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Analysis of the novel family of G protein-coupled receptor

Research Project

Project/Area Number 21370056
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional biochemistry
Research InstitutionNara Institute of Science and Technology

Principal Investigator

ITOH Hiroshi  奈良先端科学技術大学院大学, バイオサイエンス研究科, 教授 (10183005)

Co-Investigator(Kenkyū-buntansha) MIZINO Norikazu  奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (90212232)
TAGO Kenji  奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (20306111)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2011: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2010: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2009: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Keywords細胞情報伝達機構 / 受容体 / Gタンパク質 / 細胞遊走制御 / モノクローナル抗体 / シグナル伝達 / Gタンパク質共役受容体 / 機能抗体 / オーファン受容体
Research Abstract

Adhesion G protein-coupled receptors(GPCRs) have a long N-terminal extracellular domain and a seven-transmembrane domain. Most of adhesion GPCRs are orphan receptors, and the activation and signal transduction mechanisms remain to be clarified. GPR56 and Latrophilin1 belong to adhesion GPCRs. We succeed in preparing the monoclonal antibody against human GPR56, which inhibits the glioma cell migration, and have constructed several mutants. Analysis using mutants showed that an extracellular domain of Latrophilin1 has an ability to inhibit the activation of Latrophilin1 transmembarane domain as well as the GPR56 transmembrane activation.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (72 results)

All 2012 2011 2010 2009 Other

All Journal Article (29 results) (of which Peer Reviewed: 27 results) Presentation (35 results) Book (3 results) Remarks (5 results)

  • [Journal Article] Phosphorylation of doublecortin by protein kinase A orchestrates microtubule and actin dynamics to promote neuronal progenitor cell migration2012

    • Author(s)
      Toriyama M, Mizuno N, Fukami T, Iguchi T, Toriyama M, Tago K, Itoh H
    • Journal Title

      J Biol Chem

      Volume: 287 Pages: 12691-12702

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-inflammatory activity of structurally related flavonoids, Apigenin, Luteolin and Fisetin2011

    • Author(s)
      Funakoshi-Tago M, Nakamura K, Tago K, Mashino T, Kasahara T
    • Journal Title

      Int Immunopharmacol

      Volume: 11 Pages: 1150-1159

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Akt activation through the phosphorylation of erythropoietin receptor at tyrosine 479 is required for myeloproliferative disorder-associated JAK2 V617F mutant-induced cellular transformation2011

    • Author(s)
      Kamishimoto J, Tago K, Kasahara T, Funakoshi-Tago M
    • Journal Title

      Cell Signal

      Volume: 23 Pages: 849-856

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aurora kinase A critically contributes to the resistance to anti-cancer drug cisplatin in JAK2 V617F mutant-induced transformed cells2011

    • Author(s)
      Sumi K, Tago K, Kasahara T, Funakoshi-Tago M
    • Journal Title

      FEBS Lett

      Volume: 585 Pages: 1884-1890

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sutherland LC, Brachmann RK. p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM52011

    • Author(s)
      Kobayashi T, Ishida J, Musashi M, Ota S, Yoshida T, Shimizu Y, Chuma M, Kawakami H, Asaka M, Tanaka J, Imamura M, Kobayashi M, Itoh H, Edamatsu H
    • Journal Title

      Int J Cancer

      Volume: 126 Pages: 304-318

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-inflammatory activity of structurally related flavonoids, Apigenin, Luteolin and Fisetin2011

    • Author(s)
      Funakoshi-Tago M., et al
    • Journal Title

      Int.Immunopharmacol.

      Volume: 11 Issue: 9 Pages: 1150-1159

    • DOI

      10.1016/j.intimp.2011.03.012

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Akt activation through the phosphorylation of erythropoietin receptor at tyrosine 479 is required for myeloproliferative disorder-associated JAK2 V617F mutant-induced cellular transformation2011

    • Author(s)
      Kamishimoto J, et al
    • Journal Title

      Cell.Signal.

