

    • Author(s)
      下山真吾、長土居有隆、立和名博昭、浅野裕輝、山田道之、佐藤衛、胡桃坂仁志、西村善文、 明石知子
    • Organizer
      第58回質量分析総合討論会
    • Place of Presentation
      エポカルつくば
    • Related Report
      2010 Annual Research Report
  • [Presentation] 天然変性タンパク質の動的構造解析を目指して-X線小角散乱とMDシミュレーションのコラボレーション-2010

    • Author(s)
      佐藤衛
    • Organizer
      第3回タンパク質の異常凝集とその防御・修復機構に関する研究会(京都大学原子炉実験所・専門研究会)
    • Place of Presentation
      京都大学原子炉実験所
    • Related Report
      2010 Annual Research Report
  • [Presentation] Towards the dynamical structure analysis of intrinsically disordered proteins in solution by SAXS and MD simulation2010

    • Author(s)
      Mamoru Sato
    • Organizer
      The 6th Future Light Source Workshop 2010 : Science and Technology
    • Place of Presentation
      Pohang Accelerator Laboratory, Pohang, Korea
    • Related Report
      2010 Annual Research Report
  • [Presentation] Towards the structural characterization of intrinsically disordered proteins by small-angle X-ray scattering and molecular dynamics simulation2010

    • Author(s)
      Mamoru Sato
    • Organizer
      JST ERATO and CREST Joint Symposium"Future Trend in Soft material Research with Advanced Synchrotron Source-Interdisciplinary of Bio- & Synthetic- Materials and Industrial Transferring-"
    • Place of Presentation
      SPring-8
    • Related Report
      2010 Annual Research Report
  • [Presentation] 大きく揺らいでいる天然変性タンパク質の動的構造解析を目指して2010

    • Author(s)
      佐藤衛
    • Organizer
      岡崎統合バイオサイエンスセンター・サマースクール生命機能分子から生命システムの全体像に迫る-細胞内ネットワークと天然変性タンパク-
    • Place of Presentation
      岡崎統合バイオサイエンスセンター
    • Related Report
      2010 Annual Research Report
  • [Presentation] 天然変性タンパク質-タンパク質の構造・機能研究の新しいターゲット2010

    • Author(s)
      佐藤衛
    • Organizer
      PF研究会
    • Place of Presentation
      KEK小林ホール
    • Related Report
      2010 Annual Research Report
  • [Presentation] 天然変性タンパク質研究:タンパク質の構造機能研究の新しいパラダイム2010

    • Author(s)
      佐藤衛
    • Organizer
      第10回日本蛋白質科学会年会ワークショップ「天然変性タンパク質研究が目指すサイエンス」
    • Place of Presentation
      札幌コンベンションセンター
    • Related Report
      2010 Annual Research Report
  • [Presentation] MD-SAXS法でみるタンパク質のゆらぎ2010

    • Author(s)
      佐藤衛
    • Organizer
      大阪大学蛋白質研究所セミナー「次世代生命体統合シミュレーション研究開発プロジェクト・分子スケールワークショップ」ペタスケールの生体分子シミュレーション
    • Place of Presentation
      理化学研究所横浜研究所
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒトREV7の構造生物学的研究2010

    • Author(s)
      原幸大, 橋本博, 村雲芳樹, 小林俊介, 小亀敏明, 雲財悟, 明石知子, 武田俊一, 清水敏之, 佐藤衛
    • Organizer
      第27回PFシンポジウム
    • Place of Presentation
      つくば国際会議場
    • Related Report
      2009 Annual Research Report
  • [Presentation] X線小角散乱法と分子動力学シミュレーションを組み合わせたマルチドメインタンパク質の動的構造解析2009

    • Author(s)
      佐藤衛
    • Organizer
      京都大学原子炉実験所セミナー
    • Place of Presentation
      京都大学原子炉実験所
    • Year and Date
      2009-06-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] タンパク質の核内輸送受容体(トランスポーチン)の構造生物学2009

