| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2009: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Research Abstract |
HNK-1 carbohydrate has important roles in higher brain functions such as learning and memory. However, it remains unclear how HNK-1 regulates these functions. In this study, using the GlcAT-P-deficient mice, we demonstrated that loss of HNK-1 carbohydrate resulted in increased filopodia-like immature spines both in early postnatal mice and in cultured hippocampal neurons. We also identified a novel HNK-1 carbohydrate carrier molecule as AMPA type glutamate receptor subunit GluR2.
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