      Volume: 23 Issue: 5 Pages: 849-856

    • DOI

      10.1016/j.cellsig.2011.01.009

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Akt activation through the phosphorylation of erythropoietin receptor at tyrosine 479 is required for myeloproliferative disorder-associated JAK2 V617F mutant-induced cellular transformation2011

    • Author(s)
      Jun Kamishimoto
    • Journal Title

      Cellular Signalling

      Volume: 23 Pages: 849-856

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM52011

    • Author(s)
      Takahiko Kobayashi
    • Journal Title

      Int.J.Cancer

      Volume: 128 Pages: 304-318

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ric-8B stabilizes the alpha subunit of stimulatory G protein by inhibiting its ubiquitination2010

    • Author(s)
      Nagai Y, Nishimura A, Tago K, Mizuno N, Itoh H
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 11114-11120

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] κB-Ras is a nuclear-cytoplasmic small GTPase that inhibits the NF-kB activation through the suppression of transcriptional activation of p65/RelA2010

    • Author(s)
      Tago K, Funakoshi-Tago M, Sakinawa M, Mizuno N, Itoh H
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 30622-30633

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule2010

    • Author(s)
      Nishimura A, Kitano K, Takasaki J, Taniguchi M, Mizuno N, Tago K, Hakoshima T, Itoh H
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 107 Pages: 13666-13671

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gタンパク質シグナルを調節する新規プローブ2010

    • Author(s)
      西村明幸、伊東広
    • Journal Title

      細胞

      Volume: 42 Pages: 92-95

    • Related Report
      2011 Final Research Report
  • [Journal Article] Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule2010

    • Author(s)
      Akiyuki Nishimura
    • Journal Title

      Proc.Natl.Acad.Sci.USA

      Volume: 107 Pages: 13666-13671

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] kB-Ras is a nuclear-cytoplasmic small GTPase that inhibits the NF-kB activation through the suppression of transcriptional activation of p65/RelA2010

    • Author(s)
      Kenji Tago
    • Journal Title

      J.Biol.Chem.

      Volume: 285 Pages: 30622-30633

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ric-8B stabilizes the alpha subunit of stimulatory G protein by inhibiting its ubiquitination2010

    • Author(s)
      Yusuke Nagai
    • Journal Title

      J.Biol.Chem. 285

      Pages: 11114-11120

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism and role of high density lipoprotein-induced activation of AMP-activatied protein kinase in endothelial cells2010

    • Author(s)
      Takao Kimura
    • Journal Title

      J.Biol.Chem. 285

      Pages: 4387-4397

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM52010

    • Author(s)
      Takahiko Kobayashi
    • Journal Title

      Int.J.Cancer 127(In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gタンパク質シグナルを調節する新規プローブ2010

    • Author(s)
      西村明幸
    • Journal Title

      細胞 42

      Pages: 92-95

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Licochalcone A potently inhibits TNFa-induced NF-kB activation through the direct inhibition of IKK activation2009

    • Author(s)
      Funakoshi-Tago M, Tanabe S, Tago K, Itoh H, Mashino T, Sonoda Y, Kasahara T
    • Journal Title

      Mol Pharmacol

      Volume: 76 Pages: 745-753

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The polycythemia vera-associated Jak2 V617F mutant induces tumorigenesis in nude mice2009

    • Author(s)
      Abe M, Funakoshi-Tago M, Tago K, Kamishimoto J, Aizu-Yokota E, Sonoda Y, Kasahara T
    • Journal Title

      Int Immunopharmacol

      Volume: 9 Pages: 870-877

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] G-protein signalling negatively regulates the stability of aryl hydrocarbon receptor2009

    • Author(s)
      Nakata A, Urano D, Fujii-Kuriyama Y, Mizuno N, Tago K, Itoh H
    • Journal Title

      EMBO reports

      Volume: 10 Pages: 622-628

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Licochalcone A significantly suppresses LPS signaling pathway through the inhibition of NF-κB p65 phosphorylation at serine 2762009