    • Author(s)
      佐藤衛, 今崎剛, 亀井大助, 橋本博, 山田道之, 清水敏之
    • Organizer
      第9回日本蛋白質科学会
    • Place of Presentation
      熊本全日空ホテルニュースカイ
    • Related Report
      2009 Annual Research Report
  • [Presentation] Protein Dynamics Investigated by the Combined Use of Small-Angle Scattering and Molecular Dynamics Simulation2009

    • Author(s)
      佐藤衛
    • Organizer
      Workshop on Possible Scientific View from New Neutron Spectroscopy Opportunities in J-PARC
    • Place of Presentation
      Ibaraki Quantum Beam Research Center, Tokai Plaza Cafe(Tokai)
    • Related Report
      2009 Annual Research Report
  • [Presentation] X-ray and neutron structure analyses of proton transfer catalysis by endoPG I2009

    • Author(s)
      M.Sato, T.Shimizu, T.Nakatsu, K.Miyairi, T.Okuno, H.Kato
    • Organizer
      25th European Crystallographic Meeting(ECM25)
    • Place of Presentation
      The Military Museum(Askeri Muzesi)at Istanbul
    • Related Report
      2009 Annual Research Report
  • [Presentation] バイオ・ソフトマテリアルでの小角散乱利用2009

    • Author(s)
      佐藤衛, 竹中幹人
    • Organizer
      第13回SPring-8シンポジウム
    • Place of Presentation
      東京ステーションコンファレンス
    • Related Report
      2009 Annual Research Report
  • [Presentation] X線小角散乱と分子動力学シミュレーションを用いたタンパク質のダイナミクス研究2009

    • Author(s)
      佐藤衛
    • Organizer
      第58回高分子討論会
    • Place of Presentation
      熊本大学黒髪キャンパス
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒストンタンパク質H2A/H2Bのシトルリン化の解析2009

    • Author(s)
      下山真吾, 長土居有隆, 立和名博昭, 山田道之, 佐藤衛, 胡桃坂仁志, 西村善文, 明石知子
    • Organizer
      第82回日本生化学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2009 Annual Research Report
  • [Presentation] X線小角散乱法と分子動力学シミュレーションを組み合わせた天然変性タンパク質動的構造解析法の開発2009

    • Author(s)
      佐藤衛
    • Organizer
      第82回日本生化学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2009 Annual Research Report
  • [Presentation] 小角散乱と分子動力学シミュレーションを組み合わせた新しいタンパク質のダイナミックス研究2009

    • Author(s)
      佐藤衛
    • Organizer
      第2回タンパク質の異常凝集とその防御・修復機構に関する研究会
    • Place of Presentation
      京都大学原子炉実験所
    • Related Report
      2009 Annual Research Report
  • [Presentation] Towards the structural characterization of intrinsically disordered proteins by the combined use of small-angle X-ray scattering and molecular dynamics simulation2009

    • Author(s)
      佐藤衛
    • Organizer
      7th Pusan Workshop on Proteome Biophysics & 1^<st> Asia-Pacific IUP Symposium
    • Place of Presentation
      Paradise Hotel, Hae Un Dae Beach, Pusan, Korea
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト由来Mad2L2の結晶学的研究2009

    • Author(s)
      原幸大, 清水敏之, 村雲芳樹, 花房朋, 大森治夫, 佐藤衛, 橋本博
    • Organizer
      第9回日本蛋白質科学会
    • Place of Presentation
      熊本全日空ホテルニュースカイ
    • Related Report
      2009 Annual Research Report
  • [Presentation] レグインスリン結合タンパク質の結晶構造2009

    • Author(s)
      吉澤拓也, 橋本博, 雲財悟, 西内祐二, 平野久, 清水敏之, 佐藤衛
    • Organizer
      第9回日本蛋白質科学会
    • Place of Presentation
      熊本全日空ホテルニュースカイ
    • Related Report
      2009 Annual Research Report
  • [Presentation] EcoO109IメチルトランスフェラーゼのDNA認識に関する構造基盤2009

    • Author(s)
      菱木麻美, 橋本博, 岩本真, 島田隆史, 今崎剛, 喜多恵子, 清水敏之, 佐藤衛
    • Organizer
      第9回日本蛋白質科学会
    • Place of Presentation
      熊本全日空ホテルニュースカイ
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト由来Mad2L2の結晶学的研究2009

