Role of neural specific carbohydrates in neural plasticity
| Project/Area Number |
21370053
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Functional biochemistry
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
OKA Shogo 京都大学, 医学研究科, 教授 (60233300)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KAWASAKI Nana 国立医薬品食品衛生研究所, 生物薬品部, 部長 (20186167)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2009: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
|
|---|
| Keywords | 糖鎖生物学 / 神経可塑性 / HNK-1糖鎖 / グルタミン酸受容体 / N型糖鎖 / グルクロン酸転移酵素 / flexible loop / 細胞内輸送 / 遺伝子欠損マウス / グルクロン酸転移酸素 / ガラクトース転移酵素 / スパイン |
|---|
| Research Abstract |
HNK-1 carbohydrate has important roles in higher brain functions such as learning and memory. However, it remains unclear how HNK-1 regulates these functions. In this study, using the GlcAT-P-deficient mice, we demonstrated that loss of HNK-1 carbohydrate resulted in increased filopodia-like immature spines both in early postnatal mice and in cultured hippocampal neurons. We also identified a novel HNK-1 carbohydrate carrier molecule as AMPA type glutamate receptor subunit GluR2.
|
Report
(4 results)
Research Products
(54 results)