    • Author(s)
      Furusawa J, Funakoshi-Tago M, Tago K, Mashino T, Inoue H, Sonoda Y, Kasahara T
    • Journal Title

      Cell Signal

      Volume: 10 Pages: 778-785

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The acute lymphoblastic leukemia-associated JAK2 L611S mutant induces tumorigenesis in nude mice2009

    • Author(s)
      Funakoshi-Tago M, Tago K, Sumi K, Abe M, Aizu-Yokota E, Oshio T, Sonoda Y & Kasahara T
    • Journal Title

      J Biol Chem

      Volume: 284 Pages: 12680-12690

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glycyrrhiza inflata-derived chalcones, Licochalcone A, Licochalcone B and Licochalcone D, inhibit phosphorylation of NF-kB p65 in LPS signaling pathway2009

    • Author(s)
      Furusawa J, Funakoshi-Tago M, Mashino T, Tago K, Inoue H, Sonoda Y, Kasahara T
    • Journal Title

      Int Immunopharmacol

      Volume: 9 Pages: 499-507

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functions and regulatory mechanisms of Gq-signaling pathways2009

    • Author(s)
      Mizuno N & Itoh H
    • Journal Title

      Neurosignals

      Volume: 17 Pages: 42-54

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Licochalcone A potently inhibits TNFα-induced NF-kB activation through the direct inhibition of IKK activation2009

    • Author(s)
      Megumi Funakoshi-Tago
    • Journal Title

      Mol.Pharmacol. 76

      Pages: 745-753

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] G-protein signalling negatively regulates the stability of aryl hydrocarbon receptor2009

    • Author(s)
      Asuka Nakata
    • Journal Title

      EMBO reports 10

      Pages: 622-628

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functions and regulatory mechanisms of Gq-signaling pathways2009

    • Author(s)
      Norikazu Mizuno
    • Journal Title

      Neurosignals 17

      Pages: 42-54

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Functional involvement of an atypical nuclear-cytoplasmic small GTPas kB-Ras in oncogenic signaling pathway2011

    • Author(s)
      Tago K, Funakoshi-Tago M, Fukao Y, Sugiyama N, Tomita M, Mizuno N, Itoh H
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-16
    • Related Report
      2011 Final Research Report
  • [Presentation] N-terminal fragment of Latrophilin1 negatively regulates the adheison GPCR-induced signals2011

    • Author(s)
      Sasai N, Jyunkyu Kang, Ota S, Tago K, Mizuno N, Itoh H
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Involvement of Ric-8 in the Gαq-induced supression of Gs signaling2011

    • Author(s)
      Riris Jenie, Nishimura M, Tago K, Mizuno N, Itoh H
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Analysis of non-receptor type of G protein regulator Ric-8 involved in Drosophila gastrulation2011

    • Author(s)
      Takami K, Kanesaki T, Nishimura A, Nagai Y, Tago K, Mizuno N, Fuse N, Itoh H
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Doublecortin orchestrates microtubule and actin dynamics to promote neuronal progenitor cell migration in a manner dependent on phosphorylation by PKA2011

    • Author(s)
      鳥山真奈美, 多胡憲治, 水野憲一, 伊東広
    • Organizer
      2011 Annual meeting, ASCB
    • Place of Presentation
      USA.
    • Year and Date
      2011-12-04
    • Related Report
      2011 Final Research Report
  • [Presentation] Functional involvement of an atypical nuclear-cytoplasmic small GTPase kB-Ras in oncogenic signaling pathway2011

    • Author(s)
      多胡憲治
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-12-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Glycosylation of GPR56 extracellular domain affects on the signaling and the GPS cleavage2011

    • Author(s)
      太田茂之
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-12-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] N-terminal fragment of Latrophilinl negatively regulates the adhesion GPCR-induced signals2011

    • Author(s)
      佐々井直人
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-12-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 微小菅結合タンパク質doublecortinのPKAによるリン酸化を介した新規アクチン骨格制御2011