    • Author(s)
      Kodai Hara, Toshiyuki Shimizu, Yoshiki Murakumo, Tomo Hanafusa, Haruo Ohmori, Mamoru Sato, Hiroshi Hashimoto
    • Organizer
      American Crystallographic Association Meeting
    • Place of Presentation
      Toronto at Canada
    • Related Report
      2009 Annual Research Report
  • [Presentation] Structural study for regulation mechanism of plant NADPH oxidase2009

    • Author(s)
      Takashi Oda, Hiroshi Hashimoto, Naoyuki Kuwabara, Kokoro Hayashi, Chojiro Kojima, Hann Ling Wong, Tsutomu Kawasaki, Ko Shimamoto, Mamoru Sato, Toshiyuki Shimizu
    • Organizer
      American Crystallographic Association Meeting
    • Place of Presentation
      Toronto at Canada
    • Related Report
      2009 Annual Research Report
  • [Presentation] Crystal structure of DNA ADP-ribosylating protein, pierisin-12009

    • Author(s)
      Toshiyuki Shimizu, Hiroshi Hashimoto, Kiyoshi Hiraga, Tkashi Oda, Tsuyoshi Nakano, Takashi Sugimura, Keiji Wakabayashi, Mamoru Sato
    • Organizer
      American Crystallographic Association Meeting
    • Place of Presentation
      Toronto at Canada
    • Related Report
      2009 Annual Research Report
  • [Presentation] Structural basis for novel interactions between human TLS polymerases and PCNA2009

    • Author(s)
      Asami Hishiki, Hiroshi Hashimoto, Tomo Hanafusa, Keijiro Kamei, Eiji Ohashi, Toshiyuki Shimizu, Haruo Ohmori, Mamoru Sato
    • Organizer
      25th European Crystallographic Meeting
    • Place of Presentation
      The Military Museum(Askeri Muzesi)at Istanbul
    • Related Report
      2009 Annual Research Report
  • [Presentation] REV7とREV3フラグメントの複合体構造2009

    • Author(s)
      橋本博
    • Organizer
      国立遺伝学研究所研究会
    • Place of Presentation
      遺伝学研究所
    • Related Report
      2009 Annual Research Report
  • [Presentation] Crystal structure of human REV7 in complex with REV3 fragment2009

    • Author(s)
      橋本博
    • Organizer
      Joint Conference of the Asian Crystallographic Associati on and Chinese Crystallography Society
    • Place of Presentation
      Jingyi Hotel in Beijing(China)
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト由来REV7-REV3複合体のX線結晶構造解析2009

    • Author(s)
      原幸大, 清水敏之, 村雲芳樹, 小林俊介, 小亀敏明, 花房朋, 大森治夫, 武田俊一, 佐藤衛, 橋本博
    • Organizer
      第82回 日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2009 Annual Research Report
  • [Presentation] エンドグルカナーゼ阻害タンパク質の構造機能解析2009

    • Author(s)
      吉澤拓也, 橋本博, 西内祐二, 雲財悟, 平野久, 清水敏之, 佐藤衛
    • Organizer
      第82回 日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2009 Annual Research Report
  • [Presentation] Crystal structure of leginsulin binding protein from carrot2009

    • Author(s)
      吉澤拓也, 橋本博, 西内祐二, 雲財悟, 平野久, 清水敏之, 佐藤衛
    • Organizer
      第47回 日本生物物理学会年会
    • Place of Presentation
      アスティ徳島
    • Related Report
      2009 Annual Research Report
  • [Presentation] Crystal structure of human REV7 in complex with REV3 fragment2009

    • Author(s)
      Kodai Hara, Toshiyuki Shimizu, Yoshiki Murakumo, Tomo Hanafusa, Haruo Ohmori, Mamoru Sato, Hiroshi Hashimoto
    • Organizer
      第47回 日本生物物理学会年会
    • Place of Presentation
      アスティ徳島
    • Related Report
      2009 Annual Research Report
  • [Presentation] Functional characterization and low resolution solution structure of copper pumping P-type ATPase from Thermus Thermophilus HB82009

