| Project/Area Number |
21370055
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Chugoku Gakuen University (2011-2012)
Osaka University (2009-2010) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MITSUI Kaiji 大阪大学, 理学研究科, 助教 (60379279)
NAGAMORI Syushi 大阪大学, 医学研究科, 助教 (90467572)
MATSUSHITA Masafumi 大阪大学, 理学研究科, 助教 (50403100)
OHGAKI Ryuichi 大阪大学, 医学研究科, 助教 (20467525)
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| Project Period (FY) |
2009 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2011: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2009: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Keywords | エンドサイトーシス / 酵母の NHE / 細胞内局所p H 制御 / 細胞内蛋白質局在化 機構 / 細胞内 pH 調節 Na+/H+ 交換輸送体 / 細胞内小胞型 NHE / 細胞内蛋白質の輸送 / 細胞内pH調節 / Na+/H+交換輸送体 / 細胞内小胞型NHE / 酵母のNHE / 細胞内局所ｐH制御 / 細胞内蛋白質局在化機構 / Na^+/H^+交換輸送体 / 生体膜イオン輸送 / pH制御 / 膜小胞輸送 / NHE / 細胞内イオン環境 / Na+/H+交換輸送蛋白質 / オルガネラ局在 / pH調節 / 細胞内小胞輸送機構 / 蛋白質の局在化機構 / 細胞内小胞pH測定 / 細胞極性形成 / 膜イオン輸送 |
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| Research Abstract |
Na+/H+ exchangers (NHE. Or Nha) are found in the plasma or endosome membranes for the most cells of living organisms. Cytoplasmic pH is maintained at 7 while intracellular ensodome pH is set at weak acidic pH. NHEs are provided to regulate the cytoplasmic and endosome pH. However, their physiological function is still not clarified. In the present study, we focused on the physiological role of NHE localized at various endosomes and found a novel role in the intracellular protein trafficking.
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