    • Author(s)
      鳥山真奈美, 猪口徳一, 深見岳史, 多胡憲治, 水野憲一, 伊東広
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Gタンパク質シグナルにより制御されるSUMO化とその分子機構の解析2011

    • Author(s)
      多胡憲治, 多胡めぐみ, Chiocca Susannna, 水野憲一, 伊東広
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Gタンパク質シグナルにより制御されるSUMO化とその分子機構の解析2011

    • Author(s)
      多胡憲治
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      京都市
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] New insight into the regulatory mechanism of G protein signaling2011

    • Author(s)
      伊東広
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-22
    • Related Report
      2011 Final Research Report
  • [Presentation] New insight into the regulatory mechanism of G protein signaling2011

    • Author(s)
      伊東広
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      京都市
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] Gs-PKAシグナルによる微小管結合タンパク質doublecortinの新規機能の獲得2011

    • Author(s)
      鳥山真奈美, 水野憲一, 多胡憲治, 伊東広
    • Organizer
      第58回日本生化学会近畿支部例会
    • Place of Presentation
      大阪
    • Year and Date
      2011-05-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Multi-regulation of neuronal progenitor migration by G protein signaling2011

    • Author(s)
      Mizuno N
    • Organizer
      American Society for Neurochemistry 42nd Annual Meeting
    • Place of Presentation
      St. Louis USA
    • Year and Date
      2011-03-22
    • Related Report
      2011 Final Research Report
  • [Presentation] Multi-regulation of neuronal progenitor migration by G protein signaling2011

    • Author(s)
      水野憲一
    • Organizer
      American Society for Neurochemistry 42nd Annual Meeting
    • Place of Presentation
      St.Louis, USA
    • Year and Date
      2011-03-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Phosphorylation of doublecortin by G protein-PKA signaling regulates neuronal progenitor cell migration2011

    • Author(s)
      Toriyama M, Mizuno N, Tago K, Itoh H
    • Organizer
      American Society for Neurochemistry 42nd Annual Meeting
    • Place of Presentation
      St. Louis USA
    • Year and Date
      2011-03-20
    • Related Report
      2011 Final Research Report
  • [Presentation] Phosphorylation of doublecortin by G protein-PKA signaling regulates neuronal progenitor cell migration2011

    • Author(s)
      鳥山真奈美
    • Organizer
      American Society for Neurochemistry 42nd Annual Meeting
    • Place of Presentation
      St.Louis, USA
    • Year and Date
      2011-03-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Gタンパク質シグナル制御機構の新しい展開2010

    • Author(s)
      伊東広
    • Organizer
      第2回膜生物学グローバルCOE students-organized symposium
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 大脳皮質形成における神経前駆細胞移動のG蛋白質シグナルによる多重制御機構2010

    • Author(s)
      水野憲一, 鳥山真奈美, 多胡憲治, 伊東広
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会(BMB2010)
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
    • Related Report
      2011 Final Research Report
  • [Presentation] 大脳皮質形成における神経前駆細胞移動のG蛋白質シグナルによる多重制御機構2010

    • Author(s)
      水野憲一
    • Organizer
      第33回日本分子生物学会年会第83回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Doublecortinのリン酸化を介したGs-PKAシグナルによる神経前駆細胞の遊走促進2010

    • Author(s)
      鳥山真奈美
    • Organizer
      第33回日本分子生物学会年会第83回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Chemoprevention targeted on signal transduction2010

    • Author(s)
      Itoh H
    • Organizer
      International seminar on Chemoprevention for Health and Beauty
    • Place of Presentation
      Yogyakarta Indonesia
    • Year and Date
      2010-10-09
    • Related Report
      2011 Final Research Report
  • [Presentation] Chemoprevention Targeted on Signal Transduction2010

    • Author(s)
      伊東広
    • Organizer
      The International syposium on Chemoprevention for Health and Beauty
    • Place of Presentation
      Yogyakarta, Indonesia
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Structural basis of a novel targeting site for the specific inhibition of heterotrimeric G proteins2009