    • Author(s)
      Naoyuki Kuwabara, Takashi Oda, Gen Shikauchi, Hiroshi Hashimoto, Mamoru Sato, Toshiyuki Shimizu
    • Organizer
      第47回 日本生物物理学会年会
    • Place of Presentation
      アスティ徳島
    • Related Report
      2009 Annual Research Report
  • [Presentation] Structural analysis of PCNA with G178S mutation2009

    • Author(s)
      菱木麻美, 清水敏之, 明石知子, 雲財悟, 佐藤衛, 橋本博
    • Organizer
      第47回 日本生物物理学会年会
    • Place of Presentation
      アスティ徳島
    • Related Report
      2009 Annual Research Report
  • [Presentation] PCNA G178S変異体の構造解析2009

    • Author(s)
      菱木麻美, 清水敏之, 明石知子, 雲財悟, 佐藤衛, 橋本博
    • Organizer
      日本結晶学会2009年年会
    • Place of Presentation
      関西学院大学, 西宮上ヶ原キャンパス
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト由来DNAポリメラーゼζとREV1の相互作用に関する構造生物学的研究2009

    • Author(s)
      原幸大, 清水敏之, 村雲芳樹, 小林俊介, 小亀敏明, 武田俊一, 佐藤衛, 橋本博
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] 分子動力学計算及びX線小角散乱を用いた、好熱菌F1-ATPase epsilon サブユニットのATP結合に伴う構造変化の研究s2009

    • Author(s)
      苙口友隆, 山田康之, 伊藤和輝, 橋本博, 雲財悟, 佐藤衛, 池口満徳
    • Organizer
      第9回日本蛋白質科学会
    • Place of Presentation
      熊本全日空ホテルニュースカイ
    • Related Report
      2009 Annual Research Report
  • [Presentation] 分裂酵母の相同組換えに機能するSwi5とSfr1の溶液構造解析2009

    • Author(s)
      小甲裕一, 苙口友隆, 村山泰斗, 桑原直之, 山根努, 橋本博, 雲財悟, 清水敏之, 岩崎博史, 池口満徳
    • Organizer
      第9回日本蛋白質科学会
    • Place of Presentation
      熊本全日空ホテルニュースカイ
    • Related Report
      2009 Annual Research Report
  • [Presentation] Solution structures of DNA recombination mediators Swi5 and Sfr1 in fission yeast studied by small-angle X-ray scattering2009

    • Author(s)
      小甲裕一, 苙口友隆, 村山泰斗, 桑原直之, 山根努, 橋本博, 雲財悟, 清水敏之, 岩崎博史, 池口満徳
    • Organizer
      第47回 日本生物物理学会年会
    • Place of Presentation
      アスティ徳島
    • Related Report
      2009 Annual Research Report
  • [Book] 翻訳後修飾のプロテオミクス(平野久、大野茂男編集)2011

    • Author(s)
      佐藤衛、萩原央記、明石知子
    • Total Pages
      234
    • Publisher
      講談社
    • Related Report
      2011 Final Research Report
  • [Book] 翻訳後修飾のプロテオミクス(第4章:翻訳後修飾タンパク質の網羅的解析、4-13.脱イミノ化)平野久、大野茂男編集2011

    • Author(s)
      佐藤衛、萩原央記、明石知子
    • Total Pages
      234
    • Publisher
      講談社
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 抗PAD4抗体医薬の創成2010

    • Inventor(s)
      佐藤衛,金澤智,山田道之,清水敏之
    • Industrial Property Rights Holder
      横浜市立大学,名古屋市立大学
    • Filing Date
      2010-08-23
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 抗PAD4抗体医薬の創成2010

    • Inventor(s)
      佐藤衛, 金澤智, 山田道之, 清水敏之
    • Industrial Property Rights Holder
      横浜市立大学名古屋市立大学
    • Industrial Property Number
      2010-185734
    • Filing Date
      2010-08-23
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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