    • Author(s)
      西村明幸, 北野健, 高崎淳, 谷口昌要, 水野憲一, 多胡憲治, 箱嶋敏雄, 伊東広
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-09
    • Related Report
      2011 Final Research Report
  • [Presentation] Structural basis of a novel targeting site for the specific inhibition of heterotrimeric G proteins2009

    • Author(s)
      西村明幸
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      神奈川
    • Year and Date
      2009-12-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Ric-8B accelerates Gs signaling through the stabilization of the α subunit of stimulatory G protein2009

    • Author(s)
      永井裕介
    • Organizer
      The American Society for Cell Biology 49th annual meeting
    • Place of Presentation
      San Diego, CA
    • Year and Date
      2009-12-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] Ric-8B accelerates Gs signaling through the stabilization of theαsubunit of stimulatory G protein2009

    • Author(s)
      Nagai Y, Nishimura A, Tago K, Mizuno N, Itoh H
    • Organizer
      The American Society for Cell Biology 49th annual meeting
    • Place of Presentation
      San Diego USA
    • Year and Date
      2009-12-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 三量体Gタンパク質Gαsのユビキチン化はRic-8Bとの結合により抑制される2009

    • Author(s)
      永井裕介, 西村明幸, 多胡憲治, 水野憲一, 伊東広
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-24
    • Related Report
      2011 Final Research Report
  • [Presentation] 三量体Gタンパク質Gαsのユビキチン化はRic-8Bとの結合により抑制される2009

    • Author(s)
      永井裕介
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      兵庫
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Gタンパク質シグナルを調節する新規分子の作用2009

    • Author(s)
      伊東広
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-23
    • Related Report
      2011 Final Research Report
  • [Presentation] Gタンパク質シグナルを調節する新規分子の作用2009

    • Author(s)
      伊東広
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      兵庫
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Gタンパク質シグナルによるdoublecortinのリン酸化と細胞遊走の解析2009

    • Author(s)
      吉田真奈美, 水野憲一, 多胡憲治, 伊東広
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-22
    • Related Report
      2011 Final Research Report
  • [Presentation] Gタンパク質シグナルによるdoublecortinのリン酸化と細胞遊走の解析2009

    • Author(s)
      吉田真奈美
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      兵庫
    • Year and Date
      2009-10-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 3量体Gタンパク質を標的とした薬剤の作用機構2009

    • Author(s)
      伊東広
    • Organizer
      第9回日本蛋白質科学会年会
    • Place of Presentation
      熊本
    • Year and Date
      2009-06-22
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Book] Encyclopedia of Signaling Molecules Springer2012

    • Author(s)
      Urano D, Itoh H
    • Publisher
      P-Rex in press
    • Related Report
      2011 Final Research Report
  • [Book] Signal transduction mediated through adhesion-GPCRs. Adhesion-GPCRs : Structure to Function Landes Bioscience2010

    • Author(s)
      Mizuno N and Itoh H
    • Related Report
      2011 Final Research Report
  • [Book] Adhesion GPCRs : Structure to Function2010

    • Author(s)
      Norikazu Mizuno
    • Total Pages
      111
    • Publisher
      Landes Bioscience
    • Related Report
      2010 Annual Research Report 2009 Annual Research Report
  • [Remarks] ホームページアドレス

    • URL

      http://bsw3.naist.jp/itoh/home/index.html

    • Related Report
      2011 Final Research Report
  • [Remarks] Nishimura et al. PNAS(2010) 107, 13666の発表内容が日本経済新聞、朝日新聞、読売新聞、奈良新聞、日刊工業新聞、日本経済産業新聞、「KIPPO NEWS」(月刊英文・和文関西国際情報発信誌)に取り上げられる[報道関連情報]

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://bsw3.naist.jp/itoh/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://bsw3.naist.jp/itoh/home/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://bsw3.naist.jp/itoh/home/index.html

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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